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40 results about "Immunostimulating Complexes" patented technology
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Methods and compositions for inducing innate immune responses
InactiveUS20060019923A1Poorly immunostimulatoryAntibacterial agentsOrganic active ingredientsImmunostimulating ComplexesImmunology
The invention relates to TLR ligand formulations that comprise immune stimulating complexes and their use in inducing innate immunity.
Owner:CSL LTD +1
Methods and compositions for inducing innate immune responses
InactiveUS20090017021A1Heavy metal active ingredientsOrganic active ingredientsImmunostimulating ComplexesInnate immune system
Owner:COLEY PHARMA GRP INC +1
Methods and compositions for inducing innate immune responses
InactiveUS20070129320A9Antibacterial agentsOrganic active ingredientsImmunostimulating ComplexesImmunology
Owner:CSL LTD +1
Methods and compositions for inducing antigen-specific immune responses
InactiveUS20060287263A1Enhanced IFN-gamma productionIncrease productionAntibacterial agentsBiocideImmunostimulating ComplexesSpecific immunity
Vaccine compositions comprising (a) an oligonucleotide, (b) and immune stimulating complex and (c) an antigen induce a strong interferon-gamma immune response. Both oligonucleotides containing immune stimulatory motifs and oligonucleotides lacking immune stimulatory motifs contribute to an interferon-gamma response when administered with an immune stimulating complex.
Owner:COLEY PHARM GRP INC +1
Special diluent for swine mycoplasmal pneumonia vaccines and preparation method of special diluent
ActiveCN103071151AStrengthen cellsEnhance humoral immune stimulationAntibacterial agentsBacterial antigen ingredientsCholesterolVaccine antigen
Owner:JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
Stabilized synthetic immunogen delivery system
ActiveUS8088388B2Improve propertiesEffectively upregulating immune responseImpression capsPeptide/protein ingredientsSynthetic ImmunogensParticulates
Owner:UNITED BIOMEDICAL INC
Prepn and usage of outer membrane protein subunit vaccine of seawater fish morbid vibrio
InactiveCN101020051AChemical properties determinedImmunospecific stabilityAntibacterial agentsPharmaceutical non-active ingredientsDiseaseBacteroides
The present invention is preparation and usage of outer membrane protein subunit morbid vibrio vaccine for seawater fish. The vaccine is prepared through extracting two or more of Vibrio alginolyticus, Vibrio Hrveyi, Vibrio vulnificus, Vibrio parahaemolyticus, etc, and adding immunostimulating complex. The vaccine preparing process includes culturing vibrio, extracting outer membrane protein and preparing vaccine. The vaccine containing partial pathogen and no infecting component has stable immunological specificity and no hidden danger of restoring toxici. The vaccine is used in preventing fishes' skin ulcer, eyeball turbidity and other vibrio caused diseases and may be used widely for immunizing seawater fish.
Owner:GUANGDONG OCEAN UNIVERSITY
Immune enhanced gene vaccine of hepatitis B virus core antigen and preparation method thereof
InactiveCN101884793AEnhance immune responseEfficient induction of antiviral replication abilityGenetic material ingredientsDigestive systemAnti virusHepatitis B virus core Antigen
The invention relates to the technical field of gene engineering, in particular to an immune enhanced gene vaccine of a hepatitis B virus core antigen (HBcAg). The vaccine is an immune stimulating complex (ISCOM) vaccine consisting of HBcAg and OX40 ligand (OX40L) dual-gene co-expression recombinant eukaryotic vector, saponin Quil A, cholesterol and lecithin. The vaccine can promote immune response of specific T cells of the HBcAg and efficiently induce the anti-virus replication capacity of immune cells, and has good application prospect in the field of hepatitis B virus infection resistance. The invention also relates to a preparation method for the vaccine with simple and convenient operation and low cost.
Owner:ARMY MEDICAL UNIV
Chlamydial vaccines and methods of preparation thereof
InactiveUS6464979B1Strong immune responseImproving immunogenicityBacterial antigen ingredientsPeptide/protein ingredientsDiseaseImmunostimulating Complexes
Immunogenic compositions including vaccines are described that comprise an outer membrane antigen extract of a strain of Chlamydia and are effective in protection against disease caused by Chlamydia infection. The immunogenic compositions may comprise the major outer membrane protein (MOMP) of Chlamydia which may be in a homooligomeric form or complexed with at least one other antigen of Chlamydia. The immunogenic composition may include an immunostimulating complex (ISCOM) and the outer membrane antigen may be incorporated therein. The immunogenic compositions have utility as chlamydial vaccines and in diagnostic applications.
