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Traditional Tibetan medicine composition for treating nervous system diseases and preparation method thereof

A composition and white pulse disease technology, which is applied in the direction of drug combination, pharmaceutical formula, and medical raw materials derived from crustaceans, can solve the problems of long product disintegration time, cumbersome production process, and difficulty in meeting hygienic standards

Active Publication Date: 2015-09-30
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional preparation process of Ruyi Zhenbao pills is to mix all the raw materials into fine powders to make pills, which has many shortcomings, such as: cumbersome production process, not suitable for modern production, long disintegration time of the product, and difficulty in meeting hygienic standards, etc.
The patent "A Tibetan Medicine Ruyi Treasure Composition Preparation and Its Preparation Method" (CN: 102430090A) discloses a Ruyi Treasure Composition Preparation with the same formula and its preparation method. , water extract and fine powder of medicinal materials, but for crabs, buffalo horns, etc., only the method of directly crushing them into medicine

Method used

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  • Traditional Tibetan medicine composition for treating nervous system diseases and preparation method thereof
  • Traditional Tibetan medicine composition for treating nervous system diseases and preparation method thereof
  • Traditional Tibetan medicine composition for treating nervous system diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0059] Experimental example 1, alcohol extraction orthogonal test

[0060] In ethanol extraction, the main factors affecting the extraction effect are extraction time, extraction times, alcohol addition and ethanol concentration. Three levels are selected for each factor, and an orthogonal experiment of four factors and three levels is carried out to screen the optimal alcohol extraction process. See Table 1 for the design.

[0061] Table 1 Factor level table

[0062]

[0063]

[0064] Test method and results: Accurately weigh 3.75g of longan longan, 10g of sandalwood, 5g of black cumin, 41.25g of balsamic, 10g of galangal, 10g of woody, 10g of Tibetan woody, 12.5g of agarwood, 5g of clove, and 5g of nutmeg , cardamom 5g, grass fruit 3.75g, parsley 5g, cinnamon 6.25g, a total of 132.5g, after extracting the volatile oil, add 12.5g of safflower, 7.5g of cassia seed, 18.75g of short ear grass, 6.25g of ambrette seed, total 177.5g, with L 9 (3 4 ) Orthogonal table arran...

experiment example 2

[0073] Experimental example 2, water extraction orthogonal test

[0074] In water extraction, the factors that affect the extraction effect mainly include extraction time, extraction frequency and water addition. For each factor, three levels are selected, and an orthogonal test of three factors and three levels is carried out to screen the optimal water extraction process. See Table 4 for the design.

[0075] Table 4 Factor level table

[0076]

[0077] Accurately weigh 16.25g of myrobalan, 16.25g of emblica, and 12.5g of myrobalan (pitted), 45g in total, and use L 9 (3 4 ) Orthogonal table arrangement test for reflux extraction, filter the extract, filter, combine the extracts, measure the total volume, take 50ml, measure the yield of dry cream, take the extract, and measure the total polyphenol content.

[0078] For the screening index, the main evaluation index of the extraction process is the total polyphenol content, and the weight coefficient is set to 0.7, and th...

experiment example 3

[0086] Experimental example 3, volatile oil inclusion orthogonal test

[0087] In order to retain the volatile oil components as much as possible and ensure the efficacy, β-cyclodextrin was used to clathrate the volatile oil according to the preliminary test results. The ratio of β-CD to oil during inclusion (A), inclusion temperature (B), inclusion time (C) and β-CD:water (D) were investigated, and the factor levels are shown in Table 7.

[0088] Table 7 Factor level table

[0089]

[0090] Follow L9 (3 4 ) Orthogonal experiment table Arrange experiments, accurately weigh β-cyclodextrin, put it into a stoppered Erlenmeyer flask, add distilled water, heat in a boiling water bath to dissolve, lower to 40°C, and stir on a magnetic stirrer for 30 minutes. Accurately measure 2ml of volatile oil, dilute it with ethanol at a ratio of 1:1, drop the diluted volatile oil into the β-cyclodextrin solution with a dropper, stopper, and stir at constant temperature until the specified ...

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Abstract

The invention relates to a traditional Tibetan medicine composition for treating nervous system diseases and a preparation method thereof. The traditional Tibetan medicine composition comprises an ethanol extract, a volatile oil beta-cyclodextrin inclusion compound, a water extract, an acid hydrolyte and fine medicinal material powder, and a conventional auxiliary material can be added to prepare a common pharmaceutical preparation, especially microcrystalline cellulose is added to prepare a micro-pill preparation. The invention discovers that the acid hydrolyte in the composition achieves very significant contribution to anti-inflammatory and pain-easing medicaments, the drug effect is improved along with the increase of the dosage of the acid hydrolyte, but when the dosage reaches 50 weight parts, the drug effect shows a relative saturation platform stage. The volatile oil which is obtained by adopting supercritical extraction is subjected to beta-cyclodextrin inclusion, so that the yield and stability of the volatile oil are improved, and insoluble medicinal materials are subjected to superfine crushing so as to facilitate preparation. According to the preparation method, the process parameters of various preparations of traditional Tibetan medicine micro-pills are optimized.

Description

technical field [0001] The invention relates to a Tibetan medicine composition and a preparation method thereof, in particular to a Tibetan medicine composition for treating white pulse disease and a preparation method thereof. Background technique [0002] Ruyi Zhenbao Pill is a Tibetan prescription, which is the first choice for Tibetan medicine to treat white pulse disease. The prescription is found in the "Ministry of Health Drug Standards Tibetan Medicine Sub-volume". It is mainly used for distemper, old fever, white vein disease, numbness of limbs, paralysis, crooked mouth and eyes, confusion, arthralgia, gout, limb stiffness, and joint weakness. The traditional preparation process of Ruyi Zhenbao Pills is to make pills by mixing all raw medicinal materials into fine powder, which has many shortcomings, such as: cumbersome production process, not suitable for modern production, long disintegration time of the product, and difficulty in meeting hygienic standards. The ...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61K47/48A61K9/16A61P31/00A61P29/00A61P43/00A61P25/00A61P19/06A61P19/02A61K36/80A61K36/47A61K35/618A61K35/612A61K35/413A61K36/484A61K35/32A61K33/06A61K35/55
Inventor 孙山李怀平马宏伟魏永义赵延霞
Owner SHANDONG JINHE DRUG RES DEV
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