96 results about "Optical biosensor" patented technology

Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.

Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.

Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.

The invention relates to compositions and methods for detecting biomolecular interactions. The detection can occur without the use of labels and can be done in a high-throughput manner. The invention further relates to self-referencing colorimetric resonant optical biosensors and optical devices.

An evanescent-wave optical biosensor includes a hollow optical waveguide, preferably in the form of a light-conductive capillary, surrounding a central waveguide preferably in the form of an optical fiber to create a sealed cavity. A source of optical energy as from a laser is directed into one or both of the light-input ends of the capillary and fiber, such that an evanescent field extends into the cavity from one or both of the inner surface of the capillary and the outer surface of the fiber. A first biomolecular constituent is attached to one or both of the inner wall of the hollow optical waveguide and the outer surface of the second optical waveguide, such that the first biomolecular binding partner is substantially within the evanescent field if present. A first optoelectric detector is supported to receive light from the light-output end of the capillary and convert the light received into a first electrical signal, and a second optoelectric detector is supported to receive light from the light-output end of the fiber and convert the light received into a second electrical signal. A fluid within the cavity which may contain a second biomolecular constituent having a binding affinity to the first biomolecular constituent, such that if binding occurs between the biomolecular constituents, a representative change occurs in the light emerging from one or both of the output ends of the hollow and second optical waveguides and the electrical signals from the optoelectric detectors.

Biomolecular and other interactions are analyzed with a simpler construction. A biotic sample is fixed to noble metal nanoparticles, and light is irradiated from a light source to the noble metal nanoparticles through an optical fiber. Light obtained after reflection of the irradiated light by the noble metal nanoparticles is introduced to one or more optical detecting units through another optical fiber. The optical detecting unit(s) separately measure the intensity of the input light in a second band including a maximum absorption wavelength, a first band covering a longer wavelength range than the range covered by the second band, and a third band covering a shorter wavelength range than the range covered by the second band.

A method for performing a blood assay includes the steps of positioning an optical biosensor in fluid communication with a blood vessel whereby blood from the blood vessel contacts the biosensor. The biosensor includes at least one material adapted to bind to an analyte. The method also includes the steps of detecting a change in at least one optical property of the biosensor resulting from binding of the at least one material with the analyte and transmitting a continuous signal representative of the change in at least one optical property of the biosensor to a display module to provide real time analysis by a clinician.

An optical biosensor pixel for detecting the amount of light that is generated by the biosensing process and a biosensor array architecture that includes such biosensor pixels. The optical biosensor pixel includes a photodiode configured to convert an incident photon flux into a current. Additionally, the optical biosensor pixel includes an optical filter configured to select specific wavelengths and / or photon flux angles to reach the photodiode from a biological sample. The biosensor pixel further includes a trans-impedance amplifier coupled to the photodiode, where the trans-impedance amplifier is configured to convert the current into a voltage signal. Additionally, the biosensor pixel includes a 1-bit comparator coupled to the trans-impedance amplifier and a 1-bit digital-to-analog converter coupled to the 1-bit comparator, where the 1-bit digital-to-analog converter injects different levels of charge into an input of the trans-impedance amplifier at each cycle based on an output of the 1-bit comparator.

The invention relates to focusing optics (100) for a biosensor (10) which allow with simple means to accurately image an extended investigation region (13) onto a detector plane (P). To this end, the focusing optics (100) comprises at least two focusing lenslets (LL) that are arranged adjacent to each other such that they image an incident parallel light beam (L2) that is directed along a main optical axis (MOA) onto a common plane (P). The output light beam (L2) that is received by the focusing optics (100) may preferably originate from total internal reflection of a parallel input light beam (L1) at the investigation region (13) of a transparent carrier.

The invention relates to compositions and methods for detecting biomolecular interactions. The detection can occur without the use of labels and can be done in a high-throughput manner. The invention further relates to self-referencing colorimetric resonant optical biosensors and optical devices.