116 results about "Polymer free" patented technology

The present invention provides a stent including a tubular body having a plurality of reservoirs disposed therein and a therapeutic agent located in the reservoirs or located in the reservoirs and on a surface portion of the tubular body, wherein the stent is free of polymeric material. The invention also provides a drug-eluting stent made from the process of providing a polymer-free stent body having a plurality of reservoirs disposed therein, diluting a therapeutic agent in a polymer-free solvent to form an agent-solvent mixture, coating the stent with the agent-solvent mixture, and allowing the solvent to dissipate from the stent thereby leaving the agent disposed on the stent.

Methods for the application of a polymer-free coating onto a medical device using plasma electrolytic deposition, comprising: (i) optionally applying a metal precoating onto a medical device; (ii) placing the medical device in an electrolyte solution comprising an electrolyte; and (iii) establishing an electric potential under plasma electrolytic deposition conditions between an electrode and the medical device, such that the plasma electrolytic deposition conditions are adequate to sustain deposition from the electrolyte solution onto the surface of the medical device to form the coating. The invention also relates to coating compositions and coated medical devices, such as stents, made according to these methods. If desired, the polymer-free coating can be a drug-eluting coating.

Process, apparatus, compositions and application modes are provided that relate to nanofiber spinning without the use of superacids in the spinning solution. The methods employ either acids or bases for a flocculation solution. The advances disclosed therein enable the use of nanofibers, including carbon nanotubes, for a variety of applications including, but not limited to, electromechanical actuators, supercapacitors, electronic textiles, and in devices for electrical energy harvesting.

Transfers, suitable for applying complex designs to articles by the application of heat and pressure, are prepared simply and economically by printing the design onto plain paper or other fusible polymer-free substrate from a conventional ink-jet printer. The avoidance of polymer-coated paper allows the design to be transferred to fabric articles without altering the hand and feel of fabric in non-printed areas without the necessity of cutting the transfer from the substrate.

A medical device having a polymer-free outer surface layer comprising a crystalline drug selected from the group consisting of everolimus, tacrolimus, sirolimus, zotarolimus, biolimus, and rapamycin. The device may be produced by a method comprising the steps of providing a medical device; applying a solution of the drug to said portion of the outer surface to form a coating of amorphous drug; and vapor annealing the drug with a solvent vapor to form crystalline drug; wherein a seed layer of a crystalline form of said drug having a maximum particle size of about 10 μm or less is applied to at least said portion of the outer surface of the device before or after applying the drug solution, but before vapor annealing the amorphous coating.

A method for producing lactic acid, comprising producing lactic acid from a sugar-containing fermentation liquid in a fermentor by means of lactic acid-forming bacteria to result in a lactate salt, typically ammonium, sodium or potassium lactate, and isolating lactic acid by subjecting the fermented fermentation liquid to a first ultrafiltration step to result in a substantially polymer-free permeate comprising at least one lactate salt, acidifying the permeate to a pH value of below about 3.9, performing at least one additional isolation step in which the acidified permeate is subjected to nanofiltration and / or reverse osmosis, and preferably subjecting the resulting product to electrodialysis using bipolar electrodialysis membranes. Fermentation is preferably performed using whey protein as a nutrient substrate and by adding at least one protein-hydrolysing enzyme directly to the fermentor during the fermentation process so that hydrolysis of protein to amino acids takes place simultaneously with the fermentation of sugar into organic acid.

Injectable compositions containing a liquid solvent free of solid polymers, anthelmintic agent(s)and hormonal growth promoter(s), where the anthelmintic agent(s) and the hormonal growth promoter(s) are dissolved in the polymer free solvent system. The present invention additionally relates to methods of promoting animal growth and inhibiting parasitic infection / infestation with these compositions, as well as methods of preparing such compositions.

A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment include use of a nanostar modified with a photo-activatable drug, which drug is activated by the photo-response of the nanostar to electromagnetic stimulation; use of a nanostar modified with a thermally-activatable drug, which drug is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which can directly or indirectly cause the death of an undesirable cell.

A hydroalcoholic lotion is disclosed which comprises (a) a lower alcohol and water in a weight ratio of about 35:65 to 100:0, and (b) between at least 0.5% and 8% by weight thickener system comprised of at least one emulsifier present in at least 0.05% by weight wherein the composition in a polymer free state has a viscosity of at least 4,000 centipoise at 23 degrees C. and wherein the emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The hydroalcoholic composition is useful as a hand preparation such as a lotion or as a presurgical scrub replacement.

