30results about How to "Capable of large-scale production" patented technology

The method for extracting and refining aloe polysaccharide includes the following steps: uctting fresh leaf of aloe into small block, extracting with water at 40-80 deg.C, filtering extract, centrifugation and taking out supernatant fluid, adding 95% ethyl alcohol in the supernatant fluid, making the ethyl alcohol content be up to 50-80%, precipitating crude aloe polysaccharide, dissolving said crude aloe polysaccharide in water, adding 20-50% trichloroacetic acid or trifluoroacetic acid to make end concentration of trichloroacetic acid or trifluoroacetic acid be up to 2-6%, standing still, then centrifugation to remove precipitate to obtain secondary supernatant fluid, feeding it into macroporous resin column bed and using water to make elution, concentrating and adding 95% ethyl alcohol, precipitating polysaccharide, freeze-drying so as to obtain refined aloe polysaccharide.

The invention relates to a synthesizing method, partial intermediate products and final products of a chiral beta-alkamine derivative. The synthesizing method of the chiral beta-alkamine derivative is characterized by comprising the steps of: selecting commercialized materials in the market and NH2R2 as initial materials, wherein R2 is a Cl-C6 alkyl group, a C3-C6 naphthenic base and an aryl group or an aryloxy; obtaining the intermediate products and the final products through a chemical reaction process with moderate conditions, wherein R1 and R2 are the Cl-C6 alkyl group, the C3-C6 naphthenic base and the aryl group or the aryloxy, and a chiral center is in an S or R shape. The invention has the advantages that the adopted materials are easy to obtain and at low price and can meet the requirements of large-scale production, chiral compounds are used as the initial materials, optical purity is retained in consequent reaction without finding racemization, and committed steps accord with the requirements of the current green chemistry; in addition, the invention has the advantages of simple synthesizing method, good selectivity, high yield coefficient, easy operation and good market benefits.

The invention discloses a method for synthetizing chiral cyclic alkyl amino acid by amino transferase. The commercialized material ketonic acid or corresponding soluble ketonic acid salt compound in the market is selected as an initial material; the initial material is dissolved into phosphate buffer, and added to an amino supply body; pyridoxal phosphate (PLP) and amino transferase main enzyme are added to a system containing the amino supply body and main material ketonic acid or corresponding soluble ketonic acid salt compound to react under constant temperature, and obtaining a product with a high ee value, wherein n is equal to 1, 2, 3, 4, 5, or obtaining a product wherein n is equal to 0 and 1. The method is stable in technological condition, simple to operate, high in yield, low in cost, and suitable for large-scale production, and beneficial for environmental protection; and a novel train of thought and a method are provided for the preparation of chiral cyclic alkyl amino acid compound.

The invention provides a synthesis method of beta-amino acid derivative, and relative intermediate product, in particular to a synthesis method of formula (I) and relative intermediate product. The invention is characterized in that the invention uses commercialized material as formula (II) (trans-, E-type) as initial material, to obtain final product which formula is (III) via chemical reaction with mild condition. The invention has easily accessible starting material, stable technological condition and support for scaled industrial production.

The invention relates to a synthesis method of a derivative of chiral Beta-amino-alcohol and part of intermediate products and final products thereof. The method selects a raw material which is commercialized on a market or a raw material of Alpha-halogeno ketone with easy preparation as an initial raw material, wherein X is Br or Cl, the final product with the chemical formula as the accompanying drawing is obtained by reaction or wherein R1=H, 2-Cl, 3-Cl, 4-Cl, 2, 4-Cl, 4-Br, 4-F, 4-CF3 and 4-NO2; R2=H, 2-OMe, 3-OMe, 4-OMe, 4-F, 4-Cl, 4-Br, 3-Br, 3-F, 3-Cl, 2-Br, 2-Cl, 2F, 4-Me, 3-Me and 2-Me, and the chiral center is S or R; the intermediate product with the chemical formula is shown in the accompanying drawing and the chiral center is in S configuration or R configuration; and the final product with the chemical formula is shown in the accompanying drawing and the chiral center is in S configuration or R configuration.

