69 results about "Infertility female" patented technology

The invention discloses a Chinese medicinal composition for treating female infertility and a preparation method thereof. The Chinese medicinal composition comprises the following raw material medicaments: glossy privet fruit, medlar, tuber fleeceflower root, ginseng, raw astragalus, dioscorea root, achyranthes root, white paeony root, szechwon tangshen root, raw rehmannia root, prepared rehmannia root, Chinese angelica, red paeony root, oriental waterplantain rhizome, looasa lateritia gill, mongolian snakegourd root, cassia bark, medcinal evodia fruit, tangerine peel, costus root, nutgrass flatsedge, medicated leaven, malt, motherwort herb, south dodder seed, Chinese leek seed and the like. The Chinese medicinal composition can be prepared into any common oral preparations by a conventional method for preparing traditional Chinese medicinal preparation. The Chinese medicinal composition can improve symptoms such as female infertility and the like caused by deficiency of chon and ren channels, deficiency-cold of uterus, depressed emotion, qi-blood disharmony, stagnation of qi activity, obstruction of chon and ren channels, blood stagnation and coagulation, accumulation of abdominal mass, agglomeration of uterus and the like obviously, has the definite and obvious clinical curative effect and is quick in response. The Chinese medicinal composition also has the advantages of low cost, no toxic or side effect and the like.

The invention relates to a preparation for treating female sterility, in particular to a Chinese medicinal preparation for treating female sterility caused by salpingemphraxis. The Chinese medicinal preparation mainly adopts Chinese medicines by certain weight portion, such as pangolin, pseudo-ginseng, frankincense, safflower, hemlock parsley, peach kernel, rhizoma zedoariae and the like, to play the functions of sterilizing and diminishing inflammation, eliminating stasis to resolve swelling, circulating blood and dissipating stagnation, regulating the menstruation and dispersing ruffian, removing retention and circulating vital energy, dredging and lubricating the intestines on salpinx chronic inflammation, conglutination, hydrops and obstructive obstruction. Compared with the traditional treatment method, the Chinese medicinal prepration has the advantages of treating both principal and secondary aspect of disease without any pain or side effect on a patient with accurate healing efficacy on clinical tests, and significantly improving the cure rate and pregnancy rate after healing.

The present invention discloses a dedicated multi-index protein chip for female infertility detection and a kit thereof. The protein chip consists of a substrate, protein detection indexes arranged on the substrate in an array mode and a contrast coating for the detection indexes. The protein detection indexes cover ovary antigen (OAg), endometrium antigen (EAg), sperm antigen (SAg), zona pellucida antigen (ZAg), human chorionic gonadotropin antigen (HCG), trophoblast antigen (TAg) and cardiolipin antigen (CAg). The present invention overcomes the defects of the existing autoimmunological detection products on market, such as single detection function, lagged detection indexes and no integration. Besides the indexes of the product (patent application No: 200510102466.3), the protein chip also has the ACA index. The density of all indexes can be quantitatively detected, and the cross reaction of all indexes is eliminated. The present invention not only has high specificity and high sensitivity, but also has high accuracy and precision.

The invention relates to a clinical nutrition formula special for female sterility. The clinical nutrition formula contains proteins, amino acid, fat, carbohydrate, dietary fiber, macroelements, microelements, vitamins, dietary essences, medical-edible components, natural plant compounds and new resource food, wherein the dietary essences include black bean powder; the medical-edible components are selected from at least one of mint, poria, liquorice, rhizoma polygonati, chrysanthemum, dandelion, Chinese yam, Chinese dates, Houttuynia cordata, platycodon grandiflorum, honeysuckles and radix puerariae. The preparation method comprises the steps of grinding the components into powder, and preparing corresponding dose forms, wherein the medical-edible components are prepared into powder through water extraction, concentration and spray drying, and the vitamins and the fat are prepared into powder through microencapsulation. Compared with the prior art, the clinical nutrition formula is capable of providing comprehensive nutrition support to patients with female sterility, so that the malnutrition state is improved; meanwhile, by adding the medical-edible components having the efficacies of nourishing kidney, tonifying spleen and soothing liver, the pregnancy of the patients can be promoted.

