34 results about "Nerve excitability" patented technology

The invention discloses a radiofrequency ablation device which can be used for removing the renal artery sympathetic nerve, reducing excitability of the renal artery sympathetic nerve and curing resistant hypertension. The radiofrequency ablation device comprises an ablation head, a sleeve tube set, a control mechanism and a connector, wherein the ablation head is capable of clamping the tissue and performing radiofrequency ablation operation on the tissue, the sleeve tube set is composed of a plurality of tubes in an embedded mode and enables the ablation head and the control mechanism to be connected together so that the control mechanism can control movement of the ablation head, and the connector is used for enabling a radiofrequency generator to be connected with the radiofrequency ablation device so that radiofrequency energy can be transmitted to the ablation head. When the device is applied, the functions that the renal artery sympathetic nerve is removed, the excitability of the renal artery sympathetic nerve is reduced, blood pressure of a resistant hypertension patient is regulated and controlled are achieved on the basis of the radiofrequency ablation principle.

A neural prosthetic device is provided that includes one or more ion-selective membranes enabled by electrically-controlled local modulation of ion concentrations around a nerve so as to achieve different excitability states of the nerve for electrical stimulation or inhibition of nerve signal propagation. The local modulation is achieved by positioning the nerve in a bipolar perpendicular arrangement so as to modulate the ion concentrations of the one or more ion-selective membranes in situ to change the nerve excitability locally at the site of electrical stimulation or along the nerve for on-demand suppression of nerve propagation.

The invention provides an application of a peptide containing an amino acid sequence YEKLLDTEI or functional variants thereof or pharmaceutical composition containing the peptide in preparation of drugs for preventing, relieving or treating pain, particularly nociceptive pain as well as a method for preventing, relieving or treating the pain.

The invention discloses a treatment patch for acupoint application and belongs to the field of medicines. The treatment patch comprises a bottom liner layer and a cover liner layer. A base material is arranged between the bottom liner layer and the cover liner layer and is prepared from, by weight, far-infrared ceramic powder, acrylic pressure sensitive adhesives, stainless steel beads and drug extracts. Infrared rays with the wavelength being 8-15 microns generated by the far-infrared ceramic powder act on a human body and can penetrate the superficial portion of a human body, and the main biological function is the heat effect. The heat effect can reduce excitability of pain nerves and can also improve blood circulation, accelerate absorbing of morbid substances and inflammatory exudation substances, relieve irritation and pressing on nerve endings, and therefore pain can be relieved. The stainless steel beads stimulate acupoints so that local blood vessels can be expanded, blood flow is increased, blood circulation and microcirculation are improved, and therefore local tissue metabolism and nutrition can be improved, and the treatment patch has the anti-inflammatory detumescence, spasm relieving, pain easing and immunity regulation functions.

The invention discloses a radiofrequency ablation device which is used for removing the vagus nerve of the renal artery and reducing excitability of the renal sympathetic nerve. The radiofrequency ablation device comprises an ablation electrode capable of partially or wholly winding the renal artery and carrying out radiofrequency ablation operation on the renal artery and an operation mechanism for controlling movement of the ablation electrode and achieving the objective that the electrode winds the renal artery. The radiofrequency ablation device is connected with a radio frequency generator, removes the vagus nerve of the renal artery through radiofrequency ablation, reduces excitability of the renal sympathetic nerve and plays a role of regulating the blood pressure of a refractory hypertensive.

The invention provides a traditional Chinese medicine scented sachet for relieving spring drowsiness. The scented sachet is characterized in that medicines in the scented sachet give off persistent aromatic odor, which stimulates the respiratory and sensory organs of the human body to increase nervous excitation; and the scented sachet does not contain substances harmful to the human body, and is applicable to both old and young people.

