The invention discloses a GSM (Global System for Mobile Communications) based intelligent safe protection system. The GSM based intelligent safe protection system comprises a detector module, a safe protection host, an intelligent phone, a remote control module and an appliance control device; the safe protection host comprises an MCU (Microprogrammed Control Unit) main control module, a power supply module, a display module, an acousto-optic alarm, a GSM communication module and a wireless transmit-receive module A; the MCU main control module is in signal connection with the detector module through a 485 repeater; the appliance control device comprises a main control CPU (Central Processing Unit), a wireless transmit-receive module B and a repeater driving module. The GSM based intelligent safe protection system has the advantages of expanding the safe protection range and not losing the safe protection effect when being used due to a 485 bus and in combination of the repeater, achieving voice protection, short message protection, remote control protection and the like, being complete in function, good in protection effect and particularly applicable to areas such as residential areas, office buildings and rural areas, enabling one safe protection host to manage a district of communities, achieving information real-time transmission between the detector module, the appliance control device, the safe protection host and the client intelligent phone and achieving real-time control.