63 results about "Hypoxemia" patented technology

Treatment of pulmonary disorders associated with hypoxemia and / or smooth muscle constriction and / or inflammation comprises administering into the lungs as a gas compound with an NO group which does not form NO2 / NOx in the presence of oxygen or reactive oxygen species at body temperature. Treatment of cardiac and blood disorders, e.g., angina, myocardial infarction, heart failure, hypertension, sickle cell disease and clotting disorders, comprises administering into the lungs as a gas, a compound which reacts with cysteine in hemoglobin and / or dissolves in blood and has an NO group which is bound in said compound so that it does not form NO2 / NOx in the presence of oxygen or reactive oxygen species at body temperature. Exemplary of the compound administered in each case is ethyl nitrite.

A smart snore-ceasing back mat based on postural therapy comprises a master controller, a mattress portion and a smartphone end APP (application), the master controller is used for judging whether snore reaches a specific standard or not, and if yes, double air sacs of the mattress portion are bulged by an air pump so as to change a posture of a user. The smart snore-ceasing back mat is applicable to patients with an obstructive sleep apnea-hypopnea syndrome 4.1% in morbidity rate, and the obstructive sleep apnea-hypopnea syndrome is a risk factor for hypertension, diabetes, coronary disease and stroke. The smart snore-ceasing back mat is capable of monitoring and recognizing the snore in environmental noise and changing a supine sleeping posture of the user slightly and timely without affecting sleep of the user to enable the user to lie on the side by at least 30 degrees, and a respiratory tract obstruction situation of the user is mitigated by means of lying on the side so as to change a snoring and hypoxemia state of the user during sleeping; postural intervention is carried out only when a program judges necessity, the user is not forced to lie on the side in the whole night, and accordingly, the smart snore-ceasing back mat is highly comfortable and beneficial to long-term use by the user. The smart snore-ceasing back mat provides an effective and compliant domestic solution for early out-of-hospital intervention of sleep disordered breathing.

Treatment of pulmonary disorders associated with hypoxemia and / or smooth muscle constriction and / or inflammation comprises administering into the lungs as a gas a compound with an NO group which does not form NO2 / NOx in the presence of oxygen or reactive oxygen species at body temperature. Treatment of cardiac and blood disorders, e.g., angina, myocardial infarction, heart failure, hypertension, sickle cell disease and clotting disorders, comprises administering into the lungs as a gas, a compound which reacts with cysteine in hemoglobin and / or dissolves in blood and has an NO group which is bound in said compound so that it does not form NO2 / NOx in the presence of oxygen or reactive oxygen species at body temperature. Exemplary of the compound administered in each case is ethyl nitrite. Treatment of patient in need of improved oxygenation, blood flow of and / or thinning of blood comprises providing in the patient a therapeutic amount of red blood cells loaded with nitrosylated hemoglobin. A method is directed to screening drugs that increase level of nitrosoglutathione in airway lining fluid.

The invention discloses an infusion pump system with a blood oxygen and blood pressure monitor function. The system comprises an electronic infusion pump body, wherein the electronic infusion pump body is provided with a blood oxygen detection unit connected with an external blood oxygen sensor, and a blood pressure detection unit connected with an external blood pressure sensor; and the blood oxygen detection unit and the blood pressure detection unit are connected with a wireless data transmission unit which is used for transmitting signals to a system workstation. The system is reasonable in structure, and can be used for monitoring pulse oximetry, patient heart rate and blood pressure in the pain-easing treatment process, so as to timely find hyoxemia and other problems and prompt medical staff to treat as early as possible, so that the occurrence of complications can be reduced, and the occurrence of adverse response (such as sudden cardiac arrest, death) can be reduced.

The invention relates to a rolling brush type sputum scab cleaning device for an artificial airway. The rolling brush type sputum scab cleaning device comprises a ventilating pipe, a blocking air bag,a sputum sucking rolling brush and a sputum sucking tube, wherein the sputum sucking tube is of a tube body with an annular cavity composed of an inner tube and an outer tube, the sputum sucking rolling brush comprises a disc body, a sputum storage chamber is arranged inside the disc body, multiple groups of brush hair are uniformly distributed on the circumferential face of the disc body, and one sputum sucker is arranged between every two adjacent groups of brush hair. During sputum sucking, on one hand, through matching between the blocking air bag and the ventilating pipe, a negative-pressure environment can be completely isolated from the interior of a body of a sufferer, and the condition that hypoxemia occurs due to the fact that gas volume of peripheral lung tissue of the suffereris reduced due to the fact that a negative-pressure sucking force sucks gas during sputum sucking is avoided; and on the other hand, the sputum suckers can rotate, sputum adhered to the wall of the artificial airway can be scraped off and sucked off successfully through rotating operation, and thus, the effect of deep cleaning is achieved.

