165 results about "Hyposomnia" patented technology

The invention discloses 2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl) acetic acid(I) and an optical isomer(II) thereof; and the invention also discloses a method for preparing the compound and the application of the compound in the preparation of ramelteon which is a medicament for treating insomnia.

The invention discloses a new traditional Chinese medicine combination and a preparation method for malaise, palpitation and insomnia treatment; the traditional Chinese medicine combination includes the following source medicines: prepared rehmannia root, angelica, white paeony root, donkey-hide gelatin, the fruit of Chinese wolfberry, unprepared radix astragali, ginseng, radix codonopsis pilosulae, Chinese yam, rhizoma acori graminei, benzoin, storax, holy basil, spina date seed, semen boitae, cortex albiziae, polygala tenuifolia, amber, dragon's bones, oyster, the root of red-rooted salvia, leonurus, ligusticum wallichii, frankincense, myrrh, rhizoma corydalis, costustoot, rhizoma cyperi, immature bitter orange, radix curcumae, medicated leaven, agilawood and the root of three-nerved spicebush and the like. The traditional Chinese medicine combination can be prepared into any type of common oral preparation according to the conventional traditional Chinese medicine preparation method. The invention can significantly improve the symptoms of malaise, palpitation and insomnia, and also has definite clinical curative effect, significant curative and quick effect. As the traditional Chinese medicine combination basically combines medicinal and edible medicine sources specified in the National Formulary, the traditional Chinese medicine combination has low cost and basically has no toxic and side effect.

The invention discloses 2-(1,6,7,8-tetrahydrogen-2H-indeno-[5,4-b] furan-8-group) acetonitrile (I), an optical isomer (II) thereof, a preparation method of the compound and application of the compound in preparing ramelteon which is a medicament for treating insomnia.

The invention provides a sleeping promoting plus material, which consists of a surface layer 1, a middle layer 2 and a bottom layer 3, wherein the surface layer 1 is a fabric plus material layer and is the outmost layer of the plus material, the middle layer 2 is a plus material layer with the sleeping promoting effect and is arranged between the surface layer 1 and the bottom layer 3, and the bottom layer 3 is a natural fabric plus material layer. The invention discloses the sleeping promoting plus material, which has the advantages that the structure is reasonable, good ventilation performance and sweat absorption performance are realized, simultaneously, the middle layer of the plus material is treated by purpose-made Chinese herbal medicine preparations, the insomnia can be effectively avoided, the sleeping quality is improved, and the sleeping promoting plus material is pure natural and does not have the toxic or side effect. On the basis of the advantages, the plus material can be made into various products such as bed sheets, quilts and mattresses, pillow sleeves, sleep coats and the like, and the market application is very wide.

A Chinese medicine composition for treating depression, insomnia and neurasthenia, its process, quality detection method and uses. The Chinese medicine composition is prepared by using rhizoma zingiberis recens, caulis bambusae in taenia, rhizoma pinelliae preparata, rhizoma coptidis, radix paeoniae alba, ramulus cinnamomi, radix glycyrrhizae preparata, radix bupleuri, concha ostreae, and os draconis.

The invention discloses a traditional Chinese medicine preparation for treating insomnia and preparation method thereof. The preparation is made from (stir-fried) spine date seed and schisandra according to a certain weight proportion by the process of: alcohol extracting the decoction pieces, decompressing and recovering to tastelessness alcohol, concentrating to obtain alcohol extracted concentrated solution and herb residue; decocting the herb residue by water, concentrating the decoction solution and centrifuging; re-concentrating the supernatant, combining with the alcohol extracted concentrated solution, concentrating, drying to extract powder; and adding proper amount of auxiliary material or taste correcting agent and making into granules, capsules tablets or pills. The pharmacological tests shows that: the preparation in the invention has good therapeutic action to insomnia, and can tranquilize the mind.

