66results about How to "Increase risk" patented technology

Systems and methods permit the efficient and accurate aggregation and analysis of loan application data as well as the convenient display of the loan application data to a financial service provider. In one embodiment, a computing device associated with a financial service provider receives a loan application containing loan application data. The computing device performs a compliance and underwriting analysis and a verification analysis to validate inputs, authenticate customer identity, ensure compliance with regulatory requirements, and evaluate the risk posed by a loan application, among other features. If the verification analysis indicates that supplemental loan application data is required, the provider computing device generates an application status message identifying the required supplemental data. Following the compliance and underwriting analysis and the verification analysis, the provider computing device creates an electronic credit authorization document and generates an application decision message indicating approval or disapproval of the loan application.

The invention provides methods for predicting an increased risk or probability of developing endometriosis in a patient based upon the patient's KRAS variant status.

The invention comprises an elongated device adapted for insertion, including self-insertion, through the body, especially the skull. The device has at least one effector or sensor and is configured to permit implantation of multiple functional components through a single entry site into the skull by directing the components at different angles. The device may be used to provide electrical, magnetic, and other stimulation therapy to a patient's brain. The lengths of the effectors, sensors, and other components may completely traverse skull thickness (at a diagonal angle) to barely protrude through to the brain's cortex. The components may directly contact the brain's cortex, but from there their signals can be directed to targets deeper within the brain. Effector lengths are directly proportional to their battery size and ability to store charge. Therefore, longer angled electrode effectors not limited by skull thickness permit longer-lasting batteries which expand treatment options.

There is provided a portable electronic device limiting an allowable operating range thereof for security reason and a security system using the portable electronic device. A security system 10 includes a mobile-phone 100 and an item 101. The mobile-phone 100 has functions of a registering unit 501, a judging unit 503 and an operating range determining unit 504, etc. The registering unit 501 registers item information to specify the item in advance. The judging unit 503 judges, based on the presence or absence of a signal from the item, whether an item specified by the registered item information can communicate with the mobile-phone or not when an event is generated in the mobile-phone. When it is judged that the communication is possible, the operating range determining unit 504 allows a normal operation of the mobile-phone in response to an external access, and when it is judged that the communication is impossible, the operating range determining unit 504 limits the operating range of the portable electronic device in response to an external access.

The current invention concerns a method for detecting cancerous cells and / or classifying cells in a cell sample comprising the following steps: providing a cell sample; obtaining holographic information from said cell sample by digital holographic microscopy (DHM); deriving at least one cellular parameter from said holographic information, and; classifying said cells of cells sample; characterized in that said classification occurs by appointing a Scoring Factor to said cells of cell sample, based on said cellular parameters. In a second aspect, a system for the detection of cancerous cells and / or classification of cells in a cell sample is provided, employing the method as disclosed in the invention. In a final aspect, a method for updating and / or improving a database comprising thresholds linked to holographic information and the database related thereof is equally disclosed.

Implantable closure apparatus and methods for sealing or closing openings at internal body locations. The apparatus and methods may involve the delivery and attachment of a patch, patch and plug, or plug only to seal or close the opening. The closure apparatus and methods may be used to close a patent foramen ovale (PFO).

The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according to the present invention comprises at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement. The wound dressing according to the present invention provide a continuous, non-invasive and objective solution for monitoring chronic wound healing without disturbing the delicate healing process.

The present invention comprises methods and compositions for improving profiles of lipid proteins, reducing low-density lipoprotein levels, increasing high-density lipoprotein levels, decreasing the absorption of fatty acids across the intestinal epithelium and inhibiting HMG-CoA Reductase in living organisms utilizing Morinda citrifolia L activity in mammals, including humans.

Using the methods of the present invention, intermediate (int) levels of aldehyde dehydrogenase (ALDH) activity reliably distinguished leukemic CD34+CD38− cells capable of engrafting immunodeficient mice, from residual normal hematopoietic stem cells that exhibited relatively higher ALDH activity. Minimal residual disease (MRD) detected during complete remission was enriched for the CD34+CD38−ALDHint leukemic cells, and the presence of these cells after therapy highly correlated with subsequent clinical relapse. The methods of the present invention can distinguish normal from leukemic CD34+CD38− cells, and identifies those AML cells associated with relapse. Methods of prediction of relapse of AML patients and methods of treatment are also provided.

