75results about How to "Significant variability" patented technology

A composite formulation has been developed for selective, high efficacy delivery to specific regions of the mouth and gastrointestinal tract. The formulation is typically in the form of a tablet or capsule, which may include microparticles or beads. The formulation uses bioadhesive and controlled release elements to direct release to specific regions, where the drug is absorbed in enhanced amounts relative to the formulation in the absence of the bioadhesive and / or controlled release elements. This is demonstrated by an example showing delivery of gabapentin with a greater area under the curve (“AUC”) relative to the FDA reference immediate release drug, i.e., the AUC of the composite bioadhesive formulation is greater than 100% of the AUC of the immediate release drug. In the preferred embodiments, the formulation includes drug to be delivered, controlled release elements, and one or more bioadhesive elements. The bioadhesive polymer may be either dispersed in the matrix of the tablet or applied as a direct compressed coating to the solid oral dosage form. The controlled release elements are selected to determine the site of release. The bioadhesive components are selected to provide retention of the formulation at the desired site of uptake and administration. By selecting for both release and retention at a specific site, typically based on time of transit through the gastrointestinal tract, one obtains enhanced efficacy of uptake of the drug. This is particularly useful for drugs with narrow windows of absorption, and drugs with poor solubility such as the BCE class III and class IV drugs.

An electronic variable stroke device comprise a base portion containing a motor-driven screw shaft, an upper portion extending from the base portion having the screw shaft extending longitudinally therein, a traveler engaged with the screw shaft to drive it in reciprocating longitudinal motion. The traveler has an annular shape with an aperture therethrough which is driven in reciprocating longitudinal motions for use as a male sex toy. The device configuration may include a pair of screw threads spaced apart in parallel with the traveler engaged in between them, and / or multiple travelers arranged at different longitudinal positions of the screw shaft(s). A remote controller unit may be provided for ergonomic operation by the user. A network connection unit may be provided to connect the user's device to an external service provider on a network for conducting interactive sessions remotely with another user or users. The device may be adapted as a male toy that can exchange control signals with another user operating a female toy.

Methods and systems for controlling an insulin pump in response to glucose measurements are responsive to a base insulin delivery profile and a temporary insulin delivery profile. These can be used, e.g., to control blood glucose level of a subject using a continuous glucose monitor and an insulin infusion pump. During a selected time range, an insulin amount for the pump to supply is determined using the temporary insulin delivery profile. Outside that time range, the insulin amount is determined using the base insulin delivery profile. The temporary insulin delivery profile can specify an exact amount to be supplied (a “hard” profile), a nominal amount to be supplied if doing so does not drive glucose out of a desired zone (“soft”), or a soft profile with a minimum amount of insulin to be delivered (“semi-soft”).

A modular microreaction system comprising a housing and functional base modules accommodated therein. The housing has at least one fluid inlet and at least one fluid outlet. The base modules are arranged one behind another in a row in the housing and being designed such that fluid can flow successively through them in series. At least some of the base modules are constructed from a plurality of substantially rectangular foils having plate-like surfaces in essentially parallel planes which foils are connected to one another and are arranged in layers one above another, forming a foil stack. At least a first of the foils having at least one of microstructured channels, sensor elements, heating elements and combinations thereof on a plate-like surface of the at least a first of the foils. Each foil stack also has at least one foil which is provided on a plate-like surface of the at least one foil with channels which are constructed such that for one fluid line they lead from one side of the foil stack to another side of the foil stack. The base modules (2, 2′, 2″) each have at least one frame element (10), which is arranged essentially perpendicular to planes of the foils, and is connected to the foil stack in a fluid-tight manner and the foil stacks, together with the frame elements, form base elements that can be inserted into and removed from the housing (1) as a unit.

A vehicle headlight system including a light source, digital beam forming optics optically coupled to the light source, and a memory storing a plurality of light illumination patterns. The memory is electrically coupled to the digital beam forming optics. The digital beam forming optics is adapted to output light from the light source in the form of at least one of the light illumination patterns in response to at least one vehicle operating condition.

