40results about How to "Enhance pharmacodynamic activity" patented technology

The invention relates to a polysaccharide-liposome which is prepared from raw materials such as polysaccharide, phosphatides, cholesterol, surface active agent and polyethyleneglycol. The liposome has smaller grain diameter and higher envelop rate. The invention particularly relates to a lentinan liposome and provides a preparation method of the polysaccharide-liposome and a purpose of the polysaccharide-liposome used for preparing drugs with the functions of antitumor or immunity adjustment.

The invention relates to a traditional Tibetan medicine composition for treating nervous system diseases and a preparation method thereof. The traditional Tibetan medicine composition comprises an ethanol extract, a volatile oil beta-cyclodextrin inclusion compound, a water extract, an acid hydrolyte and fine medicinal material powder, and a conventional auxiliary material can be added to prepare a common pharmaceutical preparation, especially microcrystalline cellulose is added to prepare a micro-pill preparation. The invention discovers that the acid hydrolyte in the composition achieves very significant contribution to anti-inflammatory and pain-easing medicaments, the drug effect is improved along with the increase of the dosage of the acid hydrolyte, but when the dosage reaches 50 weight parts, the drug effect shows a relative saturation platform stage. The volatile oil which is obtained by adopting supercritical extraction is subjected to beta-cyclodextrin inclusion, so that the yield and stability of the volatile oil are improved, and insoluble medicinal materials are subjected to superfine crushing so as to facilitate preparation. According to the preparation method, the process parameters of various preparations of traditional Tibetan medicine micro-pills are optimized.

The invention provides a pharmaceutical composition for treating liver fibrosis. The pharmaceutical composition is a preparation prepared from the following raw medicines in parts by weight: 0-16 parts of American cockroach, 3-24 parts of turtle shell, 4-30 parts of astragalus membranaceus and 3-60 parts of lysimachia christinae hance. The invention also provides a preparation method and an application of the pharmaceutical composition. After being combined in use, the medicines play a synergistic interaction effect, so that the pharmaceutical activity is remarkably increased, the ALT level and the AST level of plasma of a body with liver fibrosis can be reduced, the Hyp level and the Collagen I level of liver tissues can be reduced, the liver fibrosis can be effectively treated and a new choice is provided for clinical medication.

The invention belongs to the technical field of pharmacies, relates to a traditional Chinese medicine raw material extract and an extraction method thereof, particularly relates to a ginkgo leaf extract and an extraction method thereof. The extraction method for the extract comprises the following steps: smashing dried ginkgo leaves with a smashing machine; and performing reflux extraction on thesmashed ginkgo leaves by ethanol to obtain the ginkgo leaf extract. By adopting the extraction method, the effective component content is controlled effectively, the medicinal effect of the medicine is improved.

The invention provides an anti-cancer pellet. The anti-cancer pellet is a preparation which is prepared from the following materials and the auxiliary material in parts by weight: 1 part of material medicines including rheum emodin, sophoridine and sophocarpidine in a ratio of (20-100):(250-2000):(500-2500) and 0.5-2 parts of auxiliary material including diluents. The invention further provides an anti-cancer colonic targeting agent and a preparation method of each preparation. According to the anti-cancer pharmaceutical composition, rheum emodin, sophoridine and sophocarpidine are selected from a plurality of anti-tumor natural medicines and reasonably combined, so that a synergistic interaction effect is brought into play, anti-tumor activity of single medicine is remarkably improved; meanwhile, the dispensed medicines are prepared into the colonic targeting agent and each medicine generates effects to colonic infection focuses, so that not only pesticide effect activity can be improved, but also side effects of digestive systems including a stomach, small intestines and the like can be reduced, and therefore, novel medicine choices are provided for treating the colorectal cancer.

The invention relates to the field of cordyceps sinensis, and particularly discloses a method for improving the quality of fermented cordyceps sinensis mycelia, which comprises the following steps: S1, slant culture, S2, shake-flask culture, S3, seed amplification culture, S4, fermentation culture, and S5, fermentation zone reculture. Components such as vitamins, jerusalem artichoke, folic acid, nucleoside precursors, brown algae liquid, cicada pollen and vegetable oil are added on the basis of an original fermentation culture medium; in addition, corn flour and silkworm chrysalis meal in the culture medium are subjected to enzymolysis in advance through a hydrolysis method; therefore, the content of nucleoside substances, D-mannitol, polysaccharide, fatty acid, ergosterol, gamma-aminobutyric acid and other active ingredients in fermented Hirsutella sinensis mycelia is increased; and the drug effect of artificially fermented cordyceps sinensis is enhanced.

