124 results about "Cancer Cause" patented technology

MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell caused by these cancer-associated chromosomal features can affect the expression of the miR gene(s) located in close proximity to that chromosomal feature. Evaluation of miR gene expression can therefore be used to indicate the presence of a cancer-causing chromosomal lesion in a subject. As the change in miR gene expression level caused by a cancer-associated chromosomal feature may also contribute to cancerigenesis, a given cancer can be treated by restoring the level of miR gene expression to normal. microRNA expression profiling can be used to diagnose cancer and predict whether a particular cancer is associated with an adverse prognosis. The identification of specific mutations associated with genomic regions that harbor miR genes in CLL patients provides a means for diagnosing CLL and possibly other cancers.

MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell caused by these cancer-associated chromosomal features can affect the expression of the miR gene(s) located in close proximity to that chromosomal feature. Evaluation of miR gene expression can therefore be used to indicate the presence of a cancer-causing chromosomal lesion in a subject. As the change in miR gene expression level caused by a cancer-associated chromosomal feature may also contribute to cancerigenesis, a given cancer can be treated by restoring the level of miR gene expression to normal. microRNA expression profiling can be used to diagnose cancer and predict whether a particular cancer is associated with an adverse prognosis. The identification of specific mutations associated with genomic regions that harbor miR genes in CLL patients provides a means for diagnosing CLL and possibly other cancers.

Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient.Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

This invention provides a method for treating a cancer caused by cancer stem cells in a subject in need thereof, comprising administering to the subject an effective amount of Antrodia camphorata extracts. The invention also provides a method for treating a cancer caused by cancer stem cells in a subject in need thereof, comprising administering to the subject an effective amount of 4-acetyl-antroquinonol B.

The invention relates to a tricyclic compound of the formula (I) and the formula (II) and pharmaceutical acceptable salts of the tricyclic compound. The compounds of the kind can be applied to inhibit mutants, such as EGFR (L858R), EGFR (delE746-A750) and EGFR (T790M), of EGFR kinase, and can also be used for treating cancer, such as the non-small cell lung cancer, caused by the mutants of the EGFR. The invention further relates to pharmaceutical compositions containing the compounds of the kind, methods for preparing the compounds of the kind and application of the compounds of the kind or the pharmaceutical compositions for preparing medicines for treating the cancers caused by the mutants of the EGFR.

The present invention relates to a tricyclic compound of formula (I) and a pharmaceutically acceptable salt thereof. The compound can be used for inhibiting mutants of epidermal growth factor receptor(EGFR) kinases, such as EGFR (delE746-A750), EGFR (L858R), EGFR (delE746-A750 / T790M), EGFR (L858R / T790M), EGFR exon 20insertion and other mutants, so the compound can be used to treat cancer caused by EGFR mutants, such as non-small cell lung cancer. The invention also relates to a medicinal composition containing the compound, a method for preparing the compound, and an application of the compound or the medicinal composition in the preparation of medicines for treating the cancers caused by EGFR mutants.

The present invention provides a monoclonal antibody for identifying HPV18 positive cervical epithelial cancer cells, and applications thereof. According to the present invention, with the monoclonal antibody, the cervical cancer biomarker HPV18E7 protein in the tumor cells can be detected in a highly specific manner so as to distinguish between the cancerous cervical epithelial cells and the abnormal cervical epithelial cells or non-cancerous cervical epithelial cells and provide basis for the accurate diagnose of the cancer caused by the HPV infection, such that the treatment can be timely taken, the cancer occurrence or cancer spreading can be prevented, and the suffering of patients can be alleviated.

The invention discloses pickled vegetable salt which is characterized by comprising the following components in parts by weight: 989-999 parts of NaC1 and 0.65-2 parts of Ca ions. The preparation method comprises the following steps: firstly, taking gypsum-model saturated brine from a deep well; secondly, adding NaOH into a brine pond to remove impurities, and preserving the Ca ions; thirdly, clearing; and fourthly, adopting a vacuum salt production process, wherein the operating parameters of a one-effect heating chamber are as follows: the pressure is 0.25-0.35MPa, the operating temperature is 127-139 DEG C, and the operating time is 3-4h; and the operating parameter of the double-effect heating chamber are as follows: the pressure is 0.15+ / -0.05MPa, the operating temperature is 111+ / -2 DEG C, and the operating time is 3-4h. The pickles pickled by the pickled vegetable salt of the invention is savory and fragile, has pure taste and bright color, and has the advantages that cancer-caused nitrite can be effectively inhibited from generating, pickled vegetable salt water can be prevented from mildewing, the pickled vegetable salt water can be maintained not to go bad, and the like.