The invention discloses a Chinese medicinal preparation for treating insomnia. The Chinese medicinal preparation is characterized by consisting of the following components by weight: 6-12 grams of Liaoning Chinese magnoliavine fruit, 6-12 grams of fried spina date seed, 6-12 grams of silktree albizzia flower, 6-12 grams of silktree albizzia bark, 6-12 grams of tuber fleeceflower stem, 6-12 grams of poria with hostwood, 6-12 grams of red-rooted salvia root and 6-12 grams of dried longan pulp. A preparation method of the Chinese medicinal preparation comprises the following step of: grinding the components into find powder. Compared with the prior art, the Chinese medicinal preparation has the advantages of convenience for taking, high curative rate, no toxic or side effect, and capability of curing insomnia within only 3-5 treatment courses.

A Chinese medicine in the form of particles for treating insomnia is prepared from 10 Chinese-medicinal materials including wild jujube, fleece flower stem, Chinese angelica root, ganoderma, etc through proportional mixing, immersing, heating, extracting, decocting, hydrolysis, including, concentrating, drying and granulating.

The invention belongs to the field of traditional Chinese medicine, and discloses herbal decoction for treating insomnia. The herbal decoction is prepared from the following TCM raw materials in parts by weight: 10-20 parts of prepared rhizome of rehmannia, 15-25 parts of Chinese yam, 5-15 parts of Indian buead, 5-15 parts of alisma, 10-20 parts of Chinese angelica, 10-15 parts of rhizoma anemarrhenae, 20-40 parts of spina date seed, 10-20 parts of cortex albiziae, 10-20 parts of tuber fleeceflower stem, 15-25 parts of mistletoe, 20-40 parts of drgonsbones, 10-20 parts of polygala tenuifolia, 15-25 parts of curcuma aromatica, 5-10 parts of coptis chinensis, 5-10 parts of liquorice, 10-20 parts of astragali radix, 5-15 parts of rhizome pinelliae preparatum, 10-15 parts of dried orange peel, 5-15 parts of rosa rugosa, 5-15 parts of tree peony bark, 10-20 parts of radix achyranthis bidentatae, 10-20 parts of polygonum multiflorum, 10-20 parts of shelled cedar seed and 10-20 parts of radix paeoniae alba. The herbal decoction prepared by dialectical compatibility of the traditional Chinese medicines obviously improves the difficulty in falling asleep, difficulty in maintaining sleep, dysphoria, soreness and weakness of waist and knees, mental and physical fatigue and other symptoms of a patient.

The invention relates to a traditional Chinese medicinal composition for treating insomnia. The composition is prepared from the following raw medicinal materials in parts by weight: 27 parts of Huai wheat, 9 parts of liquorice, 9 parts of radix sophorae flavescentis, 6 parts of periostracum cicada, 9 parts of bombyx batryticatus, 9 parts of rhizona gastrodiae, 15 parts of tender uncaria rhynchophylla, 30 parts of kudzu vine root, 12 parts of ligusticum wallichii, 9 parts of soft radix bupleuri, 27 parts of calcined keel, 12 parts of radix curcumae, 9 parts of rhizoma acori graminei, 12 parts of stir-baked fructus gardeniae, 12 parts of scutellaria baicalensis, 12 parts of red peony root, 12 parts of radix paeoniae alba, 27 parts of radix salviae miltiorrhizae, 27 parts of cortex albiziae and 30 parts of tuber fleeceflower stem. The invention also provides an application of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition has the effects of calming the liver and resolving depression, clearing heat, activating blood circulation and calming nerves, has a good curative effect in clinical treatment of liver stagnation type insomnia, and can be used for regulating neurotransmitter and hormone disturbance.

