174 results about "Viral illness" patented technology

The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E). Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

The invention relates to a traditional Chinese medicine mixture for treating livestock and poultry virosis and a preparation method thereof. The traditional Chinese medicine mixture contains the contents according to the parts by weight: 10-40 of radix isatidis, 10-40 of folium isatidis, 7-20 of honeysuckle, 3-9 of radix bupleuri, 1-6 of radix lithospermi, 5-20 of forsythia, 5-20 of scutellaria baicalensis, 3-9 of lightyellow sophora root, 2-7 of coptis chinensis, 4-11 of raidx astragali and 1-6 of liquorice. The traditional Chinese medicine mixture has reasonable compositions, convenient mixture taking, obvious effects and no mixture residues, conforms to the safe requirement of animal-derived foods and can be effectively applied to preventing and curing the infective livestock and poultry virosis of chicken flu, newcastle diseases, duck hepatitis viruses, swine fever, virus diarrhea, and the like. The traditional Chinese medicine mixture has the advantages of low cost, simple preparation process and no environmental pollution and is suitable for industrial production.

The invention relates to a composition for widely treating viral diseases. The composition contains the following raw materials, or extracts of the following raw materials, or derivatives of the extracts of the following raw materials in chemically-acceptable forms, wherein the raw materials include processed products prepared from the raw materials. The constituents of the composition are as follows: 100 parts of Baikal skullcap root, 50-150 parts of radix bupleuri and 50-150 parts of kudzu root; and according to specific circumstances, one or more selected from (but not limited to) the following raw materials can be added on this basis: radix isatidis, honeysuckle flower, Fructus Forsythiae, rhubarb, phellodendron bark, rhizoma anemarrhenae, Cyrtomium fortunei, gardenia, coptis, rhizoma cyperi, fritillaria, balloonflower and licorice root. The composition provided by the invention can be prepared into powder, liquid, paste, granules, capsules or other pharmaceutically-acceptable physical forms. The composition provided by the invention is used for preventing and treating avian influenza, epidemic hemorrhagic fever, epidemic parotitis, nameless hyperpyrexia, Newcastle diseases, swine fever, blue-ear diseases and other multiple human and animal viral diseases characterized by hemorrhage or body temperature rise, and reducing the degree of pathological damage to the body.

The invention relates generally to the treatment and prevention of human cancer and viral diseases. More specifically, this invention relates to development of a new generation of vaccines that rely on eliciting cellular immune responses, specifically induction of cytotoxic T lymphocytes (CTL), against cancer cells and virus-infected cells via administration of a polymeric nanoparticle containing a vaccine comprising a fusion peptide or a modified peptide. Such a fusion peptide is composed of an insertion signal sequence and a peptide derived from a tumor antigen or a viral antigen, which improves antigen presentation and induces CTL with higher efficiency against cancer cells and virus-infected cells. An exemplary peptide utilized in the invention is Mart-1:27-35 peptide.

The invention provides compounds of the formula (I): The compounds have activity against cyclin dependent kinases, glycogen synthase kinase and Auroa kinases and are therefore useful to treat cancer and viral diseases.

Disclosed herein are novel triazines and related compounds, the synthesis thereof, and compositions, including pharmaceutical compositions, comprising the novel triazines and related compounds. Such novel triazines and related compounds function to inhibit or block entry of viruses of the Flaviviridae family, including Hepatitis C virus (HCV), into cells that are susceptible to virus infection. These compounds are useful for the treatment, therapy and / or prophylaxis of viral diseases and infection, including HCV infection.

The present invention relates to novel heterocyclic amide compounds of Formula I: as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease.

The invention relates to a DNA (Deoxyribose Nucleic Acid)-based infectious clone of a Japanese encephalitis virus SA14-14-2 strain and a construction method of the infectious clone. The infectious clone is constructed by adopting a pBR322 plasmid as a framework vector and then inserting the full-length cDNA of the Japanese encephalitis virus SA14-14-2 vaccine strain; the 5' end of the full-length cDNA of the SA214-14-2 vaccine strain is connected with a CMV (Cucumber Mosaic Virus) promoter, a BGH (Bovine Growth Hormone) polyadenylation sequence is added at the 3' end, and gomphosis intron sequences for stabilizing are respectively added on the 356 locus and the 2217 locus of the genome cDNA. The invention also provides application of infectious clone serving as a novel viral vector, and thus a solid foundation is provided for developing a plurality of novel vaccines for preventing and treating tumours and viral diseases.

