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34 results about "Phenylpropiolic acid" patented technology
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Phenylpropiolic acid, C₆H₅CCCO₂H, formed by the action of alcoholic potash on cinnamic acid dibromide, C₆H₅CHBrCHBrCO₂H, crystallizes in long needles or prisms which melt at 136–137 °C. When heated with water to 120 °C, it yields phenylacetylene (C₆H₅CCH). Chromic acid oxidizes it to benzoic acid; zinc and acetic acid reduce it to cinnamic acid, C₆H₅CH=CHCO₂H, whilst sodium amalgam reduces it to hydrocinnamic acid, C₆H₅CH₂CH₂CO₂H. Ortho-nitrophenylpropiolic acid, NO₂C₆H₄CCCO₂H, prepared by the action of alcoholic potash on ortho-nitrocinnamic acid dibromide, crystallizes in needles which decompose when heated to 155–156 °C. It is readily converted into indigo.
Preparation method of silver nano particle loaded metal organic framework complex catalyst
InactiveCN104117390AEasy to makeImprove solubilityOrganic compound preparationOrganic-compounds/hydrides/coordination-complexes catalystsPtru catalystMetal-organic framework
The invention discloses a preparation method of a silver nano particle loaded metal organic framework complex catalyst. The preparation method of the silver nano particle loaded metal organic framework complex catalyst by adopting an impregnation method comprises the following steps: firstly, synthesizing a metal organic framework complex MIL-101; and then, preparing the silver nano particle loaded metal organic framework complex catalyst Ag@MIL-101, wherein the silver nano particle loaded metal organic framework complex catalyst is used for converting CO2 into phenylpropiolic acid via the reaction of CO2 and phenylacetylene under a mild reaction condition. The preparation method of the silver nano particle loaded metal organic framework complex catalyst, which is provided by the invention, has the advantages that the catalyst can adsorb a CO2 molecule so as to improve the solubility of the CO2 molecule in a solvent, thereby improving the reaction velocity; the catalyst is simple to prepare, belongs to a heterogenous catalyst, avoids the difficulty that a homogeneous catalyst is difficult to separate, and has an obvious technical effect.
Owner:NANKAI UNIV
Catalyst for CO2 synthesized acetylenic acid and preparation method and application thereof
ActiveCN108607603AHigh potential for industrial practical applicationsHigh yieldOrganic compound preparationOrganic-compounds/hydrides/coordination-complexes catalystsActive componentSilicon oxide
The invention relates to a preparation method of a Schiff base modified nano-silver based catalyst and application of the catalyst in reaction of CO2 synthesized acetylenic acid. The catalyst uses Schiff base modified silicon oxide as a carrier and uses nanoscale Ag as an active component, and the mass content of the catalyst is 0.1%-10.0%. The catalyst can efficiently catalyze reaction of CO2 andalkyne and convert the CO2 into acetylenic acid under the mild condition. The catalyst has the advantages of easy preparation, high activity and high stability, the yield of phenylpropiolic acid is as high as 99%, the turn over number (TON) of the phenylpropiolic acid is as high as 720, and the method is provided for preparation of the catalyst for efficient synthesis of acetylenic acid and has avery good application prospect.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
4-aryl coumarin compound and preparation method and application thereof
InactiveCN101967135AHas a chemical structureBiologically activeAntibacterial agentsOrganic chemistryBenzaldehydeElimination reaction
The invention discloses a 4-aryl coumarin compound and a preparation method and application thereof. The 4-aryl coumarin compound has a structure shown in a formula (I). The preparation method comprises the following steps: taking substituted benzaldehyde and propandioic acid as raw materials, heating under condition of existing pyridine and piperidine, and generating Perkin reaction and decarboxylic reaction to obtain a series of substituted phenylacrylic acid compounds; carrying out bromination and elimination reaction on the substituted phenylacrylic acid compounds or acetylation to protect a phenolic hydroxyl group, and then carrying out bromination and elimination reaction to obtain substituted phenylpropiolic acid compounds; and enabling the substituted phenyl propargylic acid compounds and phenolic compounds to react under the catalysis of boron trifluoride etherate and phosphorus oxychloride or trifluoroacetic acid to obtain a series of 4-aryl coumarin compounds. The compounds can be used for preparing antineoplastic medicine, anti-abnormal-angiogenesis medicine, antimicrobial medicine, antioxidation medicine and antimalarial medicine.
