81results about How to "Restore level" patented technology

MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell caused by these cancer-associated chromosomal features can affect the expression of the miR gene(s) located in close proximity to that chromosomal feature. Evaluation of miR gene expression can therefore be used to indicate the presence of a cancer-causing chromosomal lesion in a subject. As the change in miR gene expression level caused by a cancer-associated chromosomal feature may also contribute to cancerigenesis, a given cancer can be treated by restoring the level of miR gene expression to normal. microRNA expression profiling can be used to diagnose cancer and predict whether a particular cancer is associated with an adverse prognosis. The identification of specific mutations associated with genomic regions that harbor miR genes in CLL patients provides a means for diagnosing CLL and possibly other cancers.

A method is performed with an enterprise storage system comprising disk storage and sequential storage media. Alternatively, systems, subsystems, and computer media containing encoded portions are disclosed. The method serves the data storage needs of a given client coupled to the enterprise storage system via a network. A physical device level backup is performed, backing up data from the disk storage to the sequential storage media, while minimizing demands on the client. The device level backup comprises a complete image backup of data in a host device as defined from a perspective of the given client. A logical restore of data is performed on a file by file basis from physically backed data on the sequential storage media. The logical restore involves locating files requested by the client on the sequential storage media and recovering the files from the sequential storage media. The files comprise files defined in accordance with a files system defined by the client.

MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell caused by these cancer-associated chromosomal features can affect the expression of the miR gene(s) located in close proximity to that chromosomal feature. Evaluation of miR gene expression can therefore be used to indicate the presence of a cancer-causing chromosomal lesion in a subject. As the change in miR gene expression level caused by a cancer-associated chromosomal feature may also contribute to cancerigenesis, a given cancer can be treated by restoring the level of miR gene expression to normal. microRNA expression profiling can be used to diagnose cancer and predict whether a particular cancer is associated with an adverse prognosis. The identification of specific mutations associated with genomic regions that harbor miR genes in CLL patients provides a means for diagnosing CLL and possibly other cancers.

This invention provides methods of treating a mammalian subject in need of androgen therapy by orally administering to the subject testosterone, a testosterone ester, or a testosterone precursor in an oil vehicle and by administering to the subject a modulator such as finasteride or dutasteride which increases testosterone bioavailability in the subject.

Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.

Disclosed are methods and related devices for use with subjects with cerebral palsy or periventricular leukomalacia. In preferred embodiments, diffusion tensor imaging (DTI) is used to identify neural areas and transcranial magnetic stimulation (TMS) is used to stimulate neural pathways.

A computing system for implementing at least one electronic circuit with gain comprises at least one two-dimensional molecular switch array. The molecular switch array is formed by assembling two or more crossed planes of wires into a configuration of devices. Each device comprises a junction formed by a pair of crossed wires and at least one connector species that connects the pair of crossed wires in the junction. The junction has a functional dimension in nanometers, and includes a switching capability provided by both (1) one or more connector species and the pair of crossed wires and (2) a configurable nano-scale wire transistor having a first state that functions as a transistor and a second state that functions as a conducting semiconductor wire. Specific connections are made to interconnect the devices and connect the devices to two structures that provide high and low voltages.

A vehicle suspension system (19) includes a suspension (47). A lateral acceleration sensor (32) generates a lateral acceleration signal. A roll rate sensor (34) generates a roll rate signal. A controller (26) detects an irregularity in the suspension in response to the lateral acceleration signal and the roll rate signal. A method of detecting suspension irregularities in a vehicle (10) includes the generating of a lateral acceleration signal and a roll rate signal. Roll angle is determined in response to the lateral acceleration signal and roll rate signal. A roll gradient, a roll acceleration coefficient, and a roll damping parameter are determined in response to at least the roll angle. The roll gradient, the roll acceleration coefficient, and the roll damping parameter are compared to associated nominal values. A suspension irregularity is indicated in response to the comparison.

The invention relates to compositions comprising novel blends of nutritional ingredients and solid, semi-solid and beverage compositions comprising such blends. In particular, this invention relates to rehydration, energy and recovery beverages (e.g. sports drinks), compositions for support of weight management, as well as digestive, bone, cognitive and heart health.

