36 results about "Nail fungus" patented technology

A method for manufacturing molecular chlorine dioxide, by the addition of potassium iodide to a solution of alkali metal chlorite. The metal chlorite and the potassium iodide are kept separate, until the need for the generation of chlorine dioxide arises-to ensure long-shelf life. After initiation or activation of the chlorite anion to form chlorine dioxide, the beneficial properties of chlorine dioxide can be used, for different health and cosmetic purposes. Such uses include the treatment of herpes, dandruff, acne, skin rashes (e.g. poison ivy), ulcers, bed sores, warts, nail fungus, athletes foot, sun burn and gum disease; and as an antiseptic, disinfectant, and general deodorant form refrigerator sprays to oral mouthrinses.

Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a pharmaceutically acceptable base in a formulation having a pH of 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations permeate the nail and are effective in treating fungal infections of the nail and surrounding tissues.

A method of treatment of onychomychosis wherein a hydrogel is supersaturated with an antimycotic agent and supported on a backing. The assembly is placed over an infected nail for an extended period of time. The antimycotic agent diffuses through the nail to the underlying infection.

A dual action antifungal nail coat composition and method of use for ameliorating or preventing fungal infection of the nails, and onychomycosis, in particular, is disclosed. Composition embodiments in the form of one-coat type and two-coat type suitable for daily fungicidal regimens are disclosed. A preferred antifungal nail coat composition comprises an effective fungicidal amount of antifungal agent, a permeation enhancing amount of a substantially non-volatile, permeation enhancer, a film-forming amount of a hydrophilic polymer, and a pharmaceutically acceptable, volatile carrier. The composition provides a substantially water-soluble fungicidal coating on contacting a fungally susceptible or infected nail.

The present invention provides a non-water soluble, film-forming composition which adheres to body tissue and forms a pharmaceutical carrier to provide localized delivery of an antifungal agent to a treatment site. The composition will typically include: (a) an alkyl cellulose; (b) a hydroxyalkyl cellulose; (c) a pharmaceutically acceptable polar protic solvent; (d) an antifungal agent selected from the group of naftifine, ciclopirox, terbinafine, pharmaceutically acceptable salts thereof, and combinations thereof; (e) an glycol ether; (f) an antipruritic agent selected from the group of camphor, menthol, butamben picrate, metacresol, benzyl alcohol, camphorated metacresol, juniper tar, phenol, phenolate sodium, resorcinol, camphorated metacresol, carbolic acid, and combinations,; and (g) a solubility enhancing agent, a surfactant, a wetting agent, or a combination thereof. The present invention also provides for the use of the composition composition of the present invention, in treating a fungal infection (e.g., nail fungus) in a mammal afflicted with such an infection.

A hybrid catheter device for performing cutting action on a region of a tissue, using sequential laser and mechanical cutting processes, and incorporating an acoustic sensor on the end of the device, such that if a pulsed laser beam is used for the laser cutting, the absorption of that beam in the tissue being cut can provide information about the progress of the cut by means of the opto-acoustic effect. Other hybrid catheter devices incorporate blunt protrusions on the end of said device, but having sharp lateral edges, such that rotation of the catheter device generates mechanical cutting action in the tissue. The blunt protrusion ends prevents uncontrolled cutting in the forward motion. Other hybrid catheter devices enable controlled incisions into an organ wall, such as the duodenum, and held in place by means of an inflatable balloon. A dual-wavelength nail fungus treatment hybrid catheter is also shown.

Compositions for the treatment of fungal nail disease (onychomycosis), including camphor, menthol, eucalyptus and thymol are described. The ingredients are natural and very effective in treating the nail fungus.

Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic procedures consist of microscopy and culture, but due to the slow growth rate of dermatophytes typically two to four weeks are needed before a final diagnosis is obtained. The present invention is a rapid DNA extraction method extracting nucleic acids from fungi (e.g. dermatophytes and other pathogenic fungi) which can be performed from directly on hair, nail or skin specimens from humans, from naturally or experimentally infected animals or from cultured fungal colonies for the use in PCR amplification and detection assays. The present invention also includes specific primer sets for detection of any dermatophyte and for species specific detection of Trichophyton rubrum and Epidermophyton floccosum by PCR and a kit for diagnosing fungal infections.

This invention relates to the field of topical treatments for infections such as nail infections, particularly fungal infections of the nail commonly referred to as onychomycosis. Particularly, the invention relates to novel compositions containing peroxide for the treatment of such nail infections and other infections.