Owner:AVENTIS PASTEUR LTD
Production of hygrophilous monospermous bacterium main-protective antigen univalent and multivalent vitelline antibody and use in aquatic animal
InactiveCN101074260AIncrease productionLow costAntibacterial agentsEgg immunoglobulinsDiseaseProtective antigen
Production of various Aeromonas hydrophila protective antigen monovalent and multivalent vitelline antibody and its usage in prevention of aquatic animal diseases are disclosed. It utilizes minor-protective antibody to make immune irritant composite egged hen and produce vitelline antibody product. It's safe, efficient, fast, has no harm and residue. It has more output, better immune-system development and functions of nutrients-added, disease-prevention and health-care.
Owner:BIOLOGICAL TECH INST OF FUJIAN ACADEMY OF AGRI SCI +4
Chlamydial vaccines and immunogenic compositions containing an outer membrane antigen and methods of preparation thereof
InactiveUS6635746B1Strong immune responseImproving immunogenicityPeptide/protein ingredientsPeptide preparation methodsDiseaseImmunostimulating Complexes
Immunogenic compositions including vaccines are described that comprise an outer membrane antigen extract of a strain of Chlamydia and are effective in protection against disease caused by Chlamydia infection The immunogenic compositions may comprise the major outer membrane protein (MOMP) of Chlamydia which may be in a homooligomeric form or complexed with at least one other antigen of Chlamydia. The immunogenic composition may include an immunostimulating complex (ISCOM) and the outer membrane antigen may be incorporated therein. The immunogenic compositions have utility as chlamydial vaccines and in diagnostic applications.
Owner:AVENTIS PASTEUR LTD
Saponin adjuvant compositions and methods relating thereto
InactiveUS9149520B2High activityLow reactogenicityVaccinesContraceptive vaccin ingredientsAdjuvantImmunostimulating Complexes
An adjuvant composition which comprises an anionic macromolecule component particularly an ionic polysaccharide such as DEAE-dextran, and a saponin component, particularly an immunostimulating complex component. Immunogenic compositions comprising an immunogen and this adjuvant composition are also disclosed together with methods of use thereof.
Owner:ZOETIS SERVICE LLC
Method for preparation of novel subunit vaccine for treating porcine pseudorabies
InactiveCN101081298ANo latent infectionOptimized Extraction TechnologyViral antigen ingredientsAntiviralsRabiesCyst
The present invention discloses preparation process of new subunit vaccine of pig's pseudo rabies. The preparation process includes: differentially centrifuging pseudo rabies low virulent strain (PRV-FB strain), suspending the virus in PBS, regulating the protein concentration of the viral antigen, adding Mega-10 lytic virus cyst membrane protein, centrifugally extracting cyst membrane protein, adding proper amount of ISCOM matrix, bagging and dialyzing to obtain PRV type subunit vaccine. The PRV type subunit vaccine is safe and effective, and may be used in preventing and controlling pig's pseudo rabies.
Owner:陈少莺
Use of immunological stimulant compound(ISCOMs)in fish immunity by oral administration and dipping bath method
InactiveCN1879880AImprove the ability of proliferation and transformationHigh antibody titerImmunological disordersAntibody medical ingredientsStimulantT lymphocyte
The invention relates to a bath or oral application of immune activate compound in the fish immunity, wherein the invention has the advantages that: said compound ISCOMs is used to bath immunity to improve the antibody level and improve the increment transformation ability of T-lymphocyte, to induce the immune protection; when in the same dosage, the antibody level is higher than non-adjuvant group and the ISM1312 group; and the ISCOMs used in oral can improve the antibody level and improve the increment transformation ability of T-lymphocyte, to induce the immune protection.