Disclosed embodiments provide for treatment of the anulus fibrosus (AF) and intevertebral disc (IVD), including herniated discs, anular tears of the disc, or disc degeneration, while enabling surgeons to contain blood, fluid, proteins, or other materials that are placed into or migrate into or near defective regions of the spine. The invention also concentrates mesenchymal stem cells (MSCs) in the surgical area and increases the area of bone to be fused. Other aspects of the invention may be used to raise the temperature of tissues, including surgical tissues, to stimulate inflammation, thereby stimulating tissue healing. According to these embodiments, the invention places a heating element below the skin and adjacent to the tissue to stimulate the healing thereof.

The present invention provides methods for the prediction and diagnosis of autoimmune diseases, including Systemic Lupus Erythematosus, using single nucleotide polymorphism in TNFAIP3 (A20).

A process, system and financial engine which determine a portfolio's sensitivity to market risk based on market conditions are described. In particular, with these process, system and financial engine, first data representative of time horizon information and second data representative of risk tolerance information are first received, and guidelines data based on the first and second data are established. Economic and market data underlying the quantitative indicators and factors determining the qualitative indicators are received. Market risk signals based on the indicator(s) is then established. The portfolio's sensitivity is determined based on the established guidelines data and the market risk signal. Using these process, system and financial engine, it is possible to determine the current market risk level, and then recommend changes to (or adjust) the user's portfolio market risk sensitivities based on the user's time horizon (i.e., the need to access their assets within a particular time) and the determined market risk level.

A ground source heat transfer system circulates transfer fluid between heat exchange units and a ground loop. The system includes a bypass which allows the transfer fluid to continue to circulate past the exchange units while bypassing the ground loop. Monitoring the conditions of the system with temperature sensors allows the system to selectively activate the bypass whenever diverting fluid away from the ground loop can save heat or energy.

Described are optical sensing systems. The systems may perform reliably in explosive environments and provide eye protection should breakage of an optical fiber be detected. Sensors of the systems additionally may be self-managing, acquiring and transmitting sensed data as available electrical power permits.

A method, program product and implementing computer system are provided in which one or more a vehicle mounted cameras provide a video feed of the areas surrounding a camera-equipped (CE) vehicle to an on-board computer system for analysis and processing. The computer system determines which if any nearby vehicles pose an increased risk to the driver of the camera-equipped vehicle by analyzing image information obtained by the CE vehicle to determine unsafe driving patterns and / or an unsafe rate of closure of the nearby vehicle relative to said CE vehicle. The CE vehicle is also operable for accessing vehicle information contained in remote computer databases using a detected license plate number of nearby vehicles and informs the driver if the database record of the nearby vehicle indicates a possible current threat to the camera-equipped vehicle. CE vehicle performance data may also be acquired at times when CE vehicle images are taken, and such data may be associated with corresponding images and sent along with the images to be saved at remote computer systems for current and / or subsequent access and analysis.

Various radiation-attenuating agents can be administered within a patient body cavity in combination with therapeutic irradiation of the patient body cavity, such as during radiographic diagnostic imaging procedures, to attenuate the radiation incident on certain portions of the patient body cavity believed to be susceptible to harm from the incident radiation. A variety of methods are provided, including methods for detecting clinical conditions such as pulmonary embolus in a pregnant woman while mitigating uterine radiation exposure.

Compositions and methods for improving the pharmacokinetics and reducing the risk of adverse events resulting from biguanide compound administration are provided, comprising administering delayed release formulations of such compounds having a lag phase release.

A float bath and a float-forming method is provided, which can form a glass having high forming temperature without shortening the lifetime of straps for supplying electricity to heaters. A float bath 10 has a bottom 12 filled with molten tin 11, and a roof 14 for covering the bottom 12. A space in the roof 14 is separated into an upper space 20 and a lower space 21 by a roof brick layer 16, and heaters 18 are disposed through holes 17 formed in the roof brick layer 16. The thickness of the roof brick layer 16 is at least 320 mm.

Described herein are systems and methods for extracting image features from magnetic resonance imaging scans. These methods and systems are useful for both determining cancer lesion severity and disease prognosis. In particular, methods and systems are provided herein for extracting and analyzing imaging features that are correlated with breast cancer subtype and prognosis.