Owner:GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
(E)-alkenyl sulfone compound and preparation method thereof
InactiveCN107162943AGood substrate compatibilityHigh yieldOrganic compound preparationOrganic chemistry methodsOrganic solventCopper
The present invention relates to a (E)-alkenyl sulfone compound and a preparation method thereof. The preparation method comprises: dissolving a benzenesulfonyl hydrazide-based substrate and a phenylpropiolic acid substrate in an organic solvent, adding a copper catalyst, and carrying out a reaction by using oxygen in air as an oxidizing agent so as to obtain the (E)-alkenyl sulfone compound, wherein the chemical formula is defined in the specification. Compared to the method in the prior art, the method of the present invention has the following characteristics that the finally required (E)-alkenyl sulfone compound can be obtained with the inexpensive catalyst Cu2O and the green oxidant O2 without the additional additives, and the method provides good compatibility for the substrates having different electronic effects and steric hindrance on the aromatic ring, and has high yield.
Owner:TONGJI UNIV
Preparation method of 2-benzofuranone compound
ActiveCN108752299AThe synthesis method is scientific and reasonableRaw materials are easy to getOrganic chemistryChromatographic separationOrganic synthesis
The invention discloses a preparation method of a 3-benzofuranone compound and belongs to the technical field of organic synthesis. The method comprises the steps of adding a phenol derivative (0.2mmol, 30mg), phenylpropiolic acid (0.2mmol, 29mg), a 5% rhodium catalyst, a cobalt acetate hydrate, a sodium trimethylacetate hydrate, and 1.0mL methanol into a 15mL thick-wall pressure pipe, stirring for 12h at a room temperature with an orifice being opened, and after a reaction, performing silicagel column chromatographic separation to form a pure target product. The preparation method of the 3-benzofuranone compound has the characteristics that the method is scientific, reasonable, mild in condition, simple to operate, short in reaction time and the like. A reaction equation of the method isas follows as shown in the specification.
Owner:郯城县经开区医药发展有限公司
Hyperbranched polyphenyl triazole formate as well as preparation method and application thereof
ActiveCN107325284AImprove compatibilityEasy to introduceOrganic compound preparationCarboxylic acid esters preparationFormateDrug biological activity
The invention discloses hyperbranched polyphenyl triazole formate as ewll as a preparation method and application thereof. Phenylpropiolic acid triester and binary organic azide monomer are utilized to be heated and react for a certain time in a polar aprotic solvent to obtain the hyperbranched polyphenyl triazole formate. Reaction raw materials in the hyperbranched polyphenyl triazole formate disclosed by the invention are easy to obtain, no byproduct is generated in a polymerizing process, and atom economy is met; a substrate of polymerizing reaction has a wide application range and good compatibility with a functional group and can very easily lead functional radicals into; meanwhile, no metal catalyst is utilized in a polymer preparing process, and effects of catalyst residue on biological activity and photoelectric performance of the polymer are avoided. As the polymer contains a tetraphenyl ethylene structure, the polymer has better aggregation-induced emission performance; furthermore, the polymer can serve as a chemical sensor to detect multi-nitro aromatic-hydrocarbon explosives in high flexibility.
Owner:SUZHOU UNIV
Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumour agents
Owner:SIGMA TAU IND FARMACEUTICHE RIUNITE SPA
3-Sulfonylcoumarin and preparation method thereof
InactiveCN107151237AReduce usageThe conversion reaction raw materials are simple and easy to obtainOrganic chemistrySulfonyl chlorideProton NMR
The invention discloses 3-sulfonylcoumarin and a preparation method thereof. The preparation method includes: in an organic solvent, allowing arylamine and phenyl phenylpropiolate to react with rongalite to obtain 3-sulfonylcoumarin compound. The structure of the 3-sulfonylcoumarin compound is confirmed by characterization via 1H NMR (nuclear magnetic resonance), 13C NMR, HRMS (high resolution mass spectrometry) and other processes. The preparation method has the advantages that the reaction herein is performed under mild conditions, rongalite is used as a sulfur dioxide source, sulfonyl reaction is achieved directly, and the 3-sulfonylcoumarin compound is constructed; the raw materials for the reaction are simple and easily accessible, the usage of sulfonyl chloride in traditional synthetic processes is avoided, and the preparation method is suitable for large-scale preparation and has a promising application prospect.
