33 results about "Polyyne" patented technology

A high yield method for chemically synthesizing low polydispersivity carbon microspheres, nanospheres, nanocrystals, nanotubes, or nanofibers comprising dispersing a self-polymerizing end-capped polyyne in a solvent; heating the dispersed self-polymerizing end-capped tetrayne to form a polymeric material selected from the group consisting of polymer microspheres, polymer nanospheres, polymer nanocrystals, polymer nanotubes, and polymer nanofibers; and pyrolyzing the polymeric material to form a carbon material selected from the group consisting of carbon microspheres, carbon nanospheres, carbon nanocrystals carbon nanotubes, and carbon nanofibers, wherein the polydispersivity is less than 2.

The invention belongs to the field of drugs or health care products, and particularly relates to new application of a polyacetylene compound to lowering of uric acid. The polyacetylene compound has astructure shown in a formula (I): R1 and R2 are defined as in the specification. The new application of the polyacetylene compound to lowering of the uric acid is found through a hyperuricemia animalmodel. The polyacetylene compound has the significant effect on lowering the uric acid in a body, and can be used as a potential drug lowering the uric acid or treating gout.

A luminogen exhibiting aggregation induced emission is provided, wherein Tl, T2 and T3 comprise one or more polyynes as a conjugated bridge. Another AIEgen comprising a hydrophilic pydium group as a strong electron- withdrawing group, a piperazine group as an electron-donating group, and a a-cyanostilbene, wherein the AIEgen exhibits aggregation induced emission. A method of synthesizing an AIEgenand a method of labeling are also provided.

The invention belongs to the field of drugs or health care products, and particularly relates to new application of a polyacetylene compound to treating of gout. The polyacetylene compound has a structure shown in a formula (I): R1, R2, R3, and R4 are defined as in the specification. The new application of the polyacetylene compound to treating of gout is found through a hyperuricemia animal model. The polyacetylene compound has the significant effect on lowering the uric acid in a body, and can be used as a potential drug lowering the uric acid or treating gout.

The invention belongs to the technical field of medicines, and relates to a poly-acetylenic acid derivative separated from thesium chinensis, a preparation method of the poly-acetylenic acid derivative, and application in preparing medicines for treating common oral diseases.

The invention belongs to the field of functional polymer materials, and particularly discloses a substituted polyacetylene type water-phase bivalent copper ion detection probe as well as a preparationmethod and application thereof. The preparation method comprises the following steps: taking N-Boc-glycine and propargylamine as raw materials and carrying out amidation reaction to synthesize M-Gly-Boc; initiating M-Gly-Boc to polymerize under the catalysis of an organic rhodium complex, so as to prepare P-Gly-Boc; finally, removing Boc groups through trifluoroacetic acid, and obtaining a substituted polyacetylene type water-phase bivalent copper ion detection probe P-Gly-NH2 with excellent water solubility. The probe prepared by the method disclosed by the invention has specificity on detection of Cu <2+> and high anti-interference capability on other metal ions and anions, and the detection limit is determined to be 0.128 mg / L. According to the method, the practical application value of substituted polyacetylene in the field of recognition and detection is remarkably improved, and a simple, convenient and feasible solution is provided for special detection of Cu <2+> in drinking water.

The invention belongs to the field of chemical medicine, and particularly relates to a hyperuricemia medicine composition and a purpose thereof, including the purpose of a carbene compound in a structure shown as the formula (I) and pharmaceutically acceptable salts, ester, prodrug, a solvate, a polymorphic substance, a hydrate or a derivative of the carbene compound combined with hyperuricemia medicine to preparation of combined medicine for treating hyperuricemia. The invention also provides a hyperuricemia medicine composition. The hyperuricemia medicine composition comprises the compound,and either benzbromarone or lesinurad. The hyperuricemia medicine composition can achieve the equivalent or even better urate lowering effects than the hyperuricemia medicine in the prior art, but thetoxic and side effects of the hyperuricemia medicine can be obviously reduced; the safety is improved; and the hyperuricemia medicine composition can be used for treating hyperuricemia, and gout or gout complications caused by hyperuricemia.

