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Application of xylan esterification product in preparation of drugs for preventing or treating inflammatory diseases and cancer

A technology for inflammatory diseases and xylan butyrate, which is applied in the application field of xylan esterification products in the preparation of drugs for the prevention or treatment of inflammatory diseases and cancer, can solve problems such as difficult degradation, and achieve low dosage requirements , increase farmers' income and reduce pollution

Active Publication Date: 2020-08-07
CHINA PHARM UNIV +1
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Due to the characteristics of xylan not easy to degrade, according to the literature review, there is no related report on its use as a carrier for colon-cecum targeted drug delivery.

Method used

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  • Application of xylan esterification product in preparation of drugs for preventing or treating inflammatory diseases and cancer
  • Application of xylan esterification product in preparation of drugs for preventing or treating inflammatory diseases and cancer
  • Application of xylan esterification product in preparation of drugs for preventing or treating inflammatory diseases and cancer

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Embodiment Construction

[0044] Now in conjunction with embodiment, the present invention is described in detail, following embodiment is illustrative, not restrictive, is in order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further carried out Detailed description. It should be understood that the embodiments described here are only used to explain the present invention, not to limit the present invention.

[0045] 1. Preparation of Homogeneous Xylan

[0046] Specific method: Refer to "Preparation Method and Structure Identification of Corncob-derived Homogeneous Xylan" published by Wang Ying, Qu Qinghui, Wang Min, and Yin Hongping on "Pharmaceutical Biotechnology" in 2013 to obtain homogeneous xylan.

[0047] 2. Butyrylation of xylan by homogeneous modification method

[0048] Accurately weigh 100mg of homogeneous xylan (dried at 80°C), place it in a three-necked bottle equipped with a stirring...

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Abstract

The present invention relates to the preparation of various xylan esterification products, and an application thereof in a drug for preventing, alleviating and / or treating inflammatory diseases. The application of a xylan esterification product in the preparation of a drug for preventing or treating inflammatory diseases, which is characterized in that the xylan esterification product has a structure as shown in the following general formula II, the R group of the xylan esterification product of (II) having a degree of substitution of 1.0-2.0, and the degree of substitution being: the average number of substituted hydroxy groups per xylose unit of the xylan; the degree of substitution of fully substituted xylan DS=2.0, wherein n=2-2632, and R1 or R2 is a C1-C12 fatty acid. The xylan esterification product has a good therapeutic effect on inflammatory diseases and cancer caused by inflammatory diseases.

Description

technical field [0001] The invention relates to the preparation of various xylan esterification products and their application in medicines for preventing, alleviating and / or treating inflammatory diseases. Background technique [0002] Inflammatory disease is a common disease. The etiology and pathogenesis are very complex and have not yet been elucidated. However, a consensus has been reached on the common cause of the disease. Changes in external environmental factors, the influence of multiple genetic variations at the gene level, changes in the gut microbiota, and abnormal innate and adaptive immune responses are considered to be the possible causes of inflammatory diseases. Inflammatory diseases include digestive system inflammatory diseases (including hepatitis, enteritis, etc.), urinary system inflammation (including nephritis, etc.), reproductive system inflammatory diseases (including gynecological inflammation, pelvic inflammatory disease, etc.), nervous system, c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7024A61K31/715A61P29/00A61P35/00C07H13/04C07H1/00C08B37/14A61K47/61
CPCA61K31/7024A61K31/715C07H1/00C07H13/04C08B37/0057
Inventor 尹鸿萍吕杨査正其王莹王苏妍
Owner CHINA PHARM UNIV
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