Owner:JIANGXI NORMAL UNIV
A kind of hyperbranched polyphenyltriazole formate and its preparation method and application
ActiveCN107325284BImprove compatibilityEasy to introduceOrganic compound preparationCarboxylic acid esters preparationPtru catalystPhenyl group
The invention discloses a hyperbranched polyphenyltriazole formate, a preparation method and application thereof. Using phenylpropiolic acid tribasic ester and binary organic azide monomer, in polar aprotic solvent, heating and reacting for a period of time to obtain hyperbranched polyphenyltriazole formic acid ester. The reaction raw materials in the present invention are easy to obtain, and no by-products are generated during the polymerization process, which conforms to atom economy. The substrate of the polymerization reaction has a wide range of applications, has good compatibility with functional groups, and can easily introduce functional groups. At the same time, no metal catalyst is used in the preparation process of the polymer, which avoids the impact of catalyst residue on the biological activity and photoelectric performance of the polymer. Because the polymer contains a tetraphenylethylene structure, the polymer has good aggregation-induced luminescent properties, and can be used as a chemical sensor to detect polynitroaromatic explosives with high sensitivity.
Owner:SUZHOU UNIV
Woven mesoporous polymer silver-loaded catalyst as well as preparation method and application thereof
ActiveCN109420526AGood industrial practical application potentialHigh yieldOrganic compound preparationOrganic-compounds/hydrides/coordination-complexes catalystsTurnover numberActive component
The invention relates to a preparation method of a woven mesoporous polymer silver-loaded catalyst and application of the silver-loaded catalyst in synthesis of acetylenic acid from CO2. The catalysttakes a woven mesoporous polymer as a carrier and nano-scale Ag as an active component, wherein the mass content of woven mesoporous polymer to nano-scale Ag is 0.01%-1.0%. The catalyst can efficiently catalyze the reaction of the CO2 and alkyne under mild conditions for converting the CO2 into the acetylenic acid. The catalyst has the characteristics of easy preparation, high activity and high stability, wherein the yield of phenylpropiolic acid is up to 92%, and the initial Turnover Number (TON) of the phenylpropiolic acid is 9936. The method provided by the invention provides a method for preparing the catalyst for efficiently synthesizing the acetylenic acid, and has a good application prospect.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Electrochemical preparation method of alkynyl thiocyanate
ActiveCN110453241AReduce usageSimple reaction systemElectrolysis componentsElectrolytic organic productionOrganic synthesisElectrochemistry
Belonging to the technical field of electrochemical organic synthesis, the invention discloses an electrochemical preparation method of alkynyl thiocyanate. The preparation method includes the steps of: adding a solvent (acetonitrile and water), electrolyte, alkali, a thiocyanate, phenylpropiolic acid, and negative and positive electrodes into a diaphragm-free electrolytic tank, performing stirring, and carrying out reaction under a constant current condition; and at the end of the reaction, conducting separation and purification to obtain the product alkynyl thiocyanate. The electrodes used by the method are general inert electrode, have no need for electrode modification and extra adding of various metal catalysts, thereby avoiding the use of toxic, expensive and complicatedly prepared catalyst, the reaction yield is high, the reaction system is simple, and the operation is carried out under normal temperature and pressure, the method is simple and safe, and is suitable for large-scale industrial production.