The invention belongs to the technical field of traditional Chinese medicines and in particular relates to a traditional Chinese medicine composition for treating female infertility and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-10 parts of epimediums, 10-15 parts of semen cuscutae, 10-60 parts of astragalus membranaceus, 5-15 parts of human placenta, 10-15 parts of white atractylodes rhizome, 5-15 parts of angelica, 6-12 parts of ossa sepiae, 5-10 parts of pulp of dogwood fruit, 10-15 parts of fructus lycii, 3-10 parts of scutellaria baicalensis, 6-12 parts of rhizoma cyperi and 3-10 parts of ligusticum wallichii. The traditional Chinese medicine composition has the effects of warming yang, benefiting vital energy, nourishing blood, replenishing essence, regulating vital energy and removing blood stasis; the raw materials are carefully selected, metaplasia of follicle and restoration of reproductive function and organs such as the kidney, the heart, the liver and the spleen are promoted, and a remarkable treatment effect on the female infertility is achieved.

The invention relates to the field of Chinese medicaments, in particular to the field of the Chinese medicaments for treating female physiological maladies, and particularly provides a formula of a Chinese medicament for treating female infertility and a processing method of the Chinese medicament. The formula of the Chinese medicament for treating the female infertility comprises the following components: 5 to 20 grams of blister beetle, 500 grams of rhubarb, and 30 grams of common fennel. The formula of the Chinese medicament for treating the female infertility and the processing method of the Chinese medicament can disperse cold by warming meridians, nourish blood to activate channels, promote blood flow to induce menstrual flow, resolve blood stasis to relieve pain, nourish blood to regulate qi, and effectively relieve and cure female common diseases.

The invention provides a traditional Chinese medicine pill for treating female infertility and a preparation method of the traditional Chinese medicine pill. The traditional Chinese medicine pill is prepared from the following raw materials in parts by weight: 10-30 parts of angelica sinensis, 10-20 parts of salvia miltiorrhiza, 10-30 parts of ligusticum wallichii, 5-15 parts of manis pentadactyla, 30-60 parts of fructus liquidambaris, 5-10 parts of leech, 15-30 parts of American ginseng, 15-30 parts of radix astragali and 5-10 parts of liquorice. According to the traditional Chinese medicine pill, all the traditional Chinese medicines are combined for use and can complement one another; the traditional Chinese medicine pill has the functions of activating blood and dissolving stasis, softening and resolving hard mass, boosting qi and nourishing yin, regulating both qi and blood, and eliminating blood stasis and promoting pregnancy, has the excellent effect of treating female infertility caused by factors such as tubal nowhere, amenorrhea, polycystic ovarian syndrome and premature ovarian failure, and is simple in preparation method, few in toxic and side effects, easy to produce and low in cost; the wide popularization of the traditional Chinese medicine pill is facilitated.

The invention relates to a Chinese medicinal composition for treating oviduct obstruction, and a preparation method and application thereof, in particular to a Chinese medicinal composition for treating oviduct obstruction, and a preparation method of granules and application thereof, and belongs to the field of medicine. The oviduct obstruction or partially passable oviduct is the major cause for female infertility, and the oviduct obstruction cannot be treated by special-effect medicament at present. The Chinese medicinal composition consists of nine medicaments such as Chinese angelica, red paeony root, beautiful sweetgum fruit and the like, and the granules of the Chinese medicinal composition are prepared by aqueous extraction, filtering, alcohol extraction, concentration, drying under reduced pressure, pulverizing and pelleting by adding auxiliary materials. The Chinese medicinal composition has a strict formula, and is particularly suitable for treating the oviduct obstruction which belongs to qi depression to blood stasis in differentiation of traditional Chinese medical science. Experiments verify that the treatment effect is obvious. The Chinese medicinal composition has the advantages of reasonable and feasible preparation process, suitability for industrial production, quick absorption of the granules, quick response, moisture prevention, light resistance, good medicinal stability, clean and attractive appearance, small administration dosage and convenient production, transportation, carrying and storage.

The kidney-strengthening and pregnancy-assisting granule is prepared with 12 kinds of Chinese medicinal materials including angelica, ginseng, pilose antler, desert cistanche, dodder seed, etc. and through crushing, decocting, filtering, concentrating, pelletizing and other technological process. It is used for treating male's and female's sexual dysfunction, kidney deficiency, asexuality and sterility and has high curative effect.

