Anti-cancer pellet and colonic targeting agent

Abstract

The invention provides an anti-cancer pellet. The anti-cancer pellet is a preparation which is prepared from the following materials and the auxiliary material in parts by weight: 1 part of material medicines including rheum emodin, sophoridine and sophocarpidine in a ratio of (20-100):(250-2000):(500-2500) and 0.5-2 parts of auxiliary material including diluents. The invention further provides an anti-cancer colonic targeting agent and a preparation method of each preparation. According to the anti-cancer pharmaceutical composition, rheum emodin, sophoridine and sophocarpidine are selected from a plurality of anti-tumor natural medicines and reasonably combined, so that a synergistic interaction effect is brought into play, anti-tumor activity of single medicine is remarkably improved; meanwhile, the dispensed medicines are prepared into the colonic targeting agent and each medicine generates effects to colonic infection focuses, so that not only pesticide effect activity can be improved, but also side effects of digestive systems including a stomach, small intestines and the like can be reduced, and therefore, novel medicine choices are provided for treating the colorectal cancer.

Description

technical field [0001] The invention relates to an anticancer pellet and a colon targeting agent. Background technique [0002] Cancer, also known as malignant tumor (Malignant neoplasm), is a disease caused by the abnormal mechanism of controlling cell growth and proliferation. In addition to growing out of control, cancer cells can also locally invade the surrounding normal tissues and even transfer to other parts of the body through the internal circulatory system or lymphatic system. Common cancers include gastric cancer, colon cancer, liver cancer, nasopharyngeal cancer, lung cancer, and intracranial tumors. Among them, colon cancer (CC) refers to malignant tumors that occur in the cecum, ascending colon, transverse colon, descending colon, and sigmoid colon. In recent years, with the improvement of living standards and changes in living habits, the incidence of colon cancer in my country is also on the rise, ranking second only to gastric cancer among digestive tract...

AI Technical Summary

Problems solved by technology

However, there are not many traditional Chinese medicine preparations that can be clinically used to treat CC. Among the 5017 preparations contained in the "New National Chinese Patent Medicine", only Aidi Injection, Compound Mylabris Capsules, Kangaiping Pills, Xiaoaiping Tablets and Syrup, Zhemu Several Chinese patent medicines such as syrup have the effect of treating CC, and there are the following common problems: ①The drugs are all water, alcohol crude extracts or medicinal powders, the preparation level is low, and the quality controllability and stability are poor; ②Intravenous infusion or Taken orally, the drug cannot target cancer tissue, and the systemic or gastrointestinal adverse reactions are obvious; ③Widely used in the treatment of lung cancer, liver cancer, lymphoma, etc., lack of targeted treatment for CC

[0006] At present, OCTDS has developed a variety of colon-targeted drug delivery systems based on different principles, including the pH-dependent type prepared from pH-sensitive materials based on the gradually increasing pH value of the gastrointestinal tract; the time-lag type based on the constant transit time of the small intestine ; Based on the unique enzyme system produced by colonic bacteria, the enzyme-triggered type prepared from enzyme-degradable materials; in addition, there are studies on various drug release systems such as pressure-dependent type, organic acid-induced type, and pulse type.

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