The invention discloses a Chinese medicine directional sleep instrument, which comprises a sleeping pillow / cushion, an electromagnetic wave generator, and a far infrared thermal energy module, wherein the sleeping pillow / cushion comprises a sleeping pillow / cushion base; the electromagnetic wave generator is composed of permanent magnets and electromagnets for generating an alternating magnetic field; the far infrared thermal energy module is composed of heating cushion filled with carbon fiber heating wires; the electromagnetic wave generator is arranged inside or on the outer surface of the sleeping pillow / cushion base; and the heating cushion is laid in the sleeping pillow / cushion. According to the Chinese medicine directional sleep instrument, the far infrared thermal energy module and the electromagnetic wave generator are arranged at the same time, the far infrared thermal energy module can provide comfortable sleeping warm feeling, microcirculation of a human body can be adjusted, the electromagnetic wave generator generates a biological magnetic field most suitable for the human body, blood circulation of the human body can be improved, the interactive function between the two function units can reach effects of smoothening meridians, increasing blood and oxygen supply of the brain, and reducing terminal nerve excitability of brain, generation of delta waves in the case of sleeping of the human body is promoted, and insomnia symptoms are improved.

The application provides the use of a peptide containing the amino acid sequence YEKLLDTEI or a functional variant thereof or a pharmaceutical composition containing the peptide in the preparation of a drug for preventing, alleviating or treating pain, especially nociceptive pain, and preventing, alleviating or treating way of pain.

The invention discloses new application of sodium houttuyfonate in pharmacy, in particular to the application of the sodium houttuyfonate in preparing medicaments for preventing and treating myocardial hypertrophy and / or ventricular hypertrophy. The application is to prepare an in-vitro myocardial cell hypertrophyby adopting three methods of preparing an in-vivo animal model of myocardial hypertrophy and ventricular hypertrophy, culturing a myocardial cell in vitro and inducing epinephrine by isoproterenol, L-thyroxine and abdominal aorta banding. Experiment results prove that the sodium houttuyfonate can reduce the increase of left cardiac index and global cardiac index of a model animal, inhibit hypertrophy of an in-vitro myocardial cell, reduce the cAMP concentration of plasma, the content of Ang II and ET-1 of a myocardial tissue and the content of TNF-alpha and ALD of serum, and can reduce blood pressure and decrease heart rate. Experiment results suggest that the sodium houttuyfonate has the functions of resisting myocardial hypertrophy and ventricular hypertrophy, and the mechanism of the sodium houttuyfonate can be related to the inhibition of sympathetic activity, blockage of system activity of feritin-hypertensin-aldosterone, and effect of endocrine factors.

A method for treating Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig's disease, in a patient in need thereof comprises administering botulinum toxin to the patient. The botulinum toxin may be administered by subcutaneous or intradermal injection. The injection may be administered to and / or around the vicinity of a trigeminal nerve, a cervical nerve, a thoracic nerve, a lumbar nerve, and / or a sacral nerve of the patient. The administration of the botulinum toxin prevents an overproduction of glutamate, Substance P, and CGRP in a sensory system and thereby inhibits a migration of the glutamate, Substance P, and CGRP to the motor system, which otherwise would cause neuroexcitatory toxicity that results in the death of motor neurons.

The invention discloses a method for improving the protective effect of creatine on excitatory neurotoxicity, establishes an excitotoxic model of SH‑SY5Y cells treated with exogenous nitric oxide donor GSNO, and uses the model to prove that simple muscle Acid factor has a protective effect on neuroexcitotoxicity, but the effect is limited. In the SH‑SY5Y cell model treated with GSNO, the two neural creatine kinases CKBB and CKMT were nitrosylated, and the protein content and enzyme activity of the two were significantly reduced after modification; overexpression denitrosylation The modification enzyme GSNOR can significantly reduce the nitrosylation modification of CKBB and CKMT, and can significantly restore the content and activity of CKBB and CKMT. The present invention can significantly enhance the protective effect of creatine on excitotoxicity in combination with the denitrosylation modification scheme of neural creatine kinase.