The oral liquid of treating female sterility is prepared with 12 kinds of Chinese medicinal materials including costus root, angelica, bupleurum root, nutagrass flatsedge seed, human placenta, etc. The present invention compounds the essence supplementing ointment based on the Chinese medicine theory of 'regulating menstruation to impregnate' and with the medicine materials possessing functions of dispersing the stagnated liver energy, regulating vital energy, dispersing the depressed vital energy and regulating menstruation. The medicine can regulate women's internal secretion, promote blood circulation and regulate menstruation, and has high and fast curative effect and no side effect.

The invention belongs to the field of traditional Chinese medicines, and provides a traditional Chinese medicine preparation for treating infertility caused by ovulation failure. The traditional Chinese medicine preparation mainly comprises a formula capable of invigorating the kidney and replenishing essence, a formula capable of reinforcing the kidney and activating blood, and a formula capableof accelerating corpus luteum, wherein the formula capable of invigorating the kidney and replenishing essence comprises the following raw material ingredients: 15-24 g of radix rehmanniae praeparata,15-30 g of rhizoma dioscoreae, 12-18 g of fructus corni, 15-20 g of fructus lycii, 15-30 g of herba epimedii, 15-30 g of semen cuscutae, 9-12 g of vinegar-processed testudinis carapax, 12-24 g of herba cistanches, 9-12 g of cornu cervi degelatinatum, 12-18 g of radix angelicae sinensis, 9-15 g of parched paeoniae alba radix, 9-15 g of parched atractylodis macrocephalae rhizome and 6-12 g of endothelium corneum gigeriae galli. According to a rule of mutual transformation between yin and yang as well as qi and blood replenishment and deficiency change during each period of menstruation, follicle development and ovulation can be accelerated, the ovulation rate and the pregnancy rate of the anovulatory infertility can be improved, a clinical curative effect is exact, a pregnancy rate is high,and an ovulation failure problem is solved fundamentally.

The invention belongs to the technical field of gene detection, and particularly discloses a VIII type beta-tubulin gene and kit for detecting primary infertility of females. The human tubulin gene-VIII type tubulin gene, namely the TUBB8 gene, is the reason for female sterility because of immature ova during mutation. By detecting the mutation of the TUBB8 gene, the TUBB8 gene can be used as a market gene for judging female sterility because of immature ova. By the adoption of the TUBB8 gene, the TUBB8 gene can be used for evaluating or preparing a screening kit for female sterility because of immature ova. The provided TUBB8 gene can be used for guiding an operational method for clinically corresponding patients during test-tube baby operations. The TUBB8 gene can be used for evaluating or preparing the screening kit with IVF / ICSI effectiveness.

The invention belongs to the technical field of gene detection, and particularly relates to a kit for detecting mutation of a PATL2 gene for detecting female primary infertility. The mutation of the human PATL2 gene involved in the invention is a reason of female infertility caused by immature ova. Through detection of the mutation of the PATL2 gene, the PATL2 gene can be used as a marker gene for judging the female infertility caused by the immature ova. Through detection of the mutation of the PATL2 gene provided by the invention, the PATL2 gene can be used for evaluating or preparing the kit for screening the female infertility caused by the immature ova. Through judgment of the mutation of the PATL2 gene provided by the invention or not, the PATL2 gene can be used for guiding whether a corresponding clinical patient is suitable for in-vitro fertilization.

The present invention pertains to the art of Chinese medicine products and provides a Chinese medicine for treating female barrenness due to the suppression of ovulation, mainly comprising ginseng, hominis placenta, angelica, codonopsis pilosula, wolfberry and epimedium. After being prepared, the combination synergy effect of all the drugs can adjust female endocrine disorders, improve body immunity and luteal function, facilitate follicle formation, eliminate polycystic ovary, prevent more follicles ovulation, optimize the fertilized egg in the innate and avoid the occurrence of abortion and fetal malformation. Compared with a traditional method, the invention treats both symptom and root cause of the disease, improves ovulation rate, pregnancy rate and fertility rate, has no side effect and protects female health.

The invention discloses a composition for improving ovarian function and improving ovum and embryo quality and application thereof. The invention provides the composition containing nicotinamide mononucleotide, melatonin and coenzyme Q10, the ovulation rate of old animals can be remarkably improved, the maturation rate and fertilization rate of ova and the development rate of early embryos are increased, and the composition has great significance in prevention and treatment of female infertility and in-vitro production of animal embryos. The three active ingredients in the composition are endogenous substances of a biological organism, and side effects cannot be generated from published literatures, so that the safety of the composition serving as a medicine, a health care product or a biological preparation has very high safety.

