The invention relates to a low drop-out overcurrent protection circuit with controllable output. The overcurrent protection circuit comprises a main path, an auxiliary path, a reverse voltage protection circuit, a main and auxiliary path overcurrent switching and enabling inhibit control circuit, an efficiency adjustment resistor, an overcurrent sampling resistor and a limited current setting circuit; the overcurrent protection circuit has the functions of automatic overcurrent protection and output enabling / forbidding, is connected to a power entrance of a circuit in series, and can realize the functions of single event latchup resistance of satellite-bone equipment components and short circuit overcurrent protection of the circuit, thus having high practical value. The special application specific integrated circuit (ASIC) chip customized according to the low drop-out overcurrent protection circuit with controllable output well meets the application demands of satellite-bone equipment of a spacecraft and is beneficial to improvement of the equipment integration level; furthermore, the circuit overcurrent protection also has very strong universality for circuits besides the spacecraft.