The present invention relates to novel azoles, novel antiviral active components of the general formulas 1A and 1B, pharmaceutical composition, antiviral medicament, method for prophylaxis and treatment of viral diseases, particularly caused by hepatitis C viruses (HCV). In general formulas 1A and 1Bwherein: solid lines with accompanying dotted lines () represent ordinary bond or double bond, provided that one of them is an ordinary bond, the other one is double bond; X and Y accept various meanings, one of them is—nitrogen, the other—oxygen, sulfur or NH group; R1 and R2—optionally the same radicals selected from 2-(R)- and (S)-substituted N-acyl pyrrolidine derivatives; N-methyl-N-[2-(R) and (S)-substituted 2,2-disubstituted acetamides; methyl[2-(R) and (S)-substituted ((methyl)amino)-(1-oxobutan-2-yl)-2-(R)-] and (S)-iso-propyl)-carbamates. A represents aliphatic C2-C8 biradical; dioxane, cyclo- and bicycloaliphatic, alkyloxyalkyl, alkyloxyalkylenoxyalkyl, alkenyloxyalkyl, alkynyloxyalkyl biradicals and their thioanaloges; aryl and thiophene alkynylcycloalkyl, alkynyldioxane, alkynylaryl, alkylthiophene, alkenylthiophene and alkynylthiophene, alkyloxyaryl, alkenyloxyaryl, alkynyloxyaryl, alkylthioaryl, alkenylthioaryl, alkynylthioaryl, cycloalkylthiophene, aryldioxane and thiophenyldioxane biradicals. B represents: aliphatic C2-C8 radical, including 1, 2 or 3 triple C≡C bonds; aryl and thiophene, alkynylcycloalkyl, alkynyldioxane, alkynylaryl, alkylthiophene, alkenylthiophene and alkynylthiophene, cycloalkylbenzene, 4-cycloalkylbiphenyl, bicycloalkylbenzene, 4-bicycloalkylbiphenyl, cycloalkylthiophene, aryldioxane and thiophenyldioxane radicals.

The invention relates to indole-derived compounds and to the use of said compounds for the preparation of a medicament that can be used to treat diseases related to the process of splicing pre-messenger RNAs in the cell, such as Frasier syndrome, frontotemporal dementia linked to chromonsoem 17 (a form of Parkinson's disease), Leigh syndrome (a type of encephalopathy), atypical cystic fibrosis, certain neuropathologies including Alzheimer's disease linked to a mutation in the Tau protein, muscle atorphy which affects the SMN (survival of Motor Neuron) gene, depression linked to a serotonin splicing impairment, and certain cancers in which the global splicing process is affected (e.g. breast cancer, colon cancer and certain lymphomas), as well as viral diseases such as AIDS.

The invention discloses a construction method and application of an organoid virus infection model. The construction method of the organoid virus infection model comprises the following steps: (1) mixing a 3D cultured organoid with a virus infection solution, and then carrying out planarization co-incubation to complete an infection process; and (2) after infection is completed, enabling the organoid to be out of the planarization state, and returning to the 3D culture state again, so as to obtain the 3D organoid subjected to isolated culture. Establishment of the model can be used for high-throughput screening and drug research and development of antiviral drugs as well as research on viral disease pathogenesis and defense mechanisms of virus infection caused by natural occurrence or experiments, and a new strategy is provided for clinical virus of treatment infected patients.

The object of the present invention is to provide a pharmaceutical composition for preventing or treating viral infectious diseases. The compounds of the present invention have extremely potent anti-HCV activity and HCV growth inhibitory effects, and since they also only demonstrate mild cytotoxicity in vivo, a pharmaceutical composition containing the compound of the present invention is extremely useful as an anti-HCV preventive / therapeutic agent.

The invention relates to an anti-coronavirus traditional Chinese medicine composition as well as a preparation method and application thereof. The traditional Chinese medicine composition comprises traditional Chinese medicine active extract, and the active extract consists of first extract and second extract. The first extract is an aqueous extract or an alcohol-water extract of ephedra, semen armeniacae amarae, gypsum, semen coicis, rhizoma atractylodis, pogostemon cablin, polygonum cuspidatum, verbena, rhizoma phragmitis, semen lepidii, exocarpium citri grandis and artemisia apiacea, and the second extract is an aqueous extract or an alcohol-water extract of liquorice. The first extract and the second extract are independently extracted. The traditional Chinese medicine composition canbe used for treating coronavirus diseases such as novel coronavirus pneumonia.

The invention provides a pig disease preventing and treating traditional Chinese medicine (TCM) composition for improving immunity. The composition is characterized in that the composition comprises the following components in parts by weight: 5-15 parts of dangshen or ginseng or heterophylly falsestarwort root, 5-15 parts of roasted rhizoma atractylodis macrocephalae or atractylodes rhizome or astragalus, 5-15 parts of white poria or white hyacinth bean, 5-15 parts of wrinkled gianthyssop herb or fortune eupatorium herb, 5-15 parts of kudzuvine root or divaricate saposhnikovia root or largetrifoliolious bugbane rhizome, 5-10 parts of costus root or tangerine peel or immature bitter orange and 1-6 parts of prepared liquorice root. The composition has the advantages that aiming at different stages of pig virus infection, the prevention and treatment system of body resistance strengthening and pathogenic factor eliminating sequential intervention is adopted, and a new idea is provided for establishment of the pig disease prevention and treatment system; as daily prevention and health care, the immunity and resistance of pigs can be improved via active components in the TCM components such as anti-inflammatory components, anti-stress components, immune enhancers and the like; the immunity of pigs is improved to achieve the effect of pig disease prevention and treatment; the product can be widely used in pig raising production; and at present, over 80% of diseases in pig raising production are viral diseases, so the product has extensive application prospects.