The invention discloses a pharmaceutical composition with the effects of hypnosis, anti-depression and anti-anxiety, and belongs to the traditional Chinese medicine field. The pharmaceutical raw materials of the pharmaceutical composition are: 6 to 40 parts by weight of Szechuan lovage rhizome and 10 to 40 parts by weight of pinellia tuber which are taken as monarch drugs; and 3 to 20 parts by weight of cape jasmine fruit or 1 to 15 parts by weight of golden thread which are taken as ministcrial drugs. The pharmaceutical composition can be prepared into any common preparation form for internal usage. The different adjuvant drugs or guide drugs can be added on the basis of the monarch drugs and the ministcrial drugs according to the different individual differences, so as to play the better efficacy. The pharmaceutical composition of the invention has the effects of hypnosis, anti-depression and anti-anxiety, the efficacy for the treatment of insomnia, depression and anxiety disorder is exact, the onset of action is fast, and the pharmaceutical composition can also be used for the treatment of insomnia, melancholia, headache, palpitation and other diseases of the traditional Chinese medicine.

The invention discloses a medicinal composition for treating insomnia and a preparation method thereof; the medicinal composition is prepared from the following raw materials based on parts by weight: 10-20 parts of radix pseudostellariae, 20-40 parts of root of red-rooted salvia, 10-20 parts of white atractylodes rhizome, 7-15 parts of angelica, 10-20 parts of radix paeoniae alba, 10-20 parts offructus psoraleae, 10-20 parts of processed multiflower knotweed root, 7-15 parts of yam, 10-20 parts of prepared rhizome of rehmannia, 20-40 parts of seed of wild jujube, 10-20 parts of cortex albiziae, 10-20 parts of vine of tuber fleeceflower, 7-15 parts of lotus nut, 7-15 parts of processed liqruice, and 5-8 pieces of fructus ziziphi jujube. The medicine has the characteristics of obvious curative effect, good use effect, safety, convenience and unique effect on insomnia without toxic and side effect; in addition, the medicine can be taken orally, and is also convenient to take and carry.

The invention provides traditional Chinese medicine composition for treating depression insomnia. The traditional Chinese medicine composition is prepared from 30-60 parts by weight of spina date seed extract and 30-60 parts by weight of albizia flower extract, wherein the content of saponin in the spina date seed extract is larger than or equal to 85.0%, and saponin has effects of heart nourishing, mind tranquilizing, sedation, hypnosis, arrhythmia resistance and myocardial ischemia resistance, has certain pressure reduction effect and is one of main components with sedative and hypnotic effects, thereby having quite good effect of improving sleep; the total flavonoid content of the albizia flower extract is larger than or equal to 35%, and flavonoid compounds have effects of depression resistance, anxiety resistance, scavenging of hydroxyl radicals and the like and has significant pharmacological activity in aspects of treatment of depression, schizophrenia, cancer and the like. Therefore, spina date seeds and albizia flowers in the formula form a medicine pair, the composition is simple, convenient, effective and economic, has functions of soothing the liver, relieving depression, tranquilizing mind, regulating qi and harmonizing the stomach, and is used for treating emotional disorder, depression insomnia, chest distress, anorexia and the like.

The invention discloses a production process of the traditional Chinese medicine for treating anhypnia. The production process includes the following steps: 1 weighing spina date seeds, radix paeoniae alba, radix bupleuri and albizia julibrissin, adding ethanol, extracting for 1-4 times through reflux, and combining the filtrate; 2 adding water into the obtained dreg, decocting for 1-4 times, combining the decocted medicine solution, standing, and filtering to obtain filtrate; 3 combining the two kinds of obtained filtrate, concentrating, and drying in vacuum or spray mode; 4 adding water into other four medicines, decocting for 2-4 times, wherein each time lasts for 1-3 hours, combining and decocting the obtained medicine solution, standing, filtering, concentrating the filtrate, and drying in vacuum or spray mode; and 5 performing palletizing on the two obtained powder, drying the powder granules, smashing, sieving, adding magnesium stearate, starch and superfine silica powder, and filling the powder in capsules to obtain the traditional Chinese medicine for treating anhypnia. By means of the technical scheme of the production process, effective part flavonoid can be effectively extracted, simultaneously the extraction rate of the effective part saponins is improved, and accordingly, the curing effect of the 'shumian capsule' is remarkably improved.