The invention relates to a traditional Chinese medicine preparation, and specifically relates to a traditional Chinese medicine preparation for treating female infertility. At present, female infertility is a common disease; the disease is caused by multiple reasons, but the main reason is the female endocrine disorder and dyscrasia. The invention provides a traditional Chinese medicine for treating various infertility symptoms caused by female endocrine disorder and dyscrasia, and the traditional Chinese medicine has the advantages of low cost, and no side or toxic effect. The traditional Chinese medicine is composed of the following components in parts by weight: 20 to 30 parts of tortoiseshell, 20 to 30 parts of turtle shell, 20 to 30 parts of wolfberry, 20 to 30 parts of white peony root, 20 to 30 parts of radix rehmanniae preparata, 10 to 20 parts of ginseng, 10 to 20 parts of bighead atractylodes rhizome, 10 to 20 parts of Chinese angelica, 10 to 20 parts of poria cocos, 10 to 20 parts of Chinese magnoliavine, 5 to 15 parts of polygala root, and 5 to 15 parts of licorice.

The invention belongs to the technical field of gene detection, in particular to a PANX1 gene for detecting female primary infertility and a kit for detecting mutation in the gene. The invention includes pointing out for the first time that the mutation in the human PANX1 gene is the cause of female infertility caused by ovum death, thereby providing the PANX1 gene capable of being used as a marker gene for judging female infertility caused by ovum death. The invention further provides a screening kit for detecting the mutation in the PANX1 gene to evaluate female infertility caused by ovum death. Whether the mutation occurs or not in the PANX1 gene provided by the invention can be used for guiding whether a corresponding clinical patient is suitable for in-vitro fertilization surgery or not.

The invention discloses a medicine for treating female infertility, and belongs to the technical field of traditional Chinese medicines. The medicine is prepared from 25 pure traditional Chinese medicinal herbs, has the effects of promoting blood circulation to remove stasis, softening hardness to dissipate stagnation, promoting thrombolysis of obstructed oviduct, repairing tunica intima, regulating internal secretion, promoting development and maturity of ovarian follicle, can be used for treating female infertility caused by endometrium environment imbalance, leucorrhea increase, cervical polyp, intrauterine adhesion, fallopian tube obstruction, ovarian cyst, follicular maldevelopment and other multiple factors. The medicine is reasonable in compatibility, remarkable in drug effect and low in cost, is safe, and does not have side effect.

The invention belongs to the field of reproduction engineering, genetics and proteomics, and particularly relates to a new mutated human zona pellucida protein 1 (ZP1) and a coding gene thereof. The present invention provides a new amino acid sequence PRT of the mutated ZP1 protein capable of causing human zona pellucida-deleted abnormal phenotype (causing infertility in women), deoxynucleotide sequence DNA of the coding gene ZP1, nucleotide sequence mRNA, and deoxynucleotide sequence cDNA synthesized through reverse transcription of the mRNA, wherein the new amino acid sequence PRT is recorded as mutantZP11-404, the deoxynucleotide sequence DNA is recorded as mutantZP1, the nucleotide sequence mRNA is recorded as mutantZP1 (mRNA), and the deoxynucleotide sequence cDNA is recorded as mutantZP1 (cDNA). The present invention further provides two methods for detecting the mutant gene. According to the present invention, the ZP1 protein and the mRNA can be used for protein expression design in the human zona pellucida-deleted disease mechanism research, and the corresponding animal model can be established; and the DNA can be used for analyzing and identifying whether the pathogenic mutation exists in infertile patients, can be adopted as the target gene of the diagnosis of the infertility female patients, and can provide targeting site for the gene therapy of patients.