The invention relates to an aquatic animal hypoxemia experimental facility and an experimental method thereof, wherein the content of dissolved oxygen in water of the experimental facility is required to be maintained stably relatively. An aquarium with a glass cover and a water quality analysis device are used in the experimental facility; the experimental facility is characterized in that the aquarium and the water quality analysis device are connected together through a communicating pipe; the opening of the aquarium with a glass cover along the inner side is connected with a seal rubber ring which is matched with a seal cover plane; a plurality of screw holes are distributed on the seal cover plane; each screw hole is screwed in a ventilating insertion pipe with threads; the upper end of the ventilating insertion pipe is provided with a small seal nut. The experimental method comprises the following steps of: before experiment, injecting experimental water into the glass aquarium; putting experimental fish in the water; covering the aquarium with the seal cover provided with the ventilating insertion pipe; presetting the starting number of the ventilating insertion pipes of the seal cover according to the oxygen consumption of experimental fish in unit time; starting the experiment when the dissolved oxygen in the water is stabilized to the experiment-needed low oxygen level; during the experiment, if major change of the dissolved oxygen occurs in the water, taking off a part of screw nuts of the ventilating insertion pipes or increasing the sealing number to adjust the air amount of water.

The invention belongs to the medical field and relates to the application of cannabidiol (CBD) in the treatment of pulmonary hypertension. The cannabidiol can be used as a sole active ingredient or incombination with other active ingredients to prepare a drug for treating pulmonary hypertension.The present invention relates to the use of any one of (1) to (3) below for the preparation of a medicament for the treatment and / or prevention of pulmonary hypertension:(1) cannabidiol, (2) a plant extract containing cannabidiol, preferably, the plant extract is a cannabis extract, and (3) a pharmaceutical composition comprising cannabidiol and one or more pharmaceutically acceptable adjuvants. The invention finds out the effect of cannabidiol on inhibiting pulmonary hypertension through experimental research, and is especially suitable for treating pulmonary hypertension caused by hypoxemia.

The invention provides a three-channel microfluidic chip for establishing three kinds of cell in-vitro co-culture models. The three-channel microfluidic chip is characterized by comprising three flow channels capable of being used for inoculating different element cells respectively, and tiny flow channels which are designed for communication among different cells, and connected between each two flow channels in a communication manner; astrocytes in a nervus vascularis unit are taken as a bridge, and role the important role of communicating nerve cells and cerebral microvascular endothelial cells, therefore, the astrocytes are inoculated in the middle flow channel. The three-channel microfluidic chip has the advantages that (1) the nervus vascularis unit models established by the three-channel microfluidic chip can truly show the real framework in the brain of which the astrocytes are taken as the bridge and are connected with the other two element cells together, namely, nerve cells-astrocytes-cerebral microvascular endothelial cells; and (2) the three-channel microfluidic chip can represent the O2 of different concentrations, so to as further reflect the ischemic hypoxemia states of the three element cells in the nervus vascularis unit after the oxygen-glucose deprivation damage.

The invention relates to a double-lumen catheter device capable of adjusting single-pulmonary ventilation volume and positive airway pressure, comprising a main catheter and an operation side catheter and a non-operation side catheter, wherein one end of the main catheter, one end of the operation side catheter and one end of the non-operation side catheter are connected by a first Y-shaped catheter to form a tee structure; the other end of the non-operation side catheter is connected with a non-operation side catheter port; the other end of the operation side catheter is connected with an operation side catheter port; an operation side catheter body is provided with a two-way two-channel flow control mechanism capable of adjusting and controlling the ventilation volume and the positive airway pressure of the operation side catheter; and the other end of the main catheter is connected with a medical machine port. The invention has strong adaptability and wide application, can simplify the anesthesia management so as to enable the anesthesia to be safer, and can effectively prevent complicating diseases of hyoxemia and the like caused by operation cannula while providing a relatively static operation field.

