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Application of xylan esterification products in preparation of drugs for preventing or treating inflammatory diseases and cancer

An inflammatory disease and xylan ester technology, which is applied in the application field of xylan esterification products in the preparation of drugs for the prevention or treatment of inflammatory diseases and cancer, can solve problems such as difficult degradation, achieve low dosage requirements, reduce Pollution, healing effect with remarkable effect

Active Publication Date: 2018-05-29
CHINA PHARM UNIV +1
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Due to the characteristics of xylan not easy to degrade, according to the literature review, there is no related report on its use as a carrier for colon-cecum targeted drug delivery.

Method used

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  • Application of xylan esterification products in preparation of drugs for preventing or treating inflammatory diseases and cancer
  • Application of xylan esterification products in preparation of drugs for preventing or treating inflammatory diseases and cancer
  • Application of xylan esterification products in preparation of drugs for preventing or treating inflammatory diseases and cancer

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Embodiment Construction

[0044] Now in conjunction with embodiment, the present invention is described in detail, following embodiment is illustrative, not restrictive, is in order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further carried out Detailed description. It should be understood that the embodiments described here are only used to explain the present invention, not to limit the present invention.

[0045] 1. Preparation of Homogeneous Xylan

[0046] Specific method: Refer to "Preparation Method and Structure Identification of Corncob-derived Homogeneous Xylan" published by Wang Ying, Qu Qinghui, Wang Min, and Yin Hongping on "Pharmaceutical Biotechnology" in 2013 to obtain homogeneous xylan.

[0047] 2. Butyrylation of xylan by homogeneous modification method

[0048] Accurately weigh 100mg of homogeneous xylan (dried at 80°C), place it in a three-necked bottle equipped with a stirring...

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Abstract

The invention relates to preparation of multiple xylan esterification products and an application of the xylan esterification products in preparation of drugs for preventing, relieving and / or treatinginflammatory diseases. The application of the xylan esterification products in preparation of drugs for preventing or treating inflammatory diseases is characterized in that the xylan esterificationproducts have the structure shown in the general formula II. The R group substitution degree of the esterified xylan products is 1.0-2.0, the substitution degree is the average number of xylose unit substituted hydroxyls of xylan, and the substitution degree D of completely substituted xylan is 2.0; n ranges from 2 to 2632, and R1 or R2 is C1-C12 fatty acid. The xylan esterification products havegood treatment effects on inflammatory diseases and cancer caused by the inflammatory diseases.

Description

technical field [0001] The invention relates to the preparation of various xylan esterification products and their application in medicines for preventing, alleviating and / or treating inflammatory diseases. Background technique [0002] Inflammatory disease is a common disease. The etiology and pathogenesis are very complex and have not yet been elucidated. However, a consensus has been reached on the common cause of the disease. Changes in external environmental factors, the influence of multiple genetic variations at the gene level, changes in the gut microbiota, and abnormal innate and adaptive immune responses are considered to be the possible causes of inflammatory diseases. Inflammatory diseases include digestive system inflammatory diseases (including hepatitis, enteritis, etc.), urinary system inflammation (including nephritis, etc.), reproductive system inflammatory diseases (including gynecological inflammation, pelvic inflammatory disease, etc.), nervous system, c...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61K31/715A61P29/00A61P35/00C07H13/04C07H1/00C08B37/14A61K47/61
CPCA61K31/7024A61K31/715C07H1/00C07H13/04C08B37/0057
Inventor 尹鸿萍吕杨査正其王莹王苏妍
Owner CHINA PHARM UNIV
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