The invention provides a dinucleotide prodrug being novel in structure, and further provides a preparation method of a dinucleotide prodrug, and an application of the dinucleotide prodrug to preparation of drugs for treating viral infection, particularly to drugs for treating hepatitis B virus (HBV) infection and HBV relevant liver diseases. The dinucleotide prodrug compound can notably improve the target properties in the liver, can improve the accumulation capacity in liver locations, can further effectively improve the drug effect and activity, can reduce the use dosage, and can further reduce the toxic and side effects. Experimentation on animals indicates that after being absorbed in bodies, the dinucleotide prodrug compound can be rapidly distributed in extravascular tissue from a central compartment, and can be concentrated massively in the liver, and low dosage of the dinucleotide prodrug compound can be observed in other tissue. The dinucleotide prodrug compound provided by the invention also has the advantages of being high in biological availability when being taken orally, good in stability in the stomach, and long in life in vivo.

The invention discloses a preparation method of a valeriana offcinalis L. total alkaloid extract. The method comprises the following three steps: extracting valeriana offcinalis L. with water and / oran ethanol solution containing 0.1-0.5% hydrochloric acid, extracting the extract with an organic solvent, and finally purifying the extraction part with macroporous adsorption resin. The high-concentration total alkaloid extract can be separated and purified from the valeriana offcinalis L. medicinal material, and the prepared extract has very high pharmacodynamic activity.

The invention provides a compound containing a dinucleotide structure, which has a novel structure. The invention also provides a preparation method of the compound containing the dinucleotide structure, and an application of the compound in preparation of drugs for treating virus infection, especially hepatitis B virus (HBV) infection and liver diseases related to HBV. In another aspect, the invention also relates to a dinucleotide structure-containing compound with a pure optical isomer obtained by separation. The compounds containing the dinucleotide structures provided by the invention have the advantages of remarkable anti-HBV DNA activity, low dosage, high safety and the like, and also have good pharmacokinetic characteristics.

The invention discloses application of a sesquiterpene glycoside monomeric compound in preparation of lipid-lowering drugs or health care products. The chemical formula of the sesquiterpene glycoside monomeric compound is nerolidol-3-O-alpha-L-rhaminopyranosyl- (1 to 2)-[alpha-L-rhaminopyranosyl-(1 to 6)]-beta-D-glucopyranoside.

The invention provides a medicine composition for improving sleep. The medicine composition is a preparation prepared from the following active pharmaceutical ingredients in parts by weight: 3-90 parts of spina date seed, 3-90 parts of tuber fleeceflower stem, 3-90 parts of Indian bread with pine, 3-90 parts of blighted wheat, 3-90 parts of common anemarrhena rhizome and 3-90 parts of thinleaf milkwort root-bark. The invention also provides a preparation method and application of the composition. After the medicines are used in a combined manner, the synergistic effects are exerted, the pharmacological activities of the medicine composition are obviously improved, and a new choice is provided for clinical medication.

The invention discloses a preparing method for medicine for treating a peptic ulcer. The preparing method comprises the following operation steps that firstly, raw medicine materials including, by weight, 17-23 parts of ginseng, 7-12 parts of poria cocos, 5-9 parts of oriental wormwood, 5-9 parts of pogostemon cablin, 5-9 parts of raw malt, 3-7 parts of mangnolia officinalis, 3-7 parts of perilla leaves and 3-7 parts of caulis perllae are weighed; secondly, ginseng is taken and ground into power for use, the other medicine materials except ginseng are taken, added with 55-95% v / v ethanol for extraction and then filtered, alcohol extract is obtained for use, filter residues are added with water again to be decocted, the alcohol extract and the water decoction are combined and then concentrated, ginseng powder and auxiliary materials acceptable medically are then added, and the medicine is obtained. The medicine is prepared from few medicine materials through specific dosage proportions, can effectively treat a gastric ulcer, a duodenal ulcer and stomach mucosa erosion, and provides a new pharmacy choice for clinically treating the peptic ulcer. Meanwhile, through pharmacodynamic tests, the modes of alcohol and water dual extraction and ginseng used as powder in the medicine are adopted, pharmacodynamic activity can be improved, and medicine material resources can be easily used economically.

