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71 results about "Physical integrity" patented technology

Abuse-deterrent pharmaceutical compositions of opioids and other drugs

An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, a drug is modified to increase its lipophilicity. In preferred embodiments the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and preferably organic solvent insoluble, but enzymatically degradable by enzymes present in the human gastrointestinal tract. The abuse-deterrent composition retards the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion.
Owner:COLLEGIUM PHARMA INC

Inventory control and prescription dispensing system

An inventory control and prescription management and dispensing system including a dispensing vault for storing and dispensing prescriptions, the dispensing vault in communication with a central computer system that, in turn, communicates with prescription providers, insurance companies, and other third parties; the dispensing vault including robotic means for randomly accessing pre-filled prescriptions within the vault, with the vault further including RFID, bar code, and other means for verifying the content and internal location of pre-filled prescriptions; a customer interface that uses customer biometrics to ID a customer to ensure that prescriptions are only dispensed to the correct person; a patient registration system in communication with the central computer system for collecting insurance, doctor, biometric, and other information to facilitate transactions; a labeling system for labeling pre-filled prescriptions with customer specific information upon dispensing; transport container that integrate into the dispensing vault and provide secure transportation from a pharmaceutical manufacturer or repackager to the dispensing vault, security provided through RFID tags which communicate with the central computer to verify that the transport container contains the correct formulary and that the integrity of the container (temperature range, time in transit, tampering) has not been compromised; a payment system integral to the dispensing vault that is in communication with third party banks and pharmacy billing management systems, credit agencies and the central computer; a verification system for ensuring that pre-filled bottles received from the manufacturer (before they are placed into the storage locations inside the vault) have not had their integrity compromised, with this system evaluating each container's weight, size, moisture content, shape, velocity change, color, pattern, and physical integrity (all comparisons made against standards stored in the central computer).
Owner:DRAPER LONNIE

Abuse-deterrent drug formulations

An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, the drug is modified to increase its lipophilicity by forming a salt between the drug and one or more fatty acids wherein the concentration of the one or more fatty acids is one to 15 times the molar amount of the active agent, preferably two to ten times the molar amount of the active agent. In one embodiment the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and preferably organic solvent insoluble. The abuse-deterrent composition prevents the immediate release of a substantial portion of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion.
Owner:COLLEGIUM PHARMA INC

Abuse-deterrent drug formulations

An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opiods. In the preferred embodiment, the drug is modified to increase its lipophilicity by forming a salt between the drug and one or more fatty acids wherein the concentration of the one or more fatty acids is one to 15 times the molar amount of the active agent, preferably two to ten times the molar amount of the active agent. In one embodiment the modified drug is homogeneously dispersed within microparticles composed of a material that is either slowly soluble or not soluble in water. In some embodiments the drug containing microparticles or drug particles are coated with one or more coating layers, where at least one coating is water insoluble and preferably organic solvent insoluble. The abuse-deterrent composition prevents the immediate release of a substantial portion of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is broken down or dissolved gradually within the GI tract by a combination of enzymatic degradation, surfactant action of bile acids, and mechanical erosion.
Owner:COLLEGIUM PHARMA INC

Wound care device having fluid transfer and adhesive properties

This disclosure relates to a wound care device which contains capillary force one-way pumps that are capable of transporting fluid, such as wound exudate, away from a wound site to the opposite side of the wound care device, which functions as a segregated fluid reservoir. This fluid transport mechanism generally aids in reducing wound maceration by removing excess wound fluid and the protease enzymes and infectious bacteria contained within the wound fluid. The wound care device performs this function, often times for multiple days, without the loss of the physical integrity of the wound care device. In addition to providing a uni-directional fluid transport mechanism, the wound care device contains a perforated adhesive layer.
Owner:MILLIKEN & CO

Fluidizing gravity conveyor with high temperature multi-layered fluid distributor member

An apparatus for conveying fluidized high temperature finely divided dry material by gravity utilizes a multi-layered, gas permeable gas distributor member comprising (i) an upper layer a flat, rigid gas permeable, porous medium capable of withstanding temperatures up to about 2900° F. through which gas to fluidize the material will pass; (ii) a middle layer comprised of a gas permeable insulation material that maintains its physical integrity when exposed to temperature differentials ranging from about 500° F. to about 2900° F.; and (iii) a lower layer that supports the top and middle layers comprising a substantially flat plate having a plurality of openings therethrough through which fluidizing gas can pass.
Owner:FLSMIDTH AS

Chip physical integrity detecting device

ActiveCN103440452AReduce areaExtending the Coverage of Detectable VandalismPlatform integrity maintainanceActive detectionMode selection
The invention discloses a chip physical integrity detecting device and belongs to the field of chip physical integrity detection. The chip physical integrity detecting device comprises a controller, a transmitter, a metal detection net and a detector, wherein the controller is used for selecting detection modes and emitting mode selection signals according to the working state of a chip to be detected, the controller is also used for judging whether the chip to be detected is abnormal according to potential information fed back by the detector, the transmitter is used for transmitting signals to the metal detection net according to the mode selection signals, and the detector is used for detecting potential information of a signal end of the metal detection net connected with the detector according to the mode selection signals and sending the detected potential information to the controller. According to the chip physical integrity detecting device, due to the fact that work in carried out by means of switching between two detection modes, the detachable destroy behavior coverage can be enlarged; compared with a device only using an active detection mode always, the chip physical integrity detecting device has the advantage of being capable of reducing power consumption remarkably.
Owner:DATANG MICROELECTRONICS TECH CO LTD
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