33results about How to "The drug works well" patented technology

Provided are a fusion protein of Exendin-4 and its analog, the preparation method and use thereof. The fusion protein is obtained by fusing of Exendin-4 or its analog to Fc region of human IgG2 via a linking peptide, which has the better stability and prolonged serum half-life, and can be used for treating diabetes and obesity.

The invention discloses a method for producing a Fujian jewel orchid by plant tissue culture, which comprises the following three procedures: selection and sterile treatment of plants, induced culture of cluster buds and large-scale culture. The method is technically characterized in that two different culture media are used in the induced culture procedure and the large-scale culture procedure, wherein the culture medium for the induced culture comprises an MS culture medium, sucrose of 10-50g / L, agar of 6-8g / L, activated carbon of 2.0-3.0g / L, naphthylacetic acid of 0.1-3.0mg / L and 6-benzylaminopurine of 0.1-5.0mg / L, and the pH value is 5.0-7.0; and the culture medium for the large-scale culture comprises a modified MS culture medium, calcium nitrate of 600mg / L, mashed banana of 30-50g / L, sucrose of 20-40g / L, agar of 6-8g / L, activated carbon of 2.0-3.0g / L, naphthylacetic acid of 1.0-2.0mg / L and 6-benzylaminopurine of 2.0-3.0mg / L, and the pH value is 5.0-7.0. Plant tissue culture can keep the good characters of the plants. The method has the advantages of easy operation, low production cost, high yield, good quality and no environment pollution, is suitable for industrial seedling raising and can realize mass production.

The invention relates to a preparation method for alpha-TOS-loaded and dendrimer-wrapped gold nanoparticles. The method comprises the following steps: (1) adding EDC and an NH2-PEG-COOH solution into an alpha-TOS solution and reacting to obtain TOS-PEG-COOH; (2) adding the EDC and the NH2-PEG-COOH solution into folic acid and reacting to obtain FA-PEG-COOH; (3) adding a poly amidoamine dendrimer solution into an FI solution and reacting to obtain G5.NH2-FI; (4) adding the TOS-PEG-COOH and FA-PEG-COOH solution into the EDC for activation, adding into the G5.NH2-F1 water solution, and reacting to obtain a dendrimer solution; and (5) adding chloroauric acid, NaBH4, N(C2H5)3 and acetic anhydride into the above solution, and reacting to obtain the gold nanoparticles. The method is simple in preparation process, and is easy to implement.

The invention relates to a preparation method for adriamycin-loaded polyethyleneimine-hyaluronic acid-modified hectorite-coated gold nanoparticles. The preparation method comprises the steps that a PLA-PEG-COOH solution is dropwise added into an LAP solution, stirring and activating are conducted, the mixture is dropwise added into a PEI solution to obtain LAP-PLA-PEG-PEI, chloroauric acid and NaBH4 are added, and LAP-PLA-PEG-PEI-(Au<0>)50 is obtained through a reaction; an activated HA solution is dropwise added into a LAP-PLA-PEG-PEI-(Au<0>)50 aqueous solution, stirring and reacting are conducted, DOX is added, reacting under stirring is conducted, and then the adriamycin-loaded polyethyleneimine-hyaluronic acid-modified hectorite-coated gold nanoparticles are obtained. The preparation method is low in cost, simple, mild in condition and easy to operate and has good application prospects. The nanomaterial-loaded DOX has a good drug slow release effect by serving as a nano-drug slow release system and has the significant targeting property and obvious inhibiting effect on tumor cells expressed by a CD44 receptor.

The present invention relates to medicine technology and is improved mezlocillin sodium injection. The injection has one medicine weight ratio of mezlocillin sodium / Sulbactam sodium 1-16 to 1. It hasstrong antibacterial activity, wide antibacterial spectrum and thus high curative effect, and may be used in treating serious urinary tract infection, respiratory tract infection, intestinal tract, otorbinolaryngological infection, abdominal cavity infection, etc. caused by zymogenic staphylococcus, pneumococcus, enterococcus, purulent streptococcus, Hemophilus infuenzae, etc.

The present invention relates to Chinese medicine technology, and is especially of kind of quick acting analgetic Chinese medicine liquid. The present invention features that the quick acting analgetic Chinese medicine liquid is prepared through soaking gastrodia tuber, ginseng, acanthopanax bark, safflower, ledebouriella root and other ten kinds of Chinese medicinal materials inside spirit for one month. The medicine liquid is one kind of liniment, and after the medicine liquid is applied to the affected part and the affected part is massaged, the medicine liquid will reach the disease focus directly resulting in the effects of promoting blood circulation to disperse blood clots, dredging meridian, relaxing muscles and joints, eliminating wind and wetness evil, stopping pain and eliminating swelling in high effective rate.