Owner:SOUTH CHINA UNIV OF TECH
Supported carboxylation catalyst as well as preparation method and application thereof
ActiveCN113117713AHigh catalytic efficiencyGood dispersionMolecular sieve catalystsOrganic compound preparationMolecular sievePtru catalyst
The invention discloses a supported carboxylation catalyst for synthesizing phenylpropiolic acid. The catalyst comprises a catalyst supporter and a supported active component; the catalyst supporter comprises modified hydrotalcite, a modified molecular sieve and aluminum oxide; the charge balance anion of the modified hydrotalcite is carbonate; the modified molecular sieve is a cation modified molecular sieve, and the cation is at least one of lithium, sodium, potassium and cesium; and the active component is selected from at least one of metal salts AgI, AgBr, AgCl, CuI, CuBr and CuCl. According to the invention, carbonate ions are utilized to modify hydrotalcite, so that the content of carbonate ions in hydrotalcite is increased; and the molecular sieve is modified by using soluble salt of assistant ions, and assistant metal ions are loaded on the molecular sieve. The catalyst disclosed by the invention has the characteristic that active components and auxiliary components are not easy to lose, the service life of the catalyst can be prolonged, and the utilization rate of the catalyst is greatly improved.
Owner:CHINA PETROLEUM & CHEM CORP +1
Catalyst for synthesizing phenylpropiolic acid and preparation method and application of catalyst
ActiveCN111377813AHigh catalytic efficiencyGood dispersionMolecular sieve catalystsOrganic compound preparationMolecular sievePtru catalyst
The invention discloses a catalyst for synthesizing phenylpropiolic acid. The catalyst comprises hydrotalcite loaded with active metal salt and an ion exchange type molecular sieve, wherein the activemetal salt is selected from at least one of AgI, AgBr, AgCl, CuI, CuBr and CuCl, the ion exchange type molecular sieve is a cation exchange type molecular sieve, and the cation is at least one of lithium, sodium, potassium and cesium. The catalyst disclosed by the invention has the characteristics of high active center dispersity and low possibility of loss, and is used in a phenylpropiolic acidsynthesis process, so that the content of impurities in a product is reduced, the difficulty of post-treatment such as separation and refining is reduced, and generated wastes are greatly reduced.
Owner:CHINA PETROLEUM & CHEM CORP +1
Method for preparing indolone derivative
ActiveCN108658834ALow toxicityHigh yieldOrganic compound preparationCarboxylic acid amides preparationAnilineNucleophilic substitution
The invention discloses a method for preparing an indolone derivative. The method disclosed by the invention comprises the step of subjecting phenylpropiolic acid and aniline, which serve as startingraw materials, to four steps, i.e., condensation, nucleophilic substitution, palladium catalyzing coupling and hydrolyzing sequentially, thereby obtaining the indolone derivative. According to the method disclosed by the invention, the raw materials are readily available, the operation is simple and convenient, the production efficiency is high, enlarged production is facilitated, and the productis high in total yield and easy to purify.
Owner:烟台药物研究所
Synthesis method of 2-phenylacetylene seleno alcohol compound
The invention relates to a synthesis method of a 2-phenylacetylene seleno alcohol compound, which comprises the following steps: under air conditions, by using phenylpropiolic acid, selenium powder and an epoxy compound as reaction raw materials and water as a reaction solvent, carrying out cascade reaction under the joint promotion actions of a copper catalyst, a ligand, a phase transfer catalystand alkali to obtain the 2-phenylacetylene seleno alcohol compound. The method has the advantages of mild and simple reaction conditions, cheap and easily available substrate, and high yield and purity of the product, opens up a new synthetic route and method for the 2-phenylacetylene seleno alcohol compound, and has good application potential and research value.
Owner:WENZHOU MEDICAL UNIV
Phenylpropiolic acid small molecular organic compounds and synthetic method and application thereof
InactiveCN109516914ANovel structureGood anti-diabetic effectOrganic active ingredientsOrganic chemistryTreatment effectHypoglycemia
The invention relate to a category of novel phenylpropiolic acid small molecular organic compounds as shown in a structural formula (I) or stereisomers, crystals, hydrates or pharmaceutically acceptable salt and an application of the phenylpropiolic acid small molecular organic compounds or stereisomers, crystals, hydrates or pharmaceutically acceptable salt and pharmaceutical compositions comprising the compounds in preparing a GPR40 agonist and drugs for promoting insulin release, treating and / or preventing diabetes or complications, treating diabetes inducing poor therapeutic effect inducedby acquired drug-resistance and complications and the like. The invention also provides a preparation method of the phenylpropiolic acid small molecular organic compounds as shown in the structural formula (I). The phenylpropiolic acid small molecular organic compounds have good anti-diabetes effect and the risk of inducing hypoglycemia is lower than that of conventional drugs.
