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152results about How to "Transmission limit" patented technology

Cockpit module assembly including air conditioner for vehicle

In a vehicle cockpit module assembly having at least an air conditioner disposed inside a dashboard, a protrusion piece for determining an arrangement position of an air-conditioning unit of the air conditioner within the dashboard is provided at the air-conditioning unit. A front load support portion for supporting a front side load of the air-conditioning unit is constructed by a drain pipe of the air-conditioning unit, and a rear load support portion for supporting a rear side load of the air-conditioning unit is constructed by rear foot ducts of the air-conditioning unit. Accordingly, in the cockpit module assembly, the air conditioner can be stably supported in the vehicle.
Owner:DENSO CORP

Detection of infectious prion protein by seeded conversion of recombinant prion protein

The present disclosure relates to methods and compositions for the detection of infectious proteins or prions in samples, including the diagnosis of prion related diseases. One embodiment is an ultrasensitive method for detecting PrP-res (PrPSc) that allows the use of recombinant PrP-sen (rPrP-sen) as a substrate for seeded polymerization. A sample is mixed with purified rPrP-sen to make a reaction mix which is incubated to permit aggregation of the rPrP-sen with the PrP-res that may be present in the sample. Any aggregates are intermittently disaggregated by agitation (for example by sonication) and the reaction allowed to proceed to amplify target substrate. Any rPrP-res(Sc) in the reaction mix is detected to indicate the presence of PrP-res in the original sample. This assay, which is called rPrP-PMCA, is surprisingly much faster than existing PMCA methods, yet it still retains sufficient sensitivity to detect extremely low levels of PrP-res. An alternative of rPrP-PMCA is the QUIC method in which shaking of the reaction mixture is substituted for sonication. The surprising speed and efficiency of the method permits the rapid identification and diagnosis of prion disease, which can limit the transmission of prion diseases, particularly through the food supply.
Owner:UNITED STATES OF AMERICA
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