A multilayer reflector useable to reflect or transmit light over the visible wavelength range includes optically thick constituent layers. The optical thickness of the constituent layers through the thickness of the reflector defines a layer thickness profile. The layers are arranged so that the thickness profile has a tailored non-uniform distribution, such as a graded distribution or a randomized distribution. The layers desirably have an optical thickness in a range from about one to five or one to ten design wavelengths. The reflector can be a polarizer, reflecting only one normally incident polarization state, or a mirror, reflecting two normally incident orthogonal polarization states.

The invention relates a power distribution system (1) like a track lighting system comprising a power supply (2), a power bar (3) comprising several electrical conductors (4, 5, 6) for distributing the power, an electrical load (12) to be powered by the power of the power distribution system, a selector switch (11) connected to the several electrical conductors and to the electrical load, wherein the selector switch is adapted to select via which electrical conductor the power is to be received by the electrical load, and a controlling device (10) for automatically controlling the selector switch. This kind of power distribution system provides a relatively large variability of adapting the power consumption to an actual load situation, which can lead to an improved performance of the power distribution system. In particular, power balancing can be provided in a relatively simple way by automatically controlling the selector switch accordingly.

An infinitely variable diameter beverage sleeve includes a first surface configured to contact the container and extend around a circumference of the container, and a second surface configured to extend around the circumference of the container and face away from the container, and a securing device to hold the sleeve to the outside surface of the container. A first portion of the securing device is provided on one end of the sleeve on the first surface, and a second engaging portion of the securing means is provided as the second surface of the sleeve. The top edge of the sleeve is non-planar and the bottom edge of the sleeve is formed of a plurality of segments with at least two segments having a different radius of curvature.

Described and shown is a dielectric antenna (1) having a dielectric feeding section (2), a first transition section (3) comprising a dielectric rod, a dielectric emitting section (5) and, a further, second transition section (4) forming a dielectric horn, wherein the feeding section (2) can be struck with electromagnetic radiation (6), electromagnetic radiation (6) can be guided with the first transition section (3) and the second transition section (4) and the electromagnetic radiation can be emitted from the emitting section (5) as airborne waves.The object of the present invention is to provide a dielectric antenna, which is adaptable as low-loss as possible to different mounting situations, which additionally is as low-reflection as possible and, at the same time is highly bundling.The object of the above-mentioned dielectric antenna is met in that the emitting section (5) is designed as dielectric tube connecting to the second transition section (4).

The present invention generally provides carbon materials and methods for producing the carbon materials that include a polymer-like bonded carbon network, a diamond-like bonded carbon network, a graphene-like bonded carbon network, and at least one stabilizing network of at least one alloying element. The material may further include hydrogen, silicone, and oxygen. The carbon materials are generally produced using plasma deposition while accounting for both thermal and incident particle impact activation for surface reactions, which beneficially enables the production of the carbon material at relevantly low incident flux energy and / or relatively low substrate temperatures.

Described is a multi-legged instrument stand that is specifically designed to increase stability and resistance to tipping. The stand can be used with any suitable instrument, such as guitars (via a guitar hanger), microphones, etc. The stand includes a base with a body pole. A leg connector is slidably attached with the body pole, with three legs and two stabilizers being pivotally connected with the leg connector. Thus, the legs and stabilizers can collapse for storage or rotate outward to allow the stand to be positioned upon a ground surface with increased stability.

A method and means for identifying the authenticity and the genuine nature of a solid or liquid bulk material, by incorporating a marking composition containing at least one trace ion into the said bulk material, whereby the total concentration of the incorporated trace ions in the market bulk material is chosen to be lower than the corresponding concentration of the same ions in standard sea water. The authenticity and the genuine nature or the adulteration level of the marked bulk material can be tested in-the-field using electrochemical sensors, and confirmed in the laboratory using a method such as atomic absorption spectroscopy, ion chromatography or mass spectrometry.