The invention provides a processing method of sleep promoting fabric. The processing method comprises the following steps: a) preparing surface-layer yarn strips; b) processing the surface-layer yarn strips; c) preparing intermediate-layer fabric; d) preparing bottom-layer yarn strips; e) processing fabric finished product; f) baking; and g) shaping finished product. According to the invention, the processing method of the sleep promoting fabric is reasonable in working procedure arrangement and simple and convenient in process link operation; the prepared fabric has better air permeability and sweat absorption property; the intermediate layer is processed by special Chinese medicinal herb preparation, thereby effectively improving insomnia and improving sleep quality; the fabric is totally natural and has no toxic or side effect; the fabric can be processed into bedsheet, bedding, pillow cases, pajamas and other products, and is very wide in market application.

An interior-applied Chinese medicine for treating qi and blood deficiency type serious insomnia is prepared from 11 Chinese-medicinal materials including pilose asiabell root, Chinese angelica root, Chuan-xiong rhizome, rehmannia root, etc.

A liposome composition used to prepare the medicines for treating tumor, cardiovascular and cerebrovascular disease, altitude ischemia and insomnia is prepared from the mixture of aspirin, prostaglandin E1, antioxidant, 2-hydroxypropyl-beta-dextrin and gamma-dextrin, the mixture of hydrogenated soybean lecithin and yolk lecithin, and the mixture of soybean sterol, polyethanediol-2000, VC and glycine. Its preparing process is also disclosed.

Disclosed is a Chinese medicament for treating insomnia, which comprises mother-of-pearl 9g, dragon's bone 14g, root of herbaceous peony, dried rehmannia root, tuber fleeceflower stem each 15g, albizia flower 10g, arborviate seed 15g, Chinese angelica root 14g, ligumaloes 3g, bupleurum root 6g, peppermint 6g, 3 Chinese dates, turtle shell, anemarrhena rhizome, yellow corktree bark each 15g, American ginseng or pseudostellaria root, root poria each 12g, wine-treated rhubarb and peach kernel each 10g. The Chinese medicament has simplified recipe, easy preparing process and low price.

Methods of making substituted pyrazolopyrimidines generally and, more particularly, N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl}phenyl)acetamide. Such compounds have utility over a wide range of indications, including treatment of insomnia. In the practice of the present invention, improved techniques which do not require use and / or isolation of the pyrazole intermediate are disclosed, as well as improved techniques for making the reaction intermediates themselves. Such techniques offer significant advantages, including enhanced efficiency, particularly in the context of large scale manufacture.

The invention provides a medicament for treating insomnia, wherein the medicament comprises nine kinds of Chinese medicinal herbs including selfheal, root of herbaceous peony and wild jujuba seeds, and can be made into the dosage forms including capsules, tablets, granules and liquids.

The invention discloses a semen ziziphi spinosae alkaloid monomer composition zizyphusine, and a preparation method and application thereof. Zizyphusine is prepared by performing adsorption on semen ziziphi spinosae medicinal material by macroporous adsorption resin column to obtain semen ziziphi spinosae total alkaloids, performing further separation on extractive by alumina column chromatography, and finally separating eluates by HPLC. The preparation method is stable, repeatable, and high in yield, and the obtained high-purity monomer composition can be used as a contrast sample. Pharmacodynamic experiments show that the semen ziziphi spinosae alkaloid monomer zizyphusine is the active composition of semen ziziphi spinosae for giving play to resolve stagnation for tranquilization, has the effect of preventing and treating insomnia and depression, is applicable to research and development of antidepressants, is free of toxic and side effects, and has no disadvantages such as exciting uneasiness, anuria, constipation, vertigo, tremble and the like possessed by conventional antidepressants.