The invention provides a method for preparing 5-methylprazine-2-carboxylic acid. The preparation method comprises the steps: using 5-methyl-2and3- pyrazine 2-carboxylic acid as raw material, carrying out photophobism reaction in a saturated saline solution, and obtaining 5-methylprazine-2-carboxylic acid as a final product. The preparation method optimizes the process from the source on the basis of the principle of water decarboxylation, thereby being a method for effective decarboxylation in a saline solution at lower temperature. Moreover, in the preparation method, no organic solvent is added in the chemical reaction, no pollution is generated, the condition is mild, the reaction in the whole technological process has no high temperature, high selectivity and few by-products, thus the preparation method is a simple and available pollution-free method which has the capability of large-scale production.

The present invention relates to a method to produce biodegradable polyester, which comprises the following steps: (a) mixing a carbon source, a nitrogen source and water into a reactive material to perform pretreatment; (b) providing a halophilic bacterium, a starting broth and culture with the reactive material; (c) feeding the reactive material; and (d) extracting the polyester from the fermentation broth; wherein, the bacterium has a salt tolerance of 10-30%.

The invention relates to the technical field of resin synthesis and application thereof, and particularly discloses silane modified acrylic resin, a synthesis method and a primer for silicone rubber. The primer for the silicon rubber is prepared by dispersing the silane modified acrylic resin and the silane coupling agent titanate into a solvent for the primer and reacting through a catalyst. The silane modified acrylic resin provided by the invention can be used for preparing a primer for silicone rubber, and has the advantages of good adhesion, film-forming property, heat resistance, water resistance, low surface drying temperature, short time and the like; the invention relates to silane modified acrylic resin, which is prepared by dispersing (methyl) acrylic acid alkyl ester monomers, hydroxyl ester monomers, epoxy group monomers, vinyl siloxane monomers and assistant crosslinking monomers in a solvent for resin and carrying out free radical polymerization under the catalysis of an initiator, the silane modified acrylic resin obtained by the invention has excellent cohesion performance and film-forming performance, and is suitable for preparing a silicone rubber prime coat adhesive.

The invention relates to a method for preparing fluorine-containing substituted phenyl ketone. Commercial raw materials or easily prepared fluoro bromobenzene is selected as an initial raw material and is converted into a Grignard reagent, and the Grignard reagent is reacted with anhydride under the catalysis of a metal catalyst and Lewis acid to form the fluorine-containing substituted phenyl ketone, wherein R refers to -CH2CnH(2n+1) (n is equal to 0, 1, 2, 3, 4 and 5), fluorine is at an ortho-position, a meta-position, a para-position, 2 and 4 positions, 2 and 3 positions and 3 and 5 positions. By the method, the raw materials are readily available, the purity and yield are high in reaction, process conditions are stable, the operation is simple, the pollution is light, the method has been used for large-scale production, and the invention provides a new idea and method for preparing the fluorine-containing substituted phenyl ketone.

The invention relates to a method for synthesizing the derivatives of chiral pyridyl aminoalcohols, and intermediate products and final products of the same. Initial materials are selected from commercial raw materials on the market or easy-to-prepare raw materials of halogenated pyridine alkyl ketone or aromatic ring ketones, wherein X is F or Cl, R1 is C1 to C8 alkyls or C3 to C8 cycloalkyls; and final products are obtained through a process of chemical reactions under mild conditions, wherein R1 is C1 to C8 alkyls or C3 to C8 naphthene base, R2 is H or C1 to C8 alkyls, or C3 to C8 cycloalkyls or C7 to C9 benzyls, and chiral centers of alcohols have an S or R structure. The method provides a new thought and means for preparing the derivatives of chiral pyridyl aminoalcohols; the intermediate products are that the chiral centers of alcohols have an S or R structure; and the final products are that the chiral centers of alcohols have an S or R structure.

