132results about How to "Avoid induction" patented technology

The present invention provides a composition comprising an agent which specifically blocks interaction between B7-H1 and CD80 but not interaction between B7-H1 and PD-1 and a vaccine, optionally in a pharmaceutically acceptable carrier. Further provided is a method of treating or inhibiting abnormal cell proliferation or a viral infection in a host comprising the step of administering an agent which specifically blocks interaction between B7-H1 and CD80 but does not block interaction between B7-H1 and PD-1 in combination with a vaccine against the cancer to a host in need thereof.

The present invention relates to an anode material excellent in its charging and discharging characteristics and a secondary battery excellent in its charging and discharging cyclic characteristics. An anode active material is used for a nonaqueous electrolyte secondary battery including an anode having the anode active material, a cathode having a cathode active material and a nonaqueous electrolyte. The capacity of the anode is expressed by the sum of a capacity component obtained when light metal is doped and dedoped in an ionic state and a capacity component obtained when the light metal is deposited and dissolved. The light metal includes an anode base material capable of doping and dedoping the light metal in an ionic state and a fibrous material having an electric conductivity.

Structures and configurations for planar ultrawideband modular antenna arrays. One example of a PUMA array includes an unbalanced RF interface, a lattice of horizontal dipole segments directly fed with the unbalanced RF interface, the lattice being arranged in either a dual-offset dual-polarized configuration or a single-polarization configuration, and a metallic plate capacitively-coupled to the lattice of horizontal dipole segments and pinned to a ground plane with a first plated via.

Methods are described for treating an influenza viral infection or associated diseases, disorders or mechanisms in a subject, comprising administering to the subject a therapeutically effective amount of a catecholic butane of the general formula (I) or a pharmaceutically acceptable salt thereof:wherein R1 and R2 each independently represents a hydrogen, a lower alkyl, a lower acyl, an alkylene, or —OR1 and —OR2 each independently represents an unsubstituted or substituted amino acid residue or pharmaceutically acceptable salt thereof; R3, R4, R5, R6, R10, R11, R12 and R13 each independently represents a hydrogen, or a lower alkyl; and R7, R8 and R9 each independently represents a hydrogen, —OH, a lower alkoxy, a lower acyloxy, an unsubstituted or substituted amino acid residue or pharmaceutically acceptable salt thereof, or any two adjacent groups together may be an alkyene dioxy; with the proviso in certain circumstances that where one of R7, R8 and R9 represents a hydrogen, then —OR1, —OR2 and the other two of R7, R8 and R9 do not simultaneously represent —OH.

The present invention provides a haptic steering wheel switch device and a haptic steering wheel switch system including the same. The haptic steering wheel switch device comprises: a housing mounted in a steering wheel; a printed circuit board disposed inside of the housing; and a haptic rotary switch unit including a haptic rotary switch driver disposed in the housing and adapted to generate a rotational force in response to an electrical signal, a haptic rotary switching power transfer unit adapted to transfer the rotational force generated from the haptic rotary switch driver, and a haptic rotary switch knob exposed outside of the housing and connected to the haptic rotary switching power transfer unit to receive the rotational force from the haptic rotary switching power transfer unit.

The present invention provides a haptic steering wheel switch device and a haptic steering wheel switch system including the same. The haptic steering wheel switch device comprises: a housing mounted in a steering wheel; a printed circuit board disposed inside of the housing; and a haptic rotary switch unit including a haptic rotary switch driver disposed in the housing and adapted to generate a rotational force in response to an electrical signal, a haptic rotary switching power transfer unit adapted to transfer the rotational force generated from the haptic rotary switch driver, and a haptic rotary switch knob exposed outside of the housing and connected to the haptic rotary switching power transfer unit to receive the rotational force from the haptic rotary switching power transfer unit.

A printed circuit board integrated with a two-axis fluxgate sensor includes a first soft magnetic core formed lengthwise in a first axial direction, a first excitation coil formed of a metal film and wound around the first soft magnetic core, a first pick-up coil formed of a metal film and wound around the first soft magnetic core and the first excitation coil, a second soft magnetic core formed lengthwise in a second axial direction, the second axial direction being perpendicular to the first axial direction, a second excitation coil formed of a metal film and wound around the second soft magnetic core, a second pick-up coil formed of a metal film and wound around the second soft magnetic core and the second excitation coil, and a pad for establishing conductivity between the first and second excitation coils and the first and second pick-up coils and an external circuit.