A composition can include a complex, where the complex includes a photoluminescent nanostructure and a polymer free from selective binding to an analyte, the polymer adsorbed on the photoluminescent nanostructure, and a selective binding site associated with the complex.

A hydroalcoholic lotion is disclosed which comprises (a) a lower alcohol and water in a weight ratio of about 35:65 to 100:0, and (b) between at least 0.5% and 8% by weight thickener system comprised of at least one emulsifier present in at least 0.05% by weight wherein the composition in a polymer free state has a viscosity of at least 4,000 centipoise at 23 degrees C. and wherein the emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The hydroalcoholic composition is useful as a hand preparation such as a lotion or as a presurgical scrub replacement.

The invention discloses a side-chain liquid crystal polymer with aggregation-induced emission property and a preparation method thereof. A substituted cyano-distyrene compound is generated by using a substituent-containing para benzaldehyde derivative and hydroxybenzyl cyanide through Knoevenagel reaction, so that, on one hand, the substituted cyano-distyrene compound can react with polymerizable double bond-containing acids such as saturated dihalide, methacrylic acid or acrylic acid in sequence to generate a polymerizable monomer and a side-chain liquid crystal polymer with a flexible spacer is obtained through free radical polymerization; and on the other hand, the substituted cyano-distyrene compound can directly react with polymerizable double bond-containing acyl chloride such as methacryloyl chloride or acryloyl chloride to generate the polymerizable monomer and a side-chain liquid crystal polymer free of the flexible spacer is obtained through free radical polymerization. A fluorescent chromogenic group and a liquid crystal unit are combined into one; the method is simple in synthesis and easy to purify, and the obtained polymer has an obvious aggregation-induced emission effect, has excellent liquid crystal property and has a good application prospect.

A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic macromolecule and a stabilizing excipient. Described herein are microstructures having a proximal and distal layer, wherein the distal layer which contains the therapeutic molecule does not rely on the presence of a structure-forming polymer to impart the mechanical strength necessary to penetrate the skin. Methods of forming the array, and methods of using the array are contemplated.

An anti-fouling composition which comprises a cured or cross-linked polymer free of perfluoropolyether moieties and a fluid fluorinated alkyl- or alkoxy-containing polymer or oligomer. Preferably, the fluorinated alkyl- or alkoxy-containing polymer or oligomer comprises a repeating unit of the general formula: <paragraph lvl="0"><in-line-formula>-{[CFR-(CFR)m-(O)n]p-[CFR-O]q}-< / in-line-formula>wherein n is 0 or 1, m is an integer from 0 to 4, R independently is H, F, Cl, Br, or CF3, and the ratio q / p is 0-10, and the fluorine-free polymer is an organosiloxane-containing polymer comprising a repeating unit of the general structure -[SiR1R2-O]-, wherein R1 and R2 are independently hydrogen, alkyl, aryl, aralkyl, or a vinyl group.

A polymer-free method and self-draining self-cleaning apparatus for treatment of water with high total dissolved solids including optional pretreatment, precipitation / flocculation, and separation. The pH is raised by addition of caustic soda and / or soda ash. In a vertical clarifier silo, the feed is gently mixed to cause dissolved solids to precipitate and agglomerate to form suspended flocculates. The clarifier includes an internal mixer surrounded by a cylindrical tube diffuser. Rotation of the mixer provides gentle dual circulation patterns within the clarifier that allow for flocculates of a predetermined size to settle from suspension. The clarifier may also include one or more vertical recirculation lines to recirculate some of the heavier flocculates at the bottom of the vessel into the mixer chamber to enhance precipitation via the seeding effect. The suspended flocculates are stripped from the feed water in a centrifugal separator. The clarifier silo may be trailer mounted for rapid deployment.

A hydroalcoholic lotion is disclosed which comprises (a) a lower alcohol and water in a weight ratio of about 35:65 to 100:0, and (b) between at least 0.5% and 8% by weight thickener system comprised of at least one emulsifier present in at least 0.05% by weight wherein the composition in a polymer free state has a viscosity of at least 4,000 centipoise at 23 degrees C. and wherein the emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The hydroalcoholic composition is useful as a hand preparation such as a lotion or as a presurgical scrub replacement.

