164 results about "Hyposomnia" patented technology

Methods of making substituted pyrazolopyrimidines generally and, more particularly, N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl}phenyl)acetamide. Such compounds have utility over a wide range of indications, including treatment of insomnia. In the practice of the present invention, improved techniques which do not require use and / or isolation of the pyrazole intermediate are disclosed, as well as improved techniques for making the reaction intermediates themselves. Such techniques offer significant advantages, including enhanced efficiency, particularly in the context of large scale manufacture.

The invention provides harmonizing and nerves-soothing granules capable of treating insomnia. A preparation method of the harmonizing and nerves-soothing granules capable of treating insomnia comprises the following steps: taking radix bupleuri, scutellaria baicalensis, ginger processed pinellia, codonopsis pilosula, honey-fried licorice root, raw fossil fragments, raw oyster shell, fushen, rhizoma acori graminei and albizia flowers, adding with water with weight being 6-8 times that of the raw materials, decocting for 2-3 times under natural pressure, filtering the decoctions, mixing the filtered decoctions, concentrating the mixed decoction into extract with relative density being 1.30-1.35 (at 80 DEG C), carrying out drying under reduced pressure, grinding into fine powder, adding with a suitable amount of auxiliary material, and pelleting into granules, wherein during the decocting process, each time of decocting lasts for 1.5-2 h. According to the harmonizing and nerves-soothing granules, the pure Chinese herbal medicine components are selected and prepared into medicine in a scientific way, the pure Chinese herbal medicine components are refined and simple in compatibility, and act mutually, the curing basis is sufficient, and the harmonizing and nerves-soothing granules have the efficacies of being rapid in taking effect, safe without toxicity, short in course of treatment, low in cost, high in maturity, free of side effects and dependency, and can treat both symptoms and root causes of diseases.