The invention discloses a pre-stress constraint concrete structure and a manufacture method thereof. When the four categories of concrete structures of a concrete frame structure, a concrete frame-tube structure, a concrete frame-shear structure or a concrete truss-tube structure is manufactured, pre-stress ribs which are in parallel with axle lines of main beams are arranged in all main beams, thus each pre-stress rib is enabled to penetrate through all the main beams in the same axle line on the same plane, meanwhile constraint reinforced ribs are configured in the main beams, so that the main beams are enabled to form constraint beams, when the concrete strength of the poured main beams in a same layer reaches designed strength, the pre-stress ribs of all the main ribs in the same layer are subjected to tensioning and anchoring, the pre-stress ribs are all enabled to be in a tensioning state, the main beams on all different horizontal surfaces of the concrete structure are manufactured according to the method, and the pre-stress constraint concrete structure is manufactured and obtained. The pre-stress constraint concrete structure has the advantages of high bearing force in an overall structure, excellent rigidity, remarkable performance of seismic resistance, a small component cross section and lower constructional cost.