34 results about "Meta-Aminobenzoic Acids" patented technology

An organic crystalline state material on the basis of rare earth metal europium, preparation, and fluorescent recognition of antibiotics. The invention belongs to the technical field of crystalline state materials. The chemical molecular formula of the organic crystalline state material is {H3O<+>[EuNa<0.5>(TATAB)(DMF)].(solvent)<x>}n, wherein x and n refers to positive infinity, and H3TATAB refers to 4,4',4"-s-triazine-1,3,5-tri-m-aminobenzoic acid. One Eu<3+> ion and 0.5 Na<+> ion are connected to form a trimetal-cluster basic unit (Eu-Na-Eu) through six oxygen atoms on three TATAB ligands, wherein the binuclear unit is connected to form a three-dimensional network frame through the ligands. The metal-organic frame material has simple synthesis process and high crystalline purity, has a novel structure, is high in stability in a water solution, and can recognize an antibiotic, ornidazole, from a plurality of antibiotic water solutions.

The invention provides a rare earth metal europium-based organic crystalline material, and preparation and application thereof, belonging to the technical field of crystalline materials. The chemical molecular formula of the rare earth metal europium-based organic crystalline material is {[Eu(TATAB)(H2O)2].NMP.H2O}n, wherein n refers to positive infinity and TATAB represents 4,4',4''-s-triazine-1,3,5-tri-m-aminobenzoic acid. A basic unit of a metal frame structure comprises a crystallographically independent Eu<3+> ion and a TATAB ligand; Eu<3+> ions are connected through six oxygen atoms on three TATAB ligands so as to form a double-core basic unit [Eu2(CO2)3]; and double-core basic units are connected via the ligands so as to form a two-dimensional layered network framework. The invention has the advantages that the metal-organic framework material is simple to synthesize and high in crystal purity; the material has a novel structure and has high stability in an organic solvent; and the material can identify iron ions Fe<2+> and Fe<3+> at the same time.

An Eleutheronema rhadinum fry live transport method includes adding tricaine methanesulfonate, YINGJINING for fish, glucose and norfloxacin in transport water body. When transport time is less than 2 hr, inflated water box is adopted, and addition amounts of tricaine methanesulfonate, YINGJINING for fish, glucose and norfloxacin are 15 ppm, 30 ppm, 10 ppm and 2 ppm, respectively. When transport time is longer than 2 hr, oxygenated fry bag is adopted, and addition amounts of tricaine methanesulfonate, YINGJINING for fish, glucose and norfloxacin are 10 ppm, 20 ppm, 50 ppm and 5 ppm, respectively. The invention can reduce stress damage of fish body, and improve transport survival rate.

The invention relates to a rare-earth terbium-based metal organic framework material, a synthesis method and application thereof to antibiotics identification. A chemical molecular formula of the metal organic framework material is {[Tb(TATAB)(H2O)].2H2O}n, wherein TATAB is an organic ligand 4,4',4''-s-triazine-1,3,5-tri-m-aminobenzoic acid. A basic structure unit contains one free terbium ion andone complete 4,4',4''-s-triazine-1,3,5-tri-m-aminobenzoic acid; protons of three carboxyl groups in the ligand are removed and then the carboxyl groups are bridged with the adjacent terbium ion; eachterbium ion is coordinated with five ligands and one water molecule, wherein two carboxyl groups are connected with two different terbium ions respectively to form a three-dimensional network structure. The material is simple to prepare, novel in structure and is stable in a water solution; the material can be used for rapidly detecting metronidazole (MDZ), ornidazole (ODZ), ronidazole (RDZ) anddimetridazole (DTZ) in the water solution.

A transportation method of narcotized fish by atomized anesthetic includes (1) utilizing ethyl 3-aminobenzoate mesylate (abbreviated as MS-222) as anesthetic, and melting the MS-222 into distilled water or purified water to allow the solution concentration to range from 200mg / L to400mg / L and the solution temperature to range from 6 DEG C to 8 DEG C; (2) utilizing a ultrasonic atomizer, and putting the anesthetic solution into a tank of the ultrasonic atomizer to allow the atomized anesthetic to be blown out from a gas guide tube; placing the gas guide tube into a mouth of fish to be narcotized, spraying the atomized anesthetic till the fish stops struggle, and lasting for 5 seconds continuously, namely 10 to 20 seconds for each fish; (3) maintaining a wet environment during transportation of the narcotized fish, placing the narcotized fish into normal water, at temperature at 10 DEG C to 20 DEG C after reaching a destination, oxygenating continuously and allowing the narcotized fish to recover after 10 to 20 minutes.