The invention discloses a double-column top coal caving hydraulic support having a large mining height and provided with top coal recovery devices, and the largest height is larger than 6 m. The top coal recovery devices are divided into three stages: the first stage adopts a swing type tail beam, vertical swing of the swing type tail beam is controlled by two tail beam jacks hinged with a shield beam, and opening and closing of a coal discharge port are realized; the second stage adopts a retractable type coal discharge beam device, the retractable type coal discharge beam device is controlled by a plugboard jack to stretch and retract in the first-stage swing type tail beam, coal breaking teeth in a rectangular pyramid or cone shape are arranged at the upper part of the end of the second-stage coal discharge beam, and coal discharge and breaking functions are realized; the third stage adopts a hinged type coal discharge and return plate beam, the hinged type coal discharge and return plate beam is hinged to the lower part of the end of the second-stage retractable type coal discharge beam, can move with the stretching and retracting of the second-stage coal discharge beam and can be controlled by a coal return jack to retract, and coal breaking and loading functions are realized. The double-column top coal caving hydraulic support is applied to full-mechanized caving mining of hard coal resources with the thickness larger than 8 m, and the problems about top coal caving and recovery are solved obviously.

The invention provides a method for identifying whether a pregnant subject has an increased risk of preterm labour comprising measuring the progesterone concentration in a sample obtained from the subject, wherein a reduced progesterone concentration is indicative of an increased risk of preterm labour and delivery.

The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection.

In an aspect, the invention provides methods and uses of PCAT18 for diagnosing, prognosing, and treatment monitoring of prostate cancer (PCa) in a subject. In another aspect, methods of treating PCa in a subject by administering an inhibiting agent of PCAT18 are provided. Uses of PCAT18 in treating PCa in a subject, and pharmaceutical compositions comprising a therapeutic agent effective to reduce the amount of PCAT18 in cancerous prostate cells and a pharmaceutically acceptable carrier, are also provided. The transcript of PCAT18 is a long non-coding RNA (lncRNA), whose expression is significantly altered in biological samples obtained from subjects with PCa or at risk of developing PCa compared to normal individuals. Expression of PCAT18 is specific to prostate tissue and is elevated in both cancerous prostate tissue and blood plasma of subjects with PCa relative to subjects without PCa or patients with other forms of cancer.

The invention relates methods of reducing the risk or preventing the occurrence of an adverse event (AE) or a serious adverse event (SAE) associated with a medical treatment comprising inhalation of nitric oxide.

This invention concerns a method for the assessment of bone fragility and fracture risk, or osteoporosis, in a person. In said method, the concentration of gamma-carboxylated osteocalcin (COC) and optionally also the concentration of intact or total osteocalcin (IOC or TOC, respectively) in a body fluid sample of said person is measured. The concentration of gamma-carboxylated osteocalcin (COC) so obtained is compared to the mean concentration of gamma-carboxylated osteocalcin (mean COC) in similar body fluid samples of the population of the same age and sex. Alternatively, the determined ratio COC / IOC or COC / TOC for said person, is compared to the mean ratio COC / IOC or COC / TOC, (mean ratio COC / IOC or mean ratio COC / TOC) determined from measurements in similar body fluid samples of the population of the same age and sex. A measured COC that is lower than the mean COC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. Preferably, a determined ratio COC / TOC that is lower than the mean ratio COC / TOC is used as indication of osteoporosis, bone fragility or increased risk of bone fracture in said person. The invention concerns further kits for use in the assessment according to this invention.

The present invention provides gene expression profiles indicative of whether a patient afflicted with PR driven malignancies is likely to be responsive to treatment with a therapeutic compound that is an anti-progestin. By identifying such responsiveness, a treatment provider may determine in advance those patients who would benefit from such treatment, as well as identify alternative therapies for non-responders. Also, provided are methods of using gene expression profiles and assays for identifying the presence of a gene expression profile in a patient.

Among the various aspects of the present disclosure is the provision of a method of detecting ceramides as prognostic indicators. An aspect of the present disclosure provides for a prognostic indicator for risk of developing a cardiovascular-related disease, disorder, or condition and mortality risk.

A library of a DFM-improved standard logic cells that avoid pattern-degrading configurations in the M0 layer is disclosed, along with wafers, chips and systems constructed from such cells.

The present disclosure provides methods involving use of BIN1 protein levels in biological fluid of a subject in evaluating cardiac health of the subject. The method provided herein may be used to predict a risk of a poor outcome in a subject. The methods also find use in evaluating subjects for assessing patients diagnosed with heart failure. These methods are also useful in assessing therapy options and efficacy of treatment in heart failure patients.