The invention belongs to the technical field of medicines, and discloses a self-
microemulsion composition of a
tyrosine kinase inhibitor. The self-
microemulsion composition comprises the following components: 0.1-40% of the
tyrosine kinase inhibitor and 60-99.9% of a carrier, wherein the carrier comprises an
oil phase, a surfactant and a cosurfactant; and the self-
microemulsion composition spontaneously forms a microemulsion with a particle size of less than 50 nm when encountering an
aqueous medium. The
dissolution rate and the mixing uniformity of the prepared
tyrosine kinase inhibitor meetthe requirements, the
tyrosine kinase inhibitor is spontaneously dispersed in gastrointestinal fluid under gastrointestinal
peristalsis after
oral administration to form an O / W type nanoemulsion, drugmolecules are wrapped in the carrier, and the particle size of the
drug molecules is correspondingly increased, so that the membrane
permeation mode is changed after the nanoemulsion makes contact with
small intestine epidermal cells, original passive
diffusion transport is changed into
endocytosis transport, and stimulation of the nanoemulsion to gastrointestinal tracts is reduced through activecytosis or
endocytosis absorption, so that
irritation caused by too high local concentration of drugs and long-time contact with gastrointestinal walls is reduced, and side effects of the drugs on the gastrointestinal tracts can be reduced.