The invention discloses a breather applied to painless gastroscope diagnosis and treatment airway management. The breather comprises a tooth pad and an air channel which are combined and is characterized in that the tooth pad comprises a tooth pad retaining plate matched with the radian of the upper and lower lips, an elliptical tube is connected to the inner side of the middle of the tooth pad retaining plate, the air channel comprises an air channel elliptical tube, the part outside the opening of the air channel elliptical tube extends to form an air channel retaining plate adaptive to thetooth pad retaining plate, the air channel retaining plate and the tooth pad retaining plate are connected through a connector, three tube cavities are arranged in the air channel elliptical tube, themiddle cavity is a gastroscope channel, and the two cavities on two sides of the gastroscope channel are respectively an aspiration channel and an oxygen supply channel. By the breather, the problemsthat airway obstruction in a traditional method causes hypoxemia, and oropharynx secretion and gastroscope's irritation to the throat cause the bucking, apnea or blood oxygen saturation lowering of patients are solved.

Disclosed is an artificial respiration device that includes a tubular element, which forms a main channel having an upstream part at the proximal end of the tubular element and a downstream part at the distal end of the tubular element. Auxiliary channels open into the main channel and deflecting means are located internal to the main channel. The deflecting means are configured to deflect jets of respiratory gas injected into the main ckannel through the auxiliary channels so as to converge the gas at a point of convergence inside the main channel. The tubular element also includes at least one lateral safety orifice that extends through a lateral wall of the tubular element at a location sustantially opposite the point of convergence, and which is configured to communicate air from outside the tubular element to the downstream part of the main channel.

The invention provides a dedicated ventilation device of a painless gastroscope, which ensures free breath and prevents reflux. The device comprises a hood provided thereon with two inlets and a gastroscope inlet therebetween, wherein the inlet to the side is a respiration inlet connected with a breathing machine, and the gastroscope inlet is connected with a sheathed gastroscope guide tube that has one end positioned in the upper part of the hood and the other end positioned in the lower part of the hood. The device further comprises an air sac at the external part of the front end of the sheathed gastroscope guide tube in the lower part of the hood, and the air sac communicates with an air injection pipe, wherein the other end of the air injection pipe is positioned in the upper part of the hood and communicates with an air injection valve. The invention can relieve syndromes caused by respiratory depression of various degrees due to general anesthetics, such as hypoxemia, severe respiratory depression, breath and cardiac arrest, and even death caused by non-timely rescue. The invention ensures efficient respiratory support without lightening the anaesthesia in consideration of the respiratory depression, and meanwhile prevents the occurrence of reflux and aspiration. Therefore, the invention can ensure the success of gastroscopy while providing respiratory support, thereby providing safety and convenience for the painless gastroscopy.

The present invention provides methods and compositions to replace up to 90% of erythropoietin use in the treatment of anemias and hypoxias. The method employs acid and salt forms of inositol-tripyrophosphate (ITPP) isomers to shift the P50 value of hemoglobin, thereby improving the rate and efficiency of oxygenation by blood even when red blood cell counts are low. Indications for the new method include anemias and hypoxia arising from infection, chemotherapy, premature birth, altitude change, compromised lung or heart function, aplastic anemia and anemia associated with a myelodysplastic syndrome, and other causes.

The invention discloses a device that can identify artery and vein accurately, is used for deep venipuncture and catheterization and is characterized in that: the device is provided with a tube (1) the front end of which is provided with a union joint (2); a spring (3) is arranged in the tube (1) and the front end of the spring (3) is connected with a piston (4); a spring seat (5) is arranged on the tube (1) at the rear end of the spring (3) and a through hole (6) that is communicated with the intracavity of the tube (1) is arranged on the spring seat (5). The device is simple in structure and convenient in operation and can observe the blood pressure and blood fluctuation without unloading an injector, thus the blood vessel into which a puncture needle is inserted is vein or artery can be accurately identified so as to conduct catheterization operation quickly and avoid the influence on artery and vein identification caused by such factors as light indoor and hypoxaemia to reduce the suffering of sufferers resulted from misjudgement of artery and vein.