The invention discloses a traditional Chinese medicine composition for treating menoxenia and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials: 8-12 parts of Colla Corii Asini, 18-22 parts of Rhizoma Polygonati, 18-22 parts of Fructus Jujubae, 8-12 parts of Fructus Lycii, 10-14 parts of Poria cocos, 8-12 parts of Cortex Cinnamomi, 10-14 parts of Pericarpium Citri tangerinae and 8-12 parts of Radix Glycyrrhizae. The traditional Chinese medicine composition has effects of nourishing blood forregulating menstruation, benefiting the liver and kidney, and warming the uterus, and can effectively treat and regulate menoxenia, meanwhile, insomnia is improved, and the living quality of a patientis improved.

The invention discloses a preparing technique of health-care underwear. The preparing technique comprises the following steps of firstly preparing traditional Chinese medicine elements according to a certain percentage and preparing a traditional Chinese medicine mixture according to the determined technical route; secondly, dipping a certain amount of cotton, hemp or mixed fiber into the traditional Chinese medicine mixture and dip dyeing the aforesaid material; thirdly, drying the obtained fiber material for later use; and finally, preparing the obtained fiber material into knitted fabrics or woven fabrics and processing the fabrics to health-care underwear. According to the preparing technique of health-care underwear disclosed by the invention, multiple types of traditional Chinese medicine elements are integrated into the clothes fibers through the reasonable technique, meanwhile the functions of the traditional Chinese medicine are exerted respectively, thus, when the health-care underwear is worn, the health-care underwear can play the roles of calming nerves, tonifying kidney, quenching excessive thirsty and preventing hyposomnia and cardiopalmus and the like.

The invention provides harmonizing and nerves-soothing granules capable of treating insomnia. A preparation method of the harmonizing and nerves-soothing granules capable of treating insomnia comprises the following steps: taking radix bupleuri, scutellaria baicalensis, ginger processed pinellia, codonopsis pilosula, honey-fried licorice root, raw fossil fragments, raw oyster shell, fushen, rhizoma acori graminei and albizia flowers, adding with water with weight being 6-8 times that of the raw materials, decocting for 2-3 times under natural pressure, filtering the decoctions, mixing the filtered decoctions, concentrating the mixed decoction into extract with relative density being 1.30-1.35 (at 80 DEG C), carrying out drying under reduced pressure, grinding into fine powder, adding with a suitable amount of auxiliary material, and pelleting into granules, wherein during the decocting process, each time of decocting lasts for 1.5-2 h. According to the harmonizing and nerves-soothing granules, the pure Chinese herbal medicine components are selected and prepared into medicine in a scientific way, the pure Chinese herbal medicine components are refined and simple in compatibility, and act mutually, the curing basis is sufficient, and the harmonizing and nerves-soothing granules have the efficacies of being rapid in taking effect, safe without toxicity, short in course of treatment, low in cost, high in maturity, free of side effects and dependency, and can treat both symptoms and root causes of diseases.

Though the existing medicines for treating insomnia, both at home and abroad, such as apauvin, seconal, etc. can take effect for a certain time, such medicines can lead to the dependence of patiens on the medicine, meanwhile, sleep quality can not be improved at all. The invention relates to a Chinese herbal medicine which is used for treating insomnia and is made from caulis polygoni multiflori, shizandra berry, rhizome gastrodiae, rauvolfia verticillata, kiskatom, eucommia bark and rhodobryum roseum. The invention has the following advantages: no toxic side effect and no medicine dependence; the medicine is effective for insomnia with various causes, and the medicine taking for days or a week can ensure the user to get rid of the insomnia, with the efficiency as much as 100 percent and the curing rate of over 96 percent.