The present invention provides a drug combination for the treatment of infertility and its crude drug comprises the medical ingredients with their weight proportions listed as below: 10-20 amounts by weight of Rehmannia, 10-20 amounts by weight of Chinese Peony, 10-20 amounts by weight of Asiatic Dogwood, 10-20 amounts by weight of Chinese Yam, 10-20 amounts by weight of Poria, 15-25 amounts by weight of Astragalus, 15-25 amounts by weight of Codonopsis, 10-20 amounts by weight of Epimedium and 10-20 amounts by weight of Jujube. The compatibility of this drug combination invented is precise, appropriate and possess outstanding curative effects. As shown in many experiments, the drug combination invented is safe and reliable, its toxic & side-effect is low and it has obvious improvement effects on female infertility caused by androgen, fallopian tube inflammation, tubal blockage and other factors. Furthermore, it can not only significantly improve the success rate of pregnancy, but also improve immunity and enhance the body's anti-fatigue and hypoxia tolerance. In short, the invention provides a safe and reliable new choice for clinical medication.

The invention discloses a marker BTG4 gene for judging female primary infertility and a detection kit thereof. The invention belongs to the technical field of gene detection, and particularly relatesto a kit for detecting BTG4 gene mutation of female primary infertility. The mutation of the human BTG4 gene provided by the invention can cause female infertility caused by non-cleavage after ovum fertilization, so that the BTG4 gene can be used as a marker gene for judging female infertility caused by non-cleavage after ovum fertilization. The invention further relates to primers for detecting whether the BTG4 gene mutates or not, namely SEQ ID NO.2 to SEQ ID NO.11, and a screening kit for female infertility caused by no cleavage after ovum fertilization. Whether BTG4 gene mutation occurs ornot can also be used for guiding whether a clinical corresponding patient is suitable for test tube infant surgery or not.

The invention is concerned with a kind of Chinese traditional medicine to cure female infertility. It relates to 6 qian angelica, 7 qian root of herbaceous peony, 3 qian chuanxiong rhizome, 2 qian safflower, 4 qian peach kernel, 6 qian seed of celery, 4 qian herba lycopi, 10 qian medlar, 8 qian dried rhizome of adhesive rehmannia, 4 qian cyperirhizome, 8 qian Soda-apple nighe-shade herb and 4 qian pangolin. Take the said Chinese traditional medicines in proportion and dry with water for three times with 2000 g water for each time until leaving for 300 g and take the filtrate. Mix the filtrate of three times and dry with strong fire until 300 g. This herbal medicine has easy compatibility of medicines with simple preparation method with crude herb, and it has good cured effect and low price for infertility female living in remote hamlet far away from villages and towns, and it solves some problem, such as low earning, poor life and shortage of medical treatment condition.

The invention relates to a Chinese medicinal composition for treating oviduct obstruction, and a preparation method and application thereof, in particular to a Chinese medicinal composition for treating oviduct obstruction, and a preparation method of granules and application thereof, and belongs to the field of medicine. The oviduct obstruction or partially passable oviduct is the major cause for female infertility, and the oviduct obstruction cannot be treated by special-effect medicament at present. The Chinese medicinal composition consists of nine medicaments such as Chinese angelica, red paeony root, beautiful sweetgum fruit and the like, and the granules of the Chinese medicinal composition are prepared by aqueous extraction, filtering, alcohol extraction, concentration, drying under reduced pressure, pulverizing and pelleting by adding auxiliary materials. The Chinese medicinal composition has a strict formula, and is particularly suitable for treating the oviduct obstruction which belongs to qi depression to blood stasis in differentiation of traditional Chinese medical science. Experiments verify that the treatment effect is obvious. The Chinese medicinal composition hasthe advantages of reasonable and feasible preparation process, suitability for industrial production, quick absorption of the granules, quick response, moisture prevention, light resistance, good medicinal stability, clean and attractive appearance, small administration dosage and convenient production, transportation, carrying and storage.

The invention relates to the technical field of traditional Chinese medicine, and particularly discloses a traditional Chinese medicine composition used for treating infertility. The traditional Chinese medicine composition is prepared from the following raw herbal materials by weight: 6 to 14 parts of radix curcumae, 1 to 5 parts of zinnober, 4 to 7 parts of Chinese angelica, 3 to 6 parts of carthamus tinctorius, 1 to 3 parts of Chinese wolfberry, and 3 to 8 parts of radix salviae miltiorrhizae. Clinical application shows that the traditional Chinese medicine composition has obvious curative effect in treating female sterility caused by unbalanced Qi and blood, genital tract inflammatory diseases, tubal obstruction, Qi-stagnation, blood stasis and the like, and aphoria caused by spontaneous abortion and the like. Taking the traditional Chinese medicine composition, a patient can be in a favorable environment of getting pregnant, so that the pregnancy probability is improved; the physical function, the immunity and the like of a pregnant patient can also be improved, so as to reduce spontaneous abortion.