The present invention comprises an implant for placing inside the eye such that the implant comes into contact with the interior tissue of the eye such that it conforms to the inner globe geometry of the eye. Implants of the present invention may also be used to alter the focal length of the eye thereby providing a treatment method for the correction of myopia and hyperopia. The device may consist of several possible configurations, an open mesh structure, a solid metal ring, a solid polymer shape, a mesh polymer shape or combination of these. The shape may be a curve, a sphere, a ring or a combination thereof that are specifically shaped to approximate a desired portion of the interior globe of the eye in order to treat myopia or hyperopia.

Disclosed herein are bicycloaryl compounds of Formula (I) that selectively modulate nuclear receptors, preferably the androgen receptor, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, and methods of treating disease comprising administering a compound of Formula (I) to a patient in need thereof.

The present invention generally relates to distributed data storage systems. In particular, the present invention relates to optimization of the distributed storage system in terms of number of data replicas needed to ensure a desired level of data replication.

A method is provided for treating a drug-dependent individual so as to effect withdrawal from a drug of abuse, e.g., an opiate such as heroin or oxycodone, a stimulant such as cocaine, or alcohol. The method involves substitution therapy wherein a substantially nonaddicting normorphine or norcodeine derivative is substituted for the drug of abuse. The active agent has the structure of formula (I) wherein: R is H, alkyl, or acyl; X is CH(OR′) or C═O, wherein R′ is H or acyl; α is an optional double bond, with the proviso that when α is present, then X is necessarily CH(OH), or an acid addition salt thereof, wherein preferred such agents are in a stereoisomerically pure form that corresponds to that of N-[(1R)-1-cyclopropylethyl]-normorphine (1) which melts at approximately 188° C.-189° C.

The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related diseases and disorders.

Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases and conditions, including age-related obesity, age-related increases in blood lipid levels, age-related decreases in insulin sensitivity, age-related decreases in memory function, and age-related changes in eye function such as macular degeneration. The methods comprise administering nicotinamide mononucleotide (NMN) to a subject. In some embodiments, the administration can be oral administration. Also disclosed are pharmaceutical compositions comprising NMN.

A technique and equipment are provided for regenerating a potentially sulfur-burdened, noble metal catalyst (44) in a water gas shift reactor (150, 152, 154), which may be part of a fuel processing system (120) for a fuel cell power plant (110). An oxidant (91) is supplied to the reactor and catalyst during a period when the water gas shift reaction is terminated, and sulfur entities burdening the catalyst undergo an oxidation reaction to become SO2. The SO2 is then vented outside the system containing the reactor, as to the ambient. The oxidation reaction preferably occurs immediately upon the shift reaction being terminated to take advantage of the residual heat associated with the water gas shift reaction. Oxidant is conveniently admitted to the shift reactor and SO2 is vented from the reactor by appropriately-controlled valving that may work in combined alternation with the normal flow of process fuel through the shift reactor and fuel processing system.

Provided are compositions and methods for the identification and treatment of ovarian cancers, such as small cell ovarian cancers, in particular small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), which ovarian cancers are characterized by reduced SMARCA4 gene expression and / or protein function and, as a consequence, are sensitive to growth and / or survival inhibition by one or more compounds that restore SMARCA4 gene expression and / or protein function.

Disclosed is a composition with a sustainable anti-fatigue function and which helps the body to restore the level of high-energy phosphate materials and increases energy, wherein the active ingredients thereof are ribose and caffeine. The composition comprises components with the following weight parts: 1-99.9 parts ribose and 0.1-99 parts coffee or 1-99.99 parts ribose and 0.01-99 parts caffeine.

The invention discloses a traceless laser correction method for back deformation of a stainless steel plate subjected to non-penetration laser welding and belongs to the technical field of laser heat treatment. Abrasive machining is performed on the back of an external plate before or after non-penetration laser welding in the prior art to form surface wire drawing lines, so the deformation of the back of the external plate can be covered visually; by the prior art, the deformation cannot be corrected sensibly; the wire drawing lines cannot cover the welding deformation in different directions; the covering and the welding deformation in the same direction only become unclear visually. In the traceless laser correction method, laser is used as a heat source to movably heat a deformed region of the back of the external plate of a stainless steel railway vehicle body along the direction of a welding line; meanwhile, a protective gas is blown into the heated region; the mobile heating time is greater than or equal to one; and the moving direction of the heat source for each time of heating is the same. By the traceless laser correction method, traceless correction for the back deformation of the stainless steel plate of the railway vehicle subjected to non-penetration laser welding can be realized.

