274 results about "Tyrosinase inhibitor" patented technology

The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.

The tyrosinase inhibiting agent of this invention contains a solvent extract from at least one of Gardenia, Sophora and Rosa. When all three are present, it is preferred that the Gardenia extract be in the range of 15-30%, Sophora extract be in the range of 15-30%, and Rosa extract be in the range of 40-65%.

The invention discloses application of an aquilaria sinensis peel extract in preparation of whitening cosmetics. The aquilaria sinensis peel extract is prepared by a method comprising the following steps of: by taking aquilaria sinensis peel as the raw material, extracting the aquilaria sinensis peel through ethyl acetate; and drying an extracting solution to obtain the aquilaria sinensis peel extract. The aquilaria sinensis peel extract has an inhibition effect on tyrosinase and can be used for preparing a tyrosinase inhibitor in order to be applied to the whitening cosmetics.

A cosmetic and dermatological composition comprises 2, 3-dihydro-4-hydroxy-2-oxo-1-H-indole-3-acetic acid (4-hydroxy-1-oxindole-3-acetic acid) as an active ingredient for use as a melanin inhibitor and as an anti-tyrosinase enzyme inhibitor. This composition is excellent as a skin whitening agent. Since it also has potent antioxidant and anti-irritant activities it is useful in a cosmetic composition for improving hyperpigmentation disorders of the skin.

The invention relates to a tyrosinase polypeptide inhibitor, which consists of a polypeptide. In the polypeptide, one or more amino acids are further subjected to acetylation, amidation, formylation, hydroxylation, lipolyzation, methylation or phosphorylation modification. The tyrosinase inhibitor provided by the invention can be taken as a medical composition, comprises the polypeptide, and further comprises a pharmaceutically-acceptable supporting agent. The medicinal composition provided by the invention can be used for inhibiting the generation of black pigments under the action of activity inhibition of tyrosinase, and can be widely applied to cosmetics such as a whitening agent.

The invention discloses a tomato extract as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, cleaning a tomato, crushing and homogenizing to obtain a tomato homogenate liquid; mixing the tomato homogenate liquid and water to obtain a mixed liquid; extracting the mixed liquid by ultrasonic assistance with power of 30-40w for 6-10 minutes; extracting in a water-bath kettle at 45 DEG C for 30-40 minutes after the ultrasonic-assisted extraction; centrifuging on a refrigerated centrifuge at 8000r/min and 4 DEG C for 15 minutes after the extraction is completed so as to obtain supernate; filtering the supernate, controlling the pressure of the filtrate to be 0.08-0.1MPa, and concentrating at reduced pressure and 50-65 DEG C; and controlling the temperature of the concentrated residue to be minus 20-minus 40 DEG C, and freezing and drying to obtain the tomato extract. The extract is capable of inhibiting tyrosinase, can be applied to whitening skin-care products as a tyrosinase inhibitor, is safe and reliable in performance, and does not have side effect. The preparation method is simple, and is convenient to operate.

The invention discloses a hyroxy-pyridone derivative with multiple biological activities. The hyroxy-pyridone derivative has any of the following general molecular formulas (please see the specifications), wherein in the general molecular formula 1, R refers to CH2C6H5 or CH3 or CH(CH3)2 or CH(CH3)CH2CH3 or CHCH2(CH3)2 or CH2CH2SCH3, and R' refers to an alkyl radical or a hydrocarbon oxygroup; in the general molecular formula 2, R and R' refer to CH2C6H5 or CH3 or CH(CH3)2 or CH(CH3)CH2CH3 or CHCH2(CH3)2 or CH2CH2SCH3. The invention further discloses a preparation method of the hyroxy-pyridone derivative. The hyroxy-pyridone derivative can be used as a tyrosinase inhibitor or used for retaining freshness of cosmetics or foods.

The invention relates to a preparation method of Beauveria sp. extract with functiosn of a tyrosinase inhibitor and an antioxidant. The preparation method comprises the following operation steps: 1. selecting and culturing Beauveria sp. Strain; and 2. extracting and refining active components from a fermented product, wherein the refining process comprises primary refining and chromatographic refining. The Beauveria sp. and Beauveria sp. extract provided by the invention have tyrosinase inhibiting and antioxidation active effects, and the refined product has the minimum IC50 (50% inhibiting concentration) of 134.5 mu g/ml to tyrosinase and the minimum IC50 of 87.2 mu g/ml to rat liver cell lipid oxidation; the Beauveria sp. extract can be used as articles for daily use to take into effects of whitening, antioxidation, antiaging, preserving, sterilizing, anti-inflammatory and the like; because the Beauveria sp. extract is produced by microorganism fermentation, the production of the Beauveria sp. extract is not influenced by environment and natural resources, and is easy to industrialize and automatize; the process method has low production cost, simple process, stable process, and high success rate and is easy to adjust and control; and the preparation method is suitable for investment of enterprises in various scales.

Uses of 2-hydroxy-N-(4-hydroxyphenyl)-benzamide compounds in preparation of tyrosinase inhibitors are disclosed. The uses include aspects of (a) preparing the tyrosinase inhibitors or compositions inhibiting tyrosinase, (b) preparing compositions inhibiting melanogenesis and (c) preparing compositions for preventing or treating pigmentary dermatoses. Test results prove that the 2-hydroxy-N-(4-hydroxyphenyl)-benzamide can inhibit activity of intracellular tyrosinase of B16 cells at the cellular level, thus effectively reducing the amount of melanin synthesized by the B16 cells, and therefore the 2-hydroxy-N-(4-hydroxyphenyl)-benzamide compounds can be used for preventing food brownness degeneration, preparing medicines treating hyperpigmentation skin diseases and preparing whitening cosmetics.