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38results about How to "Maintain physical integrity" patented technology

Gastric retention controlled drug delivery system

The present invention provides a gastric retention controlled drug delivery system comprising: (a) a controlled release core comprising a drug, a highly swellable polymer and a gas generating agent, said core being capable of swelling and achieving floatation rapidly while maintaining its physical integrity in gastrointestinal fluids for prolonged periods, and (b) a rapidly releasing coat composition comprising the same drug as in the core and pharmaceutically acceptable excipients, wherein the coating composition surrounds the core such that the system provides a biphasic release of the drug in gastrointestinal fluids.
Owner:SUN PHARMA INDS

Orally administered drug delivery system providing temporal and spatial control

A pharmaceutical composition in the form of tablets or capsules provides a combination of temporal and spatial control of drug delivery to a patient for effective therapeutic results. The pharmaceutical composition comprises a drug, a gas generating component, a swelling agent, a viscolyzing agent, and optionally a gel forming polymer. The swelling agent belongs to a class of compounds known as superdisintegrants (e.g., cross-linked polyvinylpyrrolidone or sodium carboxymethylcellulose). The viscolyzing agent initially and the gel forming polymer thereafter form a hydrated gel matrix which entraps the gas, causing the tablet or capsule to be retained in the stomach or upper part of the small intestine (spatial control). At the same time, the hydrated gel matrix creates a tortuous diffusion path for the drug resulting in sustained release of the drug (temporal control). A preferred once daily ciprofloxacin formulation comprises 69.9% profloxacin base, 0.34% sodium alginate, 1.103% xanthan gum, 13.7% sodium bicarbonate, 12.1% cross-linked polyvinylpyrrolidone, and optionally other pharmaceutical xcipients, the formulation being in the form of a coated or uncoated tablet or capsule.
Owner:RANBAXY LAB LTD

Fire extinguishing ball

InactiveCN1713935APrevent suitable external forceExtended shelf lifeFire rescueInternal cavityEngineering
A fire extinguishing device of the explosive type is disclosed for use against conflagrations, wherein the force of detonation of the device is minimized through the use of low density / low mass components; no part of the device having sufficient mass or density to constitute a ballistic hazard, nor be hazardous in concussive shock due to the explosive burst. The present invention is composed of a lightweight casing (3) of frangible material, with a protective exterior sheathing (7). Within the internal cavity of the device, a pyrotechnic detonator (5) is located at or near the center of mass, and is actuated by fuse cord(s) (6) extending from the detonator, the end(s) of which extend(s) from the interior detonator to mounting on the exterior surface. The device is chargeable with a variety of fire-retardant chemical agents (8), including dry powders, two-part reactants, liquid components or others, singly or in combination.
Owner:法纳瓦南凯玛特

Method for drying traditional Chinese medicine materials in mixing mode through microwave vacuum and hot air

A method for drying traditional Chinese medicine materials in mixing mode through microwave vacuum and hot air comprises placing the traditional Chinese medicine materials in a microwave vacuum drying stove, drying the traditional Chinese medicine materials for 3 to 5 minutes under the condition that the vacuum ranges from 0.07Mpa to 0.09Mpa and the unit microwave power ranges from 3W to 5W, delivering the traditional Chinese medicine materials into a hot air dryer, drying the traditional Chinese medicine materials for 1 to 3 hours under the temperature ranging from 70 DEG C to 90 DEG C, and finally delivering the traditional Chinese medicine materials to the microwave vacuum drying stove again for drying under the condition of the first step till the end. The method adopts mixing of the microwave vacuum drying and the hot air drying, enables the internal structure of the traditional Chinese medicine materials to achieve the effect of swelling, loosening and cracking, improves exudation ratio of decoction of liquid medicine and shortens decoction time without damaging contents of the traditional Chinese medicine materials. Further the method can keep intrinsic body integrity of the traditional Chinese medicine materials, reduces contractibility rate of the traditional Chinese medicine materials, accelerates rehydration of the traditional Chinese medicine materials, improves product quality and reduces energy consumption.
Owner:HENAN UNIV OF SCI & TECH

Cleaning compositions

Improved treatment blocks useful in the treatment of lavatory appliances, particularly toilets are provided. The improved treatment blocks are solid block compositions which comprise at least one detersive surfactant, a hydrocarbon solvent constituent, and one or more further optional constituents, including bleach constituents. The improved treatment blocks provide improved processing and handling characteristics. Methods of producing the solid block composition and treatment blocks therefrom, as well as methods of use are also disclosed.
Owner:RECKITT BENCKISER (UK) LTD
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