The invention discloses an industrial process fault diagnosis method based on multiple classifiers and D-S evidence fusion. The method comprises the steps that firstly, independent repeated sampling is conducted according to fault data in the industrial process; secondly, the multiple classifiers are applied to new training data, respective off-line modeling models are obtained, and meanwhile the properties of all the classifiers are represented in the form of a fusion matrix; thirdly, different types of elementary probability valuation functions are calculated according to the D-S evidence theory, decisions of the multiple classifiers are selectively integrated and synthesized according to the similarity index, a combined elementary probability valuation function is obtained, and a final classified diagnosis result is obtained by means of comparison. Compared with other methods in the prior art, the industrial process fault diagnosis method can greatly improve the diagnosis effect of the industrial process, shorten delayed diagnosis time and increase the diagnosis accuracy rate, improves the monitoring performance to a great extent, enhances the comprehension ability and operation confidence of process operators in the process, and is more beneficial to automatic implementation of the industrial process.