The invention relates to a multi-grade high-efficiency low-nitrogen combustion method and a multi-grade high-efficiency low-nitrogen combustion system for a circulating fluidized bed boiler. According to the method, combustion air enters a furnace hearth through corresponding inlets respectively to divide the furnace hearth into a less oxygen combustion area, a reduction area, an oxidative combustion area and a burning-out area; the excess air coefficients of each area are respectively controlled to be 0.55-0.95, 0.75-1.15, 1.05-1.25 and greater than or equal to 1.20, so that a fuel is dispersed and uniformly combusted in the furnace hearth. The burning-out area is positioned above the upper boundary of the oxidative combustion area and has the effective height which is not less than 2.5 times of a flue gas average velocity value in the area, the upper boundaries of the remaining areas are respectively 2.0-5.5 meters, 4.5-9.0 meters and 8.0-12.0 meters away from the surface of an air distribution plate. The system which is applicable to the method comprises the furnace hearth, the air distribution plate, a primary air inlet and a secondary air inlet; at least one layer of reducing air inlet, at least one layer of oxidative air inlet and at least one layer of burning-out air inlet are respectively formed in at least one wall of the corresponding area of the furnace hearth. By virtue of the method and the system, the generation capacity of nitrogen oxides can be reduced, and high-efficiency combustion of the fuel can also be realized.