This invention enables targeting, personalized measurement, and management of cognitive skills development by users, clinicians, teachers, and parents. The invention features a game based virtual learning curriculum for targeting and developing the underlying cognitive skills of executive functions. The methods and systems of the invention provide an effective and rapid video game-based training curriculum to improve the cognitive skills such as focused attention, sustained attention, cognitive inhibition, behavioral inhibition, selective attention, alternating attention, divided attention, interference control, novelty inhibition, delay of gratification, inner voice, motivational inhibition, and self-regulation. This curriculum utilizes: (i) each of the cognitive processes that underlie attention control and impulse inhibition; (ii) the identification of measurable and trainable cognitive skills; and (iii) game design and game mechanics that effectively train and enable retention of those skills. The game-based system provides a medical professional, clinician, parent, teacher and user with the ability to measure and manage training of targeted cognitive skills to reach a desiredperformance goal.