Owner:EAST CHINA NORMAL UNIV +1
Phenylpropionic acid derivative and use thereof
InactiveUS8334314B2Strong inhibitory activityGood treatment effectBiocideSenses disorderHalogenHydrogen atom
Owner:ASAHI KASEI PHARMA
A kind of preparation method of 4-aryl coumarin compound
ActiveCN106187969BEasy to operateEasy to separate and purifyOrganic chemistryChemical synthesisMontmorillonite K-10
Owner:INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
A kind of aryl-alkyne compound and its preparation method and application
InactiveCN105294677BEasy to prepareLow costOrganic chemistryFluorescence/phosphorescenceArylChemical compound
Owner:HEBEI UNIVERSITY
4-aryl coumarin compound and preparation method and application thereof
InactiveCN101967135BHigh yieldSimple and fast operationAntibacterial agentsOrganic chemistryBenzaldehydeElimination reaction
The invention discloses a 4-aryl coumarin compound and a preparation method and application thereof. The 4-aryl coumarin compound has a structure shown in a formula (I). The preparation method comprises the following steps: taking substituted benzaldehyde and propandioic acid as raw materials, heating under condition of existing pyridine and piperidine, and generating Perkin reaction and decarboxylic reaction to obtain a series of substituted phenylacrylic acid compounds; carrying out bromination and elimination reaction on the substituted phenylacrylic acid compounds or acetylation to protect a phenolic hydroxyl group, and then carrying out bromination and elimination reaction to obtain substituted phenylpropiolic acid compounds; and enabling the substituted phenyl propargylic acid compounds and phenolic compounds to react under the catalysis of boron trifluoride etherate and phosphorus oxychloride or trifluoroacetic acid to obtain a series of 4-aryl coumarin compounds. The compounds can be used for preparing antineoplastic medicine, anti-abnormal-angiogenesis medicine, antimicrobial medicine, antioxidation medicine and antimalarial medicine.
Owner:GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
Method for catalyzing decarboxylation coupling reaction by 1,2,3-triazole monosubstituted 1,3,5-s-triazine compound coordinated with CuSO4.5H2O
InactiveCN105130722AWater and oxygen stableShort reaction timeOrganic compound preparationOrganic chemistry methodsTriazineCoupling reaction
The invention discloses a method for catalyzing decarboxylation coupling reaction by a 1,2,3-triazole monosubstituted 1,3,5-s-triazine compound coordinated with CuSO4.5H2O. By taking CuSO4.5H2O which is good in stability and cheap and easily available and the triazine compound which is stable in water and air and high in functionalization as a catalytic system, the method catalyzes decarboxylation coupling reaction on aryl halide and phenylpropiolic acid. The reaction system is free of a conventional phosphine ligand, so that the environmental pollution is reduced, and the method has good substrate applicability. The target product is easy to separate and purify and high in yield. The method disclosed by the invention is an efficient and safe decarboxylation coupling reaction system and can be applied to constructing Csp-CsP2 bonds.