The invention belongs to the field of chemical medicines, and in particular relates to new application of polyacetylenes. The invention discloses polyacetylene with a structure shown as a formula (I)and application of pharmaceutically acceptable salts, esters, prodrugs, solvates, polymorphic substances, hydrates or derivatives of the polyacetylene combined with hyperuricemia medicines in preparation of combined medicines for treating hyperuricemia. The invention also provides a hyperuricemia pharmaceutical composition, which comprises the above compound and one of febuxostat or allopurinol. The hyperuricemia pharmaceutical composition can achieve the uric acid reducing effect equivalent to or even better than that of a hyperuricemia medicine in the prior art, but can obviously reduce thetoxic and side effects of the hyperuricemia medicine and improve the safety, and can be used for treating hyperuricemia and gout or gout complications caused by hyperuricemia.

The invention discloses a method for preparing polyacetylene electrospun nanofibers, and belongs to the field of electrostatic spinning. An electrostatic spinning technique is applied to the method, the type and content of polyacetylene in spinning solutions are controlled, and accordingly, continuous polyacetylene nanofibers of which the diameter distribution is controllable to a certain degree can be obtained. To further improve the performance of the nanofibers, a conventional electrospun high polymer is selected and then blended with the polyacetylene to obtain the composite nanofibers with excellent mechanical properties. Experimental operations involved in the method are simple. The obtained polyacetylene nanofibers are flexible, have optical activity and can be curled, thereby having high applicability.

The invention discloses a stimulation responsive spiral polyyne infrared radiation material which is prepared from bromine-containing alkyne copolymers and amphipathic double-bond containing monomersthrough atom transfer radical polymerization, the material has a structure formula shown in the specification, in the formula, R1 is one of formulae shown in the specification, the polymerization degree m is an integer of 1-1000, n is an integer of 1-1000, and q is an integer of 1-1000. By using an atom transfer radical polymerization method, stimulation responsive spiral polyyne infrared radiation materials of different stimulation response are prepared from the bromine-containing alkyne copolymers and the amphipathic double-bond containing monomers, and through change of temperatures and pHvalues, low infrared emission rate regulation and control at a wave band of 8-14[mu] m are achieved. Meanwhile, the material is simple and convenient in preparation process, gentle in reaction condition, and good in thermal stability and infrared radiation performance regulation and control.

The invention belongs to the technical field of material preparation, and particularly relates to a graphdiyne composite filtering membrane as well as a preparation method and application thereof. According to the preparation method of the graphdiyne composite filtering membrane, the graphdiyne composite filtering membrane is obtained by carrying out coupling reaction on a polyyne compound and a porous material of which the surface contains copper in a solvent. The graphdiyne composite filter membrane obtained by the invention can selectively filter water molecules, potassium ions, sodium ions, magnesium ions, calcium ions, chloride ions and sulfate ions in seawater, that is, the water molecules are allowed to pass through but the potassium ions, the sodium ions, the magnesium ions, the calcium ions, the chloride ions and the sulfate ions are not allowed to pass through. The preparation method of the graphdiyne composite filtering membrane is simple to operate and low in energy consumption, and a hydrophobic graphdiyne layer can be directly grown on the surface of the porous material containing copper on the surface, so that seawater desalination is realized.

The invention relates to a boracic polyacetylene derivative suitable for fluorinion detection and a preparation method thereof, belonging to the technical field of anion detection. The boracic polyacetylene derivative is characterized thatcarbene is taken as the main chain, and the side chain has three-coordination boracic substituent groups for fluorinion detection. The preparation method comprises steps of firstly, synthesizing an alkyne monomer containing the three-coordination boracic substituent group; then, polymerizing in the presence of a catalyst, so as to obtain the designed boracic polyacetylene derivative having the function of detecting fluorinion through fluorescence. According to a polymer sensor, due to the introduction of different Ar groups with electronic transmission function, the molecular designing is more flexible, and the polymer as the detector can improve the detection sensitivity and enhances the stability and processibility of a probe.

The invention relates to a method for the preparation of a coating comprising at least one coating layer on a substrate, the method comprising the steps of a. providing monomers of the type R—(N)x-(L)m-(C═C)n-(L′)o-(N′)y—R′, wherein R is a head moiety, R′ is a tail moiety, (C≡C)n is an oligoyne moiety, L and L′ are linker moieties, N and N′ independently are branched or unbranched optionally substituted C1-C25 alkyl moieties optionally containing 1 to 5 heteroatoms, x, m, o, and y are independently 0 or 1, n is 4 to 12, and wherein the head moiety allows for an interaction with the surface of the substrate; b. bringing the monomers into contact with the substrate wherein the interaction of the head moieties of the monomers with the surface of the substrate induces at least a part of the monomers to align in a defined manner thereby forming a film on the surface and bringing the oligoyne moieties of the monomers into close contact with each other; c. inducing a reaction between oligoyne moieties by providing an external stimulus so as to at least partially cross-link the aligned monomers, thereby forming a coating layer on the substrate. The invention further relates to a coating obtainable according to the method of the invention, the use of a coating obtainable according to the method of the invention, a substrate comprising a coating obtainable according to the invention and the use of solid substrate. The invention further relates to a method for the synthesis of the monomers according to the invention.