A pharmaceutical composition for treating upper respiratory tract infection, which is a preparation prepared from the following raw materials by weight: 30-60 parts of bamboo leeches, 5-15 parts of honeysuckle, 15-25 parts of Houttuynia cordata, and 2 parts of licorice ~10 servings. After the combined use of the various herbs, the invention exerts a synergistic effect, and its pharmacodynamic activity is significantly improved, thereby providing a new choice for clinical medication.

The present invention provides a preparation method of a dinucleotide prodrug with a novel structure, and an application of the dinucleotide prodrug in preparing medicines for treating viral infection, particularly hepatitis B virus (HBV) infection and liver diseases associated with the HBV. With the dinucleoside precursor compounds, the targeting ability in the liver is significantly improved, the accumulation ability in the liver part is improved also, further the pharmacological activity is effectively improved, the use dosage is also reduced, and thus the toxic and side effects are reduced. The dinucleotide prodrug is high in oral bioavailability, and has good stability in the stomach and long half-life period in body. The provided preparation method of the dinucleotide prodrug is simple, purification is not needed after completion of reactions in multiple steps, a next reaction can be directly conducted, and operation steps are simplified.

The invention relates to a compound bactericide containing propiconazole and a preparation method thereof, the compound bactericide containing the propiconazole is prepared from the following raw materials in parts by weight: the propiconazole, 1,2-bis (3-methoxyl carbon-2-thioureido) benzene, polyethylene glycol 200, sodium dodecyl benzene sulfonate, modified white carbon black, a high-carbon alcohol fatty acid ester compound, propylene glycol, sodium silicate and plant ash; the compound bactericide containing the propiconazole is prepared from compounding the propiconazole and the 1, 2-(3-methoxy carbon-2-thioureido) benzene which are complementary in drug effects and high in drug effect activity, and the compound bactericide containing the propiconazole can be directly applied to leaves, root and stems of crops, and has the characteristics of being high in adhesive force, lasting in sterilization effect and wide in sterilization range.

The invention relates to a polysaccharide-liposome which is prepared from raw materials such as polysaccharide, phosphatides, cholesterol, surface active agent and polyethyleneglycol. The liposome has smaller grain diameter and higher envelop rate. The invention particularly relates to a lentinan liposome and provides a preparation method of the polysaccharide-liposome and a purpose of the polysaccharide-liposome used for preparing drugs with the functions of antitumor or immunity adjustment.

The invention discloses an application of matricarin in preparation of drugs for treating or preventing hyperlipidemia or health care products for improving hyperlipidemia. The invention provides the pharmacodynamic activity of the matricarin in the aspects of reducing blood fat, treating lipid accumulation and improving lipid metabolism disorder, and develops the new application of the matricarin in the aspect of medicine. Meanwhile, the plant source of the matricarin is wide, and the medicine source of hyperlipidemia is expanded.

The invention discloses a granule for treating a peptic ulcer. The granule is prepared from the following raw and auxiliary materials in parts by weight: 7-13 parts of rhizoma atractylodis macrocephalae, 7-13 parts of poria cocos, 7-13 parts of phaseolus calcaratus, 5-10 parts of astragalus membranaceus, 5-10 parts of herba artemisiae scopariae, 5-10 parts of dandelion, 3-7 parts of semen armeniacae amarum, 3-7 parts of platycodon grandiflorum, 3-7 parts of pogostemon cablin, 2-3 parts of rhizoma zingiberis and 2-3 parts of ginseng. Through specific usage and ratio, the medicines are relatively few; a gastric ulcer, a duodenal ulcer and erosive gastritis can be effectively treated; a new medication choice is provided for clinical treatment of the peptic ulcer; meanwhile, through a pharmacodynamic test, the pharmacodynamic activity can be improved by using a manner that alcohol and water double extraction is adopted and ginseng powder is taken as a raw material; and economical utilization of medicinal material resources is facilitated.