A method for treating a fungal infection in an infected nail is disclosed. An embodiment includes placing an optical delivery system designed to deliver a laser beam with light having strongly water-absorbed wavelengths to the infected nail. The diseased nail is irradiated with the laser beam, and the fluence and a duration of the laser irradiation received by the nail are adjusted such that by laser energy absorption in a surface portion of the nail a superficial heating of the nail and heat diffusion from said heated surface portion into the infected nail bed are achieved. The bottom of the nail plate in this embodiment is heated to a treatment temperature needed to inactivate the infecting organism.

Disclosed is a formulation and method for the treatment of fungal infections of the nail (onychomycosis) utilizing a topical composition comprising zinc pyrithione, a solubilizer for the zinc pyrithione, a film former, and a volatile solvent. The formulation is preferably in the form of a lacquer. The composition containing the metal pyrithione complex is topically applied to the infected nail preferably as a nail polish or lacquer which may be applied with a dropper, swab or the like to the afflicted nail surface. The treatment can be done at least two times a day, with a course of treatment lasting from several weeks to several months or until a cure is effected or a significant reduction of the infection is achieved.

Compositions and methods for treating or preventing fungal infections of the nail are provided. The topical composition includes the use of chlorine dioxide, chlorite salts, benzoyl peroxide, an alpha hydroxy acid, antifungal and antibiotic agents. Also provided is a heat-generating device for use in treating at least one nail infected with fungus and a toe sock device.

Methods and topical pharmaceutical formulations are provided for the treatment of athlete's foot (tinea pedis) and nail fungus (onychomycosis). The invention involves an anhydrous composition containing a therapeutically effective amount of salicylic acid. Repeated applications of the resulting formula over a 4-12 week period resolve most infections without the use of systemic drugs.

Compositions for the treatment of some orphan diseases and oral mucosal ulcers, many with similarities in terms of their anti-inflammatory and anti-oxidative activities, but also multiple differences in their observed abilities that can be combined to challenge the current, underlying pathophysiology. The orphan diseases of interest are Dupuytren's Contracture, Peyronie's Disease, Scleroderma, Raynaud's (or Renaud's) Phenomenon, chemotherapy / radiation induced oral mucosal ulceration, and aphthous ulcers; and more frequent skin issues of skin damage from cuts, abrasions, and burns; aging skin changes, and toe nail fungus. These can be treated with the disclosed compositions with the proper combination and alteration of ingredients:

The invention discloses an antifungal compound extract, a preparation and a preparation method of the extract. The antifungal compound extract comprises the following components in parts by weight: 1-3 parts of a gallnut extract, 1-3 parts of a fructus cnidii extract, 1-3 parts of a pogostemon cablin extract, 0.5-1.5 parts of a galangal extract, 0.5-1.5 parts of a radix sophorae flavescentis extract, 0.5-1.5 parts of a radix clematidis extract, 0.5-1.5 parts of a fructus kochiae extract and 0-80 parts of an ethanol-water solution. The components of the antifungal compound extract are extractedby adopting a hot reflux extraction method; and ethanol-separated and purified liquid obtained after separation and purification of macroporous adsorption resin has an obvious effect of resisting trichophyton rubrum and tritirachium album and can be used for preventing and treating fungal infection of human skin, hair and nails. Meanwhile, plant extracts are compounded to be prepared into powderygranules, the solubility is increased, the state is good, the medicine curative effect is long, and the medication form is convenient.

Compositions for the treatment of some orphan diseases and oral mucosal ulcers, many with similarities in terms of their anti-inflammatory and anti-oxidative activities, but also multiple differences in their observed abilities that can be combined to challenge the current, underlying pathophysiology. The orphan diseases of interest are Dupuytren's Contracture, Peyronie's Disease, Scleroderma, Raynaud's (or Renaud's) Phenomenon, chemotherapy / radiation induced oral mucosal ulceration, and aphthous ulcers; and more frequent skin issues of skin damage from cuts, abrasions, and burns; aging skin changes, and toe nail fungus. These can be treated with the disclosed compositions with the proper combination and alteration of ingredients inclusive of alpha-pinene, an aloe vera preparation, and a shea butter preparation. A process for preparation of such ingredients in a water-in-oil emulsion is described herein.

A process and composition of a gel that is effective at disinfecting wounds and killing fungal infections such as athletes foot and nail fungus and promoting healing in wounds of the skin has been developed. The invention is produced by a process of gelling hydrogen peroxide with synthetic smectite clay nanoparticles that are free of any heavy metals. Unexpectedly the gel actually promotes healing in wounds of the skin.

Disclosed herein is an apparatus including two containers assembled together in a sleeve, where the first container includes a cosmetic agent, such a nail whitening agent, and the second container includes an antifungal active pharmaceutical ingredient. Also disclosed herein are methods for assembling an apparatus for treatment of nail fungus and a method of treating nail and / or skin fungus.