The invention discloses melamine hapten and antigen as well as a preparation method and application thereof. The preparation method comprises the following steps: 1) diazotizing m-aminobenzoic acid toobtain diazotized ions of the m-aminobenzoic acid shown in the formula III; 2) carrying out coupling reaction on the obtained diazotized ions of the m-aminobenzoic acid and 2-naphthol to obtain the compound shown in the formula I. The experimental results show that the titer of antiserum obtained by utilizing the antigen of the invention to immunize animals can reach 1:3*10<6>, the lowest limit of detection is 0.05ng / mL, the hemi-inhibitory concentration is 0.4ng / mL and the generated antibody has high specificity, high sensitivity and high accuracy. Compared with the existing chromatography,the method of using the antigen and / or antibody of the invention to detect Sudan has the characteristics of low cost, simple operation, easy sample preprocessing, convenience and rapidness and is suitable for large-scale detection. Therefore, the antigen, antibody and detection method of the invention have extensive application prospects.

The invention discloses ertapenem and ertapenem side chains, as well as preparation methods of ertapenem and ertapenem side chains. L-hydroxyproline is protected by p-nitrobenzyl ester to obtain (2S,4R)-4-hydroxyl-1-(((4-Nitrobenzformyl)-oxyl)caboyl)pyrrolidine-2-carboxylic acid; then 4-nitro(1S,4S)-3-oxo-2-thia-5-azabicyclo[2.2.1]heptan-5-carboxylic anhydride can be obtained, and reacts with m-aminobenzoic acid p-nitrobenzyl ester to obtain ertapenem side chain III; and the ertapenem can be synthesized through two-step chemical reaction of condensation and deprotection to the ertapenem side chain III and a raw material MAP. An ertapenem side chain I (10), an ertapenem side chain II (13) and the ertapenem side chain III (2) which are prevailing in the market can be synthesized through simple steps, without the need of ultralow temperature, industrialization is easy, and the product purity is high, and the operation is simple and convenient.

The invention discloses an insecticide for preventing and controlling rice insect pests and a preparation method thereof. The insecticide is prepared from the following components in parts by weight: 20-30 parts of cypermethrin, 10-15 parts of tripterygium wilfordii alkaloids, 8-12 parts of pyrethrum, 5-10 parts of active polypeptide, 0.05-0.08 part of pentaerythritol stearate, 0.1-0.2 part of tricaine methanesulfonate, 2-8 parts of an emulsifier, 0.1-0.5 part of a thickening agent, 5-10 parts of a co-solvent, 0.1-0.5 part of a synergist and 20-30 parts of water. The insecticide has the beneficial effects that the effective ingredients have a synergistic effect, have prevention and control effects higher than that of a single preparation, and can be used for preventing and controlling multiple insect pests; the insecticide has quick-acting and long-acting functions for insect pests, and insect pests cannot generate drug resistance to the insecticide; and the effective ingredients coming from plant sources are widely available and reproducible, can be easily degraded in the natural environment without chemical residue, and do not pollute soil.

The invention discloses a method for rearing juvenile fishes of pampus argenteus. The method comprises the following steps of 1, specification classification, wherein after starving treatment is conducted on the juvenile fishes of pampus argenteus in a rearing system for 24 hours, the juvenile fishes are fished out through a sterilized fishing net and weighed, and the juvenile fishes of pampus argenteus with the weight of 10-15 g are put into a sterilized rearing barrel for an experiment; 2, temporary rearing, wherein the classified juvenile fishes of pampus argenteus are temporarily reared for 10-14 days for physical recovery; 3, rearing, wherein the juvenile fishes of pampus argenteus are starved for 24 hours, drainage is conducted, tricaine methanesulfonate prepared by seawater is added, after the juvenile fishes of pampus argenteus are subjected to deep anesthesia, a medicated bath continues for 0-10 minutes, and seawater is added till the original seawater volume in the step 1 isreached. By means of the method, the strong stress reaction of the juvenile fishes of pampus argenteus in normal operation can be relieved, the survival rate of the juvenile fishes of pampus argenteusis increased, operation such as water replacement, pool separation and fishing in the rearing process of the juvenile fishes of pampus argenteus can be conducted successfully, the exposure time of fish bodies in air is shortened, the death risk of the fishes is reduced, and the development of artificial rearing and fry raising work is facilitated.

