33 results about "General screening" patented technology

A set of volatile markers are determined which are characteristic of a particular condition or disease, and which will be found in the exhaled breath of a person or odor from other parts of a body or from an entity. These markers are detected in the breath odor or gaseous emanations from the body or entity noninvasively using a volatile substance detector of sufficient sensitivity, such as an artificial olfactory system. The detected marker data is processed in an artificial neural network / fuzzy filter system with an algorithm that intelligently adapts to the individual body or entity and also optionally (if necessary) with a correction algorithm to eliminate environmental and other erroneous contributions to the markers. Any number of markers may be used, depending on how well they correlate with the condition and how accurate a result is desired, i.e. general screening or accurate diagnosis and monitoring.

Biological samples including cell-free DNA fragments are analyzed to identify imbalances in chromosomal regions, e.g., due to deletions and / or amplifications in a tumor. Multiple loci are used for each chromosomal region. Such imbalances can then be used to diagnose (screen) a patient for cancer, as well as prognosticate a patient with cancer, or to detect the presence or to monitor the progress of a premalignant condition in a patient. The severity of an imbalance as well as the number of regions exhibiting an imbalance can be used. A systematic analysis of non-overlapping segments of a genome can provide a general screening tool for a sample. Additionally, a patient can be tested over time to track severity of each of one or more chromosomal regions and a number of chromosomal regions to enable screening and prognosticating, as well as monitoring of progress (e.g. after treatment).

An ingestible device adapted to travel within the gastrointestinal tract and perform diagnostic imaging of tissues therein is provided. The diagnostic image may include diagnostic information as a function of time, or as a function of distance traveled within the gastrointestinal tract. In particular, the ingestible device may be arranged to perform nuclear radiation of a radiopharmaceutical, scintillation of a scintillation liquid in response to nuclear radiation of a radiopharmaceutical, optical fluorescence of a fluorescing drug or bare gastrointestinal tissue, gastrointestinal Diagnostic imaging of tissue infrared radiation, temperature differential along the gastrointestinal tract, impedance, ultrasound reflections, magnetic resonance, and combinations thereof. The ingestible device may be suitable on the one hand for general screening of large populations and on the other hand for specific diagnosis of possible pathologies.

The invention discloses a process for washing sesame with water. The process comprises the following steps of: removing and separating impurities and stones from the sesame at first; then immersing and washing the sesame with water, stripping the sesame and separating the sesame; drying, performing color selection and magnetic separation; and finally, finishing a process of manufacturing qualified sesame meat. The whole process is extremely smooth and the transferring frequency of the sesame is low, so the production efficiency is improved greatly; various measures, such as general screening, color selection, magnetic separation and the like, are used together, so cleaning and grading can be performed simultaneously; and the later targeted deep processing of the sesame is facilitated.

The invention relates to the technical field of microorganisms, in particular to a new corona-virus nucleic acid 10-in-1 test (10-in-1 test) technology. The new corona-virus nucleic acid 10-in-1 testtechnology is a method for collecting 10 swabs collected from 10 persons in one collection tube and detecting, and the used materials comprise a virus collection tube and a collection swab. The 10-in-1 test technology provided by the invention is suitable for large-area general screening of people with low risk of new corona-virus infection, and can significantly reduce medical collection consumables required by large-scale population screening and reduce the nucleic acid detection cost of new corona-virus; according to the method, the low nucleic acid detection efficiency of a traditional collection and detection method is avoided, the SARS-CoV-2 infection can be effectively diagnosed as soon as possible, further diffusion of the SARS-CoV-2 infection can be controlled, and epidemic spreading can be prevented in time.

The invention provides a method for conducting mixed preparation of tracer composition through a boiling granulator. The method mainly includes the steps of raw material preparation, weighing and general screening, solution weighing, preparing and filtering, equipment parameter setting, no-load check of equipment, adding of raw materials, granulator starting and drug mixing, material discharging and the like. The tracer composition prepared through the method can meet performance and use requirements of products, medicament mixed preparation uniformity and product quality stability are greatly improved, and the method has the advantages that manufacturing is safe, and damage of dust to human bodies and environmental pollution are eliminated.

