The invention relates to a method for preparing the medical sustained and controlled release material, which belongs to the field of the mesoporous molecular sieve. The preparation method comprises the following steps: preparing pure silicon-based double-model mesoporous molecular sieve with double-pore structure and controllable pore canal size; dissolving silane coupler in the organic solvent, and obtaining solution A by adjusting the concentration of the silane coupler; activating the double-model mesoporous molecular sieve for 5 hours in the vacuum at 150 DEG C, then adding the molecular sieve to the solution A by a certain proportion, mixing the molecular sieve and the solution A for 5 hours at the room temperature, filtering and washing, drying the solid obtained from filtering, and then obtaining the functionalized double-model mesoporous molecular sieve; adding the medicine to the organic solvent, and obtaining solution B by adjusting the concentration of the medicine; adding the functionalized molecular sieve into the solution B according to certain proportion, mixing the molecular sieve with the solution B for 8 to 12 hours at the room temperature, filtering and washing, drying the solid obtained from washing at 60-80 DEG C, and obtaining solid powder. The preparation method has the advantages of stable structure, physiological non-toxicity, high medicine load, long medicine release time and stable medicine release rate.