118results about How to "Minimize spreading" patented technology

An improved audio coding technique encodes audio having a low frequency transient signal, using a long block, but with a set of adapted masking thresholds. Upon identifying an audio window that contains a low frequency transient signal, masking thresholds for the long block may be calculated as usual. A set of masking thresholds calculated for the 8 short blocks corresponding to the long block are calculated. The masking thresholds for low frequency critical bands are adapted based on the thresholds calculated for the short blocks, and the resulting adapted masking thresholds are used to encode the long block of audio data. The result is encoded audio with rich harmonic content and negligible coder noise resulting from the low frequency transient signal.

The addition of low concentrations of combinations of water-soluble organic salts of zinc to gels, creams, lotions or ointments can increase the ability of these products to reduce or prevent exogenous irritants from causing irritation of the underlying substrate. The addition of low concentrations of combinations of water-soluble organic zinc salts to these gels, creams, lotions or ointments also can reduce the irritation of skin or mucous membranes caused by the addition of potentially-irritating substances such as spermicides, microbicides, fungicides or other therapeutic agents to the gel, cream, lotion or ointment. The advantages of this anti-irritant approach over others, which generally employ high concentrations of single zinc salts, are the reduced potential for zinc toxicity, the reduced potential for toxicity related to zinc itself, and the preservation of the desirable biological properties of potentially-irritating therapeutic substances added to the gel, cream, lotion or ointment.

The present invention relates to humanized FcγRIIB antibodies, fragments, and variants thereof that bind human FcγRIIB with a greater affinity than said antibody binds FcγRIIA. The invention encompasses the use of the humanized antibodies of the invention for the treatment of any disease related to loss of balance of Fc receptor mediated signaling, such as cancer, autoimmune and inflammatory disease. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the humanized antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing the efficacy of a vaccine composition by administering the humanized antibodies of the invention. The invention encompasses methods for treating an autoimmune disease and methods for elimination of cancer cells that express FcγRIIB.

The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The present invention also provides the use of an anti-FcγRIIB antibody or an antigen-binding fragment thereof, as a single agent therapy for the treatment, prevention, management, or amelioration of a cancer, preferably a B-cell malignancy, particularly, B-cell chronic lymphocytic leukemia or non-Hodgkin's lymphoma, an autoimmune disorder, an inflammatory disorder, an IgE-mediated allergic disorder, or one or more symptoms thereof. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.

The present invention relates to methods and compositions which employ low concentrations of combinations of zinc salts to prevent the irritation of skin or mucous membranes that may be caused by therapeutic agents, by personal hygiene products, or by various physical, chemical, mechanical, or biological irritants, including infectious agents.

A thread dispatch mechanism dispatches threads in a multiprocessor computer system that has hardware multithreading enabled, thereby allowing each processor to execute multiple threads. The thread dispatch mechanism determines which processors are busy and cannot execute an additional thread, which processors are working on a thread but can still accept an additional thread, and which processors are idle. As threads are ready to be dispatched, each is dispatched to an idle processor instead of a processor that is already working on another thread. If there are no idle processors, the thread is dispatched to a processor working on one or more threads that can still process the new thread. In this manner the thread dispatch mechanism and method of the present invention provides greatly improved consistency in response times between threads and higher throughput compared to prior art methods of dispatching threads.

Apparatus is disclosed for steering a directional audio beam that is self-demodulated from an ultrasound carrier. The apparatus includes means for modulating a carrier signal with an audio signal and means for adjusting the amplitude and phase of at least one of the audio signal and/or the carrier signal to steer the audio beam to a desired direction. The apparatus also includes means for generating an ultrasound beam in the desired direction driven by the modulated carrier signal. The apparatus may include means for weighting the audio and/or carrier signal by a zeroth order Bessel function to synthesize a Bessel distribution source. A corresponding method for steering a directional audio beam is also disclosed. A harmonic generator may be used to generate harmonics of low frequencies in the audio signal. The harmonics may provide (upon demodulation) a psycho-acoustic impression of improved perception of low frequencies. Further, a modulated ultrasonic signal or an unmodulated audio signal may be band-passed into two or more different band-limited signals. The band-limited signals may be amplified and transmitted by ultrasonic transducers having mechanical resonance frequencies substantially equal to a characteristic frequency of the band-limited signals. Ultrasonic processing of the audio signal may include square root methods without generating large numbers of harmonics.

