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Mechanisms for control knobs and other interface devices

Mechanisms for a control knob or other interface device providing additional degrees of freedom for the knob. One embodiment provides a rotatable knob moveable also in lateral plane approximately perpendicular to the axis of rotation. A mechanism providing the lateral motion can include agate member and a plunger member that engages grooves in the gate member. A rotational sensor detects a rotational position and a lateral sensor can detect a lateral position of the knob. Another embodiment provides an actuator that includes a shaft that is coaxial with the axis of rotation and which can be moved linearly along the axis of rotation with respect to actuator housing to accommodate linear motion of the knob. In another embodiment, a gear assembly including two interlocked gears is provided to transmit rotational motion from the knob to the sensor, and the interlocked gears translate with respect to each other when the knob is translate along the rotational axis.
Owner:IMMERSION CORPORATION

Dendrimer based modular platforms

The present invention relates to novel therapeutic and diagnostic dendrimer based modular platforms (e.g., drug delivery platforms). In particular, the dendrimer based modular platforms are configured such that two or more dendrimers (e.g., PAMAM dendrimers) are coupled together (e.g., via a cycloaddition reaction) wherein each of the coupled dendrimers is functionalized (e.g., functionalized for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy). In some embodiments, the present invention provides dendrimer based modular platforms having coupled dendrimers (e.g., two or more coupled dendrimers) wherein each dendrimer is conjugated to one or more functional groups (e.g., therapeutic agent, imaging agent, targeting agent, triggering agent) (e.g., for specific targeting and/or therapeutic use of the dendrimer based modular platform). In some embodiments, the functional groups are conjugated to the dendrimers via a linker and/or a triggering agent. In addition, the present invention is directed to methods of synthesizing dendrimer based modular platforms, compositions comprising the dendrimer based modular platforms, as well as systems and methods utilizing the dendrimer based modular platforms (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, etc.)).
Owner:RGT UNIV OF MICHIGAN
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