The present invention relates to a composition for preventing or treating a
muscle disorder, which includes a chrysanthemum extract or 3,5-
dicaffeoylquinic acid as an
active ingredient, and specifically, it may be used to reduce
mRNA expression of atrogin-1 and MuRF1, which are main biomarkers involved in
muscle protein degradation and increase
mRNA expression of the mTOR
protein, which is a main biomarker involved in
muscle protein formation, and myogenin and MyoD, which are biomarkers related to muscle differentiation, thereby reducing
muscle loss, and thus the chrysanthemum extract or 3,5-
dicaffeoylquinic acid can be used in prevention and treatment of a
muscle disorder, or improvement in muscle function. In addition, the chrysanthemum extract or 3,5-
dicaffeoylquinic acid increases the activity of SIRT1 and PGC-1α, which are the main biomarkers involved in
exercise performance, thereby excellently enhancing
exercise performance. In addition, the present invention is a
natural substance and may be safely used without a
side effect, and therefore may be used as a medication, food or a cosmetic.