The invention discloses water-saving industrial silt screening equipment. The water-saving industrial silt screening equipment mainly comprises a material conveying mechanism, a residue throwing mechanism, a vibration screening mechanism, a stirring and water injecting mechanism, a left transmission assembly and a right transmission assembly, wherein the residue throwing mechanism comprises a machine body, a driving cavity, a motor, a first driving shaft, a sliding block and a first torsion spring, the vibration screening mechanism comprises a connecting rod, a first long plate, a first through groove, a second long plate, a second through groove and a screen, the stirring and water injecting mechanism comprises a material storage box, a stirring cavity, a second transmission cavity and asecond rotating shaft. The water-saving industrial silt screening equipment has the beneficial effects that a mechanical mechanism is used for driving the screen to vibrate up and down so as to screenout industrial waste residues while clear water is adopted for scouring, compared with general screening equipment, the water-saving industrial silt is high in screening speed and high in efficiency,in addition, after the water-saving industrial silt screening equipment finishes screening, silt with water is stirred to enable the water flow to enter a water pump again to be recycled through water falling fine holes, and the water-saving industrial silt screening equipment is energy-saving and environment-friendly, safe and reliable, and high in automation degree.

The invention discloses a test strip and method for detecting urine A beta amyloid protein. The test strip for detecting the urine A beta amyloid protein comprises a PVC bottom plate (7), wherein a sample pad (1), a conjugated pad (2), a chromatography pad (3) and a water absorption pad (4) which are sequentially overlapped are paved on the PVC bottom plate (7); the conjugated pad (2) is coated with colloidal gold particles conjugated with a monoclonal antibody; a detection line (5) is arranged on one side, close to the conjugated pad (2), of the chromatography pad (3); a contrast control line(6) is arranged on one side, close to the water absorption pad (4), of the chromatography pad (3); the detection line (5) is coated with an A beta amyloid protein binding polymer; and the contrast control line (6) is coated with a goat anti-mouse IgG polyclonal antibody. The method is high in sensitivity, has a detection limit of 40 pg, is rapid and economical, is suitable for conventional clinical pathological examination, is suitable for general screening of a large number of people and self-screening of home terminal users, is especially used for clinically assisting early diagnosis and pre-judgment of mild cognitive impairment (MCI), and predicts and judges whether a patient has high risk of developing MCI and AD.

The present invention provides gene combinations for screening hereditary heart disease. The gene combination is composed of fourteen genes including MYH7, MYBPC3, TNNT2, TNNI3, LMNA, DSP, SCN5A, DSG2, PKP2, KCNH2, KCNQ1, RYR2, FBN1 and LDLR. The invention also provides application of the gene combination in preparation of a reagent for detecting hereditary heart disease. Compared with traditionalmulti-gene panel methods, the method for screening the hereditary heart disease by adopting the gene combination has the advantages that the number of detected genes and the detection cost are remarkably low, and the detection coverage and accuracy are not remarkably reduced. Based on high-throughput sequencing for screening hereditary heart diseases and preventing sudden death risks, the gene combination has the advantages of being low in cost and high in cost performance, the cost and detection efficiency are balanced, the gene combination is suitable for general screening of large-scale populations, and the low-cost detection technology can benefit most populations.

The invention relates to the technical field of artificial intelligence, in particular to a screening method for recycled asphalt concrete production. Acquiring plane images of different batches of asphalt concrete to obtain corresponding feature descriptors; obtaining an optimal screening mode of the asphalt concrete of each batch based on the screening quality evaluation index, and forming a feature vector of the asphalt concrete of the corresponding batch by the optimal screening mode and the optimal screening quality evaluation index; and grouping the feature vectors to obtain a general screening mode of each group, performing similarity calculation on the real-time feature descriptor of the to-be-screened asphalt concrete and the feature descriptor corresponding to each group, and obtaining an optimal general screening mode according to the similarity to serve as a screening method of the to-be-screened asphalt concrete. The image features of the to-be-screened asphalt concrete are extracted, and the corresponding optimal screening mode is intelligently recognized, so that the screening quality is effectively improved, and the screening speed is effectively increased.