Owner:BIOLOGICAL TECH INST OF FUJIAN ACADEMY OF AGRI SCI +3
Hepatitis B virus dendritic cell therapeutic vaccine and preparation method thereof
InactiveCN101897965AEnhance immune responseAbility to efficiently induce antiviral replicationAntiviralsAntibody medical ingredientsHepatitis B virus core AntigenDendritic cell
The invention discloses a hepatitis B virus dendritic cell therapeutic vaccine and a preparation method thereof. The preparation method thereof includes the steps that: HBcAg-Fc digenic co-expression recombinant eukaryotic vector is constructed; the obtained digenic co-expression recombinant eukaryotic vector is added with saponin Quil A and then is added with cholesterol and lecithin, ice-bath ultrasonic processing is carried out, so that solution is fully mixed and emulsified, PBS dialysis is carried out, and the obtained micro floccus is immunostimulating complex; and the obtained immunostimulating complex activates and simulates dendritic cell, thus obtaining the cell therapeutic vaccine. The vaccine carries out high efficiency transfection on dendritic cell, the generated fusion protein targets the dendritic cell in high efficiency by virtue of Fc segment, thus activating the dendritic cell, promoting immune response of hepatitis B virus core antigen specificity T cell and inducing the antivirus replication capability of immune cell in high efficiency, so that the vaccine can be taken as hepatitis B virus therapeutic vaccine.
Owner:ARMY MEDICAL UNIV
IMMUNOTHERAPEUTIC METHOD INVOLVING CD123 (IL-3Ra) ANTIBODIES AND IMMUNOSTIMULATING COMPLEX
A method for the treatment of a condition which is characterized by CD 123-expressing cells in a patient comprises administering to the patient (i) an antibody or antibody fragment which binds selectively to IL-3Rα(CD 123), and (ii) an immunostimulating complex which comprises saponin, a sterol and a phospholipid.
Owner:CSL LTD
Preparation of immuno-stimulation composition for hemolycin in monad
InactiveCN1583171AImprove immunityStrong synergismAntibacterial agentsBacterial antigen ingredientsImmune effectsOrganic acid
An immunostimulating complex with stable and durable immune effect is prepared from hygrophilic monodas through liquid culturing, centrifugal separating of supernatant, treating it by saturated ammonium sulfate solution, suspending its deposit by PBS dialyzing to obtain toxic, concentrating, adding organic acid, adding Mega-10, treating at 37 deg.C for 4 hr, adding Quil A, cholesterol and lecithin, treating by organic acid, and dialyzing.
Owner:INST OF ANIMAL HUSBANDRY & VETERINARY FUJIAN ACADEMY OF AGRI SCI +3
Immunotherapeutic method involving CD123 (IL-3Rα) antibodies and immunostimulating complex
ActiveUS8920803B2Immunoglobulins against cell receptors/antigens/surface-determinantsAntibody ingredientsPhospholipinSterol
A method for the treatment of a condition which is characterized by CD 123-expressing cells in a patient comprises administering to the patient (i) an antibody or antibody fragment which binds selectively to IL-3Rα(CD 123), and (ii) an immunostimulating complex which comprises saponin, a sterol and a phospholipid.
Owner:CSL LTD
Stabilized synthetic immunogen delivery system
ActiveUS8084015B2Effectively upregulating immune responseEasy to demonstrateAntimycoticsImpression capsSynthetic ImmunogensParticulates
The present invention provides an immunostimulatory complex specifically adapted to act as adjuvant and as a peptide immunogen stabilizer. The immunostimulatory complex comprises a CpG oligonucleotide and a biologically active peptide immunogen. The immunostimulatory complex is particulate and can efficiently present peptide immunogens to the cells of the immune system to produce an immune response. The immunostimulatory complex may be formulated as a suspension for parenteral administration. The immunostimulatory complex may also be formulated in the form of w / o-emulsions, as a suspension in combination with a mineral salt suspension or with an in-situ gelling polymer for the efficient delivery of an immunogen to the cells of the immune system of a subject following parenteral administration, to produce an immune response which may also be a protective immune response.
Owner:UNITED BIOMEDICAL INC
Method of eliciting an immune response against pandemic influenza virus
ActiveUS20100291146A1SsRNA viruses negative-senseViral antigen ingredientsAdjuvantImmunostimulating Complexes
A method for eliciting or inducing a protective immune response in a subject against a pandemic subtype of influenza virus comprises administering to the subject a composition comprising (i) at least one immunogen of an endemic influenza subtype, and (ii) an immunogen-free immunostimulating complex as adjuvant.
