31 results about "Recurrent Abortions" patented technology

The invention discloses a gene mutant and application thereof. Compared with SEQ ID No. 1, the gene mutant has at least one mutation selected from a group consisting of c.1501C>T mutation and c.17C>T mutation; or compared with SEQ ID No. 2, the gene mutant has at least one mutation selected from a group consisting of c.270G>T mutation and c.1191C>G mutation. Whether a biological sample is prone to recurrent abortion can be effectively detected by detecting existence of the gene mutant in the biological sample.

The invention discloses a natural pharmaceutical composition for treating recurrent abortion, and the natural pharmaceutical composition is characterized by comprising the following effective component raw materials of seventeen drugs of radix rehmanniae, artemisia annua, salvia chinensis, dogwood, parasitic loranthus, acanthopanax fruit, asarum pulchellum, cratoneuron filicinum, bamboo fungus, fruit of argy wormwood, ventilago leiocarpa benth, white atractylodes rhizome, ginseng, pig blood, holothuria leucospilota, semen canavaliae and licorice. The natural pharmaceutical composition for treating recurrent abortion, according to traditional Chinese medicine and pharmacy theory, aims at the etiology and pathogenesis of recurrent abortion, promotes simultaneously the effects of tonifying liver and kidney, invigorating spleen and supplementing qi, clearing heat and nourishing Yin, generating blood and benefitting blood, promoting circulation and removing stasis, and has good clinical curative effect on the recurrent abortion.

The invention belongs to the technical field of traditional Chinese medicines, and relates to a medicine composition for treating recurrent abortion and a method for preparing the medicine composition. The medicine composition comprises fructus lycii, semen cuscutae, fructus broussonetiae, dried radix rehmanniae, cortex moutan, viola japonica, fruits of herba melastomatis dodecandri, cortex eucommiae, semen plantaginis, fructus alpiniae oxyphyllae and rhizoma atractylodis macrocephalae according to certain weight proportions. The medicine composition and the method have the advantages that various medicines are compatible with one another, effects of tonifying kidneys, clearing livers, nourishing and activating blood, consolidating thoroughfare and conception channels and preventing miscarriage can be realized by the aid of meaning of ' same source of livers and kidneys and joint treatment on the livers and the kidneys', ACA (anticardiolipin antibodies) can become negative by means of immunological regulation, fetuses can continue developing, the blood viscosity can be obviously reduced, the circulation flow rates can be increased, platelet aggregation and thrombosis can be resisted, placental micro-circulation can be improved, traditional Chinese medicine symptoms of patients can be treated, and the shortcoming of adverse factors of simple western medicine therapy can be overcome.

The invention provides the application of lncRNA in the diagnosis and treatment of recurrent miscarriage, and belongs to the technical fields of herbal medicine and molecular biology. The present invention found for the first time that the expression level of LINC01088 is closely related to recurrent miscarriage, and its sensitivity and specificity in the diagnosis of recurrent miscarriage are high. Further studies have shown that LINC01088 can inhibit the proliferation and invasion of trophoblast cells, and inhibit the cycle and promote the apoptosis of trophoblasts, leading to miscarriage. Therefore, lncRNAs such as LINC01088, as predictive diagnostic markers and potential therapeutic targets for recurrent miscarriage, play an important role in the diagnosis and treatment of recurrent miscarriage, so they have good practical application value.

The invention discloses a biomarker for auxiliary diagnosis of recurrent abortion and application thereof, and belongs to the technical field of biology. It is found that the migration, invasion and proliferation capacities of trophoblast cells can be changed by changing the LeY oligosaccharide on the MEST, and the MEST and the LeY oligosaccharide on the MEST can serve as biological markers for auxiliary diagnosis of the recurrent abortion, so that prediction and diagnosis of the recurrent abortion are facilitated, the embryo implantation mechanism is deeply understood, and the development of the recurrent abortion is promoted. And a new theoretical basis can be provided for clinical treatment of recurrent abortion taking glycoprotein as a target spot.

The present invention discloses a microorganism associated with recurrent abortion and an application thereof. The specific microorganism is Anaerococcus hydrogenalis and abundance of the Anaerococcushydrogenalis in patients with unexplained recurrent abortion is significantly increased, suggesting that the Anaerococcus hydrogenalis can be used as a microorganism marker applied in an early diagnosis of the unexplained recurrent abortion.

The invention discloses a gene mutant and application thereof. Compared with SEQ ID No. 1, the gene mutant has at least one mutation selected from a group consisting of c.1501C>T mutation and c.17C>T mutation; or compared with SEQ ID No. 2, the gene mutant has at least one mutation selected from a group consisting of c.270G>T mutation and c.1191C>G mutation. Whether a biological sample is prone to recurrent abortion can be effectively detected by detecting existence of the gene mutant in the biological sample.