The invention provides a traditional Chinese medicine composition for calming nerves and helping sleep as well as an external preparation and application thereof. Active components of the traditionalChinese medicine composition comprise, by weight, 8-12 parts of roses, 8-15 parts of albizia flowers, 8-13 parts of juncus effuses, 8-13 parts of rosemary, 8-15 parts of agilawood, 5-12 parts of sandalwood, 8-13 parts of radix aucklandiae and 5-12 parts of agastache rugosus. In the formula, albizia flower is used as a monarch drug for relieving depression and quieting spirit, juncus effusus is used for clearing away the heart-fire and relieving restlessness, rosemary is used for invigorating the spleen and calming the nerves and agilawood is used as a ministerial drug, wherein the three medicines are ministerial drug; the rose is used for promoting qi circulation and relieving depression, and sandalwood, elecampane and agastache rugosus are used for refreshing the spleen and calming the nerves, so that these four medicines are adjuvant drugs; therefore, the whole formula has the effects of dispelling melancholy, soothing the nerves and helping sleep, is suitable for general population,is especially suitable for people difficult to fall asleep, awake early and have dreaminess, and can significantly improve insomnia symptoms.

The invention discloses a traditional Chinese medicine composition for treating insomnia. The traditional Chinese medicine composition for treating insomnia is prepared from the following components in parts by weight of 10-30 parts of spina date seed, 10-20 parts of tuber fleeceflower stem, 10-20 parts of dried radix rehmanniae, 3-8 parts of Chinese-date, 5-15 parts of lily, 5-15 parts of cortex albiziae, 5-15 parts of calcined keel and 3-7 parts of honey-fried licorice root. The traditional Chinese medicine composition is accurate in curative effect, high in total effective rate, low in toxic and side effects, wide in formula drug source, low in price, and good in development and application prospects, and can be prepared into various drugs required for clinic treatment according to common methods of the traditional Chinese pharmacology.

The invention relates to a device for treating insomnia. A constant current generating module is connected to a control module and a power module; the control module is used for controlling the constant current generating module to generate constant current; a first electrode and a second electrode are connected to the constant current generating module; the first electrode is a positive electrode and the second electrode is a negative electrode; power-on currents of the first electrode and the second electrode are more than 0mA and less than 5mA; and power-on durations of the first electrode and the second electrode range from 15min to 40min. Through DC electrical simulation, electroencephalogram signal detection and insomnia diagnosis, and in accordance with the neural electrophysiological characteristics of the insomnia, the insomnia treating device provided by the invention, according to an intensity-duration curve and biological effects of an electrical simulation waveform, can design the electrical simulation waveform which is capable of effectively inducing neurons excitation, and is low in electrode corrosion and free from tissue injury.

The invention relates to a traditional Chinese medicine health-care medicine pillow improving an insomnia symptom. The traditional Chinese medicine health-care medicine pillow is characterized that the medicine formula adopted in the medicine pillow comprises, by weight, 5g-8g of ligusticum wallichii, 5g-8g of eucommia ulmoides, 5g-8g of salviae miltiorrhizae, 5g-8g of cortex moutan, 5g-8g of radix angelicae, 5g-8g of atractylodes macrocephala, 5g-8g of kaori grass, 5g-8g of folium mori, 5g-8g of folium artemisiae argyi, 5g-8g of chrysanthemums, 3g-5g of rhizoma nardostachyos, 3g-5g of mint, 3g-5g of borneol and 3g-5g of cortex albiziae. The traditional Chinese medicinal materials are put into a packing bag with auxiliary materials added, the packing bag is formed by sewing cloth and comprises an inner layer and an outer layer, the traditional Chinese medicinal materials are sealed in the inner bag, one end of the outer bag is provided with an opening enabling the inner bag to be taken and placed, the medicine pillow is manufactured, and the auxiliary materials comprise buckwheat husks, silk floss and plant fibers. The medicine pillow has the advantages that the specific medicinal effect of the traditional Chinese medicinal materials is used, the sleep of people with a poor sleep symptom or potential symptoms is improved, and the adverse effects caused by long-term medication or generated in the treatment process are reduced.

The invention relates to a capsule for treating insomnia, which is prepared from the following raw materials (by weight portions): hairy vein agrimony 200-250 parts, green chiretta 120-160 parts, spatholobus stem 120-160 parts, prepared rehmannia root 120-160 parts, rehmannia root 120-160 parts, mimosa-tree bark 120-160 parts, and tuber of multiflower knotweed 120-160 parts.