The invention relates to a compound feed for Scylla serrata, a preparation method, and an application method thereof. The compound feed comprises a solid part and a liquid part, wherein the solid part is composed of fish meal, strong flour, soybean meal, peanut meal, beer yeast, fish oil, shrimp shell powder, cuttlefish paste, phospholipids, plasma protein powder, choline chloride, compound vitamins, compound mineral substances, a decladding element, sodium diacetate, betaine, butylated hydroxyanisole, phytase and beta-carotene. The preparation method of the invention comprises the steps of raw material smashing and sifting, mixing, conditioning, granulating, drying and packaging, ant the like. The feed prepared by the method of the invention has the advantages of good food calling effect, good palatability, high feed utilization, rich and overall nutrient, a raised feed utilizing rate of the Scylla serrata, reduced pool pollution, and significant environmental protection effect.