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100 results about "Affinity Reagent" patented technology

In chemistry and biology, a compound that binds specific substances, such as proteins or nucleic acids. Many affinity reagents are antibodies. They are used to analyze tissue samples to help diagnose diseases.

Use of biomolecular targets in the treatment and visualization of brain tumors

The present invention relates to the use of proteins that are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of therapeutic and imaging agents, which specifically bind to one or more of the identified brain tumor protein targets. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.
Owner:MEDAREX INC

Bispecific intracellular delivery vehicles

A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
Owner:GENEVANT SCI GMBH +1
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