The present invention includes a wireless communication system. The wireless communication system includes a plurality of transceiver antennae. Each transceiver is spatially separate from at least one other transceiver antenna. Each transceiver antenna includes a transceiver antenna polarization. At least one transceiver antenna has a polarization that is different than at least one other transceiver antenna. Each transceiver antenna transmits a corresponding data stream. The wireless communication system further includes a plurality of receiver antennae. The receiver antennae receive at least one data stream. The transceiver antenna polarization of each transceiver antenna is pre-set to optimize separability of the received data streams. A transmission channel between the transceiver antennae and the receiver antennae can be estimated with a channel matrix. The pre-set transceiver antenna polarization of each transceiver antenna can be determined by minimizing a singular value spread of the channel matrix. A pre-set receiver antenna polarization of each receiver antenna can also be determined by minimizing a singular value spread of the channel matrix.

This invention relates to stents comprising an effective amount of a c-Jun N-terminal kinase (“JNK”) Inhibitor, the stents being useful for treating or preventing a cardiovascular or renal disease. The invention also relates to the treatment or prevention of cardiovascular or renal disease, such as atherosclerosis or restenosis, comprising implanting into a patient in need thereof of a stent comprising an effective amount of a JNK Inhibitor.

The present invention is directed oncolytic Herpes simplex-l viruses whose replication is controlled using a tetracycline operator/repressor system. The invention also includes DNA sequences used in making the viruses and methods in which these viruses are used in the treatment of cancer patients with solid tumors.

A III-nitride compound device which has a layer of AlInN (7) having a non-zero In content, for example acting as a current blocking layer, is described. The layer of AlInN (7) has at least aperture defined therein. The layer of AlInN (7) is grown with a small lattice-mismatch with an underlying layer, for example an underlying GaN layer, thus preventing added crystal strain in the device. By using optimised growth conditions the resistivity of the AlInN is made higher than 10₂ ohm·cm thus preventing current flow when used as a current blocking layer in a multilayer semiconductor device with layers having smaller resistivity. As a consequence, when the AlInN layer has an opening and is placed in a laser diode device, the resistance of the device is lower resulting in a device with better performance.

Methods and apparatus for removing skin blemishes and wrinkles by abrasion using a burr are disclosed. In one example a hand-held device (10) is used. It has a body (11) into the proximal end of which a low-voltage motor (14) is removably clipped and onto the distal end of which a shield or fitment (12) is removably attached. A rotary burr (20) is located within the shield so as to be rotatably coupled to the motor shaft. Preferably, the burr (20) and the shield (12) are attachable and removable as a single-use disposable fitment. The shield (12) may be located off-center with respect to the burr (20) so that rotation of the shield with respect to the body (11) will to expose more or less of the burr. A slot (32) may be formed in the wall of the shield (12) to discharge skin debris onto the skin being treated where it can be wiped away.

An earphone cushion for a communications headset. The cushion includes a resilient pad affixed within a bag. The pad includes a foam disk for engagement with a headset earphone. The periphery of the cover is gathered by means of an elastic band for grasping the earphone.

The present invention relates to methods and compositions for the diagnosis, treatment, management, or prevention of plasma cell disorders, including systemic light-chain amyloidosis (AL) and multiple myeloma (MM). In particular, the invention encompasses the use of anti-CD32B antibodies, analogs, derivatives or fragments thereof, or compounds or agents that bind to CD32B and modulate CD32B activity in the plasma cells of mammals. The invention also encompasses the use of anti-CD32B antibodies, analogs, derivatives or fragments thereof, or CD32B binding compounds or agents in combination with or in addition to other cancer therapies for the treatment, prevention, management, or amelioration of a plasma cell disorder characterized by the expression of CD32B, or one or more symptoms thereof. The invention further relates to the use of anti-CD32B antibodies, analogs, derivatives or fragments thereof for the detection of aberrant or altered expression of CD32B in plasma cells, to diagnosis and/or characterize a plasma cell disorder.

The present invention relates to a hygiene nudging system for improving the overall cleanliness of a room or an area having one or more predetermined surfaces, comprising a dispenser unit configured to dispense cleaning wipes for cleaning the one or more surfaces, a control unit connected with the dispenser unit, wherein the system comprises a nudging unit connected with the control unit, the control unit being configured to control the nudging unit, the nudging unit is configured to issue an indication when activated by the control unit, and a first sensor is connected with the dispenser unit and the control unit, the first sensor being configured to detect dispensing from the dispenser unit and to signal the detection of dispensing to the control unit, whereby the control unit deactivates the nudging unit. The present invention also relates to a facility comprising one or more hygiene nudging systems according to the present invention. Further, the present invention relates to a monitoring and nudging system, to a method for improving an overall cleanliness of a room or an area and to use of the hygiene nudging system according to the present invention.