The invention discloses a preparation method of a compound as shown in the formula I. The method comprises the following steps: (1) M-aminobenzoic acid and maleic anhydride are mixed and reacted to obtain the compound as shown in the formula II. (2)The compound of formula II and acetic anhydride are mixed and reacted to obtain the compound as shown in the formula III.(3) The compound of the formula III, N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)-carbonyl diimine hydrochloride are mixed and reacted to obtain the compound as shown in the formula IV. And (4) the compound of the formula IV and phosphatidyl ethanolamine are reacted in mixed solvents to obtain the compound as shown in the formula I. The mixed solvent consists of chloroform, methanol and water, the volume ratio thereof is 9: 1: 0.1-9: 0.5; wherein, R represents aliphatic hydrocarbon of C11\C13\C15\C17.

An N-protective group-(2S,4S)-2-[(3-hydroxycarbonyl)-phenylaminoformyl]- pyrrolidine-4-yl thiol as the intermediate of Ertapeinan is prepared through reaction between trans-4-hydroxy-L-phrrolidine and p-nitrobenzylcarbonyl chloride to obtain N-p-nitrobenzyloxy carbonyl-trans-4-hydroxy-4-hydroxy-L-pyrrolidine, reaction by one-pot method to obtain thiolactone, and reaction on meta-aminobenzoic acid.

The invention discloses insect kinin analogs and an application of the insect kinin analogs in control of pests and phytopathogen. A structural formula A of a prepared compound is shown in the specification, wherein Raa represents H and (non-natural) natural amino acids and comprises Gly, beta-Ala, GABA (gamma amino acid butyric acid), Pro, Hyp, Inp, 1-amino-cyclohexanecarboxylic acid, o-aminobenzoic acid, 2-amino-cyclohexanecarboxylic acid, m-aminobenzoic acid, Asp, Asn, N-Me-Ala, N-Me-Val and the like. The novel insect kinin analogs with the formula A are obtained with a method of modification of peptidomimetics, and the analogs are prepared with a solid-phase polypeptide synthesis method. A research proves that a target compound with the formula A has excellent insecticidal activity, particularly has a good control effect on aphids, also has better in-vitro antifungal activity for seven kinds of tested phytopathogen and has further development and application value.

The invention discloses a preparation method and application of a triazine compound with a polyvinyl chloride light stabilization function, belonging to the technical field of functional organic molecule synthesis. The main points of the preparation method are as follows: the triazine compound has a structure; in the invention, low-price m-aminobenzoic acid is taken as an initial raw material, andthe triazine compound with a novel structure is obtained through a series of simple and effective synthesis methods. The triazine compound obtained by the method has good polyvinyl chloride light stabilization function.

The invention discloses a method for measuring the residual quantity of ethyl 3-aminobenzoate in an aquatic product and relates to the technical field of physicochemical detecting of drug residues in aquatic products. An aquatic product sample is extracted through a mixed solution, purified through a QuEChERS reagent bag and centrifuged, and then the drug residual quantity in the aquatic product is measured through HPLC-MS / MS analysis. The method specifically comprises the following steps that preparing is conducted, wherein the fish body is dissected, subjected to homogenate and stored in a refrigerator at the low temperature of minus 20 DEG C; extracting is conducted; purifying is conducted, wherein liquid supernatant is sucked and filtered through 0.22 microns of organic phase filter membrane, and then the HPLC-MS / MS analysis is conducted. The method overcomes the defect that preprocessing is complex or a plurality of kinds of solid phases need to extract columellae for purification in an existing method, and mixed solution extracting is provided. According to the method, interferences are few, preprocessing is easy, convenient and quick, the solvent is saved, and accuracy and sensitivity are achieved.

The invention discloses a method for efficiently anesthetizing a loach parent. The method includes the steps that A, a selected loach parent is fished out, and is placed in a prepared plastic basin after being drained off; B, anesthetic is dissolved in clear water, and is poured into the plastic basin after being dissolved; C, the loach parent reacts fiercely, the upper portion of the plastic basin is covered with another plastic basin so as to prevent the loach parent from jumping out, and anesthesia is completed after 3-5 minutes; D, oxytocic begins to be injected, the loach parent is placed in clear water after injection is completed, and after reviving completely in 5-10 minutes, the loach parent is placed in spawning equipment for awaiting delivery; tricaine methanesulfonate is selected to serve as the anesthetic; the using dosage of the anesthetic is 10 mg / kg, and the anesthetic is dissolved in 10-30 ml of clear water in the using process. The method is easy to implement and simple and convenient to operate, the fast anesthetic effect is achieved through the skin permeation action, and therefore the spawning induction efficiency of loaches is improved obviously.