The invention provides a high myopia gene detection kit and a high myopia genetic risk assessment system and method. The high myopia genetic risk assessment system comprises an acquisition module, a detection module, a prediction module and an assessment module, and the acquisition module is used for acquiring a DNA sample of a testee; the detection module comprises the high myopia gene detection kit and is used for performing genetic typing on the DNA sample; the prediction module comprises a high myopia genetic risk prediction model and is used for scoring the high myopia genetic risk of the testee; and the assessment module comprises a high myopia risk grading system and is used for determining the high myopia genetic risk grade of the testee. According to the high myopia gene detection kit, through large-scale whole-genome correlation analysis of high myopia queue crowds, a machine learning method is used to construct and select the optimal genetic risk prediction model, the high myopia genetic risk assessment system and method special for Chinese crowds are provided, and general screening of the high myopia genetic risk level of large-scale population is realized.

The invention discloses multiplex real-time fluorescent PCR detection primers and probes for TP53 gene SNP loci and multiplex real-time fluorescent PCR detection kit. The primers are upstream primers AC1-F and AC1-R, AC2-F and AC2-R; the probes are AC1 C-P, AC1 A-P, AC2 A-P and AC2 G-P; the 5 'ends of the probes are labeled with fluorescent groups and the 3' ends are labeled with quenching groups, wherein the nucleotide sequences of AC1-F, AC1-R, AC2-F, AC2-R, AC1 C-P, AC1 A-P, AC2 A-P and AC2 G-P are as shown in SEQ ID NO: 1-8 respectively. The primers, the probes and the kit are used for detecting the TP53 gene SNP loci, and have the advantages of simple method, accuracy, high sensitivity, low cost, high flux and suitability for general screening.

The invention discloses a channel field data application and analysis model system. The system comprises a channel data analysis model, a data source database, object screening, object comparison, correlation analysis indexes and trend prediction, wherein the channel data analysis model comprises statistics based on channels of a disposal institution, statistics based on auction announcements, statistics based on subject matters, statistics based on auction stages and statistics based on years; the data source database comprises seven databases; the object screening comprises general screening, foreclosure and network auction screening; wherein the object comparison comprises two main display areas which can perform field information display on the selected object in a list form; the correlation analysis index is divided into a left functional area and a right functional area, the left functional area is a condition screening and index selection functional area, and the right functional area is a graph display area; the trend prediction is divided into left and right functional areas, the left is a conditional screening and index selection functional area, the right is a graph display area, and the left specifically displays a result.

The invention discloses water-saving industrial silt screening equipment. The water-saving industrial silt screening equipment mainly comprises a material conveying mechanism, a residue throwing mechanism, a vibration screening mechanism, a stirring and water injecting mechanism, a left transmission assembly and a right transmission assembly, wherein the residue throwing mechanism comprises a machine body, a driving cavity, a motor, a first driving shaft, a sliding block and a first torsion spring, the vibration screening mechanism comprises a connecting rod, a first long plate, a first through groove, a second long plate, a second through groove and a screen, the stirring and water injecting mechanism comprises a material storage box, a stirring cavity, a second transmission cavity and asecond rotating shaft. The water-saving industrial silt screening equipment has the beneficial effects that a mechanical mechanism is used for driving the screen to vibrate up and down so as to screenout industrial waste residues while clear water is adopted for scouring, compared with general screening equipment, the water-saving industrial silt is high in screening speed and high in efficiency,in addition, after the water-saving industrial silt screening equipment finishes screening, silt with water is stirred to enable the water flow to enter a water pump again to be recycled through water falling fine holes, and the water-saving industrial silt screening equipment is energy-saving and environment-friendly, safe and reliable, and high in automation degree.

The invention discloses a group of markers used for diagnosis of delayed preeclampsia. According to the invention, differential expression genes of peripheral blood cells of a delayedpreeclampsia patient and a normal pregnant woman are screened on the basis of a gene chip technology, hub genes in disease occurrence are analyzed and screened through a co-expression network, and diagnostic values ofthe markers in practical application are verified through fluorescent quantitative PCR. The markers are high in specificity, good help can be provided for differential diagnosis of the delayed preeclampsia, meanwhile, the method has the advantages of non-invasiveness and simplicity for detecting specimen, and a new strategy can be provided for general screening of clinical suspected delayed preeclampsia pregnant women.