This new art is medicine that kills (cures) thick ugly toe / finger nail fungus, (or any kind of nail fungus) and the major difference with this medicine, is that this medicine is applied to the external body using a combination of sodium monofluorophosphate, sodium fluoride, and a cream / gum base. After this medicine is applied, the toe / finger nail is covered with a plastic / rubber “toe / finger housing” for 24 hours a day, and any type of nail fungus will be dead in 6 to 10 days. This “toe / finger housing” also works with other medicine.

Systems and methods for a laser-assisted topical treatment of nail fungal infections are provided. The laser-assisted topical treatment includes a laser that is configured to output a beam that penetrates the infected nail and creates a channel therethrough. The laser-assisted topical treatment further includes a treatment agent comprising a vehicle and a drug. The treatment agent is applied to an exterior surface of the infected nail so that the treatment agent may flow into the channel.

A gel formulation is combined with a fungicidal concentrate which is a liquid mixture of about 1.2 to 16 ml parts by volume of ultra pure water having an electrical resistance of 16–26 megohms, total dissolved solids of less than 0.04 parts per million and a specific conductance of less than 0.10 mho with about 1.2 to 16 parts by volume of Willard Water as prepared in accordance with U.S. Pat. No. 3,893,943, together with one liter of a gel formulation ingredient containing 10% by weight urea, based on the weight of the gel formulation. The fungicidal liquid concentrate is applied directly to a fungal nail to soften the fungal nail and control the growth of fungi.

This invention relates to the field of topical treatments for infections such as nail infections, particularly fungal infections of the nail commonly referred to as onychomycosis. Particularly, the invention relates to novel compositions containing peroxide for the treatment of such nail infections and other infections.

A method for treating or preventing one of a fungal infection of a nail and a condition of a skin surface excluding an oral cavity. The method includes the step of applying a composition to one of a nail surface adjacent to the infection of the nail and the skin surface having the condition. The composition comprises a plant-based bioactive and between about 0.2% to about 3.0% by weight of a metal chlorite salt. The composition does not contain a therapeutically effective amount of chlorine dioxide.

The invention discloses an efluconazole microemulsion composition, which is an efluconazole microemulsion solution or an efluconazole microemulsion gel, and the raw material formula of the efluconazole microemulsion solution includes: Azole 0.1%-1.0%, oil phase 5%-15%, emulsifier 15%-30%, co-emulsifier 15%-30%, water 30%-60%, oil phase selected from triacetin, oleic acid Glyceride and isopropyl myristate, the emulsifier is selected from Tween 80, Tween 60 and lecithin, and the co-emulsifier is selected from propylene glycol, ethanol and glycerin; the raw material formula of efluconazole microemulsion gel contains Efluconazole microemulsion solutions and gel materials. The efluconazole microemulsion solution of the present invention has good stability, has an ideal microemulsion particle size, and can effectively improve the skin permeability of the drug; Permeability and retention can improve the compliance of clinical treatment of onychomycosis and play a sustained release effect.

Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic procedures consist of microscopy and culture, but due to the slow growth rate of dermatophytes typically two to four weeks are needed before a final diagnosis is obtained. The present invention is a rapid DNA extraction method extracting nucleic acids from fungi (e.g. dermatophytes and other pathogenic fungi) which can be performed from directly on hair, nail or skin specimens from humans, from naturally or experimentally infected animals or from cultured fungal colonies for the use in PCR amplification and detection assays. The present invention also includes specific primer sets for detection of any dermatophyte and for species specific detection of Trichophyton rubrum and Epidermophyton floccosum by PCR and a kit for diagnosing fungal infections.

A gel formulation is combined with a fungicidal concentrate which is a liquid mixture of about 1.2 to 16 ml parts by volume of ultra pure water having an electrical resistance of 16-26 megohms, total dissolved solids of less than 0.04 parts per million and a specific conductance of less than 0.10 mho with about 1.2 to 16 parts by volume of Willard Water as prepared in accordance with U.S. Pat. No. 3,893,943, together with one liter of a gel formulation ingredient containing 10% by weight urea, based on the weight of the gel formulation. The fungicidal liquid concentrate is applied directly to a fungal nail to soften the fungal nail and control the growth of fungi.

Compositions for the topical treatment of fungal infections in nails, comprising at least one physiologically acceptable carboxylic acid capable of reducing the pH in keratinous tissue, in particular nails, of a treated person below 4.0, preferably in the range of 1.5-4.0, a physiologically acceptable carrier comprising at least one C1-C4 alkyl ester of lactic acid, and at least one physiologically acceptable fluorescent whitening agent. The invention relates to the use of said composition for the preparation of a product suitable for treatment of fungal infections. The invention also relates to the use of said composition for the treatment of a fungal infection.