A hydroalcoholic lotion is disclosed which comprises (a) a lower alcohol and water in a weight ratio of about 35:65 to 100:0, and (b) between at least 0.5% and 8% by weight thickener system comprised of at least one emulsifier present in at least 0.05% by weight wherein the composition in a polymer free state has a viscosity of at least 4,000 centipoise at 23 degrees C. and wherein the emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The hydroalcoholic composition is useful as a hand preparation such as a lotion or as a presurgical scrub replacement.

The invention discloses a fluorine-containing polymer and a preparation method thereof. One or more fluorinated monomers is / are subjected to liquid polymerization by using polyfluothane oxy ether acid as an emulsifier to obtain the fluorine-containing polymer free of perfluoro-octanoic acid or perfluoro-octylsulfonic acid, wherein the polyfluothane oxy ether acid is a halogen-terminated or hydrogen-terminated polyfluothane oxy ether acid emulsifier. The technical scheme mainly relates to the following three improvements: (1) the polyfluothane oxy ether acid or salt thereof selected instead of PFOA / PFOS as the fluorine-containing emulsifier can be effectively used in aqueous emulsion polymerization reaction of fluorinated monomers; (2) the prepared fluorine-containing polymer is free of perfluoro-octanoic acid or perfluoro-octylsulfonic acid, and thus, satisfies the environmental requirement; and (3) the fluorine-containing polymer conforms to the cost accounting, can greatly enhance the single-kettle yield of the equipment on the premise of not increasing the production equipment and personnel, and meanwhile, can enhance the polymerization time, polymerization yield and other production indexes.

The present invention provides solution to the problem involved in preparation of metal nanosponges using templates and polymers. The instant invention is successful in providing a simple, template free single step process for the preparation of metal nanosponges having porous low density and high surface area. These metal nanosponges were found to be good self-supported substrates for surface-enhanced Raman spectroscopy (SERS) and have shown significant anti-bacterial activity.

A hair care composition directed to 8-16% of one or more surfactants; 0.01-10% of one or more surfactant soluble antidandruff agents; 0.01-5% of one or more cationic polymer having a molecular weight (MW) of about 250,000 to about 2,600,000 g / mol and a charge density (CD) of from about 0.25 to about 7.0 meq / g; wherein CD+8×10−7*MW-1.5≥0 and wherein the composition has a deposition efficiency of from about 1.4× to about 3× that of a control composition wherein the control composition comprises 14% SLE1S, no polymeric constituents, 1% of the surfactant soluble antidandruff agent at a pH of about 6.

The disclosed technology relates to pure polyitaconic acid homo- and co-polymers free of the less reactive tri-substituted vinyl monomers (e.g., citraconic acid or mesaconic acid) that may be used, for example, as builders in detergent applications, such as in the personal and home care market.

A textile having sufficient water repellency, oil repellency and soil releasability before and after cleaning can be prepared by a method of preparing a treated textile has the steps of (1) preparing a treatment liquid containing a water- and oil-repellent agent and a stain blocking agent, (2) bringing the pH of the treatment liquid to at most 7, (3) applying the treatment liquid to the textile, (4) thermally treating the textile with steam, and (5) washing the textile with water and dehydrating the textile, wherein the water- and oil-repellent agent has a combination of (A) a fluorine-containing polymer comprising a repeat unit derived from vinyl chloride and / or vinylidene chloride, and (B) a fluorine-containing polymer free from a repeat unit derived from vinyl chloride and / or vinylidene chloride.

The invention discloses a making method of dispersing carbon black through surface grafting modifying method, which is characterized by the following: making a series of polymer with HTEMPO terminal group polymerized by controllable free radiacal; decomposing HTEMPO into polymer free radical under higher temperature; making non-paired electron on the surface of carbon black catch polymer free radical; obtaining the modified carbon black grafted by polymer; dispersing the modified carbon black in multiple organic solvents; applying in the PTC material, air-sensitive material and ink domain.

An easily spreadable furniture polish composition that provides dusting benefits and imparts shine with minimal residue to a surface to be treated. The furniture polish composition includes a film former, an aqueous carrier, an anionic associative polymer free of acrylates / C10-C30 alkyl acrylate crosspolymers, and is substantially free of organic solvents. In one embodiment, the anionic associative polymer is a hydrophobically-modified alkali-soluble emulsion polymer.

