The invention provides a medicinal stone hot compress moxibustion matrix, a medicinal stone hot compress moxibustion comprising the matrix and a medicinal component and a preparation method thereof, the matrix in the medicinal stone hot compress moxibustion is continuously heated at constant temperature and fever, which makes the pore of corresponding acupoints expand after the skin is heated, andthe active ingredient of the medicine can penetrate into the subcutaneous area ,directly reach the focus, is safe and effective, avoids oral administration and wounds, and reduces the pain of patients in the treatment process. Wherein the traditional Chinese medicine formula has no irritation, mild medicinal property, external treatment of internal diseases, inheritance of the essence of traditional Chinese medicine, strong targeting effect on symptoms, accurate medicine application and outstanding medicine effect; according to the preparation method, the fermentation technology is applied onthe basis of the traditional medicine, the macromolecular effective components in the medicine are decomposed into small molecules which are easy to absorb under the action of microorganisms, the small molecules of the medicine can directly reach the focus under the auxiliary action of the matrix, the treatment of both symptoms and root causes is achieved, the needle therapy is realized, the foureffects of acupuncture therapy, moxibustion therapy, medicine therapy and thermotherapy are integrated, the applicability is wide, and the cure rate is high.