The invention relates to a horizontal screening machine. The horizontal screening machine is characterized in that a rotating shaft is arranged in a screening machine body; the rotating shaft and a motor transmission shaft are connected through a transmission belt; a row of rotating hammers is mounted on the rotating shaft; 2-6 rows of screening holes are formed in the outer side surface of the screening machine body; and an object collecting tank is formed in the outer side of the outer side surface of the screening machine body. The horizontal screening machine uses a motor for driving a crushing hammer inside to crush materials, is higher in efficiency, and is provided with the rotating hammers inside for stirring the materials, can crush the materials during screening, can greatly improve the screening efficiency, can improve the efficiency by 2-3 times compared with a general screening machine, and is lower in cost.

The embodiment of the invention provides a nucleic acid general screening detection method and system, electronic equipment and a storage medium. The method comprises the following steps: receiving afirst number input by a user; reading name information and certificate number information of the subject, and binding the name information and the certificate number information; receiving a sample number adding request triggered by a user in the identity information acquisition page, determining a sample number of the subject, and binding; generating a second number based on the first number, thename information, the certificate number information and the sample number; generating an electronic report based on the second number and a detection result of the subject; and receiving a nucleic acid report query request triggered by a user, and displaying the generated electronic report. According to the embodiment, the requirement of nucleic acid common sieve detection can be met, all examinees in the nucleic acid common sieve only have the differences of names, identity card numbers and the like, the name information and the certificate number information of the examinees are read and bound with the first number, so that terminal operation of old people and children is avoided, and the working efficiency of on-site workers can be greatly improved.

The invention provides an SNCG / NMP22 joint inspection colloidal gold test strip. The test strip sequentially comprises a sample pad, a gold conjugate pad, a reaction film and an absorption pad from asample adding end, wherein the gold conjugate pad contains a first mouse anti-SNCG antibody and a first anti-NMP22 antibody, and the reaction film contains a second mouse anti-SNCG antibody and a second anti-NMP22 antibody. The SNCG / NMP22 joint inspection colloidal gold test strip prepared according to the invention not only can be used for completing conventional detection in hospitals, but alsocan be carried to home to complete detection, and compared with a colloidal gold test strip of a single antibody, the specificity and sensitivity of cancer detection can be improved, and the SNCG / NMP22 joint inspection colloidal gold test strip is more suitable for general screening of tumors.

The present invention relates to a method for screening metal matrix protease inhibitors at the cell level, comprising: (1) designing primers to amplify the full-length cDNA of metal matrix proteases by PCR; (2) constructing expression using Retro X Tet Off as a carrier system; (3) transfect the cell line with the vector constructed above, and screen positive clones, and when the cells cover the bottom of the dish, replace the culture medium with a DOX-free medium to induce the expression of MMPs; (4 ) to screen out matrix metalloproteinase inhibitors. The present invention establishes a method based on the Tet-off expression system, which can simulate the action environment of MMP to the greatest extent, and is used for the screening of MMP inhibitors, which is more accurate than the in vitro screening of general metal matrix protease inhibitors.

The invention discloses an M protein ultraviolet spectroscopy detection method, and belongs to the technical field of M protein detection. The detection method is implemented through the reaction ratio of the patient sample size to the accessory protein detection reagent dosage and by combining a light source, operation is easy and convenient, result interpretation is easy, and the positive resultspecificity is high. The method is suitable for all kinds of serum or plasma and is not affected by anticoagulants. Detection can be carried out as long as venous blood or arterial blood sampling iscarried out on patients. The method is low in detection reagent cost, all medical laboratories can bear the method at present, and the problem that the patients are hard to see a doctor and expensivecan be relieved to a great extent. According to the method, large-scale general screening is carried out on all the patients in the medical laboratories, the clinical laboratories are promoted to findsuspicious M proteinemia patients in the early stage, and the patients can be diagnosed and treated early.