The invention belongs to the field of liquid crystal displays, and particularly relates to an alkali-soluble resin polymer for a color light filter and a light-sensitive resin composition. The alkali-soluble resin polymer disclosed by the invention is manly obtained by polymerization of 1,2-phthalic acid mono [2-[(1-oxo-2-allyl)oxygen]ethyl] ester, an unsaturated carboxylic acid or anhydride monomer (b1), an unsaturated carboxylic acid or anhydride monomer (b1) containing hydroxyl, an N-maleimide monomer (b3) and an unsaturated polymeric monomer (b4). According to the alkali-soluble resin polymer provided by the invention, the 1,2-phthalic acid mono [2-[(1-oxo-2-allyl)oxygen]ethyl] ester is selected and added; compared with the polymerized alkali-soluble resin polymer free of the monomer in the prior art, the alkali-soluble resin polymer has the advantages of relatively good storage stability, developing property, solvent resistance, and good matching property with a coloring agent, has low acid value, but has good developing property.

The invention belongs to the field of coal flame-retardant dust suppressants. The invention specifically discloses a nitrogen-phosphorus-silicon synergistic coal flame-retardant dust suppressant and apreparation method thereof. The nitrogen-phosphorus-silicon synergistic coal flame-retardant dust suppressant comprise the following components: 0.08 to 0.12 part of a phosphorus-based flame retardant, 0.10 to 0.14 part of a nitrogen-containing silane coupling agent, 0.01 to 0.05 part of an aldehyde compound, 100.0 to 200.0 parts of a solvent, 0.18 to 0.36 part of a silicon flame retardant, 0.1-0.4 part of a pH regulator, 83.0 to 125.0 parts of deionized water, 57.0 to 95.0 parts of alcohol, 1.0 to 2.0 parts of a natural polymer, 10.0 to 20.0 parts of a monomer, 4.0 to 8.0 parts of a pH buffer agent, 0.1 to 0.4 part of an initiator, 0.02 to 0.08 part of a cross-linking agent, 0.2 to 0.4 part of a surfactant and 0.2 to 1.0 part of a plasticizer. The preparation method comprises the following steps: grafting a nitrogen-containing silane coupling agent onto phosphorus flame retardant molecules by using an aldehyde compound, then hydrolyzing the silicon-based flame retardant, carrying outdehydration reaction between hydroxyl groups on the hydrolyzed silicon-based flame retardant and surface hydroxyl groups on the silicon-based flame retardant to obtain a nitrogen-phosphorus-silicon synergistic flame retardant, and finally organically combining the nitrogen-phosphorus-silicon synergistic flame retardant with dust suppression components such as a natural polymer, a monomer, glycerol and a surfactant in the same system through a polymer free radical polymerization reaction, so that the flame retardant has flame retardance and dust suppression properties.

A multilayer composite has a generally adhesion resistant, protective layer and an adjacent second polymeric film. The composition of the protective layer includes a fluoropolymer and the second polymeric film is a polymer free of fluoropolymer. The size of the protective layer facing the second polymeric layer is rendered bondable to the non-fluoropolymer of the second polymeric layer prior to assembling the layers in the composite. The composite is well adapted to being produced in a vertical coating tower. The tower utilizes a carrier web onto which the fluoropolymer layer and second polymeric layer are deposited from respective casting films. Mirror image composites can be formed simultaneously on opposite sides of the carrier web.

The one step process of removal of chromophore / dye / organic pollutant from a solution comprising a polymer free titanium oxide gel i.e. high zeta potential is disclosed. The concentration of the chromophores is removed up to 95-100%.

Method of making valve seats by thermally spraying bulk material. The method includes the steps of: (i) preparing a cylindrical polymeric mandrel having an outside dimension not greater than the desired inside dimension of the desired insert, the mandrel having no means to provide for separation of the sprayed material from the mandrel, (ii) thermal spraying separate particles of one or more types of steel or nickel alloys in the presence of a controlled oxidizing medium under conditions that allow firstly, melting of the mandrel and its infiltration into the sprayed material and secondly to form a subsequent polymer free dense metallic bulk composite material (iii) after cooling, machining and cutting into discrete seat shapes for implanting into the final product.