The invention discloses a device and method for large-scale continuous preparation of metal nanoparticles, and belongs to the technical field of preparation of metal nanoparticles. The device comprises a micro-flow injection pump, micro-flow channels, a Y-shaped three-way pipe, a heating plate system for reaction temperature control and a temperature control product collection pool. The channels are parallel and straight, the structure is flat and straight, the solvent circulation resistance is small, and the defect that traditional micro-flow channels are blocked is overcome; the applicability to a platform is strong, and various solvents and various metals can react; the reaction conditions are uniform; and segmented heating is achieved, multi-point accurate regulation and control are achieved, and the large-scale production capacity is achieved.

The invention relates to a low-cost efficient synthesis process of both a chiral catalyst chiral (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine and a hydrochloride thereof. According to the process, rawmaterials which can be commercially obtained easily and are environmentally friendly are used; a one-kettle method is used for operation; through esterification reaction, Boc protecting group addition on amino group, Grignard reaction and Boc protecting group removal, high-optical-purity (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine hydrochloride is obtained. The process is simplified; the production cost is reduced; the requirements of green chemistry at present are met. The content of (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine and the hydrochloride thereof, prepared by the process, is higher than 99.0 percent; the optical purity is not smaller than 99.5 percent; the total yield is higher than 80 percent.

The invention relates to a method for preparing 2-aldehyde oxazole, comprising the steps of selecting commercial material on the market or easily-prepared oxazole as original raw material; dropping n-butyllithium to the organic phase solution of the main material oxazole at low temperature; and adding N-formoxyl piperidine to the reaction system, and obtaining solid lithium salt with high nuclear magnetic purity. The nuclear magnetic purity is higher than 98.0% stably and the yield is 75.0-85.0%. The synthetic method for obtaining 2-aldehyde oxazole by diluted acid hydrolysis has stable process condition, moderate chemical reaction conditions, simple operation and low pollution during the whole production and provides a new idea and a method for preparing 2-aldehyde oxazole.

The present invention relates to a method to produce biodegradable polyester, which comprises the following steps: (a) mixing a carbon source, a nitrogen source and water into a reactive material to perform pretreatment; (b) providing a halophilic bacterium, a starting broth and culture with the reactive material; (c) feeding the reactive material; and (d) extracting the polyester from the fermentation broth; wherein, the bacterium has a salt tolerance of 10-30%.

The method for extracting and refining aloe polysaccharide includes the following steps: uctting fresh leaf of aloe into small block, extracting with water at 40-80 deg.C, filtering extract, centrifugation and taking out supernatant fluid, adding 95% ethyl alcohol in the supernatant fluid, making the ethyl alcohol content be up to 50-80%, precipitating crude aloe polysaccharide, dissolving said crude aloe polysaccharide in water, adding 20-50% trichloroacetic acid or trifluoroacetic acid to make end concentration of trichloroacetic acid or trifluoroacetic acid be up to 2-6%, standing still, then centrifugation to remove precipitate to obtain secondary supernatant fluid, feeding it into macroporous resin column bed and using water to make elution, concentrating and adding 95% ethyl alcohol, precipitating polysaccharide, freeze-drying so as to obtain refined aloe polysaccharide.

The application relates to the technical field of resin synthesis and its application, and specifically discloses a silane-modified acrylic resin, a synthesis method and a primer for silicone rubber. A primer for silicone rubber is prepared by dispersing the above-mentioned silane-modified acrylic resin and silane coupling agent titanate in a solvent for the primer and reacting with a catalyst. The silane-modified acrylic resin of the present application can be used to prepare a primer for silicone rubber, which has the advantages of good adhesion, film-forming property, heat resistance, water resistance, low surface-drying temperature and short time; a silane-modified Acrylic resin, the silane-modified acrylic resin is composed of (meth)acrylic acid alkyl ester monomers, hydroxyl ester monomers, epoxy monomers, vinyl siloxane monomers, cross-linking monomers The silane-modified acrylic resin obtained in this application has excellent cohesive properties and film-forming properties, and is suitable for the preparation of silicone rubber primers. adhesive.