The invention relates to a synthesis method of a pharmaceutical intermediate m-aminobenzoic acid. The synthesis method mainly comprises: adding 3 mol cuprous chloride, 4-5 mol toluene solution and 5 mol m-nitrobenzoic acid solution to a reaction container, heating the solution to a temperature of 60-70 DEG C, controlling the stirring speed at 110-130 rpm, maintain for 90-110 min, adjusting the pHvalue of the solution to 9-10 with a sodium hydroxide solution, cooling the solution to a temperature of 5-10 DEG C, crystallizing, adding 6 L ethanol solution, washing, washing with a sodium chloridesolution, washing with a nitromethane solution, washing with an ethylenediamine solution, and dewatering with a dewatering agent to obtain the finished product m-aminobenzoic acid.

The invention discloses a high-voltage-resistant m-ABA-SiO2 / alicyclic epoxy resin nano composite insulating material and a preparation method thereof, and the preparation method comprises the following steps: grafting a voltage stabilizer m-amino benzoic acid on SiO2 nano particles, and introducing the SiO2 nano particles into an alicyclic epoxy resin matrix. In the nano composite insulating material disclosed by the invention, a part of charges are trapped under the interface action of the SiO2 nano particles and the alicyclic epoxy resin, and part of high-energy electrons are captured by amino benzoic acid at the same time, so that the charge distribution condition of a matrix under a certain voltage is improved, and the voltage breakdown resistance strength is improved.

The invention relates to an innovation-type preparation method of an ertapenem side chain (represented by the formula 1). The method comprises the steps: (1) with amino protected thiolactone (represented by the formula I) as a raw material, under an acidic condition, with SiO2 and gamma-Al2O3 as carriers, and with a catalyst prepared with palladium as an active ingredient, carrying out a hydrogenation deprotection reaction, to obtain deprotected thiolactone (represented by the formula 2); and (2) carrying out a reaction of the compound 2 and m-aminobenzoic acid, to obtain the target compound (represented by the formula 1). With easily-available, relatively-inexpensive and amino protected thiolactone having a mature preparation process as the raw material, the improved palladium catalyst is innovatively used for hydrogenation deprotection, the compound 2 is obtained, and then the compound 2 is subjected to a reaction with m-aminobenzoic acid to prepare the target compound; the preparation method has the advantages of cheap and easily available raw materials, high product yield, low production cost, economy, safety and environmental protection, and is more suitable for industrialized production.

Provided are macrocyclic compounds having one or more transmembrane segment-thermoresponsive segment moiety. Also provided are dimers comprising two macrocyclic units, which have one or more transmembrane segment-thermoresponsive segment moiety, joined by one or more crosslinking moieties. The macrocyclic compounds and macrocyclic units have a macrocyclic backbone comprise alternating alpha amino acid and meta-aminobenzoic acid moieties. The macrocyclic compounds and dimers can be used to deliver a cargo (e.g., cell-interacting agents such as, for example, drugs and cryoprotectants) to, for example, an organ, tissue, or an individual, A cargo may be encapsulated in lipid vesicles.

The invention relates to a Taiwan loach fertilized egg hatching method without changing water in whole process. According to the method, the temperature of water for hatching is maintained at 23-26 DEG C, and Taiwan loach fertilized eggs are sprinkled on a yarn frame of a hatching pool; the Taiwan loach fertilized eggs are hatched, when egg membranes start to be dissolved, a parathesin mesylate solution is sprayed in the hatching pool, the concentration of the water for hatching thus reaches 1-2 ppm, and the water for hatching is also heated by 1-2 DEG C; after all of the egg membranes are removed, the yarn frame is taken out, an oxygen-increasing machine is kept in an off-state for 10 + / - 5 minutes and then turned on, heating is stopped, high-efficiency EM bacteria are sprayed to adjust the water quality, and the fertilized eggs continue to be placed in the hatching pool for 60-72 hours. By means of the method, water conservation is achieved, the hatching rate is high, the egg membranes can be thoroughly removed, and the little Taiwan loaches are healthy and strong.