Owner:CSL LTD
Special diluent for swine mycoplasmal pneumonia vaccines and preparation method of special diluent
ActiveCN103071151BStrengthen cellsImprove the effectiveness of anti-virus protectionAntibacterial agentsBacterial antigen ingredientsCholesterolLevamisole
The special diluent for swine mycoplasma pneumonia vaccine of the present invention mainly contains recombinant P97R1 protein immunostimulatory complex (ISCOM-P97R1), and may also contain other aqueous adjuvant components, including levamisole, or / and astragalus polysaccharide, or / and carboxy bohm. Each ml solution of the diluent contains 0.1-1 mg of QuilA, 0.02-0.2 mg of cholesterol, 0.02-0.2 mg of phosphatidylcholine, 0.4-4 mg of P97R1 antigen, and may further contain 2-20 mg of levamisole , or / and astragalus polysaccharide 20-100 mg, or / and carbomer 3-10 mg, and the rest is phosphate buffer. This diluent is specially used for dissolving or diluting Mycoplasma pneumoniae vaccine, including live vaccine and inactivated vaccine. It has the dual effects of supplementing the protective spectrum of vaccine antigens and enhancing the immune stimulating ability of vaccine cells and humoral, which can significantly improve the protective efficacy of vaccines against viruses. At the same time, due to the use of the water solvent system, it also has the advantages of simple operation, good needle penetration, and no obvious toxic and side effects.
Owner:JIANGSU ACAD OF AGRI SCI
Gene vaccine of sperm-specific cationic channel protein CatSper1 and preparation method thereof
InactiveCN101816799APrevent movementLower average litter rateGenetic material ingredientsAntibody medical ingredientsBALB/cCholesterol
The invention relates to a vaccine, in particular to a gene vaccine of sperm-specific cationic channel protein CatSper1. The vaccine is an immune-stimulating complex type vaccine composed of CatSper1-BAFF digenic recombinant eukaryotic vector, saponin Quil A, cholesterol and lecithin; and the vaccine can inhibit the movement of sperms, perform specific reduction of the average farrowing rate and number born of BALB / c mouse and have good application prospect in the immunological contraception field. The invention also relates to a preparation method of the vaccine which has simple operation and low cost.
Owner:ARMY MEDICAL UNIV
Cancertestis antigen HCA587 protein vaccine and application thereof
InactiveCN102178940AInhibition of growth rateInhibit growthAntibody medical ingredientsAntineoplastic agentsImmunostimulating ComplexesMouse tumor
The invention discloses a Cancertestis antigen HCA587 protein vaccine and application thereof. The protein vaccine comprises HCA587 protein, complete Freud's adjuvant, incomplete Freud's adjuvant, ISCOM (immunostimulating complex) and CpG ODN-1826. The HCA587 protein vaccine can induce CD4 and CD8T cell immune response and humoral immune response, can prevent the growth of mouse tumors, can prolong the survival time of mice with tumor, can inhibit the growth speed of the tumors and has a good antitumor effect. The invention lays the scientific function for the clinical application of the HCA587 protein vaccine.
Owner:PEKING UNIV
Preparation technique of Vibrio vulnificus whole-cell immunity stimulated compound vaccine and use thereof in aquatic animal
InactiveCN101361971AToxicLive bacteria bio-content doubledAntibacterial agentsBacteriaZymogenVirulent characteristics
The invention relates to a preparation technology of vibrio vulnificus whole-bacteria immunity stimulated compound vaccine and the application thereof in aquatic animals. The technology comprises the following steps: (1) pre-amplification and expansion cultivation of the vibrio vulnificus is carried out, (2) blanching is imposed on the vibrio vulnificus in zymogen liquid cultivated, (3) non-viable bacteria inspection is carried out on the bacteria liquid blanched, (4) the inactivated vibrio vulnificus is collected by a centrifuge, (5) an ultrasonic crushing is taken on the inactivated vibrio vulnificus collected, (6) immunity stimulated compound ingredients are prepared, and (7) the immunity stimulated compound is prepared by ultrasonic treatment. The virulence of the vibrio vulnificus selected is quite strong (LD50 is about 200cfu / g), the cultivation condition and optimized culture medium can double the biological content of viable bacteria in the fermentation broth, and the biomass of the vibrio vulnificus cultivated is more than 50mg / ml, thus providing energetic technological support for the industrialized fermentation production of the vibrio vulnificus.
Owner:BIOLOGICAL TECH INST OF FUJIAN ACADEMY OF AGRI SCI
Saponin adjuvant compositions and methods relating thereto
InactiveUS20120251566A1High activityLow reactogenicityOrganic active ingredientsVaccinesAdjuvantImmunostimulating Complexes
An adjuvant composition which comprises an anionic macromolecule component particularly an ionic polysaccharide such as DEAE-dextran, and a saponin component, particularly an immunostimulating complex component. Immunogenic compositions comprising an immunogen and this adjuvant composition are also disclosed together with methods of use thereof.
