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Application of gamboge extract to treating pulmonary arterial hypertension

A technology of pulmonary arterial hypertension and extract, which is applied in the field of application of Garcinia cambogia extract in the treatment of pulmonary arterial hypertension, can solve the problems of lack of cure methods for pulmonary arterial hypertension, and achieve a strong clinical effect

Inactive Publication Date: 2017-01-25
CHINA AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs can alleviate the symptoms of PAH to a certain extent. The median survival time of patients receiving treatment is only 2.7 years. At present, there is still no effective cure for pulmonary hypertension. Therefore, it is particularly important to find new specific therapeutic drugs

Method used

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  • Application of gamboge extract to treating pulmonary arterial hypertension
  • Application of gamboge extract to treating pulmonary arterial hypertension
  • Application of gamboge extract to treating pulmonary arterial hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 compound A, compound B are to hypoxia-induced pulmonary arterial hypertension influence test

[0031] Male Sprague Dawley (SD) rats were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., with a body weight of 200 ± 20 g, and were randomly divided into 7 groups (n=10 in each group) (common feed was purchased from the Academy of Military Sciences, and the rats were fed every day. mice ad libitum), that is, the first group of normal oxygen control group, the second group of hypoxic model control group, the second group of hypoxic model corn oil control group, the fourth group of compound A low dose group (10mg / kg / d ), the fifth group compound A high-dose group (50mg / kg / d), the sixth group Gamboge extract B (10mg / Kg / day); the seventh group feeds Garcinia cambogia extract B (50mg / Kg / day) . Rats in the normal control group were subjected to normal pressure and normoxia (21% O 2 ) environment, and the rest of the rats in each group...

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Abstract

The invention provides application of gamboge extract to treating pulmonary arterial hypertension, relates to plant extract, and particularly discloses application of gamboge extract, a compound A shown in a structural formula (I) and a compound B shown in a structural formula (II) to treating pulmonary arterial hypertension. The gamboge extract and the compounds can be used as unique active components for preparing medicines for treating pulmonary arterial hypertension. The application has the advantages that as discovered in experimental research, effects of inhibiting the pulmonary arterial hypertension can be realized by the gamboge extract, the compound A in the gamboge extract and the compound B in the gamboge extract, and accordingly the gamboge extract, the compound A and the compound B are particularly applicable to treating the pulmonary arterial hypertension due to hypoxemia; novel breakthrough is made on research on the gamboge extract and pathogenic molecular mechanisms of the pulmonary arterial hypertension, and theoretical bases and targets can be provided for screening novel medicines for preventing and treating secondary pulmonary arterial hypertension and clinically treating the secondary pulmonary arterial hypertension.

Description

technical field [0001] The present invention relates to plant extracts, in particular to the application of Garcinia cambogia extract in treating pulmonary hypertension. Background technique [0002] Pulmonary arterial hypertension (PAH) has complex etiology and is caused by a variety of heart, lung or pulmonary vascular diseases. The pathological features of pulmonary arteriole vascular remodeling and pulmonary artery smooth muscle proliferation. It is manifested by increased pulmonary circulation pressure and resistance, increased right ventricular load, right ventricular insufficiency, and reduced pulmonary blood flow, which can cause a series of clinical manifestations. Pulmonary hypertension often develops progressively during the course of the disease. Increased pulmonary artery vascular tone leads to right heart failure, a disease that seriously threatens human life and health. In particular, patients with idiopathic arterial PAH can only be diagnosed about 2 years ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P11/00A61P9/12
CPCA61K31/352A61K2300/00
Inventor 李向东郭仰东王娜
Owner CHINA AGRI UNIV
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