44results about How to "Enabling delivery" patented technology

Described here are devices, systems and methods for closing the left atrial appendage. Some of the methods described here utilize one or more guide members having alignment members to aid in positioning of a closure device. In general, these methods include advancing a first guide having a first alignment member into the left atrial appendage, advancing a second guide, having a second alignment member, into the pericardial space, aligning the first and second alignment members, advancing a left atrial appendage closure device into the pericardial space and adjacent to the left atrial appendage, and closing the left atrial appendage with the closure device. In these variations, the closure device typically has an elongate body having a proximal end and a distal end, and a closure element at least partially housed within the elongate body. The closure element comprises a loop defining a continuous aperture therethrough.

A novel mapping paradigm is provided for the visual display of information in the form of an improved navigational aid. Unlike today's road maps which use a point-arc-polygon paradigm, the new mapping paradigm uses a compressed linear-pictographic-topological design that typically depicts roads as vertical linear pictograms. Further, the display has a columnar layout, whereby the descriptive elements are grouped together by type, and displayed one above the other in columns. In this manner, the mapping paradigm also serves to increase traveler safety, provide navigation assistance during address-less trips, create valuable advertising space and new promotional opportunities, and dramatically increases the travelers' communications and entertainment options.

Described are nanoparticulate formulations of a benzodiazepine, such as lorazepam, that does not require the presence of polyethylene glycol and propylene glycol as stabilizers, and methods of making and using such formulations. The formulations are particularly useful in aerosol and injectable dosage forms, and comprise nanoparticulate benzodiazepine, such as lorazepam, and at least one surface stabilizer. The formulations are useful in the treatment of status epilepticus, treatment of irritable bowel syndrome, sleep induction, acute psychosis, and as a pre-anesthesia medication.

A non-scaled, linearly compressed pictographic mapping system is provided for the visual display of information in a navigational aid. Unlike today's road maps which use a point-arc-polygon paradigm, the new mapping uses a non-scaled, linearly-compressed pictographic design that shows roads as linear pictograms. The display has a columnar layout, whereby the descriptive elements are grouped together by type, and displayed one above the other in columns. The maps may also contain icons representing points of interest arranged in a cloud fashion. In this manner, the mapping paradigm also serves to increase traveler safety, provide navigation assistance during address-less trips, create valuable advertising space and new promotional opportunities, and dramatically increases the travelers' communications and entertainment options.

A method, system and apparatus for delivering enhanced programming information. In some non-limiting embodiments the method comprises obtaining channel grid information for identifying a programming event, the programming event being associated to an occurrence interval. The method further comprises receiving a dynamic program description associated with the programming event. Receiving of the dynamic program description is executed during the occurrence interval associated to the programming event. The channel grid information is then augmented with the dynamic program description. The disclosed method, system and apparatus enable the subscriber to ascertain the current status of the programming event occurring on one or more channels to potentially enable the subscriber to make a more informed decision as to which specific programming event to select for viewing.

A scalable parallel injector array has a support structure for holding injector tubes in a spatial pattern in order to enable delivery of fluidic materials simultaneously to a group of specific target areas in the brain or a body part. Each injector is individually connectible at one end to a displacement-controlled pump and is designed at the other end to be inserted into the brain or body part. The injector tubes are connected to the pump by fluid-filled tubing. The spatial pattern is patient- and/or application-customizable, and the length of the injector tubes is customizable in order to more precisely reach individual target areas. A clamping device may be used to attach the injector array to a stereotaxic arm or other support structure. The action of the pump permits controlled simultaneous delivery of the fluidic materials to the target areas.

A computer-implemented method and system for trading of debt securities (bonds), where multiple dealers participate and compete on a single platform (100). Dealers and investors have respective interfaces (250, 230) for communicating. In one aspect, dealers announce new debt security issues (400), the investors communicate an indication of interest (IOI) (500) in purchasing the new debt security issues, and the issues are allocated to the investors. In another aspect, issues from multiple dealers are made available to investors on a secondary trading market in a searchable format (1000). In response to price inquiries sent by the investors (1200), the dealers provide offers (1300) which are briefly held and released to the investor concurrently to allow the investor to consider all offers together. In another aspect, the dealers post bid and offer terms for actively traded issues (1700) that are updated in real-time to avoid the need for the inquiry procedure.

A receivables transaction management platform is configured for facilitating management of international trade receivables transactions. The platform includes a task manager layer and a platform functionality layer. The task manager layer is configured for facilitating management of transaction information workflow tasks and export receivables tasks. The platform functionality layer is accessible by at least a portion of the managers and is configured for enabling facilitation of the transaction information workflow tasks and the export receivables tasks. Managing the transaction information workflow tasks and export receivables tasks includes facilitating preparation of a document and data portfolio required for settlement of an international trade receivables transaction, facilitating electronic submission of the document and data portfolio to a designated recipient and facilitating acceptance of the document and data portfolio. The platform functional components are configured for enabling user workflow functionality, data mapping functionality, data analysis functionality, data storage functionality and third party access functionality.

The present invention is directed to a prosthesis for treating an aneurysm, and delivery systems and methods therefor. The prosthesis includes a radially expanding distal section coupled to a helical section, the helical section including a localized feature configured to exclude or retard blood flow into an aneurysm. Methods of loading the prosthesis onto a specially-designed delivery system that facilitates proper orientation of the prosthesis within a target vessel, and methods of using the delivery system to deliver the prosthesis, also are provided.

It is an object of the present invention to provide a targeting agent, which enables the delivery of a drug to tumor sites or the imaging of tumor sites by utilizing its effect of accumulating to such tumor sites. The present invention provides a targeting agent for tumor site, which comprises a hydrophilic polymer-modified carrier coated with a gelatin-like protein that has repeats of a sequence represented by Gly-X—Y characteristic to collagen and has two or more sequences of cell adhesion signals in a single molecule wherein X and Y each independently represent an amino acid and a plurality of Gly-X—Y sequences may be the same or different.