Owner:ZOETIS SERVICE LLC
Gene vaccine of sperm-specific cationic channel protein CatSper1 and preparation method thereof
InactiveCN101816799BPrevent movementEasy to prepareGenetic material ingredientsAntibody medical ingredientsBALB/cCholesterol
The invention relates to a vaccine, in particular to a gene vaccine of sperm-specific cationic channel protein CatSper1. The vaccine is an immune-stimulating complex type vaccine composed of CatSper1-BAFF digenic recombinant eukaryotic vector, saponin Quil A, cholesterol and lecithin; and the vaccine can inhibit the movement of sperms, perform specific reduction of the average farrowing rate and number born of BALB / c mouse and have good application prospect in the immunological contraception field. The invention also relates to a preparation method of the vaccine which has simple operation and low cost.
Owner:ARMY MEDICAL UNIV
Preparation method of novel subunit vaccine of pig pseudorabies
InactiveCN101332297ANo latent infectionOptimized Extraction TechnologyAntiviralsAntibody medical ingredientsRabiesTGE VACCINE
The invention discloses a manufacturing method of a novel subunit vaccine of pseudorabies in pigs. The invention is characterized in that the manufacturing method is that: the PRV-FB strain cell virus is differentially centrifugated, the virus is then suspended in the PBS again, the Mega-10 lytic virus envelope protein is added after the protein concentration of the viral antigen is regulated, the envelope protein is extracted by a centrifugation method and a moderate amount of ISCOM stroma is added, finally, the PRV novel subunit vaccine can be made after bagging and dialyzing. The invention takes the low virulent strain (V-FB strain) of the pseudorabies as the basic virus to extract the PRV-FB envelope protein which is used as the immunogen; by applying a novel Immunostimulating Complexes (ISCOM) vaccine-producing technology, the safe and effective novel subunit vaccine of pseudorabies in pigs which can be used for preventing and controlling the pseudorabies in pigs is developed.
Owner:陈少莺
Application of immunological stimulant compound in preparing fish immunity preparation
InactiveCN100569285CImprove the ability of proliferation and transformationHigh antibody titerImmunological disordersAntibody medical ingredientsImmunologic preparationImmune complex deposition
The invention discloses an application of an immunostimulating compound in preparing fish immune preparation, and the immune preparation is an oral immune preparation or a bath immune preparation. The advantage of the present invention is that: the oral immune preparation or bath immune preparation made of the immune stimulating compound ISCOMs can not only increase the antibody level, but also improve the proliferation and transformation ability of T lymphocytes and induce immune protection. When immunized with the same dose, the antibody titer of ISCOMs group was significantly higher than that of no adjuvant group and ISM1312 adjuvant group. Similarly, oral immunization with ISCOMs can not only increase the antibody level, but also improve the proliferation and transformation ability of T lymphocytes and induce immune protection.
Owner:BIOLOGICAL TECH INST OF FUJIAN ACADEMY OF AGRI SCI +3
Saponin adjuvant compositions and methods relating thereto
InactiveUS9579379B1High activityLow reactogenicityVaccinesContraceptive vaccin ingredientsAdjuvantMedicine
An adjuvant composition which comprises an anionic macromolecule component particularly an ionic polysaccharide such as DEAE-dextran, and a saponin component, particularly an immunostimulating complex component. Immunogenic compositions comprising an immunogen and this adjuvant composition are also disclosed together with methods of use thereof.
Owner:ZOETIS SERVICE LLC
Preparation of immuno-stimulation composition for hemolycin in monad
InactiveCN1292794CStrong immune protectionImprove immunityAntibacterial agentsBacterial antigen ingredientsImmune effectsOrganic acid
An immunostimulating complex with stable and durable immune effect is prepared from hygrophilic monodas through liquid culturing, centrifugal separating of supernatant, treating it by saturated ammonium sulfate solution, suspending its deposit by PBS dialyzing to obtain toxic, concentrating, adding organic acid, adding Mega-10, treating at 37 deg.C for 4 hr, adding Quil A, cholesterol and lecithin, treating by organic acid, and dialyzing.
Owner:INST OF ANIMAL HUSBANDRY & VETERINARY FUJIAN ACADEMY OF AGRI SCI +3
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