A machine for depositing and dispensing coins includes a first portion containing devices for reception of the deposited coins and for recognition and sorting of the coins based on the denomination thereof, a second portion) containing a plurality of internal hoppers configured to selectively contain the coins sorted by denomination and a third portion containing coin processing means for processing the coins in the dispensing step, a seat being present in the third portion for the temporary housing of a till configured to be filled with predetermined compositions of coins of the various denominations coming from the internal hoppers, the machine further including coin conveying means adapted to receive, at the seat, coins coming from the internal hoppers or from the recognition and sorting devices and to convey them to a higher zone of the machine, where a coin path selector is disposed at the end of the coin conveying means to the higher zone of the machine, the coin path selector being movable between a first position where it enables the conveyance of the coins into an internal collection container and a second position wherein it enables the dispensing of the coins outside the machine.

The present invention is directed compositions derived from green coffee bean extract and methods for the use and manufacture of such compositions. The compositions of the invention have unique ratios of chlorogenic acids which offer a therapeutic effect in the treatment of a variety of conditions and disorders. Methods for using the compositions of the invention include, but not limited to, methods for treating obesity and methods for regulating serum lipids.

A roll-on product, including magnesium hydroxide; propanediol; glycerin and glycine soja (soybean), is advantageously used as a deodorant and / or for transdermal magnesium delivery to the human body. Combinations of a magnesium source (especially magnesium hydroxide), with propanediol, and in some formulations with glycerin and glycine soja (soybean) are advantageous for transdermal delivery of magnesium to the body via a roll-on product, a stick, a spray, a lotion, gel, cream, etc. Magnesium deficiency is addressed via products easily used by an ordinary consumer for dermal application.

The present invention comprises an implant for placing inside the eye such that the implant comes into contact with the interior tissue of the eye such that it conforms to the inner globe geometry of the eye. Implants of the present invention may also be used to alter the focal length of the eye thereby providing a treatment method for the correction of myopia and hyperopia. The device may consist of several possible configurations, an open mesh structure, a solid metal ring, a solid polymer shape, a mesh polymer shape or combination of these. The shape may be a curve, a sphere, a ring or a combination thereof that are specifically shaped to approximate a desired portion of the interior globe of the eye in order to treat myopia or hyperopia

The invention relates to an adjustable well lid with the outer portion being square and the inner portion being round and a mounting and adjusting method of the adjustable well lid. The adjustable well lid comprises a well lid body with the outer portion being square and the inner portion being round on the upper portion, independent load bearing modules on the lower portion and adjusting bolts connected and supported between the well lid body with the outer portion being square and the inner portion being round on the upper portion and the independent load bearing modules. The number of the independent load bearing modules is four, and load bearing portions are located on a roadbase. Each adjusting bolt is composed of a bolt rod on the lower portion, an integrated nut in the middle and anunthreaded rod on the upper portion. The bolt rods are in threaded connection with reserved screw holes in the load bearing modules. The diameter of each integrated nut is larger than the aperture ofa corresponding reserved through hole in the well lid body, so that the well lid body with the outer portion being square and the inner portion being round on the upper portion is flushed with the roadbase. The unthreaded rods penetrate through the reserved through holes of the well lid body with the outer portion being square and the inner portion being round, and a clamping opening is formed inthe end face of each unthreaded rod. According to the adjustable well lid, various possibilities that problems appear in the stages of construction, use and maintenance are avoided, meanwhile, operation is convenient and economical, and daily roads are safe to use and comfortable.

Provided herein are novel nucleic acid sequences, vectors comprising such nucleic acid sequences, host cells comprising such vectors, and transgenic animals comprising such nucleic acid sequences, and related molecules and methods relating thereto. Such novel nucleic acid sequences, vectors comprising such nucleic acid sequences, host cells comprising such vectors, and transgenic animals comprising such nucleic acid sequences, and related molecules and methods provide conditional overexpression of genes, such as myostatin, and transgenic animals conditionally overexpression genes, such as myostatin.