The invention discloses a drug composition containing baricitinib and a preparation method and application of the drug composition. The drug composition comprises the baricitinib and an auxiliary material which can be received pharmaceutically, wherein the auxiliary material comprises a filling agent and a disintegrating agent. The preparation method of the drug composition comprises the steps that the filling agent and the disintegrating agent are evenly mixed, so that the mixed auxiliary material is obtained; and then a baricitinib crude drug and the mixed auxiliary material are evenly mixed or pelletizing liquor containing the baricitinib crude drug is evenly mixed with the mixed auxiliary material, and drug-carrying pellets of the solid drug composition containing the baricitinib are obtained through pelletizing. According to the drug composition containing the baricitinib and the preparation method and application of the drug composition, the solid drug composition which can be dissolved out rapidly in vitro and contains the baricitinib is prepared by controlling the particle size of the baricitinib, using microcrystalline cellulose, mannitol and the like in the hydrophilic auxiliary material as the filling agent, and using croscarmellose sodium and the like as the disintegrating agent; and the preparation technique is simple and suitable for industrialization.

The invention relates to a pharmaceutical composition for treating hepatitis, a pharmaceutical preparation as well as an application and a preparation method thereof and belongs to the technical fieldof pharmaceutical preparations for treating hepatitis. The pharmaceutical composition preparation comprises the following components in parts by weight: 7.82-9.00 parts of creeping dichondra monomer,2.37-2.71 parts of berchemia lineata monomer, 1.66-2.15 parts of verbena monomer, 12.57-20.36 parts of radix stephaniae tetrandrae monomer, 1.20-1.74 parts of patrinia monomer, 2.56-3.17 parts of herba epimedii monomer, 0.62-0.77 part of astragalus monomer, 14.30-17.88 parts of red paeony root and 8.25-11.02 parts of salvia miltiorrhiza monomer. The previous medicinal monomers are selected, the auxiliary materials are added, and the pharmaceutical preparation prepared according to the conventional preparation process is applied to treating acute and chronic hepatitis caused by liver-gallbladder dampness-heat and qi-stagnation and blood stasis, achieves unexpected treatment effects, has low toxicity while treating hepatitis and is an ideal medicine.

The invention discloses a traditional Chinese medicinal composition for treating bedsore, which belongs to the field of traditional Chinese medicines. No ideal medicament for treating bedsore during II stage and III stage is clinically invested at present, therefore, the invention provides the traditional Chinese medicinal composition for treating bedsore. The traditional Chinese medicinal composition is mainly prepared from egg, butter and calcined borax. The egg, the butter and the calcined borax are mixed so as to enhance the efficacies of healing sore and generating skin. Unexpected technical effects for treating the bedsore are obtained; and unexpected synergism for wound infection caused by bedsore and burn is obtained.

The present invention discloses Chinese medicine for curing traumatic injury and its preparation process. Its composition includes: notoginseng: ligusticum: dahurian angelica root: Chinese angelica root: wingless cockroach; carthamus flower: corydalis tuber=26-34:4-10:4-10:4-10:4-10:4-10:5:11. Its effective rate can be up to 100%.

The invention discloses an intelligent medicament package and a production method thereof. The intelligent medicament package comprises a blister for holding a medicament and an external package which is used for holding the blister and is integrally and electrically connected with the blister. According to the intelligent medicament package and the production method thereof disclosed by the invention, the defects of low medicament dependence, poor medical service persistency, high medical treatment cost, poor medicament test accuracy, fewer functions and the like in the prior art are overcome, and the advantages of high medicament dependence, good medical service persistency, low medical treatment cost, good medicament test accuracy and comprehensive functions are realized.