The invention discloses a polyacetylene type cowbane extract (S)-Virol C having a following chemical formula shown in the specification. The synthesis of the polyacetylene type cowbane extract (S)-Virol C does not need a chiral source reagent; and as an asymmetric addition method is adopted to obtain an important intermediate with high optical activity, the cost is reduced and the reaction operation and a synthetic route are simplified to ensure that the preparation process is more efficient and environment-friendly.

The invention belongs to the field of medicines, and in particular relates to the use of polyacetylenic compounds for reducing uric acid. The polyalkyne compound has a structure shown in formula (I): R 1 and R 2 As shown in the definition of the description of the present invention. The present invention finds through the animal model of hyperuricemia that the polyalkyne compound of the present invention has significant uric acid-lowering effect in vivo, and can be used as a potential uric acid-lowering or gout-treating drug.

The present application relates to emitters exhibiting aggregation-induced luminescence, wherein T1, T2 and T3 comprise one or more polyynes as conjugate bridges. The present application also relates to an AIEgen comprising: a hydrophilic pyridyl group as a strong electron-withdrawing group; a piperazine group and an α-cyano-stilbene as an electron-donating group; wherein the AIEgen exhibits aggregation induced luminescence. The present application also relates to a method for synthesizing AIEgen, and further relates to a labeling method, the method comprising: incubating an object having cells with a conjugate formed by conjugating AIEgen with an antibody; and selecting by light-up imaging Target cells are selectively stained by AIEgen's fluorescence emission based on antibody degradation following cellular internalization of the conjugate through endocytosis.

The invention belongs to the field of medicines or health care products, and in particular relates to the new application of polyacetylenes in reducing uric acid. The polyalkyne compound has a structure shown in formula (I): R 1 and R 2 As shown in the definition of the description of the present invention. The research of the present invention finds that the polyalkyne compound isolated from Snow Chrysanthemum has uric acid-lowering activity and has no obvious toxic and side effects, and can be used to treat hyperuricemia and gout or gout complications caused by hyperuricemia.

The invention relates to the fields of organic chemistry and metal organic chemistry, and discloses a chain polyacetylene compound, a preparation method of the compound, and an application of the compound to prepare a metal fused heterocyclic compound. The provided chain polyacetylene compound has the structure shown in the formula I. The invention further discloses a preparation method of the chain polyacetylene compound and an application of the chain polyacetylene compound to synthesize the metal fused heterocyclic compound. The chain polyacetylene compound contains multiple functional groups, is controllable in structure, and can be directly used to synthesize the metal fused heterocyclic compound with high efficiency. The chain polyacetylene compound is simple in synthetic method and can be fast effectively obtained.

The invention discloses a single-walled carbon nanotube packaged super-long linear carbon chain and a preparation method thereof. A single-walled carbon nanotube coated one-dimensional super-long linear carbon chain product can be prepared. According to the method, a short carbon chain CnH2 (polyyne) with sp orbit hybrid bonds is packaged in an open single-walled carbon nanotube (SWCNT) in the diameter of 0.6-1.3 nm, and then heat treatment is carried out in an inert gas or high-vacuum environment , and a fusion reaction of a short carbon chain in a confinement space of a single-walled carbon nanotube is utilized to generate an ultra-long linear carbon chain (LLCC), so that the ultra-long linear carbon chain coated with the single-walled carbon nanotube is obtained. The method serves as an effective means for efficiently preparing high-purity single-walled carbon nanotube coated super-long linear carbon chains (LLCC@SWCNT, single-walled carbon nanowires), fills up the blank of single-walled carbon nanowire samples all the time, and provides experimental material guarantee for foundation and application research of sp-based carbon nanomaterials.

The invention belongs to the field of medicines, and in particular relates to the use of a polyalkyne compound for treating gout. The polyalkyne compound has a structure shown in formula (I): R 1 , R 2 , R 3 and R 4 As shown in the definition of the description of the present invention. The present invention finds through the animal model of hyperuricemia that the polyalkyne compound of the present invention has significant uric acid-lowering effect in vivo, and can be used as a potential uric acid-lowering or gout-treating drug.

