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Preparation method of sustained and controlled release medicine material

A drug and controlled-release drug technology, applied in drug combinations, pharmaceutical formulations, chemical instruments and methods, etc., can solve problems such as the inability to maintain the blood drug concentration in the target area for a long time, the inability to deliver the drug to the target area, and side effects, etc., to achieve No physiological activity, biocompatibility, short cycle and simple steps

Inactive Publication Date: 2010-11-17
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Several major problems in drug treatment include: (1) the drug cannot be delivered to the target area accurately; (2) the effective blood drug concentration in the target area cannot be maintained for a long time; (3) the blood drug concentration in the non-target area is relatively low. High, there is a risk of side effects

Method used

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  • Preparation method of sustained and controlled release medicine material
  • Preparation method of sustained and controlled release medicine material
  • Preparation method of sustained and controlled release medicine material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Synthesis experiment: Dissolve 2.61g of cetyltrimethylammonium bromide in 104g of distilled water, stir until dissolved, pipette 8ml of ethyl orthosilicate into the solution, add freshly prepared ammonia, adjust the pH to 9, and maintain the stirring speed 500pm / min to produce a white blocky gel, suction filtration, washing, filtration, the obtained white powder is dried, and the dried product is heated to 550 ° C and calcined for 6 hours to obtain a 3nm primary pore and 20nm secondary pore structure. Double model mesoporous molecular sieve;

[0038] Molecular sieve functionalization: add 0.002 mol of triaminotriethoxysilane to 100 ml of absolute ethanol to make the concentration of triaminotriethoxysilane 0.02 mol / L to obtain solution A1. The bimodal mesoporous molecular sieves were vacuum activated at 150 °C for 5 h. 1 g of activated double-model mesoporous molecular sieve was added to solution A1, stirred at room temperature for 5 hours, filtered and washed, and the...

Embodiment 2

[0043] Synthesis experiment: Dissolve 2.61g of cetyltrimethylammonium bromide in 104g of distilled water, stir until dissolved, pipette 8ml of ethyl orthosilicate into the solution, add freshly prepared ammonia, adjust the pH to 9, and maintain the stirring speed 500pm / min to produce a white blocky gel, suction filtration, washing, filtration, the obtained white powder is dried, and the dried product is heated to 550 ° C and calcined for 6 hours to obtain a 3nm primary pore and 20nm secondary pore structure. Double model mesoporous molecular sieve;

[0044] Molecular sieve functionalization: add 0.005mol of triaminotriethoxysilane to 100ml of methanol to make the concentration of triaminotriethoxysilane 0.05mol / L to obtain solution A1. The bimodal mesoporous molecular sieves were vacuum activated at 150 °C for 5 h. 1 g of activated double-model mesoporous molecular sieve was added to solution A1, stirred at room temperature for 5 hours, filtered and washed, and the solid obta...

Embodiment 3

[0048] Synthesis experiment: Dissolve 2.61g of cetyltrimethylammonium bromide in 104g of distilled water, stir until dissolved, pipette 8ml of ethyl orthosilicate into the solution, add freshly prepared ammonia, adjust the pH to 9, and maintain the stirring speed 500pm / min to produce a white blocky gel, suction filtration, washing, filtration, the obtained white powder is dried, and the dried product is heated to 550 ° C and calcined for 6 hours to obtain a 3nm primary pore and 20nm secondary pore structure. Double model mesoporous molecular sieve;

[0049] Molecular sieve functionalization: 0.01 mol of triaminotriethoxysilane was added to 100 ml of absolute ethanol to make the concentration of triaminotriethoxysilane 0.1 mol / L to obtain solution A1. The bimodal mesoporous molecular sieves were vacuum activated at 150 °C for 5 h. 1 g of activated double-model mesoporous molecular sieve was added to solution A1, stirred at room temperature for 5 hours, filtered and washed, and...

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Abstract

The invention relates to a method for preparing the medical sustained and controlled release material, which belongs to the field of the mesoporous molecular sieve. The preparation method comprises the following steps: preparing pure silicon-based double-model mesoporous molecular sieve with double-pore structure and controllable pore canal size; dissolving silane coupler in the organic solvent, and obtaining solution A by adjusting the concentration of the silane coupler; activating the double-model mesoporous molecular sieve for 5 hours in the vacuum at 150 DEG C, then adding the molecular sieve to the solution A by a certain proportion, mixing the molecular sieve and the solution A for 5 hours at the room temperature, filtering and washing, drying the solid obtained from filtering, andthen obtaining the functionalized double-model mesoporous molecular sieve; adding the medicine to the organic solvent, and obtaining solution B by adjusting the concentration of the medicine; adding the functionalized molecular sieve into the solution B according to certain proportion, mixing the molecular sieve with the solution B for 8 to 12 hours at the room temperature, filtering and washing,drying the solid obtained from washing at 60-80 DEG C, and obtaining solid powder. The preparation method has the advantages of stable structure, physiological non-toxicity, high medicine load, long medicine release time and stable medicine release rate.

Description

technical field [0001] The invention relates to a preparation method of a drug sustained and controlled release material, in particular to the preparation of a functionalized pure silicon-based double-model mesoporous molecular sieve with a double-porous structure and controllable pore size according to the chemical and physical properties of the drug. technical background [0002] Several major problems faced by drug treatment include: (1) the drug cannot be accurately delivered to the target area; (2) the effective blood drug concentration in the target area cannot be maintained for a long time; (3) the blood drug concentration in the non-target area is relatively high. high, there is a risk of side effects. In order to solve this problem, slow-release and controlled-release agents came into being. In recent years, the research on sustained-release and controlled-release preparations has developed rapidly. In 1999, the global sales of such products approached 10 billion ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02C01B39/00A61K31/192A61K31/616A61P29/00
Inventor 孙继红高琳
Owner BEIJING UNIV OF TECH
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