The invention belongs to the technical field of traditional Chinese medicine, and particularly provides traditional Chinese medicinal eye drops. The traditional Chinese medicinal eye drops are prepared from the following raw materials in parts by weight: 12 to 26 parts of buerger pipewort flower, 10 to 18 parts of fructus viticis, 12 to 25 parts of mulberry leaves, 15 to 30 parts of dandelion, 12 to 35 parts of medlar, 12 to 20 parts of chrysanthemum, 20 to 35 parts of parmelia saxitilis, 8 to 15 parts of bamboo leaves, 2 to 20 parts of cape jasmine, 10 to 15 parts of cinnamon leaves, 12 to 28 parts of dichrocephala auriculata, 12 to 23 parts of eupatorium fortunei, 10 to 14 parts of angelica sinensis, 8 to 40 parts of digitaria sanguinalis, 10 to 12 parts of madder, 10 to 15 parts of lily, 5 to 10 parts of honeysuckle, 6 to 8 parts of mint, 10 to 14 parts of red-rooted salvia root, and 8 to 14 parts of sophora flower. The traditional Chinese medicinal eye drops provided by the invention are good in medicinal cure effect and quick in effect, act on eyes directly, do not have a toxic or side effect, have the effects of clearing heat, detoxifying, nourishing blood for improving eyesight and dispelling wind and heat, and have remarkable treatment effects on trachoma and the symptom, such as dryness and pain of eyes; eye dryness and slight discomfort can be relieved effectively, and the effect of moistening and improving eyesight can also be achieved; therefore, the traditional Chinese medicinal eye drops are worth being popularized and applied widely.

The invention discloses a traditional Chinese medicine composition capsule for treating a climacteric syndrome and a preparation method of the traditional Chinese medicine composition capsule. The traditional Chinese medicine composition capsule is prepared by the following steps: heating and refluxing white peony root, bupleurum, rhizoma cyperi, costusroot, sichuan lovage rhizome, fructus aurantii, pinellia ternata prepared with ginger, fried melia toosendan, fructus amomi rotundus and liquorice; collecting volatile oil, carrying out water extraction and alcohol precipitation, merging extract powder with a cyclodextrin inclusion, and adding calcium hydrogen phosphate and superfine silica powder, so as to prepare the capsule. The traditional Chinese medicine disclosed by the invention has a good medicine effect on treatment of the climacteric syndrome, and is long in storage time, and high in stability; the bitter taste of the medicine can be concealed; and discomfort of patients caused by medication is reduced.

A method for measuring blood levels of DNA that is released upon death from specialized cells in the body, by using PCR or a quantitative probe technology to detect amplified methylated and demethylated forms of cell-specific gene DNA, representing normal tissue and cell specific origin, respectively. Using probes permits the sensitive and specific identification of demethylated cell-specific DNA patterns that are present only in the dying cells. The method offers a bioassay for detecting β cell loss in diabetes based on circulating demethylated insulin gene DNA, and circulating demethylated myelin oligodendrocyte protein (MOG) genes of oligodendrocytes in multiple sclerosis, for example, and may be useful for screening, monitoring of disease progression, and selection and monitoring of therapies.

The invention discloses six-ingredient rehmannia soft capsules and a preparation method thereof. When the preparation method provided by the invention is used, relatively more active ingredients of a medicament can be extracted, impurities are removed, and medicinal effects are better played, so that the dosage of the medicament is reduced.

The invention discloses a traditional Chinese medicine decoction for treating lumbar disc herniation. The decoction is prepared from the following raw materials in parts by weight: 3-4 parts of centipedes, 5-7 parts of scorpions, 2-4 parts of bombyx batryticatus, 8-10 parts of angelica sinensis, 6-8 parts of radix paeoniae rubra, 2-4 parts of obscured homalomena rhizome, 4-6 parts of semen cuscutae, 3-4 parts of radix cyathulae, 6-8 parts of radix rubiae, 5-10 parts of processed myrrh, 2-4 parts of aralia chinensis, 3-4 parts of Chinese starjasmine stem, 5-7 parts of rhizoma drynariae, 4-6 parts of ephedra sinica stapf, 6-10 parts of prepared rhubarb, 3-4 parts of eucommia ulmoides, 6-8 parts of uncaria rhynchophylla, 2-3 parts of processed semen strychni, 6-8 parts of rhizoma cibotii, 2-4 parts of fructus psoraleae, 6-8 parts of fennel, 3-4 parts of lactuca indica and 4-6 parts of roots of illicium henryi. The traditional Chinese medicine decoction is prepared from multiple medicinal materials which are synergized one another, has a remarkable curative effect, is safe and reliable, is simple in taking, and does not have side effect. The traditional Chinese medicine decoction has the effects of soothing the liver, calming endogenous wind, tonifying the liver and kidneys, strengthening tendons and bones, removing dampness, dispelling cold, dredging meridians, relieving pain, inducing diuresis and diminishing swelling, and can be used for effectively treating the symptom of lumbar disc herniation and relieving the pain of patients.