The invention provides a mint oil preparation which comprises mint oil, glycerin, and distilled water.

The invention relates to application of an acellular fat extracting solution to treatment of lung diseases. Specifically, the application of an acellular fat extract is provided and used for preparing a composition or a preparation, and the composition or the preparation is selected from one or more of the following applications: (i) prevention and / or treatment of acute respiratory distress syndrome and / or acute lung injury; (ii) prevention and / or treatment of hypoxemia; (iii) improvement of lung tissue inflammation; (iv) improvement of lung tissue injury; (v) prevention and / or treatment of systemic inflammatory response syndrome; and (vi) prevention and / or treatment of multiple organ function failure. The acellular fat extract can be used for effectively preventing and / or treating acute respiratory distress syndrome, acute lung injury, hypoxemia, lung tissue inflammation, lung tissue injury, systemic inflammatory response syndrome and multi-organ function failure.

The invention relates to an intelligent control system of a sleeping apnea electric body turning bed. The system comprises a blood oxygen monitoring device, a controller and an operating display and is characterized in that the blood oxygen monitoring device transmits a blood oxygen signal monitored in the sleeping process of a patient to a controller which is internally provided with an oxygen reduction driving module, the electric body turning bed is driven to turn or restore to a flat lying position by the controller when the oxygen reduction and oxygen reduction time of blood oxygen reduction caused by apnea reach corresponding threshold values, sleep monitoring information is displayed on an operating display, the intelligent control system is installed on the electric body turning bed to produce a sleeping apnea electric body turning bed which provides a novel clinical solution scheme for improving hypoxemia in the sleeping process of a sleep apnea syndrome patient.

The present invention relates to a set of biomarkers, which can be used to determine the risk of developing hypoxemia for subjects undergoing open heart surgery with the use of cardiopulmonary bypass (CPB).

The disclosed freeze-dried preparation for injection comprises carbamide peroxide and dextran by the mass ratio of 0.001-2 : 0.001-2, the invention also discloses the method for preparing the carbamide peroxide freeze-dried preparation and its use, wherein the preparation is prepared through dissolving carbamide peroxide and dextran in water while keeping the condition of filling nitrogen, filtering, recrystallizing during freeze-drying procedure, and slowing down the release speed during clinical application. The invention can be applied for treating various hypoxemia and fetal distress caused by acute anoxia.

The present invention provides methods and compositions to replace up to 90% of erythropoietin use in the treatment of anemias and hypoxias. The method employs acid and salt forms of inositol-tripyrophosphate (ITPP) isomers to shift the P50 value of hemoglobin, thereby improving the rate and efficiency of oxygenation by blood even when red blood cell counts are low. Indications for the new method include anemias and hypoxia arising from infection, chemotherapy, premature birth, altitude change, compromised lung or heart function, aplastic anemia and anemia associated with a myelodysplastic syndrome, and other causes.

The invention discloses a painless gastroendoscopic oxygen-inhalation mask. The painless gastroendoscopic oxygen-inhalation mask comprises an arc-shaped mask body; a gastroscope hole is formed in the middle part of the mask body and directly faces the mouth of a patient; an oxygen hole is formed in the mask body; an oxygen conveying tube joint is arranged on the oxygen hole; an aluminum plate which directly faces the nose of the patient is arranged on the mask body; a ventilating hole is formed in the mask body and positioned at the side edge of the gastroscope hole and the oxygen hole; a mask side is arranged on the side edge of the mask body; a fixing belt is arranged on the mask side. According to the mode above, the painless gastroendoscopic oxygen-inhalation mask has the advantages that the oxygen inhalation and gastroendoscopic examination can be synchronously performed during painless gastroendoscopic operation; the concentration of inhaled oxygen can be increased; the risk that the concentration of inhaled oxygen under a nasal catheter is small and hyoxemia easily occurs can be overcome; in addition, the structure is simple, and the operation is easy.