The present disclosure provides for an ophthalmic testing system that may prescreen for ophthalmic diseases and systemic diseases. In some embodiments, an OTS may provide general screening results and relatives scores to patients that may be at risk for diabetic retinopathy, macular degeneration, or Alzheimer's. In some implementations, the OTS may offer self-screening features without collecting personal information that may identify the individual. In some embodiments, the OTS may use artificial intelligence and machine learning and machine learning to provide accurate and instant analysis and results to a user.

In view of the technical problem that in the current detection standard system for meat, animal-derived detection methods can only be qualitative or semi-quantitative, and the severity of adulteration cannot be judged, the present invention provides quantitative determination based on high performance liquid chromatography tandem mass spectrometry A variety of methods for meat of animal origin. In order to achieve the purpose of the present invention, the present invention screens characteristic polypeptides of standard meat samples of chicken, duck, pork, beef and mutton, and applies the characteristic polypeptides to quantitatively detect adulteration of meat samples. The quantitative detection method of the present invention comprises: pretreatment of the meat sample to be tested, and detection of characteristic polypeptides in the meat sample by high performance liquid chromatography-mass spectrometry. The invention also provides a relatively general screening method for standard meat-like characteristic polypeptides. Provide effective technical means for the supervision of meat sample adulteration in the meat market.

The invention relates to thioether compounds containing pyrimidine, thiadiazole ring and amide structures and an application thereof; the bactericidal activity of the compounds on colletotrichum orbiculare, botrytis cinerea and rhizoctonia solani are measured, and the general screening concentration is 50 mg / L; measurement results indicate that the compounds (I) having nonsubstituted H in a benzene ring show a certain inhibitory activity on all the tested strains; the compounds Ia (Rn=p-chloro), Id (Rn=o-methyl), Ie (Rn=m-methyl) and If (Rn=p-methyl) have all the inhibition rates on colletrichum orbiculare of more than or equal to 50%, wherein the inhibition rate of the Ie is 77.31%; the compounds Id (Rn=o-methyl), Ie (Rn=m-methyl) and If (Rn=p-methyl) have all the inhibition rates on botrytis cinerea of more than or equal to 50%, wherein the inhibition rate of the Ie is more than 60%; the compounds Id (Rn=o-methyl) and Ie (Rn=m-methyl) have the inhibition rates on rhizoctonia solani of more than or equal to 40%.

The invention discloses a primer and probe composition and a kit for detecting achondroplasia related FGFR3 gene variation sites. The related FGFR3 gene variation sites comprise a first site and a second site, wherein the first site is NM_000142.5: exon10: c.1138G > A: p.Gly380Arg, and the second site is NM_000142.5: exon10: c.1138G > C: p.Gly380Arg; the nucleotide sequence of an upstream primer of the first site and the second site is as shown in SEQ ID NO.1, and the nucleotide sequence of a downstream primer of the first site and the second site is as shown in SEQ ID NO.2; the nucleotide sequence of a wild probe at the first site and a wild probe at the second site is shown as SEQ ID NO.3, and the nucleotide sequence of a mutation probe at the first site is shown as SEQ ID NO.4; and the nucleotide sequence of a mutation probe at the second site is as shown in SEQ ID NO.5. The primer and probe composition is high in accuracy, low in false positive rate, low in cost, free of high-end instruments, simple in result interpretation, suitable for general screening and capable of reducing the birth rate of children suffering from achondroplasia.

The invention relates to thioether compounds containing pyrimidine, thiadiazole ring and amide structures and an application thereof; the bactericidal activity of the compounds on colletotrichum orbiculare, botrytis cinerea and rhizoctonia solani are measured, and the general screening concentration is 50 mg / L; measurement results indicate that the compounds (I) having nonsubstituted H in a benzene ring show a certain inhibitory activity on all the tested strains; the compounds Ia (Rn=p-chloro), Id (Rn=o-methyl), Ie (Rn=m-methyl) and If (Rn=p-methyl) have all the inhibition rates on colletrichum orbiculare of more than or equal to 50%, wherein the inhibition rate of the Ie is 77.31%; the compounds Id (Rn=o-methyl), Ie (Rn=m-methyl) and If (Rn=p-methyl) have all the inhibition rates on botrytis cinerea of more than or equal to 50%, wherein the inhibition rate of the Ie is more than 60%; the compounds Id (Rn=o-methyl) and Ie (Rn=m-methyl) have the inhibition rates on rhizoctonia solani of more than or equal to 40%.