Owner:SHAANXI NORMAL UNIV
Method for synthesizing alpha-alkynyl substituted ether compounds
ActiveCN107556269AImprove compatibilityThe synthesis method is simple and easy to obtainOrganic chemistryPhenolPropiolic acid
The invention discloses a method for preparing alpha-alkynyl substituted ether compounds. The method comprises the following steps: taking propiolic acid as a raw material, and synthesizing substituted phenylpropiolic acid under conditions of substituted iodobenzene, 1,8-diazabicyclo[5.4.0]undec-7-ene, (beta-4)-platinu and dimethyl sulfoxide; taking substituted phenylpropiolic acid and p-bromophenol as raw materials, and synthesizing p-bromophenyl substituted phenylpropiolic acid ester under the conditions of 4-dimethylaminopyridine and N,N'-Dicyclohexylcarbodiimide; and performing an alkynylation reaction on the p-bromophenyl substituted phenylpropiolic acid ester in participation of tert-butyl hydroperoxide, cesium carbonate and tetrahydrofuran, and finally synthesizing alpha-alkynyl substituted ether products. According to the method disclosed by the invention, simple and readily available acetylene esters serve as an alkynylation reagent, and the target products, namely alpha-alkynyl substituted ether compounds, are synthesized in a green and environmental-friendly manner under mild conditions. The compounds play an important role in construction of multiple medical intermediates and bio-active structures.
Owner:NANJING UNIV OF SCI & TECH
Method and system for preparing phenylpropionic acid
InactiveCN109796323AEasy to operateFlexible useOrganic compound preparationCarboxylic compound preparationOxygenAcid preparations
The invention provides a method and system for preparing phenylpropionic acid. The phenylpropionic acid preparation method comprises the following steps of: putting an amino acid solution and a dissolving agent into a reaction tank, dissolving, stirring, reacting and standing; adding a PH regulator into the reaction tank and heating and stirring until the current PH value of the solution in the reaction tank is equal to a PH threshold value; adding phenylpropanal and a catalyst into the reaction tank, and continuously injecting oxygen to control oxidation reaction between the phenylpropanal and the oxygen; continuously heating the reaction tank and when the current temperature in the reaction tank is equal to a temperature threshold value, continuously heating the reaction tank at the temperature threshold value until the phenylpropanal is completely oxidized to obtain crude phenylpropionic acid; injecting the crude phenylpropionic acid into a low-pressure separation tank for low-pressure separation, and heating and rectifying the separated crude phenylpropionic acid to obtain refined phenylpropionic acid. The phenylpropionic acid preparation method and the phenylpropionic acid preparation system have the advantages of convenience in operation, flexibility in use and high preparation stability.
Owner:江西华尔盛科贸有限公司
Synthetic method of α-alkynyl substituted ether compounds
ActiveCN107556269BImprove compatibilityThe synthesis method is simple and easy to obtainOrganic chemistryCarbenePropiolic acid
Owner:NANJING UNIV OF SCI & TECH
Treatment agent for removing methanol, normal butanol and isobutanol in amino resin workshop waste water
InactiveCN105110442AStrong complexing abilityFast precipitationWater contaminantsWater/sewage treatment by flocculation/precipitationIsobutanolAcetophenone
The invention relates to a treatment agent for removing methanol, normal butanol and isobutanol in amino resin workshop waste water. The agent is prepared from the following components: 1,3,3-trimethyl-2-oxo bicyclo[2.2.2]octane, dihydro flavonoid glycosides, S(-)-2-amino-6- n-propylamino-4,5,6,7-tetrahydro-benzothiazole dihydrochloride, 4-octylphenol ethoxylate, 3', 4'-dihydroxy-2-(methylamino)acetophenone hydrochloride, 4-acetoxy-3-methoxy-(2-propenyl)benzene, acetic acid 4-methoxybenzyl ester, 6,6,10-trimethyl-bicyclo-3,1,1-heptyl-2-olefinic, 2-[[1-(3-acetylthio-2-methylpropanoyl)pyrrolidine-2-carboxamido]amino]-3-benzenepropanoic acid and the like. The treatment agent has high complexing capacity with target substances and high complex precipitation velocity, the removal rate can reach 99.9%, and small dosage does not harm water body.