An electronic switch for controlling a device (170) by switching a function of the device at least in dependency on a sleep stage of a human, the switch comprising an EEG data interface configured to receive brain activity data from an EEG sensor (120) configured to monitor electrical activity of the brain of the human during a training phase, an EEG sleep classifier (125) configured to classify sleep stages of the human from the received brain activity data, a body data interface configured to receive body activity data from an alternative sensor (30) configured to monitor a bodily function of the human both during the training phase and during a subsequent usage phase, the alternative sensor being different from the EEG sensor, an alternative sleep classifier (135) and a machine learning system (140), the machine learning system being configured to train the alternative sleep classifier (135) to classify a sleep stage of the human from the received body activity data, the learning system using sleep stages classified by the EEG sleep classifier (125) and concurrent body activity data received from the alternative sensor as training data, wherein in the usage phase the device (170) is controlled in dependency on sleep stages of the human classified by the alternative sleep classifier (135), and control logic (150) configured to at least determine that the classified sleep stage is one of a set of particular sleep stages and to switch a function of the device at least in dependency on said determination.

The invention relates to a method for retarding agricultural non-point source pollution by comprehensively applying biological carbon and a nitrification inhibitor, belongs to the field of agricultural non-point source pollution research, and is dedicated to retarding non-point source pollution caused by nitrogen gas losses and subsequent atmospheric deposition in a paddy field and vegetable field ecosystem. According to the method, the biological carbon and the nitrification inhibitor are applied in fields of a rice-wheat crop rotation rice field and intensive vegetable cultivation ecosystem, therefore emission of gaseous nitrogen, such as N2O and NOx, is effectively reduced, and the atmospheric deposition is reduced to retard the non-point source pollution; the utilization rate and the yield of crops are increased, and nitrate nitrogen content of soil and migration of nitrate nitrogen to a water body are reduced to retard the non-point source pollution. The method is a brand-new, rapid, simple and efficient non-point source pollution retarding method, can be used for a wide variety of agricultural ecosystems, is convenient to operate and easily available in material, can be widely applied to prevention and control research on the agricultural non-point source pollution to paddy fields and vegetable fields, and provides an effective means for deeply researching the agricultural non-point source pollution.

A method for producing map images of current velocity vectors at the surface sea is described in which beams of electromagnetic waves are emitted towards the surface using a system, towards the left forward and right forward sides of the track of the system, and towards the left aft and right aft sides of the track, from two antennas at a distance from each other along the direction of the track and along a direction perpendicular to the track, and values of roll angle and length of the antenna base connecting the two antennas are determined using differential interferometries applied to the electromagnetic waves reflected by the surface between beams emitted forwards and backwards, the map images being built up using an along-track type differential interferometry, using roll angle and antenna base length values obtained.

The light source is based on a high-efficiency solid-state laser source of the excitation coherent radiation and a single crystal phosphor which is machined in a form of an optic element for emitted light parameterisation. The single crystal phosphor is produced from a single crystal material on the basis of garnets of the (Ax, Lu1-x)aAlbO12:Cec general formula or from a single crystal material on the basis of perovskite structure of the B1-qAlO3:Dq general formula. The efficient light source shall be utilized e.g. in the automotive industry.

A combination furniture includes a base, a main cushion, two armrests, a backrest, and a fastener assembly. The top surface of the base is concavely provided with plural strip-shaped coupling grooves. The main cushion has a bottom plate provided with plural coupling strips integrally projecting from the bottom plate for being coupled with the coupling grooves. The two armrests have a pair of combining parts formed in parallel and slidingly and transversely installed on two sides of the base, respectively. The backrest has a pair of fixing parts formed on the backrest in parallel for correspondingly overlapping the two combining parts of the two armrests. The fastener assembly fastens the combining parts and the corresponding fixing parts to the base. Therefore, the combination furniture is easily assembled, manufactured, and transported.

Described are shoes with a rigid heel portion, and a collar arranged above the rigid heel portion. The collar includes a first collar portion and a second collar portion, the first collar portion and the second collar portion are configured to partially engage an ankle of a wearer of the shoe on a lateral side, a medial side, and a rear side of the ankle when worn. The first collar portion is more flexible than the rigid heel portion, and the second collar portion is more flexible than the first collar portion.

A user interface device (1) comprises a non-flexible part (3); at least one flexible part (5) coupled to the non-flexible part (3); and at least one sensor, for detecting bending of a respective flexible part (5) with respect to the non-flexible part (3), and for producing a command in response to sensing bending of the respective flexible part (5).