The invention belongs to the technical field of traditional Chinese medicine composition preparation and relates to a medicine composition for treating female kidney deficiency sterility. The traditional Chinese medicine composition comprises the following raw materials and components in parts by weight: 13-16 parts of amethyst, 12-15 parts of human placenta powder, 11-15 parts of raspberry powder, 10-15 parts of Chinese dodder seed powder, 12-18 parts of schisandra chinensis powder, 10-15 parts of glossy privet fruit powder, 9-12 parts of eucommia ulmoides powder, 9-12 parts of cornu cervi degelatinatum, 9-12 parts of white mustard seed powder, 8-9 parts of pangolins, 12-16 parts of liquidambar formosana powder, 8-9 parts of spina gleditsiae, 8-12 parts of cowherb seed powder, 15-20 partsof corn cervi pantotrichum, 15-20 parts of swimming bladders and 10-15 parts of ginseng. The medicine composition is reasonable in raw material matching, simple in preparation process, free of side effect, good in treatment effect, low in price, good in effect of balancing yin and yang, nourishing kidney and enriching essence, good in function in activating and nourishing blood, and applicable tofemale deficiency sterility because of kidney deficiency.

The invention relates to a pharmaceutical composite for preventing and curing infertility of female and a preparation method and use thereof. The pharmaceutical composite comprises the following medicines of raw material: radix bupleuri, radix paeoniae alba, cortex moutan, angelica sinensis, rhizoma atractylodis macrocephalae, poria cocos, rhizoma corydalis, radix curcumae, fructus ligustri lucidi, abalone shell, leonurus, costus root, liquorice, mentha haplocalyx and ginger which are optimally prepared into the composite by weight part. The composite of the invention has the characteristics of no side effect, convenient taking, high cure rate and remarkable effect, and is worth popularizing and using in clinic.

The invention belongs to the technical field of gene detection, and particularly relates to a kit for detecting TRIP13 gene mutation of female primary infertility. The invention relates to a human TRIP13 gene, and the mutation of the human TRIP13 gene is a reason for female infertility caused by immature ova. By detecting the mutation of the TRIP13 gene, the TRIP13 gene can be used as a marker gene for judging female infertility caused by immature ova. The TRIP13 gene mutation provided by the invention can be used for evaluating or preparing a screening kit for female infertility caused by immature ova. Whether the TRIP13 gene is mutated or not can be used for guiding whether corresponding clinical patients are suitable for test tube baby operations or not.

Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

A method of genotyping women experiencing infertility for non-physical reasons in order to identify the presence of the rs4238001 and / or rs10846744 mutation of the SCARB1 gene and, upon identifying the presence of one or both genetic mutations, administering a tailored therapeutic regimen to restore fertility by either one or a combination of 1) mediating the flux of cholesterol resulting from the mutation by therapeutic use of the cholesterol medication probucol and / or other cholesterol altering medications, and / or 2) amplifying the presence of hormone progesterone by therapeutic use of progestational and progestin medications.

The invention discloses a medicine for treating female sterility, and belongs to the traditional Chinese medicine technology field. The medicine is composed of the following raw materials, by weight, 10-20 parts of Chinese angelica, 20-30 parts of safflower, 15-25 parts of ligusticum wallichii, 10-20 parts of spatholobus stem, 20-40 parts of radix astragali, 20-40 parts of radix codonopsis, 10-20 parts of morinda officinalis, 10-20 parts of cornus officinalis, 10-20 parts of rhizoma arisaematis, 20-30 parts of fructus liquidambaris, 15-25 parts of Chinese violet, 20-40 parts of licorice, 15-25 parts of mutmeg, 15-25 parts of bighead atractylodes rhizome, 8-16 parts of scutellaria baicalensis, 15-25 parts of motherwort, 5-15 parts of parasitic loranthus, 5-15 parts of semen brassicae, 5-15 parts of rhizoma sparganii, 10-16 parts of rhizoma atractylodis and 10-20 parts of ligustrum lucidum. The medicine has functions of warming kidney, invigorating blood circulation, resolving hard lump, invigorating spleen, tonifying kidney and promoting ovulation, has good curative effects on female sterility, has a low cost, is safe, and has no side effects.