The invention provides a pharmaceutical composition for treating chronic pharyngitis, which is a preparation prepared from raw materials in the following weight proportions: 30-60 parts of bamboo leek, 5-15 parts of honeysuckle, 9-15 parts of Scrophulariaceae, Ophiopogon japonicus 6~12 parts. The invention also provides the preparation method and application of the pharmaceutical composition. After the combination of various medicines is used in the invention, the synergistic effect is exerted, and the efficacy and activity of the medicine are significantly improved, which provides a new choice for clinical medicine.

The invention relates to the technical field of medicines, in particular to a medicine product. The medicine product comprises a compound (a), or salt or ester or a solvent compound, which can be pharmaceutically accepted, of the compound (a), or stereoisomer of the compound (a), and one or more beta-lactam antibiotics or derivatives of the beta-lactam antibiotics, wherein the compound (a) has a structure shown in a formula (I) (please see the specifications for the formula (I)). Meanwhile, the invention further relates to application of the medicine product to preparation of medicines for treating and / or preventing bacterial infectious diseases, preferably, bacteria have medicine resistance caused by the beta-lactamase.

The invention discloses a traditional Chinese medicine powder for preventing and treating upper respiratory infection. The traditional Chinese medicine powder is mainly prepared from 10-14% of rhizomaatractylodis, 10-14% of chrysanthemum, 10-14% of mint, 10-14% of radix angelicae, 7-11% of agastache rugosus, 7-11% of anise, 4-8% of clove, 4-8% of acorus calamus, 4-8% of folium artemisiae argyi, 4-8% of pericarpium citri reticulatae, 4-8% of radix paeoniae alba and 2-6% of liquorice. The medicines are mixed and ground into the powder, the powder is sieved by a 80-150-mesh sieve, the sieved powder is subpackaged by medicine bags, and each bag contains 10-20g of the powder for later use at a normal temperature. According to the traditional Chinese medicine powder disclosed by the invention,after the medicines are combined and prepared into the powder, a synergistic effect is exerted, pharmacological activity is remarkably improved, a new choice is provided for clinical medication, and the traditional Chinese medicine powder is convenient to prepare, free of secondary processing, very convenient to use, good in absorption effect and good in curative effect.

The invention provides a pharmaceutical composition for treating liver fibrosis. The pharmaceutical composition is a preparation prepared from the following raw medicines in parts by weight: 0-16 parts of American cockroach, 3-24 parts of turtle shell, 4-30 parts of astragalus membranaceus and 3-60 parts of lysimachia christinae hance. The invention also provides a preparation method and an application of the pharmaceutical composition. After being combined in use, the medicines play a synergistic interaction effect, so that the pharmaceutical activity is remarkably increased, the ALT level and the AST level of plasma of a body with liver fibrosis can be reduced, the Hyp level and the Collagen I level of liver tissues can be reduced, the liver fibrosis can be effectively treated and a new choice is provided for clinical medication.

The invention discloses a preparation method of valerian root total alkaloid extract, which comprises extracting valerian root with water and / or an ethanol solution containing 0.1-0.5% hydrochloric acid, extracting the extract with an organic solvent, and finally extracting the extracted part Macroporous adsorption resin purification in three steps. The invention can separate and purify the high-concentration total alkaloid extract from the valerian medicinal material, and the prepared extract has high medicinal activity.

The invention relates to an application of a saussurea involucrata flavonoid composition in preparation of a pharmaceutical preparation for treating arthritis diseases, the saussurea involucrata flavonoid composition comprises four components, and the four components are rutin, myristyl ether, isoquercitrin and luteolin-7-o-glucoside respectively. A large number of animal experiments prove the pharmacodynamic activity of the flavonoid composition provided by the invention, the flavonoid composition can be used for preparing various clinically applied pain relieving and pain easing medicines and arthritis treatment medicines, and compared with a Chinese patent medicine preparation prepared by directly applying saussurea involucrata, the composition has the effects of high pharmacodynamic activity, small clinical dosage, quick response, low side effect and the like. The dosage form of the medicine can be conventional tablets or capsules, and some new dosage forms of the medicine with higher absorptivity or better storability can be prepared according to the characteristics of the medicine components.