The present invention relates to compounds of Formulas I and II,wherein B1, B2, B3, B4, C1, C2, ring D, L1, L2 and R1-4 are defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and Aurora and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders.

The invention relates to a method for analyzing molecular typing based on gastric mucosal lesion proteomics, different gastric mucosal lesion proteomics molecular subtype characteristics and correlation between the molecular typing and the subtype characteristics and the gastric mucosal lesion progress. A protein marker database related to gastric cancer and gastric mucosal lesion progress is established by calculating the relationship between protein expression and gastric mucosal tissue pathological state, proteome molecular subtype and gastric mucosal lesion progress, and a gastric mucosallesion sample disease progression risk scoring system is established. According to the invention, a molecular epidemiological research means is combined with bioinformatics analysis and machine learning, microscopic and macroscopic gastric cancer cause risk factors are integrated, a gastric mucosal lesion molecular typing framework and a progress risk prediction model are established, and a foundation is laid for finally constructing a comprehensive and systematic gastric cancer prevention strategy.

The invention discloses anti-caries and anti-allergy polishing paste and a preparation method of the anti-caries and anti-allergy polishing paste. The anti-caries and anti-allergy polishing paste is prepared from the following components in percentage by weight: 0.5% of quaternary ammonium salt, 2% of a nonionic surfactant, 0.25% of sodium pyrophosphate, 0.85% of CMC, 0.5% of sodium benzoate, 5% of sediment amino calcium formate, 45% of hydrogen phosphate dehydrate, 22% of glycerol, 0.1-0.3 % of edible essence, 0.1-0.3 % of an edible preservative, 0.2% of a sweetening agent, 0.08-0.2 % of a refreshing agent, and 0.0001-0.0002% of a pigment. Ammonium hexafluorosilicate is taken as the functional material and added into the polishing paste, compared with the existing anti-allergy toothpaste, the anti-caries and anti-allergy polishing paste provided by the invention has the more obvious anti-allergy efficacy, in addition, the anti-caries and anti-allergy polishing paste is good in mouthfeel and contains no alcohol, so that the risk of cancer caused by the alcohol is reduced, and thus the product is safe; no side effects including teeth color change are caused; meanwhile, the anti-caries and anti-allergy polishing paste has the effects of preventing caries and killing bacteria, and can well maintain the health of the oral cavity.

The invention relates to preparation of multiple xylan esterification products and an application of the xylan esterification products in preparation of drugs for preventing, relieving and / or treatinginflammatory diseases. The application of the xylan esterification products in preparation of drugs for preventing or treating inflammatory diseases is characterized in that the xylan esterificationproducts have the structure shown in the general formula II. The R group substitution degree of the esterified xylan products is 1.0-2.0, the substitution degree is the average number of xylose unit substituted hydroxyls of xylan, and the substitution degree D of completely substituted xylan is 2.0; n ranges from 2 to 2632, and R1 or R2 is C1-C12 fatty acid. The xylan esterification products havegood treatment effects on inflammatory diseases and cancer caused by the inflammatory diseases.

The invention provides a short peptide capable of inhibiting the growth of cancer cell, which is characterized in that the identity and similarity of the amino acid main sequence of the short peptide fragments, the analogues, the derivatives and the variants of the short peptide to the amino acid main sequence of the short peptide are greater than or equal to 70% and 90% respectively; the short peptides, the nucleotides, the short peptide fragments, the short peptide analogues, the short peptide derivatives and the short peptide variants can be used in preparing drugs for curing leukaemia caused by various lesion cell proliferation of non-solid tumor human myeliod line, curing various cancers caused by human solid tumor cancer cell proliferation, inhibiting hypertension, and diagnosing and detecting the occurrence and the malignancy of cancers; the short peptides and the nucleotides also can be used in preparing drugs which are used as protease inhibitor, accelerator, affinity reagent, or detection reagent. The short peptide capable of inhibiting the growth of cancer cell has an advantage of overcoming the defect of serious harmful effect on the normal cell of human body when the existing cancer drugs are used for inhibiting or killing the cancer cell.

Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient.Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

The invention discloses a preparation and extraction method of bacterium-inhibiting phycomycete health-care handmade soap. The bacterium-inhibiting phycomycete health-care handmade soap is prepared from basic oil, active extract and a base material, wherein the basic oil comprises coconut oil, castor oil and olive oil; the active extract comprises neolitsea aurata fruit extract, grateloupia ramosissima extract and shitake mushroom extract according to the preferable weight ratio of 1 to (0.5 to 3) to (0.1 to 5); the base material comprises potassium hydroxide and a sapindus mukurossi peel extracting solution. The liquid handmade soap disclosed by the invention realizes sterilization, bacterium-inhibiting and anti-corrosion aims by utilizing the natural plant neolitsea aurata fruit extract,the grateloupia ramosissima extract and the shitake mushroom extract; the liquid handmade soap does not contain a chemical substance preservative and skin irritation is reduced; sensitization, internal secretion interfering and cancer causing risks of the chemical preservative are avoided; the handmade soap provided by the invention contains nutrient components in plants and crystalline tourmaline powder is cooperated with the nutrient components, so that a product has cleaning and dirt-removing, antibacterial and moisturizing and health-care effects, is easy to degrade and has no residues; the handmade soap has no harms to human body health and water environment, and resource integration and cyclic reutilization are realized.

The embodiment of the invention discloses a method and electric equipment for achieving ultrasound cranial focusing. Under the condition of not performing CT imaging on the head of a to-be-treated object, by simply inputting head nuclear magnetic resonance image data of the object into a target model obtained through training, synthesized head CT image data output by the target model can be obtained, the electric equipment can generate an ultrasonic emission sequence according to a head three-dimensional digital model and a three-dimensional digital model of an ultrasonic transducer array, andthe electric equipment controls the ultrasonic transducer array to emit an ultrasonic wave according to the ultrasonic emission sequence, so that cranial focusing of the head of the to-be-treated object can be achieved, and therapy such as ultrasonic deep brain stimulation or ultrasonic thermal ablation is performed; the risk of cancer caused by irradiation during CT imaging of the to-be-treatedobject is eliminated, the safety of therapy is improved, the therapy steps can also be simplified, the therapy time is greatly shortened, and the therapy cost is reduced.

The invention provides a novel method for preparing 3-(3-chloropropyl)-4-oxopyrrolidine-1-ethyl carboxylate, aiming at solving the technical problems of a traditional 3-(3-chloropropyl)-4-oxopyrrolidine-1-ethyl carboxylate synthesis method in the prior art that a flow is complicated, the environmental hazards are great, the safety is low and the yield is low. The technology takes glycine ethyl ester and ethyl acrylate as starting raw materials, and steps of taking benzylamine as a raw material and carrying out debenzylation in a subsequent process are reduced; a process for preparing the 3-(3-chloropropyl)-4-oxopyrrolidine-1-ethyl carboxylate is greatly simplified; an existing technology needs 6-step reaction, and the technology only needs 5-step reaction, so that the operation is simplified and a production period is shortened; the method is applicable to large-scale industrial production. The technology does not take the benzylamine as the starting raw material, and the generation ofa cancer-causing high-hazard substance, i.e., benzyl chloride, is directly stopped from the source; harms to an ecological environment and body health of people are effectively avoided; a reaction process is safe and accords with environmental protection requirements of China better; the total yield is greatly improved and the yield is greater than or equal to 50 percent.

The invention discloses a medicinal composition for treating late gastric cancer. The medicinal composition comprises the following raw materials in part by weight: 10 to 30 parts of ginseng, 50 to 150 parts of Yangtao actinidia root, 50 to 100 parts of glaucescent fissistigma root, 50 to 120 parts of loosestrife herb, 10 to 30 parts of bunge auriculate root, 10 to 20 parts of root of pseudo-ginseng, 10 to 30 parts of astragalus and 5 to 15 parts of dried ginger. The medicament has remarkable curative effect on the gastric cancer caused by various cancer cells, has low toxic or side effect, and is convenient to take.