An antibiotic in the form of injection for treating different infection caused by different bacteria and septicemia is an improvement on mezlocillin sodium, and contains mezlocillin sodium and tazobactam sodium in a ratio of (1-16):1. Its advantages are broad spectrum and high curative effect.

The invention belongs to the technical field of health wine preparation, and discloses radix puerariae health wine and a preparation method thereof. The radix puerariae health wine is prepared from, by mass, 8-20 parts of radix puerariae, 4-5 parts of erycibe obtusifolia benth, 3-6 parts of rhizoma cibotii, 5-6 parts of fructus momordicae, 8-11 parts of folium mori, 3-4 parts of black sesame, 5-8 parts of lily, 2-3 parts of lysimachia christinae hance, 1-2 parts of fresh ginger, 2-4 parts of flos carthami, 4-7 parts of sappan wood, 4-5 parts of herba lycopi, 3-4 parts of circium japonicum, 5-7 parts of glossy privet fruit, 1-4 parts of common yam rhizome, 2-4 parts of platycodon grandiflorum, 2-5 parts of dendrobe and 1-3 parts of dandelion. Effective components in the radix puerariae are extracted by treating the radix puerariae, and the effective components are mixed with the kaoliang spirit, so that the effect of the extract is exerted; by adding erycibe obtusifolia benth, rhizoma cibotii, fructus momordicae and folium mori into the kaoliang spirit, the health-care and health-preserving effects of the radix puerariae wine can be improved. The preparation method is simple, and large-scale preparation and popularization can be realized.

A Chinese medicine for treating tumor, especially the tumor in blood system is prepared from the extract of astragalus root and the pharmacologically acceptable carrier and for excipient.

The invention relates to a pharmaceutical composition containing a Japanese stephania root, which is characterized in that the medicine combination is prepared from the following raw materials in parts by weight: 5-10 parts of Japanese stephania root, 2-8 parts of selfheal, 7-12 parts of lily, 3-5 parts of Fructus forsythiae and 3-5 parts of Chinese wolfberry fruit. The invention has the advantages that the preparation of the pharmaceutical composition is simple, the pharmaceutical composition has the functions of clearing heat and detoxifying and curing vascular headache, the curative effect of the pharmaceutical composition is good, toxic and side effects do not exist and the pharmaceutical composition has the efficacies of clearing liver and improving vision.

The invention provides a traditional Chinese medicine preparation for treating gout. The traditional Chinese medicine preparation is prepared from, by weight, 1-20 parts of Rhizoma Coptidis, 1-20 parts of Cortex Phellodendri, 1-30 parts of Hemsleya Sphaerocarpa and 1-30 parts of Radix Sophorae Tonkinensis. The traditional Chinese medicine preparation is one of external ointment, external patch, external poultice and external spray and prepared by steps: respectively slicing, segmenting or grinding raw materials into powder, wetting with ethanol water, boiling, adding ethanol water to original solution quantity when water quantity is decreased by evaporation, taking out decoction, filtering through a plate-and-frame filter press or an appropriate filter, and keeping filtrate for standby application; adding ethanol water into residues, re-boiling, and taking out decoction for standby application; pressing residues, combining press liquid with all decoction, standing, and filtering through the filter; concentrating the filtrate in an evaporating pan to a thick paste state; mixing with an ointment base material to obtain the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is remarkable in curative effect and has prominent anti-inflammation and abirritation effects according to pharmacodynamic experiments.

The present invention relates to Chinese medicine technology, and is especially of kind of quick acting analgetic Chinese medicine liquid. The present invention features that the quick acting analgetic Chinese medicine liquid is prepared through soaking gastrodia tuber, ginseng, acanthopanax bark, safflower, ledebouriella root and other ten kinds of Chinese medicinal materials inside spirit for one month. The medicine liquid is one kind of liniment, and after the medicine liquid is applied to the affected part and the affected part is massaged, the medicine liquid will reach the disease focus directly resulting in the effects of promoting blood circulation to disperse blood clots, dredging meridian, relaxing muscles and joints, eliminating wind and wetness evil, stopping pain and eliminating swelling in high effective rate.

A Chinese patent medicine in the form of tablet or pill for treating asthma is prepared from 19 Chinese-medicinal materials including toad, white pepper, ginseng, tendrilled fritillary bulb, borax etc. Its advantage is high curative effect. Its unique preparing process is also disclosed.