Panthenol combined with natural organic extracts are well suited for reducing skin irritation that is normally elicited by exposure to irritant active agents or compounds, particularly found in hair permanent and relaxing compositions, hair colorants and depilatories.

In a fluxgate sensor integrated in a semiconductor substrate and a method for manufacturing the same, the fluxgate sensor includes a soft magnetic core formed on the semiconductor substrate, an excitation coil winding the soft magnetic core and being insulated by first and second insulating layers deposited above and below the soft magnetic core, respectively, and a pick-up coil, winding the soft magnetic core and being insulated by third and fourth insulating layers deposited above and below the excitation coil, respectively.

The present invention is an alternating current rotary sputter cathode in a vacuum chamber. The apparatus includes a housing containing a vacuum and a cathode disposed therein. A drive shaft is rotatably mounted in the bearing housing. A rotary vacuum seal is located in the bearing housing for sealing the drive shaft to the housing. An at least one electrical contact is disposed between a power source and the cathode for transmittal of an oscillating or fluctuating current to the cathode. The electrical contact between the power source and the cathode is disposed inside of the vacuum chamber, greatly reducing, and almost eliminating, the current induced heating of various bearing, seals, and other parts of the rotatably sputter cathode assembly.

A gas separation apparatus combines the technologies of electrostatic precipitators and centrifugal particle separators into a single unit. At an inlet into the gas separation apparatus, a water spray is introduced into the gas stream. The water spray may include various chemical additives, typically selected to react with or neutralize the particulates as they are mixed with the water or for other benefit. The resulting water and particulate mixture, which is much more dense than air, is centrifugally separated and collected through a drain tube outlet. In addition to the centrifugal forces applied to the gas and water stream, an electrical field of magnitude sufficient to produce coronal discharge is also applied to a central electrode. The electric field is generated between the cylinder wall and the central electrode, to assist the centrifugal forces and thereby remove additional particulate beyond that ordinarily removed by a standard centrifugal separator. A vortex finder surrounds the central electrode and protects the electrode from undesirable exposure to water splashes or the like, while assisting with the centrifugal separation. The novel separation apparatus and technique offer particular synergy when applied to the effluent stream from a fossil-fuel electric power plant or other similar gas streams.

The present invention is directed to a method of inhibiting CYP3A4 induction. The method involves administering a compound of the following formula:R1—X—(CH2)n—N═C═Swith R1, X, and n defined herein, binds to a Pregnane X Receptor or Steroid and Xenobiotic Receptor (SXR or NR1I2) under conditions effective to inhibit CYP3A4 gene induction. The present invention also include a method of administering a compound, described herein, together with the CYP3A4 inducer to prevent a loss of efficacy in the subject to whom the CYP3A4 inducer is repeatedly administered. In addition, such compounds can be administered to block the interaction between a CYP3A4 inducer and another drug being administered that is a substrate of CYP3A4.

A substrate holding device for clamping a substrate in a processing chamber in which plasma processing is carried out includes a chuck main body having positive and negative electrodes and, a chuck plate having a rib portion capable of bringing the peripheral edge portion of the substrate into surface contact therewith and multiple support portions provided upright and arranged at predetermined intervals in an internal space surrounded by the rib portion, a DC power supply for applying a DC voltage between the two electrodes, an AC power supply for passing an alternating current through the capacitance of the chuck plate, and first measuring means for measuring the alternating current passing through the capacitance of the chuck plate, and further includes removing means for removing an AC component superimposed on the alternating current from a plasma produced in the processing chamber during plasma processing.