The invention discloses an after-burning type regenerator with ultralow nitrous oxide discharging and a regeneration technology thereof, and belongs to the field of regenerator devices. The after-burning type regenerator is characterized in that a regenerator shell (11) is divided into a lean-phase zone (2) on the upper portion and a dense-phase zone (1) on the lower portion; a cyclone separating device is arranged in the lean-phase zone (2); an after-burning air pipeline is connected with one side of the cyclone separating device; an exhaust pipe is arranged on the upper portion of the cyclone separating device, and a particulate exhausting opening is formed in the lower portion of the cyclone separating device; a main wind distributing device is arranged in the dense-phase zone (1); a catalyst to be generated conveying pipe (5) is arranged on one side of the dense-phase zone (1); and a regenerated catalyst outputting pipe (7) is arranged on the lower portion of the dense-phase zone (1). A main air blower and an after-burning air blower provide main air and after-burning air correspondingly, an after-burning mode of hypoxemia in the regenerator and afterburning in the cyclone separating device is adopted, by adjusting burning atmosphere in the regenerator, burning-out of solid and gaseous combustible materials is realized by using after-burning, and ultralow nitrous oxide discharging is realized.

The invention discloses a disposable closed phlegm suction and collection device. The device comprises a closed phlegm suction pipe body, wherein the phlegm suction pipe body comprises a Y-shaped connector and a phlegm suction pipe which are sequentially connected; a phlegm suction pipe sealing film is fixedly arranged at the outer part of the phlegm suction pipe, and a negative pressure control valve is arranged at the bottom of the phlegm suction pipe; a pipe orifice A and a port cap of the pipe orifice A are arranged at the bottom of the negative pressure control valve; the Y-shaped connector comprises a tracheal socket at the top end, a respirator connecting orifice and a drug injection opening at the lateral end; a sealing push plate is arranged between the phlegm suction pipe and theY-shaped connector and is used for controlling the phlegm suction pipe to be unblocked and closed; a transfusion medicinal bag is connected on the side wall of the pipe body between the phlegm suction pipe and the sealing push plate through a connecting pipe; a tee joint is fixedly arranged on the connecting pipe; a phlegm deposit bottle is movably connected with the pipe orifice A; a first pipebody and a second pipe body are fixedly arranged at the top of the phlegm deposit bottle, and outlets of the first pipe body and second pipe body are respectively a pipe orifice B and a pipe orifice C. The disposable closed phlegm suction and collection device can effectively solve the problem of closed phlegm collection, avoids alveoli collapse and hyoxemia of a patient and solves the problem ofcross infection of medical staff.

The invention relates to the field of medical instruments, in particular to a coaxial double-lumen bronchial cannula which comprises a tracheal cannula body, an inner trachea is arranged in the tracheal cannula body, one end of the inner trachea is fixedly connected with the inner wall of the tracheal cannula body, the other end of the inner trachea penetrates out of the tracheal cannula body, and a cavity is formed between the inner trachea and the tracheal cannula body. An upper ventilation hole channel is formed in the joint of the inner trachea and the inner wall of the trachea cannula body, a lower ventilation hole channel is formed in the lower end of the trachea cannula body, a first air bag is arranged on the outer surface of the inner trachea and arranged in the cavity, and a second air bag is arranged on the outer surface of the end, extending out of the trachea cannula body, of the inner trachea. A third air bag is arranged on the outer surface of the trachea cannula body. Single-lung and double-lung ventilation and two-lung isolation are achieved only by adjusting the inflation state of the air bag, frequent intubation is not needed, intubation damage is small, the difficulty is low, the problems that a bronchus plugging tube is difficult to fix, plugging side lung collapse is difficult, and hypoxemia occurs are solved, and clinical requirements are met.

The invention discloses a special mask capable of pressurizing and supplying oxygen for painless gastroscopy. The special mask consists of two elastic bands, an oxygen supply gastroscopy mask, an L-shaped oxygen supply tube, an exhaust tube half-hole sealing adjusting nozzle and a gastroscopy tube protection hollow mouth part. The designed oxygen supply gastroscopy mask can provide high-concentration oxygen for the mouth and the nose of a patient to ensure sufficient oxygen supply when the patient is subjected to an oxygen deficit condition during gastroscopy, and besides, the mask can supply oxygen in a pressurized manner at the first time when the patient suffers from bronchial spasm, so that the oxygen supply of the patient can be recovered more quickly, and the occurrence of hypoxemia can be well avoided; and under the condition of tooth biting, the gastroscopy tube protection hollow mouth part can well protect the gastroscope from being bitten, and accidents of injuring the body of a patient are prevented or reduced.