The invention discloses ertapenem and ertapenem side chains, as well as preparation methods of ertapenem and ertapenem side chains. L-hydroxyproline is protected by p-nitrobenzyl ester to obtain (2S,4R)-4-hydroxyl-1-(((4-Nitrobenzformyl)-oxyl)caboyl)pyrrolidine-2-carboxylic acid; then 4-nitro(1S,4S)-3-oxo-2-thia-5-azabicyclo[2.2.1]heptan-5-carboxylic anhydride can be obtained, and reacts with m-aminobenzoic acid p-nitrobenzyl ester to obtain ertapenem side chain III; and the ertapenem can be synthesized through two-step chemical reaction of condensation and deprotection to the ertapenem side chain III and a raw material MAP. An ertapenem side chain I (10), an ertapenem side chain II (13) and the ertapenem side chain III (2) which are prevailing in the market can be synthesized through simple steps, without the need of ultralow temperature, industrialization is easy, and the product purity is high, and the operation is simple and convenient.

The invention relates to a synthetic method of a compound and in particular relates to a synthetic method of 2,4,6-trichloro-3-nitrobenzoic acid. The method is characterized by taking m-aminobenzoic acid as a raw material and synthesizing 2,4,6-trichloro-3-nitrobenzoic acid through three steps of chlorination, diazotization and hydrolysis. The synthetic method has the advantages of mild reaction conditions and high yield.

The invention relates to a method for producing m-dimethylaminobenzoic acid. The method comprises the steps: carrying out stirred hydrogenation on m-nitrobenzoic acid, which serves as a raw material, in a manner of taking palladium-on-carbon as a catalyst and taking a mixture of methanol and ethers as a solvent at the temperature of 30 DEG C to 60 DEG C under normal pressure (water column of 30cm to 50cm) so as to produce m-aminobenzoic acid, adding a formaldehyde solution after hydrogen absorption of nitro reduction of a first step is completed, and continuing to carry out stirred hydrogenation under the same temperature and pressure; and stopping the reaction after hydrogen absorption of hydrogenation of a second step is completed, carrying out filtration to recover the catalyst for next-time use, concentrating the filtrate to distill off the solvent, carrying out filtration to collect a product, washing the product with a small volume of water, and then, drying the product at the temperature of 100 DEG C, thereby obtaining the product, i.e., m-dimethylaminobenzoic acid. According to the method, the yield is 90% to 93%, and the melting point is 151 DEG C.

The invention discloses a preparation method of a compound as shown in the formula I. The method comprises the following steps: (1) M-aminobenzoic acid and maleic anhydride are mixed and reacted to obtain the compound as shown in the formula II. (2)The compound of formula II and acetic anhydride are mixed and reacted to obtain the compound as shown in the formula III.(3) The compound of the formula III, N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)-carbonyl diimine hydrochloride are mixed and reacted to obtain the compound as shown in the formula IV. And (4) the compound of the formula IV and phosphatidyl ethanolamine are reacted in mixed solvents to obtain the compound as shown in the formula I. The mixed solvent consists of chloroform, methanol and water, the volume ratio thereof is 9: 1: 0.1-9: 0.5; wherein, R represents aliphatic hydrocarbon of C11\C13\C15\C17.

The invention discloses pandalus borealis flavoring food and a processing technique. The pandalus borealis flavoring food is prepared from, by weight, 200-300 parts of pandalus borealis, 10-20 parts of edible oil, 1-3 parts of Sichuan pepper powder, 3-5 parts of chili powder, 2-4 parts of thirteen spices, 0.02-0.04 part of tricaine methanesulfonate, 0.1-0.2 part of inositol niacinate, 7-9 parts of ginger juice, 8-12 parts of garlic juice, 0.1-0.3 parts of sorbitol, 9-16 parts of lactose and 4-7 parts of salt. The pandalus borealis flavoring food and the processing technique have advantages that original delicate flavor and color of pandalus borealis can be well kept, flavorings are great in flavoring performance, fresh shrimp flavor as well as crispiness of fried products can be achieved, and nutrition loss is low; the processing technique is simple, small in required equipment amount and low in production cost, and the prepared pandalus borealis flavoring food is unique in flavor and different from products on the market in taste.