The invention provides a touch control substrate and a manufacturing method and touch control display device thereof, and belongs to the technical field of touch control. The problem that crosstalk is prone to happening between all touch control electrodes of an existing touch control substrate can be solved. The touch control substrate comprises a plurality of touch control electrodes which are connected with corresponding touch control leads. At least part of the touch control electrodes comprise overlapping areas. The overlapping areas of the corresponding touch control electrodes are overlapped with the touch control leads of the rest of the touch control electrodes. Shielding electrodes located between the corresponding touch control electrodes and the touch control leads are arranged in at least part of the overlapping areas.

The invention relates to a carburetor arrangement of a portable handheld work apparatus and includes a carburetor (1), an accelerator pump (2) and a venting pump (3). The venting pump (3) acts on the accelerator pump (2) via a venting line (4). A check valve (5) is mounted in the venting line (4) in such a manner that its outlet end (6) is directed in the direction of the venting pump (3). A pretensioning device (7) is provided which holds a valve body (8) of the check valve (5) closed below a selected difference pressure between the outflow end (6) and an opposite-lying inflow end (9). A support device (10) which acts on the valve body (8) and is actuable, at one end, by pressure at the outflow end (6) without considering pressure at the other end (9) or by pressure on the inflow end (9) without considering the pressure on the other end (6).

The present invention relates to the treatment of dopamine-related dysfunction using full D1 dopamine receptor agonists in an intermittent dosing protocol with a short, but essential, “off-period.” The D1 agonist concentration is reduced during the “off-period” to obtain a plasma concentration of agonist that suboptimally activates D1 dopamine receptors for a period of time to prevent induction of tolerance. Specifically, the method comprises the steps of periodically administering to a patient a full D1 agonist with a half-life of up to about 6 hours at a dose resulting in a first plasma concentration of agonist capable of activating D1 dopamine receptors to produce a therapeutic effect. The dose is reduced at least once every 24 hours to obtain a second lower plasma concentration of agonist that results in suboptimal activation of D1 dopamine receptors for a period of time sufficient to prevent induction of tolerance.

A fluxgate sensor is integrated in a printed circuit board. The fluxgate sensor has two bar-type (or rectangular-ring shaped) soft magnetic cores to form a closed magnetic path on a printed circuit board and an excitation coil in the form of a metal film is wound around the two bar-type soft magnetic cores either in a united structure that winds the two bar-type soft magnetic cores altogether, or in a separated structure that winds the two bar-type soft magnetic cores respectively, both in a pattern of number ‘8’. A pick-up coil is mounted on the excitation coil, either winding the two bars altogether, or respectively, in a solenoid pattern. The fluxgate sensor integrated in the printed circuit board can be mass-produced at a cheap manufacturing cost. The fluxgate sensor also can be made compact-sized, and at the same time, is capable of forming a closed-magnetic path. As a result, flux leakage is minimized, and the fluxgate sensor has a high sensitivity as it detects the magnetic field through a variable driving.

A carrying device includes: a supply portion (16) for supplying a recording sheet (3) from a supply roll (11) wound with the recording sheet (3); a platen (18), which is opposed to a recording head (7) for performing recording on the recording sheet (3) supplied from the supply portion (16), for supporting the recording sheet (3); a take-up portion (20) in which the recording sheet (3) on which recording has been performed by the recording head (7) is taken up by a take-up roll (12); and a suction fan (52) for sucking the recording sheet (3) supported on the platen (18). The platen (18) is provided with, in a position corresponding to an area in which recording is performed by the recording head (7), a plurality of recessed portions (48), which are formed from an upstream side to a downstream side of the platen (18) in a carrying direction of the recording sheet (3) and are surrounded by projected walls (49), aligned in a width direction of the recording sheet (3). In bottom surfaces in the recessed portions (48), there are provided a plurality of suction holes (51) for sucking the recording sheet (3) by the suction fan (52). As a result, quality of recording by the recording head is increased by suppressing occurrence of wrinkles on a recording material which is carried.

The present invention describes a method to detect connective tissue pathologies associated with Graves' disease ophthalmopathy and other antibody mediated inflammatory autoimmune diseases. The detection method comprises obtaining a sample from a patient suffering from an antibody-mediated inflammatory autoimmune disorder and measuring Interleukin 16 (IL-16) or RANTES produced by thyroid associated ophthalmopathy fibroblasts to indicate the presence or severity.

