The invention provides a self-crosslinking water-borne wood paint emulsion and a synthetic method thereof, relating to the technical field of coatings. The self-crosslinking water-borne wood paint emulsion contains the following raw materials in percentage by weight: 25%-60% of an acrylic emulsion, 2%-6% of isophorone diisocyanate, 2%-7% of glyceryl triacetate, 10%-45% of acrylic monomers, 20%-50%of a waterborne polyurethane resin emulsion, 0.2%-2% of an emulsifying agent, 3%-6% of nano-crystalline cellulose, 0.2%-1.5% of a defoaming agent and the balance of deionized water. By taking the self-crosslinking acrylic emulsion as a main raw material and utilizing the self-crosslinking acrylic monomers, isophorone diisocyanate, the waterborne polyurethane resin emulsion, glyceryl triacetate and nano-crystalline cellulose and other raw materials, the prepared self-crosslinking water-borne wood paint emulsion has relatively high crosslinking density, the hardness, boiling water resistance, solvent resistance, light remaining property, color remaining property and impact resistance of a coating film are relatively excellent, and the content of volatile organic compounds is low, so that the environmental pollution is avoided, and the human healthy is guaranteed.