The invention provides an SNCG / SCC-Ag joint inspection colloidal gold test strip. According to the test strip, a sample pad, a gold conjugate pad, a reaction film and an absorption pad are sequentially formed from a sample adding end, wherein the gold conjugate pad contains a first mouse anti-SNCG antibody and a first anti-SCC-Ag antibody, and the reaction film contains a second mouse anti-SNCG antibody and a second anti-SCC-Ag antibody. The SNCG / SCC-Ag joint inspection colloidal gold test strip prepared according to the invention not only can be used for completing conventional detection in hospitals, but also can be carried to home to complete detection, and compared with a colloidal gold test strip of a single antibody, the specificity and sensitivity of cancer detection can be improved, and the SNCG / SCC-Ag joint inspection colloidal gold test strip is more suitable for general screening of tumors.

The invention provides a helicobacter pylori (Hp) antigen and fecal occult blood (Fit) joint detection colloidal gold test strip. A sample pad, a gold conjugate pad, a reaction membrane and an absorption pad are sequentially formed from a sample adding end; the gold conjugate pad contains a first mouse anti-Hp monoclonal antibody Hp-Ab1 and / or a first mouse anti-hemoglobin monoclonal antibody Hb-Ab1; and a second mouse anti-Hp monoclonal antibody Hp-Ab2 and / or a second mouse anti-hemoglobin monoclonal antibody Hb-Ab2 are / is contained on the reaction membrane. According to the test strip, sample detection indexes can be accurately quantified, subjectivity of manual interpretation is avoided, conventional detection can be completed in hospitals, and self-detection can be achieved at home. Compared with a test strip for a single substance to be detected, the test strip has the advantage that multiple indexes of one sample can be detected at the same time. The Hp antigen index is suitable for auxiliary diagnosis and eradication treatment effect evaluation of helicobacter pylori infection; and the Fit index is suitable for clinical diagnosis and curative effect observation of lower digestive tract hemolytic diseases and colorectal cancer. Combined detection of the Hp antigen index and Fit index is more suitable for general screening of gastrointestinal tumors, and reduces the cancer death rate.

A test strip and method for detecting urine Aβ amyloid protein. The test strip for detecting urine Aβ amyloid protein includes a PVC bottom plate (7), and the PVC bottom plate (7) is laid with sequentially overlapped sample pads (1), conjugated binding pads (2), and chromatography pads ( 3) and a water-absorbing pad (4); the conjugated pad (2) is coated with colloidal gold particles conjugated with the monoclonal antibody; the chromatography pad (3) close to the conjugated pad (2) a A detection line (5) is provided on one side, and a control line (6) is provided on the side close to the absorbent pad (4). The detection line (5) is coated with Aβ amyloid-binding polymer, and the control line ( 6) Coated with goat anti-mouse IgG polyclonal antibody. The method has high sensitivity, the detection limit is 40 pg, fast, economical, suitable for routine clinical pathological examination, suitable for general screening of a large number of people and self-screening of home end users, especially for clinically assisting mild cognitive impairment (MCI) Early diagnosis and pre-judgment, and predict whether the patient has a high risk of developing MCI and AD.

The invention discloses a general screening kit and detection method for animal-derived components based on melting curve technology, and relates to the technical field of molecular biology detection. The invention designs universal primers and molecular beacon fluorescent probe compositions for the gene fragments with specific structural characteristics in the genomes of 9 kinds of livestock and poultry animals. Taking the genomic DNA of the sample to be tested as a template, applying the kit and method disclosed in the present invention to carry out real-time fluorescent PCR detection and melting curve analysis, by comparing the shape of the melting peak of the sample to be tested and the corresponding characteristic melting temperature (Tm value), Realize the rapid identification of 9 kinds of animal-derived components of livestock and poultry under the condition of a single tube. The system of the invention is simple in structure, low in application cost, high in sensitivity, strong in specificity and good in applicability, and can be used for rapid screening of animal-derived components in food, feed and other samples and identification of adulteration and counterfeiting.