The present invention provides a health-care medicine composition and its preparation method. Said method includes the following steps: making photosynthetic bacterial pool, Chinese herbal medicine liquor, mineral solution and honey undergo the process of biological fermentation, then making them be combined with lactic acid microbial pool, yeast microbial pool, Cram-positive actinomycetes bacterial pool and filamentous microbial pool of fermentation line to form five family microbial community to obtain mother culture, then making said mother culture and nucleic acid, vitamin, SOD and amino acid undergo the process of biological emulsification so as to obtain the invented composition. Said composition has extensive application in preparation of medicine for curing broad-spectrum bacterial disease, broad-spectrum viral disease, damaged gene and diseases due to damaged cell, and specially for preventing and curing SARS.

The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby blocking importation of specific proteins or molecular complex into the nucleus of a cell. The invention encompasses methods of use of such compounds for treatment or prevention of infectious diseases, such as parasitic and viral diseases, including, for example, malaria and acquired immunodeficiency syndrome. The use of the compounds to detect certain specific protein structures which are present in nuclear localization sequences is also taught.

The present invention is directed to methods and compositions employing 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine (“H2G”) or derivatives or analogs thereof for the treatment of viral diseases, as well as for the treatment of other conditions, including, but not limited to, cancer, chronic fatigue syndrome, Alzheimer's disease, multiple sclerosis and Graves' disease. The H2G or derivative or analog thereof can be administered in a pharmaceutical composition and can be administered with an additional antiviral therapeutic agent or another agent for the treatment of other conditions.

The present invention provides compounds of formula I:These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK2, CDK2, MK2, SRC, SYK, and Aurora-2. Accordingly, compounds and compositions of the invention are useful for treating or lessening the severity of a variety of disorders, including, but not limited to, heart disease, diabetes, Alzheimer's disease, immunodeficiency disorders, inflammatory diseases, allergic diseases, autoimmune diseases, destructive bone disorders such as osteoporosis, proliferative disorders, infectious diseases and viral diseases.

The invention provides an antibacterial and antiviral pig disease preventing and treating traditional Chinese medicine (TCM) composition. The composition is characterized in that the composition comprises the following components in parts by weight: 15-25 parts of pinellia tuber, 10-20 parts of dangshen or ginseng or heterophylly falsestarwort root, 10-20 parts of baical skullcap root or dandelion, 10-20 parts of radix glycyrrhizae preparata, 10-20 parts of dried ginger or prepared common monkshood branched root, 5-10 parts of coptis root or turmeric root tuber or Chinese pulsatilla root, 10-20 parts of Chinese date or black date or red date and 10-20 parts of kudzuvine root or divaricate saposhnikovia root or largetrifoliolious bugbane rhizome. The composition has the advantages that aiming at different stages of pig virus infection, the prevention and treatment system of body resistance strengthening and pathogenic factor eliminating sequential intervention is adopted, and a new idea is provided for establishment of the pig disease prevention and treatment system; the immunity and resistance of pigs can be improved via active components in the TCM components such as anti-inflammatory components, anti-stress components, immune enhancers and the like; the immunity of pigs is improved to achieve the effect of pig disease prevention and treatment; the product can be widely used in pig raising production; and at present, over 80% of diseases in pig raising production are viral diseases, so the product has extensive application prospects.

The invention provides echinacea purpurea extract powder and a preparation method and application thereof, which can solve the problems of large dosage, slow response, low bioavailability, easy moisture absorption and agglomeration and serious waste of medicament resources of the powder which is prepared by a traditional preparation method. The echinacea purpurea extract powder comprises echinacea purpurea extract and micro-powder silica gel serving as a carrier material. The preparation method comprises the steps of crushing the raw medicament material echinacea purpurea, extracting the material by a microwave method, recovering ethanol, performing concentration on the material under reduced pressure, adsorbing the micro-powder silica gel and drying, compounding and packaging the material. The echinacea purpurea extract powder has high dissolution rate and high dissolution capability of the effective ingredient, ensures convenient storage and use of the echinacea purpurea superfine powder by adding the micro-powder silica gel serving as a moisture remover, an anti-caking agent and a flow aid and has a good effect for enhancing the immune function; and the echinacea purpurea extract powder is used for animals of low immune function and improving the immunity effect of vaccine so as to cure various bacterial diseases and viral diseases by matching with other medicaments.