The invention belongs to the field of medical technology and specifically relates to a benzene sulfonamide pyrazole kinase inhibitor shown in a general formula (I) as described in the specification and pharmaceutically acceptable salts or stereoisomer thereof. In the general formula (I), R1, R2, R3, m and n are as defined in the specification. The invention also relates to a preparation method for the above-mentioned compound, a medicinal preparation and a pharmaceutical composition containing the compound and application of the compound and the pharmaceutically acceptable salts or stereoisomer thereof in preparation of drugs used for treating and / or preventing diseases correlated or non-correlated to cancers caused by b-RAF mutation.

The invention relates to an antagonistic bacterium strain capable of being used for prevention and control of a plant root cancer. The classification name of the antagonistic bacterium is ochrobactrum oryzae which was preserved in China General Microbiological Culture Collection Center on September 2, 2014 with the preservation number of CGMCC No. 9634. The strain is used for prevention and control of the root cancer caused by infection of A. tumefaciens to a plant and biological treatment of soil infected by the A. tumefaciens.

The invention discloses a medicine for treating lung cancer, breast cancer and lymph cancer and a preparation method thereof. The medicine is composed of traditional Chinese medicines and western medicines, and components of the medicine mainly contain drugs such as fibrous ginseng root, astragalus membranaceus, Juncaceae, ginseng, bighead atractylodes rhizome, gynostemma pentaphyllum, dried tangerine peel, radix codonopsis, poria, Rhizoma Pinelliae, costusroot, Amomum villosum, rhubarb, boat-fruited sterculia seed, Semiaquilegia, Radix Actinidiae chinensis, solanum nigrum, solanum lyratum, Glabrous sarcandra Glabrous Herb, crotalaria sessiliflora, trichosanthes kirilowii Maxim, musk, bezoar, toad, borneol, centipede, rhizoma picrorhizae, a pulse-activating injection, an acanthopanax senticosus injection, a Shuanghuanglian injection, a bupleurum injection and the like. By combination of traditional Chinese medicine and western medicine and according to the practical medical treatment principle of treating cancer caused by three accumulated poisons (heat toxin, damp toxin and drug toxin), treatment effect is remarkable, cost is low, normal cells of human body will not be hurt, human immune function is reinforced, metabolism is promoted, and healing confidence of patients is enhanced.

The invention provides an oligopeptide for treating solid tumors and leukaemia and application thereof. The sequence is SEQ ID NO:1-15. The oligopeptide can be used for treating leukaemia caused by nonsolid tumor human medullary system various pathology hyperplasia and various cancers caused by human solid tumor cancer cell proliferation.

Detection of mutations associated with hereditary diseases is complicated by the diploid nature of mammalian cells. Mutations present in one allele are often masked by the wild-type sequence of the other allele. Individual alleles can be isolated from every chromosome within somatic cell hybrids generated from a single fusion. Nucleic acids from the hybrids can be analyzed for mutations in an unambiguous manner. This approach was used to detect two cancer-causing mutations that had previously defied genetic diagnosis. One of the families studied, Warthin Family G, was the first kindred with a hereditary colon cancer syndrome described in the biomedical literature.

The invention discloses a medicament for preventing and treating a reproductive organ cancer. The medicament is characterized by containing one or more of salt-base compounds of chloroquine, hydroxychloroquine and amodiaquine. The medicament can be used for preventing and treating the reproductive organ cancer caused by human papillomavirus (HPV) infection.

The invention relates to a traditional Chinese medicine preparation for preventing and treating cancers, which comprises the following selected raw material medicines in part by weight: Chinese angelica, raw rehmannia roots, manyleaf paris rhizome, honeysuckle, amur corktree bark, red salvia roots, astragalus roots, fossil fragments, Chinese lobelia herbs, oldenlandia diffusa and licorice roots. The preparation comprises pills, tablets, oral liquids and capsules prepared by using the traditional preparation process or modern preparation process. The combination of the selected medicinal materials has the efficacy of clearing heat, cooling blood, activating blood circulation, eliminating stasis, dispelling wind and heat and inducing astringency. The preparation increases the immunity function of bodies through oral administration and has good curative effect on cancers caused by various reasons. Clinic application finds that the preparation has the advantages of rapid effect taking, obvious curative effect, good tolerance, low cost and no any toxic or side effect.