Owner:李海兰
Aryl-alkyne compound as well as preparation method and application thereof
InactiveCN105294677AEasy to prepareLow costOrganic chemistryFluorescence/phosphorescenceSynthesis methodsEthylene Dichloride
The invention discloses an aryl-alkyne compound (2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-8-yl 3-phenylpropiolate) as well as preparation and application of the compound. A synthesis method of the aryl-alkyne compound comprises the following steps: under the condition that the temperature is 0 DEG C, dissolving 8-hydroxyjulolidine and phenylpropiolic acid into dichloromethane and adding a condensing agent EDC (Ethylene Dichloride) and an alkali DMAP (Dimethylaminopyridine) and stirring and reacting at 20 to 30 DEG C for 5 to 8 hours; after the reaction, concentrating; carrying out silica-gel column chromatography on concentrated liquid; then eluting, decompressing and evaporating to remove the solvent to obtain a product. The compound can be used as a reagent for detecting the concentration of trivalent gold ions by a fluorescent spectrometry. Firstly, the aryl-alkyne compound provided by the invention has a simple preparation method and low cost and is prepared from the 8-hydroxyjulolidine and the phenylpropiolic acid through a one-step reaction; secondly, the compound can be used as a trivalent gold detection reagent and has high sensitivity and selectivity on Au<3+>; a detection result is not interfered by other metal ions; a detection method is simple and a detection process is carried out in a water phase and can be realized with the help of a fluorescence spectrophotometer.
Owner:HEBEI UNIVERSITY
A kind of 3-sulfone base coumarin and preparation method thereof
InactiveCN107151237BReduce usageThe conversion reaction raw materials are simple and easy to obtainOrganic chemistrySulfonyl chlorideAcyl group
Owner:JIANGXI NORMAL UNIV
3-Amide-4-phenylcoumarin and preparation method thereof
InactiveCN110294729ASolve the problem of high synthetic costAvoid the disadvantages of using highly toxic and precursor reagentsOrganic chemistryPotassium persulfateSynthesis methods
The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of 3-amide-4-phenylcoumarin. Phenylpropiolic acid ester, oxamide, potassium persulfate, silver nitrate, natrium aceticum and a solvent are added into a reaction container in sequence for standby use; nitrogen is introduced into the reaction container, so that the inside of the reactioncontainer is in a nitrogen atmosphere; the reaction container is placed in an environment at 60-120 DEG C, a reaction is conducted at the stirring speed of 500-1,000 r / min, in the reaction process, the concentration of the phenylpropiolic acid ester in reaction liquid is monitored, and after it is monitored that the phenylpropiolic acid ester reacts completely, the reaction is finished; the reaction liquid is filtered and concentrated, and the 3-amide-4-phenylcoumarin is obtained. According to the synthesis method, under the mild condition, the 3-amide-4-phenylcoumarin is efficiently prepared, the cleanliness of the synthesis reaction is improved, the environmental pollution is reduced, and the adopted raw materials are single in type; the cost is reduced, and the economical efficiency ofthe technology is improved.
Owner:LIAONING UNIVERSITY OF PETROLEUM AND CHEMICAL TECHNOLOGY
A kind of preparation method of indolinone derivative
ActiveCN108658834BRaw material stabilityEasy to operateOrganic compound preparationCarboxylic acid amides preparationCombinatorial chemistryAniline
Owner:烟台药物研究所
1,2,3‑triazole monosubstituted 1,3,5‑s-triazine compounds synergistically cuso 4 ·5h 2 o Catalytic decarboxylation coupling reaction method
InactiveCN105130722BWater and oxygen stableShort reaction timeOrganic compound preparationOrganic-compounds/hydrides/coordination-complexes catalystsTriazineCoupling reaction
The invention discloses a method for catalyzing decarboxylation coupling reaction by a 1,2,3-triazole monosubstituted 1,3,5-s-triazine compound coordinated with CuSO4.5H2O. By taking CuSO4.5H2O which is good in stability and cheap and easily available and the triazine compound which is stable in water and air and high in functionalization as a catalytic system, the method catalyzes decarboxylation coupling reaction on aryl halide and phenylpropiolic acid. The reaction system is free of a conventional phosphine ligand, so that the environmental pollution is reduced, and the method has good substrate applicability. The target product is easy to separate and purify and high in yield. The method disclosed by the invention is an efficient and safe decarboxylation coupling reaction system and can be applied to constructing Csp-CsP2 bonds.
Owner:SHAANXI NORMAL UNIV
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