The present invention relates to the field of functional polymer materials, and discloses a substituted polyacetylene grafted divinyl benzene microsphere chiral chromatographic packing and a preparation method thereof. The preparation method comprises the following steps: (1) carrying out amidation reaction on N-t-butyloxycarboryl-alanine and propargylamine to synthesize M1; (2) carrying out amidation reaction on acryloyl chloride and propargylamine to synthesize M2; (3) initiating copolymerization of M1 and M2 to obtain a copolymer; (4) carrying out copolymerization on divinyl benzene in the presence of an initiator to obtain PDVB microspheres; and (5) carrying out graft copolymerization on the copolymer and the PDVB microspheres under the action of an initiator and a cross-linking agent to obtain a core-shell structure, and dispersing the core-shell structure in a Cu<2+> aqueous solution for helical conformation induction to obtain the chiral chromatographic packing. The defect of poor stability of the spiral polymer-based composite material is overcome, and the stability of the spiral polymer-based composite material is greatly improved by graft copolymerization of double-bond-containing substituted polyacetylene and highly-crosslinked rigid PDVB.

The invention is an infrared microwave compatible stealth composite material based on helical polyyne and its preparation method. The composite material is composed of a propargyl amine monomer containing chiral cholic acid substituents in a core-shell conductive polymer / double metal nickel base The surface of oxide nanomaterials is in-situ polymerized into a composite of helical polyyne. The core-shell conductive polymer / double metal nickel-based oxide nanomaterial is composed of amine conductive polymer monomers on the surface of double metal nickel-based oxides. Self-polymerized, bimetallic nickel-based oxides are prepared from the third main group metal salt and nickel nitrate by hydrothermal reaction and high-temperature roasting, and the helix formed by in-situ polymerization of propargylamine monomers containing chiral cholic acid substituents The general structural formula of the polyyne is: the degree of polymerization n is 500-3000; the thermal decomposition temperature of the polyyne is 200°C-450°C, and the absolute value of the specific optical rotation at room temperature is 5°-70°.

The invention discloses a method for preparing electrostatic spraying polyacetylene particles and belongs to the field of electrostatic spinning. According to the method, an electrostatic spraying technology is utilized, a helix substituted acetylene polymer polyphenylene (PPA) and helix substituted propyne polymers (PFA (perfluoroalkoxy), PSA (polysulfonamide), PCFM, PX (para xylene)) are adoptedas representatives, and polyacetylene particles with uniform particle size distribution can be prepared by controlling the concentration of a polymer electrostatic spraying solution and adjusting related electrostatic spraying parameters. In order to further enrich the types and preparation methods of the polyacetylene particles, a copolymer of two monomers (FA / PA) copolymer and a comixture of polymers (PFA / PPA) of the monomers are further adopted for electrostatic spraying, by adjusting a copolymer composition ratio and a comixture composition ratio, structures, morphologies and chiral properties of particles can be adjusted, and multiple types of morphology adjustable polymer particles can be prepared. The method is simple to operate, uniform in particle size distribution, good in dispersibility and good in applicability.

The present disclosure is directed to a traceless directing group in a radical cascade. The chemo- and regioselectivity of the initial attack in skipped oligoalkynes is controlled by a propargyl alkoxy moiety. Radical translocations lead to the boomerang return of radical center to the site of initial attack where it assists to the elimination of the directing functionality via β-scission in the last step of the cascade. In some aspects, the reaction of the present invention is catalyzed by a stannane moiety, which allows further via facile reactions with electrophiles as well as Stille and Suzuki cross-coupling reactions. This selective radical transformation opens a new approach for the controlled transformation of skipped oligoalkynes into polycyclic ribbons of tunable dimensions.

A method for the synthesis of carbon-based structures, particularly graphene substructures and ribbons, from oligo- and poly-alkyne starting materials.

The invention belongs to the technical field of polymer degradation, and discloses an accurate degradation method of a polyalkyne ester compound. The accurate degradation method comprises the following steps: carrying out accurate degradation reaction on the polyalkyne ester compound and benzamidine in an organic solvent, and carrying out subsequent treatment to obtain a diazacyclo ketone compoundand a diol compound, wherein the diazacyclo ketone compound is an imidazolone compound and / or a pyrimidone compound; and the degradation reaction is carried out in a normal-pressure air environment.The method is simple and can be carried out in a normal-pressure air environment, a catalyst is not needed, a degradation product is easy to purify, and the structure can be regulated and controlled.