A pharmaceutical composition for treating upper respiratory tract infection, which is a preparation prepared from raw materials in the following weight ratio: 7-60 parts of bamboo leek, 2-15 parts of honeysuckle, 3-25 parts of Houttuynia cordata, Tingli 2 to 10 parts of licorice, 2 to 10 parts of licorice. After the combination of various medicines is used in the invention, the synergistic effect is exerted, and the efficacy and activity of the medicine are significantly improved, which provides a new choice for clinical medicine.

The invention relates to a traditional Tibetan medicine composition for treating nervous system diseases and a preparation method thereof. The traditional Tibetan medicine composition comprises an ethanol extract, a volatile oil beta-cyclodextrin inclusion compound, a water extract, an acid hydrolyte and fine medicinal material powder, and a conventional auxiliary material can be added to prepare a common pharmaceutical preparation, especially microcrystalline cellulose is added to prepare a micro-pill preparation. The invention discovers that the acid hydrolyte in the composition achieves very significant contribution to anti-inflammatory and pain-easing medicaments, the drug effect is improved along with the increase of the dosage of the acid hydrolyte, but when the dosage reaches 50 weight parts, the drug effect shows a relative saturation platform stage. The volatile oil which is obtained by adopting supercritical extraction is subjected to beta-cyclodextrin inclusion, so that the yield and stability of the volatile oil are improved, and insoluble medicinal materials are subjected to superfine crushing so as to facilitate preparation. According to the preparation method, the process parameters of various preparations of traditional Tibetan medicine micro-pills are optimized.

The invention discloses a preparation method of compound isatis root electuary. The preparation method utilizes low-temperature boiling pressure reduction extraction on medicinal materials such as isatis root. Compared with the conventional extraction method, the preparation method improves an effective component recovery rate, delays a thermal degradation speed and prolongs an intermediate soup storage life and a final product validity period and improves activity of pharmacodynamics. The vacuum extraction method has a wide application prospect for heat sensitive component-containing medicinal material extraction.

The invention provides an American cockroach processed product fired with wheat brans. In the processed product, the content of polypeptide is above 30%, the content of total amino acids is above 10%, and the content of grease is within 10%. Researches reveal that the American cockroach processed product fried with the wheat brans is remarkably increased in content of effective components such as the total amino acids and the polypeptide, obviously reduced in content of liposoluble constituents and obviously improved in pharmaceutical activity, so that a new choice is provided for clinical medication.

The invention provides an anti-cancer pellet. The anti-cancer pellet is a preparation which is prepared from the following materials and the auxiliary material in parts by weight: 1 part of material medicines including rheum emodin, sophoridine and sophocarpidine in a ratio of (20-100):(250-2000):(500-2500) and 0.5-2 parts of auxiliary material including diluents. The invention further provides an anti-cancer colonic targeting agent and a preparation method of each preparation. According to the anti-cancer pharmaceutical composition, rheum emodin, sophoridine and sophocarpidine are selected from a plurality of anti-tumor natural medicines and reasonably combined, so that a synergistic interaction effect is brought into play, anti-tumor activity of single medicine is remarkably improved; meanwhile, the dispensed medicines are prepared into the colonic targeting agent and each medicine generates effects to colonic infection focuses, so that not only pesticide effect activity can be improved, but also side effects of digestive systems including a stomach, small intestines and the like can be reduced, and therefore, novel medicine choices are provided for treating the colorectal cancer.

The invention relates to an application of a saussurea involucrata flavonoid composition in preparation of a pain relieving and pain easing pharmaceutical preparation, the saussurea involucrata flavonoid composition comprises four components, and the four components are rutin, myristyl ether, isoquercitrin and luteolin-7-o-glucoside respectively. A large number of animal experiments prove the pharmacodynamic activity of the flavonoid composition provided by the invention, the flavonoid composition can be used for preparing various clinically applied pain relieving and pain easing medicines and arthritis treatment medicines, and compared with a Chinese patent medicine preparation prepared by directly applying saussurea involucrata, the composition has the effects of high pharmacodynamic activity, small clinical dosage, quick response, low side effect and the like. The dosage form of the medicine can be conventional tablets or capsules, and some new dosage forms of the medicine with higher absorptivity or better storability can be prepared according to the characteristics of the medicine components.