The invention provides an
enterobacter ludwigii SXZ-N5 strain producing
huperzine A and huperzine B and application thereof. The strain is capable of producing
huperzine A and huperzine B. The strainis named as SXZ-N5 and belongs to
enterobacter ludwigii. The strain is collected in China Center for Type Culture Collection Center. The address is Wuhan University, Wuhan, China. The
postal code is 430072. The strain has a collection date of September 14, 2017, and a collection number of CCTCC NO: M2017511. The 16S rDNA sequence of the strain is shown as SEQ ID NO.1. The
enterobacter ludwigii SXZ-N5 strain disclosed by the invention can be used for fermenting to prepare the
huperzine A and huperzine B. Microbial
fermentation conditions are as follows: a culture medium formula: 4.0g of
yeast powder, 8.0g / L of peptone, 7.0g / L of
sodium chloride, 9.0g / L of glucose, the pH value of 6.0; as well as culture conditions comprising 28 DEG C and 200
revolutions per minute, and fermented culture isperformed by 10 days.