The invention provides a method for preparing a key intermediate of a beta-methylcarbapenem antibiotic. The method comprises the steps that a Dieckmann concentration route is used, beta-methyl-ADC-8 is taken as a starting raw material, so that the synthesis of the key intermediate is firstly solved, and the reaction only requires two steps to form the intermediate. N, N'-dicyclohexylcarbodiimide is taken as a condensating agent for a condensation reaction, and cheap NaH (sodium hydride) is taken as alkali for an alkylation reaction; similarly, the NaH is taken as a catalyst to perform a Dieckmann concentration reaction so that ring-shaped beta-keto ester can be formed with a high yield, and a trapping agent is utilized to remove benzenethiol generated in a system, so as to prevent sulfur ether impurities from being generated in a final product; and a one-pot reaction is adopted to directly perform esterification so that the final product of the key intermediate of the beta-methylcarbapenem antibiotic is formed. The method is mild in reaction condition, simple in operation, stable in processing, high in purity and yield and provides a choice for large-scale production.

The invention relates to a low-cost efficient synthesis process of both a chiral catalyst chiral (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine and a hydrochloride thereof. According to the process, rawmaterials which can be commercially obtained easily and are environmentally friendly are used; a one-kettle method is used for operation; through esterification reaction, Boc protecting group addition on amino group, Grignard reaction and Boc protecting group removal, high-optical-purity (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine hydrochloride is obtained. The process is simplified; the production cost is reduced; the requirements of green chemistry at present are met. The content of (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine and the hydrochloride thereof, prepared by the process, is higher than 99.0 percent; the optical purity is not smaller than 99.5 percent; the total yield is higher than 80 percent.

The invention relates to a method for preparing phenylboronic acid-2-methyl formate. A starting material is a commercial raw material on the market or easy-to-prepare bromobenzoic acid methyl ester; aThe invention relates to a method for preparing phenylboronic acid-2-methyl formate. A starting material is a commercial raw material on the market or easy-to-prepare bromobenzoic acid methyl ester; and under a condition of low temperature, n-butyl lithium is dripped into a mixture of the main raw material of bromobenzoic acid methyl ester and a boric acid ester compound to form the phenylboronicnd under a condition of low temperature, n-butyl lithium is dripped into a mixture of the main raw material of bromobenzoic acid methyl ester and a boric acid ester compound to form the phenylboronicacid-2-methyl formate through hydrolysis. The method has the advantages of readily available raw materials, high reaction purity and yield, stable process conditions, simple operation and suitabilityacid-2-methyl formate through hydrolysis. The method has the advantages of readily available raw materials, high reaction purity and yield, stable process conditions, simple operation and suitabilityfor large-scale production and provides a new thought and means for preparing the phenylboronic acid-2-methyl formate.for large-scale production and provides a new thought and means for preparing the phenylboronic acid-2-methyl formate.

The invention discloses a method for reducing a ketone compound by using two alcohol dehydrogenases. Commercial materials in market or easy-to-obtain ketone compound are selected as initial raw materials, wherein R1 and R2 are respectively C1-C8 straight-chain alkyl, C5-C10 cycloalkyl, C5-C10 aryl or pyridyl group. The aryl or pyridyl group is not substituted or is substituted by one or more following groups: halogen, alkoxy or C1-C5 straight-chain alkyl. The reaction steps comprise feeding, dehydrogenase adding, reaction, and post-treatment. Especially, with the method, high-optical-purity chiral alcohol products can be obtained, and subsequent treatment purification operation is simple and safe. The method has the advantages of stable process condition, simple operation, and suitability for large-scale productions. Novel idea and method are provided for preparing chiral alcohol compounds.