The invention relates to a split oxygen-uptake-breathing-type gastroscope occlusion device kit. The split oxygen-uptake-breathing-type gastroscope occlusion device kit comprises an oropharynx breathing passage and an occlusion device, wherein the oropharynx breathing passage comprises a locating part with an upper groove, the locating part is used for being matched with the occlusion device so as to locate the oropharynx breathing passage, the inner end of the locating part is connected with an arc-shaped pressing part with an upper groove, an inside-out limiting part is arranged at the outer end of the locating part, the upper groove of the locating part and the upper groove of the arc-shaped pressing part are in complete run-through, a locating chamber for enabling a gastroscope to pass through is formed in the occlusion device, and the oropharynx breathing passage can penetrate through the locating chamber and stretch into a throat of a sufferer. The kit has the characteristics that hypoxemia of an obesity patient caused by difficult breathing during painless gastroscope examination can be effectively avoided, and the kit can be inserted during operation.

The invention provides application of gamboge extract to treating pulmonary arterial hypertension, relates to plant extract, and particularly discloses application of gamboge extract, a compound A shown in a structural formula (I) and a compound B shown in a structural formula (II) to treating pulmonary arterial hypertension. The gamboge extract and the compounds can be used as unique active components for preparing medicines for treating pulmonary arterial hypertension. The application has the advantages that as discovered in experimental research, effects of inhibiting the pulmonary arterial hypertension can be realized by the gamboge extract, the compound A in the gamboge extract and the compound B in the gamboge extract, and accordingly the gamboge extract, the compound A and the compound B are particularly applicable to treating the pulmonary arterial hypertension due to hypoxemia; novel breakthrough is made on research on the gamboge extract and pathogenic molecular mechanisms of the pulmonary arterial hypertension, and theoretical bases and targets can be provided for screening novel medicines for preventing and treating secondary pulmonary arterial hypertension and clinically treating the secondary pulmonary arterial hypertension.

The invention belongs to the technical field of medical treatment, and particularly relates to a method for testing novel coronavirus pneumonia, which comprises the following steps: 1) disease symptoms: the disease symptoms take fever, weakness and dry cough as main manifestations; few patients are accompanied by nasal obstruction, running nose, pharyngalgia, diarrhea and other symptoms; critical patients mostly suffer from dyspnea or hypoxemia one week after diseased, and severe patients quickly develop into acute respiratory distress syndrome, sepsis shock, metabolic acidosis difficult to correct, blood coagulation dysfunction and multi-organ function failure. According to the method for testing novel coronavirus pneumonia, the novel coronavirus S protein-ODC422-461 fusion protein can be used for inducible expression in DC cells, tumor antigen presentation of the DC cells is facilitated, the antigen presentation efficiency of in-vivo T cells is improved, the T cells are activated to kill tumor cells, in addition, the fusion protein can be used for cell therapy, the fusion protein has a short half-life period, and the fusion protein has small toxicity and side effects as a drug.

The invention discloses an oropharyngeal channel special for an endoscope. The oropharyngeal channel comprises a tongue pressing bent plate cooperating with an oropharyngeal air channel of a human body in shape, an air inlet cavity, an exhaust cavity, an oxygen interface and a carbon dioxide monitoring interface, wherein the inner end of the tongue pressing bent plate is used for being inserted into the air channel of a patient, panels are arranged at the outer end of the tongue pressing bent plate and used for cooperating with the outer edge of the lip or the outer sides of teeth of the patient in an abutting mode, and an opening allowing the endoscope to pass is formed in the panels; the air inlet cavity is formed in the tongue pressing bent plate and used for supplying oxygen to the patient, and oxygen outlets of the air inlet cavity are formed close to the panels; the exhaust cavity is formed in the tongue pressing bent plate and used for enabling the patient to exhale air, and an air inlet of the exhaust cavity comprises an end inlet located in the end surface of the inner end of the tongue pressing bent plate; the oxygen interface is arranged on the panels and communicates with the air inlet cavity; and the carbon dioxide monitoring interface is arranged on the panels and communicates with the exhaust cavity. The end-expiratory carbon dioxide index of the patient can be monitored while large-flow oxygen supply is performed in a painless endoscopy process, and the occurrence rate of hypoxemia of the patient is effectively reduced.