The present invention relates to compositions comprising extracts of Durio zibethinus. The compositions of the present invention are useful for improving the appearance, texture, and / or moisture of mammalian skin. In particular, the compositions of the present invention decrease inflammation in the skin, inhibit matrix metalloprotease-9, which degrades skin proteins such as collagen and elastin, and inhibit melanogenesis in the skin.

A method for promoting auto-induction of transcription of cloned DNA in cultures of bacterial cells grown batchwise is disclosed. The transcription is under the control of a promoter whose activity can be induced by an exogenous inducer whose ability to induce said promoter is dependent on the metabolic state of said bacterial cells. Initially, a culture media is provided which includes: i) an inducer that causes induction of transcription from said promoter in said bacterial cells; and ii) a metabolite that prevents induction by said inducer, the concentration of said metabolite being adjusted so as to substantially preclude induction by said inducer in the early stages of growth of the bacterial culture, but such that said metabolite is depleted to a level that allows induction by said inducer at a later stage of growth. The culture medium is inoculated with a bacterial inoculum, the inoculum comprising bacterial cells containing cloned DNA, the transcription of which is induced by said inducer. The culture is then incubated under conditions appropriate for growth of the bacterial cells. Also disclosed is a method for improving the production of a selenomethionine-containing protein or polypeptide in a bacterial cell, the protein or polypeptide being produced by recombinant DNA techniques, the bacterial cell encoding a vitamin B12-dependent homocysteine methylase. The method for improving the production of this protein or polypeptide includes culturing the bacterial cell in a culture medium containing vitamin B12. Finally, disclosed is a method for suppressing transcription of cloned DNA in cultures of bacterial cells grown batchwise, said transcription being under the control of a promoter whose activity can be induced by an exogenous inducer whose ability to induce said promoter is dependent on the metabolic state of said bacterial cells.

This invention disclose novel uses of omega-3 rich phospholipids for treating diabetes type II, metabolic syndrome, sustained ventricular tachycardia and inflammatory disease. In addition to improving fertility in asthenozoospermic males. The invention also discloses the use of omega-3 rich phospholipids in healthy subject for improving physical endurances, reducing delayed onset muscle soreness as well as preventing obesity.

The invention provides a thermal field structure for growing large-sized silicon carbide monocrystal. The structure integrally comprises a crucible, a crucible cover, a seed crystal rod, an upper insulating layer structure, a lower insulating layer structure, a lateral insulating layer structure and an induction coil, wherein the crucible is divided into a cylindrical bottomless structure and a crucible support, the cylindrical bottomless structure is put on the crucible support and is made of a high-purity graphite material, and the crucible support is made of a high-temperature-resistance insulating material; the lower end of the seed crystal rod has a seed crystal tray structure, and is moved along with height reduction of a solid raw material in the sublimating process; the induction coil structure outside the lateral insulating layer structure can be moved downwards from top, so that a reasonable interval between a growing interface of crystal and a raw material can be ensured. The thermal field structure can be used for reducing the probability of crystal fracture and effectively reducing the defects of micropipe, stress and the like inside the crystal, and realizes the growth of large-sized half-insulating silicon carbide monocrystal.

The present invention provides methods for modulating an immune response by administering a composition comprising a Toll-like receptor agonist and an immune mediator which downregufates the expression of the anti-inflammatory cytokine IL-10 and upregulates the expression of the pro-inflammatory cytokine IL-12. The methods can be used to provide therapeutic treatment for cancerous conditions and infectious diseases.

A fixing unit for fixing a toner image onto a sheet passing between a first element and a second element pressed against the first element includes a looped coil surface formed with a coil so that the coil surface generates a magnetic field for induction-heating the first element, the coil surface including an inner edge defining an opening region; an upright wall disposed inside the opening region, an opening being formed in the upright wall; a center core disposed along the opening region, the center core including a conductive shaft and a magnetic tube configured to at least partially cover the conductive shaft; and a nonconductive cap inserted into the opening, the nonconductive cap partially covering the conductive shaft to electrically insulate the coil from the conductive shaft.