The invention relates to the technical field of medicine synthesis, in particular to a synthesis method of chloroquine phosphate, and particularly provides a synthesis method of high-purity chloroquine phosphate. The synthesis method comprises the following steps: (1) condensation: reacting 4, 7-dichloroquinoline with 2-amido-5-diethylamine pentane to obtain a chloroquine crude product; and (2) refining: recrystallizing to obtain chloroquine with higher purity. (3) salifying: stirring and crystallizing the refined chloroquine and phosphoric acid for 2-3 hours, and filtering to obtain a chloroquine phosphate crude product; and (4) purification: recrystallizing the chloroquine phosphate crude product to obtain high-purity chloroquine phosphate. The method is high in atom utilization rate, high in yield, high in product purity, less in solid waste, beneficial to environmental protection and convenient for industrial application, and has a relatively good industrial prospect.

The invention relates to a method for preparing 2-aldehyde oxazole, comprising the steps of selecting commercial material on the market or easily-prepared oxazole as original raw material; dropping n-butyllithium to the organic phase solution of the main material oxazole at low temperature; and adding N-formoxyl piperidine to the reaction system, and obtaining solid lithium salt with high nuclear magnetic purity. The nuclear magnetic purity is higher than 98.0% stably and the yield is 75.0-85.0%. The synthetic method for obtaining 2-aldehyde oxazole by diluted acid hydrolysis has stable process condition, moderate chemical reaction conditions, simple operation and low pollution during the whole production and provides a new idea and a method for preparing 2-aldehyde oxazole.

The invention provides a method for preparing 5-methylprazine-2-carboxylic acid. The preparation method comprises the steps: using 5-methyl-2and3- pyrazine 2-carboxylic acid as raw material, carrying The invention provides a method for preparing 5-methylprazine-2-carboxylic acid. The preparation method comprises the steps: using 5-methyl-2and3- pyrazine 2-carboxylic acid as raw material, carryingout photophobism reaction in a saturated saline solution, and obtaining 5-methylprazine-2-carboxylic acid as a final product. The preparation method optimizes the process from the source on the basisout photophobism reaction in a saturated saline solution, and obtaining 5-methylprazine-2-carboxylic acid as a final product. The preparation method optimizes the process from the source on the basisof the principle of water decarboxylation, thereby being a method for effective decarboxylation in a saline solution at lower temperature. Moreover, in the preparation method, no organic solvent is adof the principle of water decarboxylation, thereby being a method for effective decarboxylation in a saline solution at lower temperature. Moreover, in the preparation method, no organic solvent is added in the chemical reaction, no pollution is generated, the condition is mild, the reaction in the whole technological process has no high temperature, high selectivity and few by-products, thus theded in the chemical reaction, no pollution is generated, the condition is mild, the reaction in the whole technological process has no high temperature, high selectivity and few by-products, thus thepreparation method is a simple and available pollution-free method which has the capability of large-scale production.preparation method is a simple and available pollution-free method which has the capability of large-scale production.

The invention provides a synthesis method of beta-amino acid derivative and a relative intermediate product, in particular to a synthesis method of the formula (I) and a relative intermediate product.The invention is characterized in that the invention uses commercialized material as formula (II) (trans-, E-type) as initial material, to obtain final product which formula is (III) via chemical reaction with mild condition. The invention has easily accessible starting material and stable technological condition, and is suitable for scaled industrial production.

The invention relates to a synthesizing method, partial intermediate products and final products of a chiral beta-alkamine derivative. The synthesizing method of the chiral beta-alkamine derivative is characterized by comprising the steps of: selecting commercialized materials in the market and NH2R2 as initial materials, wherein R2 is a Cl-C6 alkyl group, a C3-C6 naphthenic base and an aryl group or an aryloxy; obtaining the intermediate products and the final products through a chemical reaction process with moderate conditions, wherein R1 and R2 are the Cl-C6 alkyl group, the C3-C6 naphthenic base and the aryl group or the aryloxy, and a chiral center is in an S or R shape. The invention has the advantages that the adopted materials are easy to obtain and at low price and can meet the requirements of large-scale production, chiral compounds are used as the initial materials, optical purity is retained in consequent reaction without finding racemization, and committed steps accord with the requirements of the current green chemistry; in addition, the invention has the advantages of simple synthesizing method, good selectivity, high yield coefficient, easy operation and good market benefits.