42results about How to "Formation" patented technology

The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound [18F]florbetaben or [18F]AV-45 having <Chemistry Formula 11> and <Chemistry Formula 12>, respectively, by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

The present invention relates to methods and systems for the detection of specific sequences of nucleic acids or oligonucleotides. It relates more particularly to a conjugated enzyme based assay system utilizing reflective and / or transmissive optical bio-discs for detection of specific sequences of nucleic acids. In the assay according to the present invention, an enzyme reaction is used to detect the presence of an analyte (DNA or RNA) in a microchannel in an optical bio-disc. The analyte is immobilized by hybridization with a specific capture probe on a capture layer on the surface and the signal that is generated is localized and specific. The signal can be in the form of a pellet, a fluorescent product, and / or a colored product, and can be detected and quantified by an optical bio-disc reader utilized in conjunction with the inventions hereof. This assay is thus quantitative in nature.

In accordance with the present invention, there is provided a method for manufacturing a semiconductor package. The method comprises the initial step of applying first and second photoresist layers to respective ones of opposed first and second surfaces of a metal plate which includes a die paddle and a plurality of leads extending at least partially about the die paddle in spaced relation thereto. The first and second photoresist layers are then patterned to expose the die paddle and prescribed portions of each of the leads. Thereafter, first and second conductive layers are applied to portions of respective ones of the first and second surfaces which are not covered by the first and second photoresist layers. The first and second photoresist layers are then removed to facilitate the creation of an exposed area in each of leads which is not covered by the first and second conductive layers. Next, a semiconductor die is attached to a portion of the first conductive layer covering the die paddle and electrically connected to portions of the first conductive layer covering the leads. The semiconductor die, the die paddle, the leads and the first and second conductive layers are then encapsulated with a package body such that portions of the second conductive layer covering the die paddle and the leads, and the exposed area of each of the leads are exposed in a common surface of the package body. Finally, the exposed area of each of the leads is etched to facilitate the division of the leads into an inner set extending at least partially about the die paddle and an outer set extending at least partially about the inner set.

An interior permanent magnet rotary motor of the present invention has N slots and P permanent magnet magnetic pole sections, (⅔<=P / N<= 43 / 45). Po is an irreducible fraction Po / No of the P / N is an odd number, and a pole arc ratio ψp equals θpp / θp. θpp is an angle between two line segments assumed for a pair of flux barriers, each of which connects the center of a rotor core and one of corners of the section of each flux barrier that is closest to the surface of the rotor core. θp is an angle obtained by dividing 360° by the number of the permanent magnet pole sections. The pole arc ratio indicated by Ψp (0<4n<1) is determined by the expression of Ψp=2mP / N+P / 4LCM (P, N)−2n, where LCM (P, N) is the least common multiple between P and N, m and n are arbitrary natural numbers.

The present invention relates to the production of proteins in a cell or host cell. The invention uses a TRAnscription Pause (TRAP) sequence to enhance a protein expression characteristic of a protein expression unit. The TRAP sequence is thought to prevent, at least in part, formation of antisense RNA or to, at least in part, prevent transcription to enter the protein expression unit. In one embodiment, the invention provides a method for expression of at least one protein of interest in a cell comprising providing the cell with at least one protein expression unit that comprises a promoter functionally linked to an open reading frame encoding at least one protein of interest, characterized in that the protein expression unit further comprises at least one TRAP sequence and wherein the TRAP sequence is functionally located downstream of the open reading frame and at least in part prevents formation of antisense RNA. In another embodiment, the TRAP sequence is functionally located upstream of the promoter and at least in part prevents transcription to enter the expression unit. Preferably, the expression protein unit further comprises at least one STabilizing Anti-Repressor sequence.

The present invention relates to a drill comprising a cemented carbide or high speed steel substrate and a coating wherein the coating comprises: a first layer system having a multilayered structure covering substantially the whole active part of the drill, a second layer system having a multilayered structure covering only the tip area of the drill.Drills according to the present invention have good wear resistance and improved properties when reconditioning the drill.The present invention also relates to a method of making a drill according to the present invention.

A method for production of artificial skin by administering matrix metalloproteinase inhibitor or matrix metalloproteinase inhibitor and matrix protein production promoting agent. The matrix metalloproteinase inhibitor is N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride.

The present invention relates to the production of proteins in a cell or host cell. The invention uses a TRAnscription Pause (TRAP) sequence to enhance a protein expression characteristic of a protein expression unit. The TRAP sequence is thought to prevent, at least in part, formation of antisense RNA or to, at least in part, prevent transcription to enter the protein expression unit. In one embodiment, the invention provides a method for expression of at least one protein of interest in a cell comprising providing the cell with at least one protein expression unit that comprises a promoter functionally linked to an open reading frame encoding at least one protein of interest, characterized in that the protein expression unit further comprises at least one TRAP sequence and wherein the TRAP sequence is functionally located downstream of the open reading frame and at least in part prevents formation of antisense RNA. In another embodiment, the TRAP sequence is functionally located upstream of the promoter and at least in part prevents transcription to enter the expression unit. Preferably, the expression protein unit further comprises at least one STabilizing Anti-Repressor sequence.

A process for preparing an emulsion or a dispersion comprising crystalline particles of at least one active principal that comprises contacting a solution of at least one solute in a solvent or mixture of solvents in a first flowing stream with a non-solvent in a second flowing stream wherein the non-solvent and solvent are not miscible with each other, so as to form an emulsion or a dispersion. Super saturation is brought about by suitable means, and the emulsion or dispersion is subjected to ultrasonic irradiation to mediate crystal nucleation.

A hybrid supercapacitor, including at least one negative electrode that includes a statically capacitive active material, an electrochemical redox active material, or a mixture thereof, at least one positive electrode that includes a statically capacitive active material, an electrochemical redox active material, or a mixture thereof, at least one separator that is situated between the at least one negative electrode and the at least one positive electrode, and an electrolyte composition, with the condition that at least one electrode includes a statically capacitive active material, and at least one electrode includes an electrochemical redox active material, the electrolyte composition being a liquid electrolyte composition and including at least one liquid, aprotic, organic solvent, at least one conducting salt, and at least one additive.

A method for production of artificial skin by administering matrix metalloproteinase inhibitor or matrix metalloproteinase inhibitor and matrix protein production promoting agent. The matrix metalloproteinase inhibitor is N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride.

A structure and method of producing a semiconductor structure including a semi-insulating semiconductor layer, a plurality of isolated devices formed over the semi-insulating semiconductor layer, and a metal-semiconductor alloy region formed in the semi-insulating semiconductor layer, where the metal-semiconductor alloy region electrically connects two or more of the isolated devices.